Pharmaco-toxicological aspects of thymol in veterinary medicine. A systematic review
- Autores
- Pérez, Denisa Soledad; Giantin, Mery; Pauletto, Marianna; Dacasto, Mauro
- Año de publicación
- 2025
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Introduction: Thymol, a phenolic compound present in essential oils, has shown promising pharmacological properties and potential veterinary applications. This systematic review aims to evaluate the pharmacological and toxicological eects of thymol on animals. Materials and methods: A comprehensive search following PRISMA 2020 guidelines was conducted across databases including PubMed, Scopus, Google Scholar, Web of Science, and LILACS. Various health descriptors, medical subject headings terms, and their synonyms were used to identify studies examining thymol’s eects in animals, including its in vitro, in vivo, and in silico toxicity, as well as its possible environmental impact. Only relevant experimental studies from the last 12 years were included, provided they assessed thymol itself, one of its primary phytoadditive sources, or a blend where thymol was at least as concentrated as other components. The protocol was registered in Open Science Framework (DOI: https://doi.org/10.17605/OSF.IO/B6SF9). Results: A total of 1.472 records were identified, with 176 meeting inclusion criteria. Studies spanned from 2012 to 2024, indicating that thymol exhibits antimicrobial, antiviral, antifungal, antiparasitic, anti-inflammatory, and antioxidant properties, among others. However, thymol displays dosedependent toxicity, especially at high levels, aecting mainly the liver and kidneys. Discussion: Thymol holds substantial potential as a therapeutic agent in veterinary medicine due to its beneficial eects and relatively low toxicity. Nonetheless, further research is needed to establish safe and eective dosages across dierent animal species.
Fil: Pérez, Denisa Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina
Fil: Giantin, Mery. Università di Padova; Italia
Fil: Pauletto, Marianna. Università di Padova; Italia
Fil: Dacasto, Mauro. Università di Padova; Italia - Materia
-
THYMOL
PHARMACOLOGICAL EFFECTS
TOXICOLOGICAL EFFECTS
VETERINARY APPLICATIONS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/269605
Ver los metadatos del registro completo
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Pharmaco-toxicological aspects of thymol in veterinary medicine. A systematic reviewPérez, Denisa SoledadGiantin, MeryPauletto, MariannaDacasto, MauroTHYMOLPHARMACOLOGICAL EFFECTSTOXICOLOGICAL EFFECTSVETERINARY APPLICATIONShttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4Introduction: Thymol, a phenolic compound present in essential oils, has shown promising pharmacological properties and potential veterinary applications. This systematic review aims to evaluate the pharmacological and toxicological eects of thymol on animals. Materials and methods: A comprehensive search following PRISMA 2020 guidelines was conducted across databases including PubMed, Scopus, Google Scholar, Web of Science, and LILACS. Various health descriptors, medical subject headings terms, and their synonyms were used to identify studies examining thymol’s eects in animals, including its in vitro, in vivo, and in silico toxicity, as well as its possible environmental impact. Only relevant experimental studies from the last 12 years were included, provided they assessed thymol itself, one of its primary phytoadditive sources, or a blend where thymol was at least as concentrated as other components. The protocol was registered in Open Science Framework (DOI: https://doi.org/10.17605/OSF.IO/B6SF9). Results: A total of 1.472 records were identified, with 176 meeting inclusion criteria. Studies spanned from 2012 to 2024, indicating that thymol exhibits antimicrobial, antiviral, antifungal, antiparasitic, anti-inflammatory, and antioxidant properties, among others. However, thymol displays dosedependent toxicity, especially at high levels, aecting mainly the liver and kidneys. Discussion: Thymol holds substantial potential as a therapeutic agent in veterinary medicine due to its beneficial eects and relatively low toxicity. Nonetheless, further research is needed to establish safe and eective dosages across dierent animal species.Fil: Pérez, Denisa Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; ArgentinaFil: Giantin, Mery. Università di Padova; ItaliaFil: Pauletto, Marianna. Università di Padova; ItaliaFil: Dacasto, Mauro. Università di Padova; ItaliaFrontiers Media2025-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/269605Pérez, Denisa Soledad; Giantin, Mery; Pauletto, Marianna; Dacasto, Mauro; Pharmaco-toxicological aspects of thymol in veterinary medicine. A systematic review; Frontiers Media; Frontiers in Veterinary Science; 12; 8-2025; 1-412297-1769CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/journals/veterinary-science/articles/10.3389/fvets.2025.1562641/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fvets.2025.1562641info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:18:11Zoai:ri.conicet.gov.ar:11336/269605instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:18:11.355CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Pharmaco-toxicological aspects of thymol in veterinary medicine. A systematic review |
title |
Pharmaco-toxicological aspects of thymol in veterinary medicine. A systematic review |
spellingShingle |
Pharmaco-toxicological aspects of thymol in veterinary medicine. A systematic review Pérez, Denisa Soledad THYMOL PHARMACOLOGICAL EFFECTS TOXICOLOGICAL EFFECTS VETERINARY APPLICATIONS |
title_short |
Pharmaco-toxicological aspects of thymol in veterinary medicine. A systematic review |
title_full |
Pharmaco-toxicological aspects of thymol in veterinary medicine. A systematic review |
title_fullStr |
Pharmaco-toxicological aspects of thymol in veterinary medicine. A systematic review |
title_full_unstemmed |
Pharmaco-toxicological aspects of thymol in veterinary medicine. A systematic review |
title_sort |
Pharmaco-toxicological aspects of thymol in veterinary medicine. A systematic review |
dc.creator.none.fl_str_mv |
Pérez, Denisa Soledad Giantin, Mery Pauletto, Marianna Dacasto, Mauro |
author |
Pérez, Denisa Soledad |
author_facet |
Pérez, Denisa Soledad Giantin, Mery Pauletto, Marianna Dacasto, Mauro |
author_role |
author |
author2 |
Giantin, Mery Pauletto, Marianna Dacasto, Mauro |
author2_role |
author author author |
dc.subject.none.fl_str_mv |
THYMOL PHARMACOLOGICAL EFFECTS TOXICOLOGICAL EFFECTS VETERINARY APPLICATIONS |
topic |
THYMOL PHARMACOLOGICAL EFFECTS TOXICOLOGICAL EFFECTS VETERINARY APPLICATIONS |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/4.3 https://purl.org/becyt/ford/4 |
dc.description.none.fl_txt_mv |
Introduction: Thymol, a phenolic compound present in essential oils, has shown promising pharmacological properties and potential veterinary applications. This systematic review aims to evaluate the pharmacological and toxicological eects of thymol on animals. Materials and methods: A comprehensive search following PRISMA 2020 guidelines was conducted across databases including PubMed, Scopus, Google Scholar, Web of Science, and LILACS. Various health descriptors, medical subject headings terms, and their synonyms were used to identify studies examining thymol’s eects in animals, including its in vitro, in vivo, and in silico toxicity, as well as its possible environmental impact. Only relevant experimental studies from the last 12 years were included, provided they assessed thymol itself, one of its primary phytoadditive sources, or a blend where thymol was at least as concentrated as other components. The protocol was registered in Open Science Framework (DOI: https://doi.org/10.17605/OSF.IO/B6SF9). Results: A total of 1.472 records were identified, with 176 meeting inclusion criteria. Studies spanned from 2012 to 2024, indicating that thymol exhibits antimicrobial, antiviral, antifungal, antiparasitic, anti-inflammatory, and antioxidant properties, among others. However, thymol displays dosedependent toxicity, especially at high levels, aecting mainly the liver and kidneys. Discussion: Thymol holds substantial potential as a therapeutic agent in veterinary medicine due to its beneficial eects and relatively low toxicity. Nonetheless, further research is needed to establish safe and eective dosages across dierent animal species. Fil: Pérez, Denisa Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tandil. Centro de Investigación Veterinaria de Tandil. Universidad Nacional del Centro de la Provincia de Buenos Aires. Centro de Investigación Veterinaria de Tandil. Provincia de Buenos Aires. Gobernación. Comision de Investigaciones Científicas. Centro de Investigación Veterinaria de Tandil; Argentina Fil: Giantin, Mery. Università di Padova; Italia Fil: Pauletto, Marianna. Università di Padova; Italia Fil: Dacasto, Mauro. Università di Padova; Italia |
description |
Introduction: Thymol, a phenolic compound present in essential oils, has shown promising pharmacological properties and potential veterinary applications. This systematic review aims to evaluate the pharmacological and toxicological eects of thymol on animals. Materials and methods: A comprehensive search following PRISMA 2020 guidelines was conducted across databases including PubMed, Scopus, Google Scholar, Web of Science, and LILACS. Various health descriptors, medical subject headings terms, and their synonyms were used to identify studies examining thymol’s eects in animals, including its in vitro, in vivo, and in silico toxicity, as well as its possible environmental impact. Only relevant experimental studies from the last 12 years were included, provided they assessed thymol itself, one of its primary phytoadditive sources, or a blend where thymol was at least as concentrated as other components. The protocol was registered in Open Science Framework (DOI: https://doi.org/10.17605/OSF.IO/B6SF9). Results: A total of 1.472 records were identified, with 176 meeting inclusion criteria. Studies spanned from 2012 to 2024, indicating that thymol exhibits antimicrobial, antiviral, antifungal, antiparasitic, anti-inflammatory, and antioxidant properties, among others. However, thymol displays dosedependent toxicity, especially at high levels, aecting mainly the liver and kidneys. Discussion: Thymol holds substantial potential as a therapeutic agent in veterinary medicine due to its beneficial eects and relatively low toxicity. Nonetheless, further research is needed to establish safe and eective dosages across dierent animal species. |
publishDate |
2025 |
dc.date.none.fl_str_mv |
2025-08 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/269605 Pérez, Denisa Soledad; Giantin, Mery; Pauletto, Marianna; Dacasto, Mauro; Pharmaco-toxicological aspects of thymol in veterinary medicine. A systematic review; Frontiers Media; Frontiers in Veterinary Science; 12; 8-2025; 1-41 2297-1769 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/269605 |
identifier_str_mv |
Pérez, Denisa Soledad; Giantin, Mery; Pauletto, Marianna; Dacasto, Mauro; Pharmaco-toxicological aspects of thymol in veterinary medicine. A systematic review; Frontiers Media; Frontiers in Veterinary Science; 12; 8-2025; 1-41 2297-1769 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
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openAccess |
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Frontiers Media |
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Frontiers Media |
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