Aqueous dispersions of oleic acid nanodroplets for thymol encapsulation
- Autores
- Gutiérrez González, Paula; Fernández Peña, Laura; Lucia, Alejandro; Ortega, Francisco; Rubio, Ramón G.; Guzmán, Eduardo
- Año de publicación
- 2024
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- This study focuses on the use of oleic acid to disperse thymol as nanodroplets, stabilized by a mixture of alkylpolyglucoside and lecithin, in an aqueous environment. This approach aims to develop innovative platforms for the encapsulation and release of poorly water-soluble molecules such as thymol, useful for drug delivery and insecticide systems. The results highlight the critical role of controlling the content and concentration of the oil phase (thymol-oleic acid mixture) in achieving optimal thymol dispersion and nanodispersion stability. The interplay between the ability of oleic acid to inhibit thymol crystallization and the maximum dispersible oil amount is crucial. It affects the dispersion of thymol within the nanodroplets and influences coalescence and Ostwald ripening phenomena. The balance between oleic acid and thymol content is key: while oleic acid stabilizes dispersions, higher thymol content increases droplet size, potentially triggering destabilization. The uneven distribution of thymol within the droplets, revealed by fluorescence spectroscopy, suggests that up to three different chemical environments exist. This investigation may pave the way for the development of efficient platforms to improve access to biologically relevant, poorly soluble molecules.
Fil: Gutiérrez González, Paula. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
Fil: Fernández Peña, Laura. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
Fil: Lucia, Alejandro. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ecología y Desarrollo Sustentable; Argentina
Fil: Ortega, Francisco. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
Fil: Rubio, Ramón G.. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
Fil: Guzmán, Eduardo. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España - Materia
-
THYMOL
NANODROPLETS
ENCAPSULATION
NANODISPERSION - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/261812
Ver los metadatos del registro completo
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Aqueous dispersions of oleic acid nanodroplets for thymol encapsulationGutiérrez González, PaulaFernández Peña, LauraLucia, AlejandroOrtega, FranciscoRubio, Ramón G.Guzmán, EduardoTHYMOLNANODROPLETSENCAPSULATIONNANODISPERSIONhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1This study focuses on the use of oleic acid to disperse thymol as nanodroplets, stabilized by a mixture of alkylpolyglucoside and lecithin, in an aqueous environment. This approach aims to develop innovative platforms for the encapsulation and release of poorly water-soluble molecules such as thymol, useful for drug delivery and insecticide systems. The results highlight the critical role of controlling the content and concentration of the oil phase (thymol-oleic acid mixture) in achieving optimal thymol dispersion and nanodispersion stability. The interplay between the ability of oleic acid to inhibit thymol crystallization and the maximum dispersible oil amount is crucial. It affects the dispersion of thymol within the nanodroplets and influences coalescence and Ostwald ripening phenomena. The balance between oleic acid and thymol content is key: while oleic acid stabilizes dispersions, higher thymol content increases droplet size, potentially triggering destabilization. The uneven distribution of thymol within the droplets, revealed by fluorescence spectroscopy, suggests that up to three different chemical environments exist. This investigation may pave the way for the development of efficient platforms to improve access to biologically relevant, poorly soluble molecules.Fil: Gutiérrez González, Paula. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; EspañaFil: Fernández Peña, Laura. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; EspañaFil: Lucia, Alejandro. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ecología y Desarrollo Sustentable; ArgentinaFil: Ortega, Francisco. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; EspañaFil: Rubio, Ramón G.. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; EspañaFil: Guzmán, Eduardo. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; EspañaElsevier Science2024-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/261812Gutiérrez González, Paula; Fernández Peña, Laura; Lucia, Alejandro; Ortega, Francisco; Rubio, Ramón G.; et al.; Aqueous dispersions of oleic acid nanodroplets for thymol encapsulation; Elsevier Science; Colloids and Surfaces A: Physicochemical and Engineering Aspects; 690; 6-2024; 1-90927-7757CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0927775724006368?via%3Dihubinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.colsurfa.2024.133775info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:42:49Zoai:ri.conicet.gov.ar:11336/261812instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:42:49.767CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Aqueous dispersions of oleic acid nanodroplets for thymol encapsulation |
title |
Aqueous dispersions of oleic acid nanodroplets for thymol encapsulation |
spellingShingle |
Aqueous dispersions of oleic acid nanodroplets for thymol encapsulation Gutiérrez González, Paula THYMOL NANODROPLETS ENCAPSULATION NANODISPERSION |
title_short |
Aqueous dispersions of oleic acid nanodroplets for thymol encapsulation |
title_full |
Aqueous dispersions of oleic acid nanodroplets for thymol encapsulation |
title_fullStr |
Aqueous dispersions of oleic acid nanodroplets for thymol encapsulation |
title_full_unstemmed |
Aqueous dispersions of oleic acid nanodroplets for thymol encapsulation |
title_sort |
Aqueous dispersions of oleic acid nanodroplets for thymol encapsulation |
dc.creator.none.fl_str_mv |
Gutiérrez González, Paula Fernández Peña, Laura Lucia, Alejandro Ortega, Francisco Rubio, Ramón G. Guzmán, Eduardo |
author |
Gutiérrez González, Paula |
author_facet |
Gutiérrez González, Paula Fernández Peña, Laura Lucia, Alejandro Ortega, Francisco Rubio, Ramón G. Guzmán, Eduardo |
author_role |
author |
author2 |
Fernández Peña, Laura Lucia, Alejandro Ortega, Francisco Rubio, Ramón G. Guzmán, Eduardo |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
THYMOL NANODROPLETS ENCAPSULATION NANODISPERSION |
topic |
THYMOL NANODROPLETS ENCAPSULATION NANODISPERSION |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
This study focuses on the use of oleic acid to disperse thymol as nanodroplets, stabilized by a mixture of alkylpolyglucoside and lecithin, in an aqueous environment. This approach aims to develop innovative platforms for the encapsulation and release of poorly water-soluble molecules such as thymol, useful for drug delivery and insecticide systems. The results highlight the critical role of controlling the content and concentration of the oil phase (thymol-oleic acid mixture) in achieving optimal thymol dispersion and nanodispersion stability. The interplay between the ability of oleic acid to inhibit thymol crystallization and the maximum dispersible oil amount is crucial. It affects the dispersion of thymol within the nanodroplets and influences coalescence and Ostwald ripening phenomena. The balance between oleic acid and thymol content is key: while oleic acid stabilizes dispersions, higher thymol content increases droplet size, potentially triggering destabilization. The uneven distribution of thymol within the droplets, revealed by fluorescence spectroscopy, suggests that up to three different chemical environments exist. This investigation may pave the way for the development of efficient platforms to improve access to biologically relevant, poorly soluble molecules. Fil: Gutiérrez González, Paula. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España Fil: Fernández Peña, Laura. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España Fil: Lucia, Alejandro. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ecología y Desarrollo Sustentable; Argentina Fil: Ortega, Francisco. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España Fil: Rubio, Ramón G.. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España Fil: Guzmán, Eduardo. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España |
description |
This study focuses on the use of oleic acid to disperse thymol as nanodroplets, stabilized by a mixture of alkylpolyglucoside and lecithin, in an aqueous environment. This approach aims to develop innovative platforms for the encapsulation and release of poorly water-soluble molecules such as thymol, useful for drug delivery and insecticide systems. The results highlight the critical role of controlling the content and concentration of the oil phase (thymol-oleic acid mixture) in achieving optimal thymol dispersion and nanodispersion stability. The interplay between the ability of oleic acid to inhibit thymol crystallization and the maximum dispersible oil amount is crucial. It affects the dispersion of thymol within the nanodroplets and influences coalescence and Ostwald ripening phenomena. The balance between oleic acid and thymol content is key: while oleic acid stabilizes dispersions, higher thymol content increases droplet size, potentially triggering destabilization. The uneven distribution of thymol within the droplets, revealed by fluorescence spectroscopy, suggests that up to three different chemical environments exist. This investigation may pave the way for the development of efficient platforms to improve access to biologically relevant, poorly soluble molecules. |
publishDate |
2024 |
dc.date.none.fl_str_mv |
2024-06 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/261812 Gutiérrez González, Paula; Fernández Peña, Laura; Lucia, Alejandro; Ortega, Francisco; Rubio, Ramón G.; et al.; Aqueous dispersions of oleic acid nanodroplets for thymol encapsulation; Elsevier Science; Colloids and Surfaces A: Physicochemical and Engineering Aspects; 690; 6-2024; 1-9 0927-7757 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/261812 |
identifier_str_mv |
Gutiérrez González, Paula; Fernández Peña, Laura; Lucia, Alejandro; Ortega, Francisco; Rubio, Ramón G.; et al.; Aqueous dispersions of oleic acid nanodroplets for thymol encapsulation; Elsevier Science; Colloids and Surfaces A: Physicochemical and Engineering Aspects; 690; 6-2024; 1-9 0927-7757 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0927775724006368?via%3Dihub info:eu-repo/semantics/altIdentifier/doi/10.1016/j.colsurfa.2024.133775 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science |
publisher.none.fl_str_mv |
Elsevier Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) |
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CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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13.070432 |