Modulation of the noradrenergic activity index by neural stimulus, and its participation in ovarian androstenedione release during the luteal phase

Autores
Bronzi, Cynthia Daniela; Vega Orozco, Adriana Soledad; Delgado, Silvia Marcela; Casais, Marilina; Rastrilla, Ana Maria; Sosa, Zulema Yolanda
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective: To investigate the participation of catecholamines in the association between peripheral innervation and luteal steroidogenesis. Design: Animal study. Setting: University animal laboratory. Animal(s): Six to eight virgin adult Holtzman-strain female rats in control and experimental groups on diestrus days 1 and 2. Intervention(s): Removal of the coeliac ganglion-superior ovarian nerve-ovary system, with catecholaminergic agonist or antagonist added in the ganglion compartment (experimental group only). The control group received no treatment. Main Outcome Measure(s): Ovarian neurotransmitters and their catabolites measured by reverse-phase highpressure liquid chromatography, and A2 measured by radioimmunoassay. Result(s): On day 1, dopamine and catabolite increased whereas norepinephrine decreased, and the noradrenergic neuronal activity index was higher. On day 2, dopamine levels decreased, norepinephrine increased, and dopaminergic neuronal activity was higher. The release of A2 was decreased by addition of norepinephrine to the ganglions on day 1, but was increased by the norepinephrine antagonist on day 2. Hence, norepinephrine increased A2 release, and propranolol diminished it. Conclusion(s): Ganglionic activity is modified by noradrenergic stimulus, leading to different ovarian A2 release profiles. The peripheral nervous system is a modulator in these homeostatic mechanisms.
Fil: Bronzi, Cynthia Daniela. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas. Laboratorio de Biología de la Reproducción; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina
Fil: Vega Orozco, Adriana Soledad. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas. Laboratorio de Biología de la Reproducción; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina
Fil: Delgado, Silvia Marcela. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas. Laboratorio de Biología de la Reproducción; Argentina
Fil: Casais, Marilina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas. Laboratorio de Biología de la Reproducción; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina
Fil: Rastrilla, Ana Maria. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas. Laboratorio de Biología de la Reproducción; Argentina
Fil: Sosa, Zulema Yolanda. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas. Laboratorio de Biología de la Reproducción; Argentina
Materia
ANDROSTENEDIONE
NEUROTRANSMITTERS
OVARY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/141868
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/141868
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Modulation of the noradrenergic activity index by neural stimulus, and its participation in ovarian androstenedione release during the luteal phaseBronzi, Cynthia DanielaVega Orozco, Adriana SoledadDelgado, Silvia MarcelaCasais, MarilinaRastrilla, Ana MariaSosa, Zulema YolandaANDROSTENEDIONENEUROTRANSMITTERSOVARYhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Objective: To investigate the participation of catecholamines in the association between peripheral innervation and luteal steroidogenesis. Design: Animal study. Setting: University animal laboratory. Animal(s): Six to eight virgin adult Holtzman-strain female rats in control and experimental groups on diestrus days 1 and 2. Intervention(s): Removal of the coeliac ganglion-superior ovarian nerve-ovary system, with catecholaminergic agonist or antagonist added in the ganglion compartment (experimental group only). The control group received no treatment. Main Outcome Measure(s): Ovarian neurotransmitters and their catabolites measured by reverse-phase highpressure liquid chromatography, and A2 measured by radioimmunoassay. Result(s): On day 1, dopamine and catabolite increased whereas norepinephrine decreased, and the noradrenergic neuronal activity index was higher. On day 2, dopamine levels decreased, norepinephrine increased, and dopaminergic neuronal activity was higher. The release of A2 was decreased by addition of norepinephrine to the ganglions on day 1, but was increased by the norepinephrine antagonist on day 2. Hence, norepinephrine increased A2 release, and propranolol diminished it. Conclusion(s): Ganglionic activity is modified by noradrenergic stimulus, leading to different ovarian A2 release profiles. The peripheral nervous system is a modulator in these homeostatic mechanisms.Fil: Bronzi, Cynthia Daniela. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas. Laboratorio de Biología de la Reproducción; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; ArgentinaFil: Vega Orozco, Adriana Soledad. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas. Laboratorio de Biología de la Reproducción; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; ArgentinaFil: Delgado, Silvia Marcela. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas. Laboratorio de Biología de la Reproducción; ArgentinaFil: Casais, Marilina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas. Laboratorio de Biología de la Reproducción; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; ArgentinaFil: Rastrilla, Ana Maria. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas. Laboratorio de Biología de la Reproducción; ArgentinaFil: Sosa, Zulema Yolanda. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas. Laboratorio de Biología de la Reproducción; ArgentinaElsevier Science Inc.2011-03-15info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/141868Bronzi, Cynthia Daniela; Vega Orozco, Adriana Soledad; Delgado, Silvia Marcela; Casais, Marilina; Rastrilla, Ana Maria; et al.; Modulation of the noradrenergic activity index by neural stimulus, and its participation in ovarian androstenedione release during the luteal phase; Elsevier Science Inc.; Fertility and Sterility; 95; 4; 15-3-2011; 1211-12160015-02821556-5653CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.fertstert.org/article/S0015-0282(10)02730-5/fulltextinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.fertnstert.2010.10.034info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:10:12Zoai:ri.conicet.gov.ar:11336/141868instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:10:13.432CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Modulation of the noradrenergic activity index by neural stimulus, and its participation in ovarian androstenedione release during the luteal phase
title Modulation of the noradrenergic activity index by neural stimulus, and its participation in ovarian androstenedione release during the luteal phase
spellingShingle Modulation of the noradrenergic activity index by neural stimulus, and its participation in ovarian androstenedione release during the luteal phase
Bronzi, Cynthia Daniela
ANDROSTENEDIONE
NEUROTRANSMITTERS
OVARY
title_short Modulation of the noradrenergic activity index by neural stimulus, and its participation in ovarian androstenedione release during the luteal phase
title_full Modulation of the noradrenergic activity index by neural stimulus, and its participation in ovarian androstenedione release during the luteal phase
title_fullStr Modulation of the noradrenergic activity index by neural stimulus, and its participation in ovarian androstenedione release during the luteal phase
title_full_unstemmed Modulation of the noradrenergic activity index by neural stimulus, and its participation in ovarian androstenedione release during the luteal phase
title_sort Modulation of the noradrenergic activity index by neural stimulus, and its participation in ovarian androstenedione release during the luteal phase
dc.creator.none.fl_str_mv Bronzi, Cynthia Daniela
Vega Orozco, Adriana Soledad
Delgado, Silvia Marcela
Casais, Marilina
Rastrilla, Ana Maria
Sosa, Zulema Yolanda
author Bronzi, Cynthia Daniela
author_facet Bronzi, Cynthia Daniela
Vega Orozco, Adriana Soledad
Delgado, Silvia Marcela
Casais, Marilina
Rastrilla, Ana Maria
Sosa, Zulema Yolanda
author_role author
author2 Vega Orozco, Adriana Soledad
Delgado, Silvia Marcela
Casais, Marilina
Rastrilla, Ana Maria
Sosa, Zulema Yolanda
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv ANDROSTENEDIONE
NEUROTRANSMITTERS
OVARY
topic ANDROSTENEDIONE
NEUROTRANSMITTERS
OVARY
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective: To investigate the participation of catecholamines in the association between peripheral innervation and luteal steroidogenesis. Design: Animal study. Setting: University animal laboratory. Animal(s): Six to eight virgin adult Holtzman-strain female rats in control and experimental groups on diestrus days 1 and 2. Intervention(s): Removal of the coeliac ganglion-superior ovarian nerve-ovary system, with catecholaminergic agonist or antagonist added in the ganglion compartment (experimental group only). The control group received no treatment. Main Outcome Measure(s): Ovarian neurotransmitters and their catabolites measured by reverse-phase highpressure liquid chromatography, and A2 measured by radioimmunoassay. Result(s): On day 1, dopamine and catabolite increased whereas norepinephrine decreased, and the noradrenergic neuronal activity index was higher. On day 2, dopamine levels decreased, norepinephrine increased, and dopaminergic neuronal activity was higher. The release of A2 was decreased by addition of norepinephrine to the ganglions on day 1, but was increased by the norepinephrine antagonist on day 2. Hence, norepinephrine increased A2 release, and propranolol diminished it. Conclusion(s): Ganglionic activity is modified by noradrenergic stimulus, leading to different ovarian A2 release profiles. The peripheral nervous system is a modulator in these homeostatic mechanisms.
Fil: Bronzi, Cynthia Daniela. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas. Laboratorio de Biología de la Reproducción; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina
Fil: Vega Orozco, Adriana Soledad. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas. Laboratorio de Biología de la Reproducción; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina
Fil: Delgado, Silvia Marcela. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas. Laboratorio de Biología de la Reproducción; Argentina
Fil: Casais, Marilina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas. Laboratorio de Biología de la Reproducción; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis; Argentina
Fil: Rastrilla, Ana Maria. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas. Laboratorio de Biología de la Reproducción; Argentina
Fil: Sosa, Zulema Yolanda. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Bioquímica y Ciencias Biológicas. Laboratorio de Biología de la Reproducción; Argentina
description Objective: To investigate the participation of catecholamines in the association between peripheral innervation and luteal steroidogenesis. Design: Animal study. Setting: University animal laboratory. Animal(s): Six to eight virgin adult Holtzman-strain female rats in control and experimental groups on diestrus days 1 and 2. Intervention(s): Removal of the coeliac ganglion-superior ovarian nerve-ovary system, with catecholaminergic agonist or antagonist added in the ganglion compartment (experimental group only). The control group received no treatment. Main Outcome Measure(s): Ovarian neurotransmitters and their catabolites measured by reverse-phase highpressure liquid chromatography, and A2 measured by radioimmunoassay. Result(s): On day 1, dopamine and catabolite increased whereas norepinephrine decreased, and the noradrenergic neuronal activity index was higher. On day 2, dopamine levels decreased, norepinephrine increased, and dopaminergic neuronal activity was higher. The release of A2 was decreased by addition of norepinephrine to the ganglions on day 1, but was increased by the norepinephrine antagonist on day 2. Hence, norepinephrine increased A2 release, and propranolol diminished it. Conclusion(s): Ganglionic activity is modified by noradrenergic stimulus, leading to different ovarian A2 release profiles. The peripheral nervous system is a modulator in these homeostatic mechanisms.
publishDate 2011
dc.date.none.fl_str_mv 2011-03-15
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/141868
Bronzi, Cynthia Daniela; Vega Orozco, Adriana Soledad; Delgado, Silvia Marcela; Casais, Marilina; Rastrilla, Ana Maria; et al.; Modulation of the noradrenergic activity index by neural stimulus, and its participation in ovarian androstenedione release during the luteal phase; Elsevier Science Inc.; Fertility and Sterility; 95; 4; 15-3-2011; 1211-1216
0015-0282
1556-5653
CONICET Digital
CONICET
url http://hdl.handle.net/11336/141868
identifier_str_mv Bronzi, Cynthia Daniela; Vega Orozco, Adriana Soledad; Delgado, Silvia Marcela; Casais, Marilina; Rastrilla, Ana Maria; et al.; Modulation of the noradrenergic activity index by neural stimulus, and its participation in ovarian androstenedione release during the luteal phase; Elsevier Science Inc.; Fertility and Sterility; 95; 4; 15-3-2011; 1211-1216
0015-0282
1556-5653
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.fertstert.org/article/S0015-0282(10)02730-5/fulltext
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.fertnstert.2010.10.034
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc.
publisher.none.fl_str_mv Elsevier Science Inc.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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