Aqueous dispersions of oleic acid nanodroplets for thymol encapsulation

Autores
Gutiérrez González, Paula; Fernández Peña, Laura; Lucia, Alejandro; Ortega, Francisco; Rubio, Ramón G.; Guzmán, Eduardo
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This study focuses on the use of oleic acid to disperse thymol as nanodroplets, stabilized by a mixture of alkylpolyglucoside and lecithin, in an aqueous environment. This approach aims to develop innovative platforms for the encapsulation and release of poorly water-soluble molecules such as thymol, useful for drug delivery and insecticide systems. The results highlight the critical role of controlling the content and concentration of the oil phase (thymol-oleic acid mixture) in achieving optimal thymol dispersion and nanodispersion stability. The interplay between the ability of oleic acid to inhibit thymol crystallization and the maximum dispersible oil amount is crucial. It affects the dispersion of thymol within the nanodroplets and influences coalescence and Ostwald ripening phenomena. The balance between oleic acid and thymol content is key: while oleic acid stabilizes dispersions, higher thymol content increases droplet size, potentially triggering destabilization. The uneven distribution of thymol within the droplets, revealed by fluorescence spectroscopy, suggests that up to three different chemical environments exist. This investigation may pave the way for the development of efficient platforms to improve access to biologically relevant, poorly soluble molecules.
Fil: Gutiérrez González, Paula. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
Fil: Fernández Peña, Laura. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
Fil: Lucia, Alejandro. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ecología y Desarrollo Sustentable; Argentina
Fil: Ortega, Francisco. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
Fil: Rubio, Ramón G.. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
Fil: Guzmán, Eduardo. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
Materia
THYMOL
NANODROPLETS
ENCAPSULATION
NANODISPERSION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/261812
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Aqueous dispersions of oleic acid nanodroplets for thymol encapsulationGutiérrez González, PaulaFernández Peña, LauraLucia, AlejandroOrtega, FranciscoRubio, Ramón G.Guzmán, EduardoTHYMOLNANODROPLETSENCAPSULATIONNANODISPERSIONhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1This study focuses on the use of oleic acid to disperse thymol as nanodroplets, stabilized by a mixture of alkylpolyglucoside and lecithin, in an aqueous environment. This approach aims to develop innovative platforms for the encapsulation and release of poorly water-soluble molecules such as thymol, useful for drug delivery and insecticide systems. The results highlight the critical role of controlling the content and concentration of the oil phase (thymol-oleic acid mixture) in achieving optimal thymol dispersion and nanodispersion stability. The interplay between the ability of oleic acid to inhibit thymol crystallization and the maximum dispersible oil amount is crucial. It affects the dispersion of thymol within the nanodroplets and influences coalescence and Ostwald ripening phenomena. The balance between oleic acid and thymol content is key: while oleic acid stabilizes dispersions, higher thymol content increases droplet size, potentially triggering destabilization. The uneven distribution of thymol within the droplets, revealed by fluorescence spectroscopy, suggests that up to three different chemical environments exist. This investigation may pave the way for the development of efficient platforms to improve access to biologically relevant, poorly soluble molecules.Fil: Gutiérrez González, Paula. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; EspañaFil: Fernández Peña, Laura. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; EspañaFil: Lucia, Alejandro. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ecología y Desarrollo Sustentable; ArgentinaFil: Ortega, Francisco. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; EspañaFil: Rubio, Ramón G.. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; EspañaFil: Guzmán, Eduardo. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; EspañaElsevier Science2024-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/261812Gutiérrez González, Paula; Fernández Peña, Laura; Lucia, Alejandro; Ortega, Francisco; Rubio, Ramón G.; et al.; Aqueous dispersions of oleic acid nanodroplets for thymol encapsulation; Elsevier Science; Colloids and Surfaces A: Physicochemical and Engineering Aspects; 690; 6-2024; 1-90927-7757CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0927775724006368?via%3Dihubinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.colsurfa.2024.133775info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T12:15:30Zoai:ri.conicet.gov.ar:11336/261812instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 12:15:30.908CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Aqueous dispersions of oleic acid nanodroplets for thymol encapsulation
title Aqueous dispersions of oleic acid nanodroplets for thymol encapsulation
spellingShingle Aqueous dispersions of oleic acid nanodroplets for thymol encapsulation
Gutiérrez González, Paula
THYMOL
NANODROPLETS
ENCAPSULATION
NANODISPERSION
title_short Aqueous dispersions of oleic acid nanodroplets for thymol encapsulation
title_full Aqueous dispersions of oleic acid nanodroplets for thymol encapsulation
title_fullStr Aqueous dispersions of oleic acid nanodroplets for thymol encapsulation
title_full_unstemmed Aqueous dispersions of oleic acid nanodroplets for thymol encapsulation
title_sort Aqueous dispersions of oleic acid nanodroplets for thymol encapsulation
dc.creator.none.fl_str_mv Gutiérrez González, Paula
Fernández Peña, Laura
Lucia, Alejandro
Ortega, Francisco
Rubio, Ramón G.
Guzmán, Eduardo
author Gutiérrez González, Paula
author_facet Gutiérrez González, Paula
Fernández Peña, Laura
Lucia, Alejandro
Ortega, Francisco
Rubio, Ramón G.
Guzmán, Eduardo
author_role author
author2 Fernández Peña, Laura
Lucia, Alejandro
Ortega, Francisco
Rubio, Ramón G.
Guzmán, Eduardo
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv THYMOL
NANODROPLETS
ENCAPSULATION
NANODISPERSION
topic THYMOL
NANODROPLETS
ENCAPSULATION
NANODISPERSION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv This study focuses on the use of oleic acid to disperse thymol as nanodroplets, stabilized by a mixture of alkylpolyglucoside and lecithin, in an aqueous environment. This approach aims to develop innovative platforms for the encapsulation and release of poorly water-soluble molecules such as thymol, useful for drug delivery and insecticide systems. The results highlight the critical role of controlling the content and concentration of the oil phase (thymol-oleic acid mixture) in achieving optimal thymol dispersion and nanodispersion stability. The interplay between the ability of oleic acid to inhibit thymol crystallization and the maximum dispersible oil amount is crucial. It affects the dispersion of thymol within the nanodroplets and influences coalescence and Ostwald ripening phenomena. The balance between oleic acid and thymol content is key: while oleic acid stabilizes dispersions, higher thymol content increases droplet size, potentially triggering destabilization. The uneven distribution of thymol within the droplets, revealed by fluorescence spectroscopy, suggests that up to three different chemical environments exist. This investigation may pave the way for the development of efficient platforms to improve access to biologically relevant, poorly soluble molecules.
Fil: Gutiérrez González, Paula. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
Fil: Fernández Peña, Laura. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
Fil: Lucia, Alejandro. Universidad Nacional de Luján. Instituto de Ecología y Desarrollo Sustentable. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Ecología y Desarrollo Sustentable; Argentina
Fil: Ortega, Francisco. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
Fil: Rubio, Ramón G.. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
Fil: Guzmán, Eduardo. Universidad Complutense de Madrid. Facultad de Ciencias Químicas; España
description This study focuses on the use of oleic acid to disperse thymol as nanodroplets, stabilized by a mixture of alkylpolyglucoside and lecithin, in an aqueous environment. This approach aims to develop innovative platforms for the encapsulation and release of poorly water-soluble molecules such as thymol, useful for drug delivery and insecticide systems. The results highlight the critical role of controlling the content and concentration of the oil phase (thymol-oleic acid mixture) in achieving optimal thymol dispersion and nanodispersion stability. The interplay between the ability of oleic acid to inhibit thymol crystallization and the maximum dispersible oil amount is crucial. It affects the dispersion of thymol within the nanodroplets and influences coalescence and Ostwald ripening phenomena. The balance between oleic acid and thymol content is key: while oleic acid stabilizes dispersions, higher thymol content increases droplet size, potentially triggering destabilization. The uneven distribution of thymol within the droplets, revealed by fluorescence spectroscopy, suggests that up to three different chemical environments exist. This investigation may pave the way for the development of efficient platforms to improve access to biologically relevant, poorly soluble molecules.
publishDate 2024
dc.date.none.fl_str_mv 2024-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/261812
Gutiérrez González, Paula; Fernández Peña, Laura; Lucia, Alejandro; Ortega, Francisco; Rubio, Ramón G.; et al.; Aqueous dispersions of oleic acid nanodroplets for thymol encapsulation; Elsevier Science; Colloids and Surfaces A: Physicochemical and Engineering Aspects; 690; 6-2024; 1-9
0927-7757
CONICET Digital
CONICET
url http://hdl.handle.net/11336/261812
identifier_str_mv Gutiérrez González, Paula; Fernández Peña, Laura; Lucia, Alejandro; Ortega, Francisco; Rubio, Ramón G.; et al.; Aqueous dispersions of oleic acid nanodroplets for thymol encapsulation; Elsevier Science; Colloids and Surfaces A: Physicochemical and Engineering Aspects; 690; 6-2024; 1-9
0927-7757
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0927775724006368?via%3Dihub
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.colsurfa.2024.133775
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846782569068101632
score 12.982451

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