Synthesis and characterization of binary and ternary complexes of diclofenac with a methyl-β-CD and monoethanolamine and in vitro transdermal evaluation

Autores
Mora, Maria Julia; Longhi, Marcela Raquel; Granero, Gladys Ester
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Here, we describe the chemical characterization of the inclusion complex between diclofenac (DCF) and methyl-β-cyclodextrin (M-β-CD) in the presence or absence of monoethanolamine (MEA). Several techniques were used to analyze the complex both in solution and in the solid state. Solubility of DCF was increased by the addition of M-β-CD. However, the DCF solubility increase was more significant by the addition of M-β-CD in the presence of MEA. In vitro permeation experiments through excised human skin revealed that DCF was enhanced by M-β-CD. Nevertheless, further improvement in the flux and the permeability coefficient of DCF was obtained by the ternary system DCF-M-ß-CD-MEA. The aim of our work was to develop a ternary inclusion complex of diclofenac with methyl-β-cyclodextrin and monoethanolamine. This complex may be a promising formulation for percutaneous administration of diclofenac.
Fil: Mora, Maria Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Granero, Gladys Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Materia
DICLOFENAC
M-Β-CD
MEA
SKIN PERMEATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/187653
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Synthesis and characterization of binary and ternary complexes of diclofenac with a methyl-β-CD and monoethanolamine and in vitro transdermal evaluationMora, Maria JuliaLonghi, Marcela RaquelGranero, Gladys EsterDICLOFENACM-Β-CDMEASKIN PERMEATIONhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Here, we describe the chemical characterization of the inclusion complex between diclofenac (DCF) and methyl-β-cyclodextrin (M-β-CD) in the presence or absence of monoethanolamine (MEA). Several techniques were used to analyze the complex both in solution and in the solid state. Solubility of DCF was increased by the addition of M-β-CD. However, the DCF solubility increase was more significant by the addition of M-β-CD in the presence of MEA. In vitro permeation experiments through excised human skin revealed that DCF was enhanced by M-β-CD. Nevertheless, further improvement in the flux and the permeability coefficient of DCF was obtained by the ternary system DCF-M-ß-CD-MEA. The aim of our work was to develop a ternary inclusion complex of diclofenac with methyl-β-cyclodextrin and monoethanolamine. This complex may be a promising formulation for percutaneous administration of diclofenac.Fil: Mora, Maria Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaFil: Granero, Gladys Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; ArgentinaElsevier2010-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/187653Mora, Maria Julia; Longhi, Marcela Raquel; Granero, Gladys Ester; Synthesis and characterization of binary and ternary complexes of diclofenac with a methyl-β-CD and monoethanolamine and in vitro transdermal evaluation; Elsevier; European Journal of Medical Chemistry; 45; 9; 9-2010; 4079-40880223-52341768-3254CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0223523410004393info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejmech.2010.05.068info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:03:11Zoai:ri.conicet.gov.ar:11336/187653instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:03:11.342CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Synthesis and characterization of binary and ternary complexes of diclofenac with a methyl-β-CD and monoethanolamine and in vitro transdermal evaluation
title Synthesis and characterization of binary and ternary complexes of diclofenac with a methyl-β-CD and monoethanolamine and in vitro transdermal evaluation
spellingShingle Synthesis and characterization of binary and ternary complexes of diclofenac with a methyl-β-CD and monoethanolamine and in vitro transdermal evaluation
Mora, Maria Julia
DICLOFENAC
M-Β-CD
MEA
SKIN PERMEATION
title_short Synthesis and characterization of binary and ternary complexes of diclofenac with a methyl-β-CD and monoethanolamine and in vitro transdermal evaluation
title_full Synthesis and characterization of binary and ternary complexes of diclofenac with a methyl-β-CD and monoethanolamine and in vitro transdermal evaluation
title_fullStr Synthesis and characterization of binary and ternary complexes of diclofenac with a methyl-β-CD and monoethanolamine and in vitro transdermal evaluation
title_full_unstemmed Synthesis and characterization of binary and ternary complexes of diclofenac with a methyl-β-CD and monoethanolamine and in vitro transdermal evaluation
title_sort Synthesis and characterization of binary and ternary complexes of diclofenac with a methyl-β-CD and monoethanolamine and in vitro transdermal evaluation
dc.creator.none.fl_str_mv Mora, Maria Julia
Longhi, Marcela Raquel
Granero, Gladys Ester
author Mora, Maria Julia
author_facet Mora, Maria Julia
Longhi, Marcela Raquel
Granero, Gladys Ester
author_role author
author2 Longhi, Marcela Raquel
Granero, Gladys Ester
author2_role author
author
dc.subject.none.fl_str_mv DICLOFENAC
M-Β-CD
MEA
SKIN PERMEATION
topic DICLOFENAC
M-Β-CD
MEA
SKIN PERMEATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Here, we describe the chemical characterization of the inclusion complex between diclofenac (DCF) and methyl-β-cyclodextrin (M-β-CD) in the presence or absence of monoethanolamine (MEA). Several techniques were used to analyze the complex both in solution and in the solid state. Solubility of DCF was increased by the addition of M-β-CD. However, the DCF solubility increase was more significant by the addition of M-β-CD in the presence of MEA. In vitro permeation experiments through excised human skin revealed that DCF was enhanced by M-β-CD. Nevertheless, further improvement in the flux and the permeability coefficient of DCF was obtained by the ternary system DCF-M-ß-CD-MEA. The aim of our work was to develop a ternary inclusion complex of diclofenac with methyl-β-cyclodextrin and monoethanolamine. This complex may be a promising formulation for percutaneous administration of diclofenac.
Fil: Mora, Maria Julia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Longhi, Marcela Raquel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
Fil: Granero, Gladys Ester. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Unidad de Investigación y Desarrollo en Tecnología Farmacéutica; Argentina
description Here, we describe the chemical characterization of the inclusion complex between diclofenac (DCF) and methyl-β-cyclodextrin (M-β-CD) in the presence or absence of monoethanolamine (MEA). Several techniques were used to analyze the complex both in solution and in the solid state. Solubility of DCF was increased by the addition of M-β-CD. However, the DCF solubility increase was more significant by the addition of M-β-CD in the presence of MEA. In vitro permeation experiments through excised human skin revealed that DCF was enhanced by M-β-CD. Nevertheless, further improvement in the flux and the permeability coefficient of DCF was obtained by the ternary system DCF-M-ß-CD-MEA. The aim of our work was to develop a ternary inclusion complex of diclofenac with methyl-β-cyclodextrin and monoethanolamine. This complex may be a promising formulation for percutaneous administration of diclofenac.
publishDate 2010
dc.date.none.fl_str_mv 2010-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/187653
Mora, Maria Julia; Longhi, Marcela Raquel; Granero, Gladys Ester; Synthesis and characterization of binary and ternary complexes of diclofenac with a methyl-β-CD and monoethanolamine and in vitro transdermal evaluation; Elsevier; European Journal of Medical Chemistry; 45; 9; 9-2010; 4079-4088
0223-5234
1768-3254
CONICET Digital
CONICET
url http://hdl.handle.net/11336/187653
identifier_str_mv Mora, Maria Julia; Longhi, Marcela Raquel; Granero, Gladys Ester; Synthesis and characterization of binary and ternary complexes of diclofenac with a methyl-β-CD and monoethanolamine and in vitro transdermal evaluation; Elsevier; European Journal of Medical Chemistry; 45; 9; 9-2010; 4079-4088
0223-5234
1768-3254
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0223523410004393
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ejmech.2010.05.068
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier
publisher.none.fl_str_mv Elsevier
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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