Biosensors for studies on adhesion-mediated cellular responses to their microenvironment

Autores
Saffioti, Nicolas Andres; Cavalcanti Adam, Elisabetta Ada; Pallarola, Diego Andres
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Cells interact with their microenvironment by constantly sensing mechanical and chemical cues converting them into biochemical signals. These processes allow cells to respond and adapt to changes in their environment, and are crucial for most cellular functions. Understanding the mechanism underlying this complex interplay at the cell-matrix interface is of fundamental value to decipher key biochemical and mechanical factors regulating cell fate. The combination of material science and surface chemistry aided in the creation of controllable environments to study cell mechanosensing and mechanotransduction. Biologically inspired materials tailored with specific bioactive molecules, desired physical properties and tunable topography have emerged as suitable tools to study cell behavior. Among these materials, synthetic cell interfaces with built-in sensing capabilities are highly advantageous to measure biophysical and biochemical interaction between cells and their environment. In this review, we discuss the design of micro and nanostructured biomaterials engineered not only to mimic the structure, properties, and function of the cellular microenvironment, but also to obtain quantitative information on how cells sense and probe specific adhesive cues from the extracellular domain. This type of responsive biointerfaces provides a readout of mechanics, biochemistry, and electrical activity in real time allowing observation of cellular processes with molecular specificity. Specifically designed sensors based on advanced optical and electrochemical readout are discussed. We further provide an insight into the emerging role of multifunctional micro and nanosensors to control and monitor cell functions by means of material design.
Fil: Saffioti, Nicolas Andres. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina
Fil: Cavalcanti Adam, Elisabetta Ada. Max Planck Institute for Medical Research. Department Of Cellular Biophysics; Alemania
Fil: Pallarola, Diego Andres. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina
Materia
BIOMATERIALS
CELL ADHESION
CELL–CELL ADHESION
ELECTROCHEMISTRY
EXTRACELLULAR MATRIX
INTEGRINS
MECHANOBIOLOGY
OPTICAL MICROSCOPY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/169108
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/169108
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Biosensors for studies on adhesion-mediated cellular responses to their microenvironmentSaffioti, Nicolas AndresCavalcanti Adam, Elisabetta AdaPallarola, Diego AndresBIOMATERIALSCELL ADHESIONCELL–CELL ADHESIONELECTROCHEMISTRYEXTRACELLULAR MATRIXINTEGRINSMECHANOBIOLOGYOPTICAL MICROSCOPYhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Cells interact with their microenvironment by constantly sensing mechanical and chemical cues converting them into biochemical signals. These processes allow cells to respond and adapt to changes in their environment, and are crucial for most cellular functions. Understanding the mechanism underlying this complex interplay at the cell-matrix interface is of fundamental value to decipher key biochemical and mechanical factors regulating cell fate. The combination of material science and surface chemistry aided in the creation of controllable environments to study cell mechanosensing and mechanotransduction. Biologically inspired materials tailored with specific bioactive molecules, desired physical properties and tunable topography have emerged as suitable tools to study cell behavior. Among these materials, synthetic cell interfaces with built-in sensing capabilities are highly advantageous to measure biophysical and biochemical interaction between cells and their environment. In this review, we discuss the design of micro and nanostructured biomaterials engineered not only to mimic the structure, properties, and function of the cellular microenvironment, but also to obtain quantitative information on how cells sense and probe specific adhesive cues from the extracellular domain. This type of responsive biointerfaces provides a readout of mechanics, biochemistry, and electrical activity in real time allowing observation of cellular processes with molecular specificity. Specifically designed sensors based on advanced optical and electrochemical readout are discussed. We further provide an insight into the emerging role of multifunctional micro and nanosensors to control and monitor cell functions by means of material design.Fil: Saffioti, Nicolas Andres. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martin. Instituto de Nanosistemas; ArgentinaFil: Cavalcanti Adam, Elisabetta Ada. Max Planck Institute for Medical Research. Department Of Cellular Biophysics; AlemaniaFil: Pallarola, Diego Andres. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martin. Instituto de Nanosistemas; ArgentinaFrontiers Media2020-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/169108Saffioti, Nicolas Andres; Cavalcanti Adam, Elisabetta Ada; Pallarola, Diego Andres; Biosensors for studies on adhesion-mediated cellular responses to their microenvironment; Frontiers Media; Frontiers in Bioengineering and Biotechnology; 8; 10-2020; 1-212296-4185CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fbioe.2020.597950/fullinfo:eu-repo/semantics/altIdentifier/doi/10.3389/fbioe.2020.597950info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:18:28Zoai:ri.conicet.gov.ar:11336/169108instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:18:28.221CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Biosensors for studies on adhesion-mediated cellular responses to their microenvironment
title Biosensors for studies on adhesion-mediated cellular responses to their microenvironment
spellingShingle Biosensors for studies on adhesion-mediated cellular responses to their microenvironment
Saffioti, Nicolas Andres
BIOMATERIALS
CELL ADHESION
CELL–CELL ADHESION
ELECTROCHEMISTRY
EXTRACELLULAR MATRIX
INTEGRINS
MECHANOBIOLOGY
OPTICAL MICROSCOPY
title_short Biosensors for studies on adhesion-mediated cellular responses to their microenvironment
title_full Biosensors for studies on adhesion-mediated cellular responses to their microenvironment
title_fullStr Biosensors for studies on adhesion-mediated cellular responses to their microenvironment
title_full_unstemmed Biosensors for studies on adhesion-mediated cellular responses to their microenvironment
title_sort Biosensors for studies on adhesion-mediated cellular responses to their microenvironment
dc.creator.none.fl_str_mv Saffioti, Nicolas Andres
Cavalcanti Adam, Elisabetta Ada
Pallarola, Diego Andres
author Saffioti, Nicolas Andres
author_facet Saffioti, Nicolas Andres
Cavalcanti Adam, Elisabetta Ada
Pallarola, Diego Andres
author_role author
author2 Cavalcanti Adam, Elisabetta Ada
Pallarola, Diego Andres
author2_role author
author
dc.subject.none.fl_str_mv BIOMATERIALS
CELL ADHESION
CELL–CELL ADHESION
ELECTROCHEMISTRY
EXTRACELLULAR MATRIX
INTEGRINS
MECHANOBIOLOGY
OPTICAL MICROSCOPY
topic BIOMATERIALS
CELL ADHESION
CELL–CELL ADHESION
ELECTROCHEMISTRY
EXTRACELLULAR MATRIX
INTEGRINS
MECHANOBIOLOGY
OPTICAL MICROSCOPY
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Cells interact with their microenvironment by constantly sensing mechanical and chemical cues converting them into biochemical signals. These processes allow cells to respond and adapt to changes in their environment, and are crucial for most cellular functions. Understanding the mechanism underlying this complex interplay at the cell-matrix interface is of fundamental value to decipher key biochemical and mechanical factors regulating cell fate. The combination of material science and surface chemistry aided in the creation of controllable environments to study cell mechanosensing and mechanotransduction. Biologically inspired materials tailored with specific bioactive molecules, desired physical properties and tunable topography have emerged as suitable tools to study cell behavior. Among these materials, synthetic cell interfaces with built-in sensing capabilities are highly advantageous to measure biophysical and biochemical interaction between cells and their environment. In this review, we discuss the design of micro and nanostructured biomaterials engineered not only to mimic the structure, properties, and function of the cellular microenvironment, but also to obtain quantitative information on how cells sense and probe specific adhesive cues from the extracellular domain. This type of responsive biointerfaces provides a readout of mechanics, biochemistry, and electrical activity in real time allowing observation of cellular processes with molecular specificity. Specifically designed sensors based on advanced optical and electrochemical readout are discussed. We further provide an insight into the emerging role of multifunctional micro and nanosensors to control and monitor cell functions by means of material design.
Fil: Saffioti, Nicolas Andres. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina
Fil: Cavalcanti Adam, Elisabetta Ada. Max Planck Institute for Medical Research. Department Of Cellular Biophysics; Alemania
Fil: Pallarola, Diego Andres. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de San Martin. Instituto de Nanosistemas; Argentina
description Cells interact with their microenvironment by constantly sensing mechanical and chemical cues converting them into biochemical signals. These processes allow cells to respond and adapt to changes in their environment, and are crucial for most cellular functions. Understanding the mechanism underlying this complex interplay at the cell-matrix interface is of fundamental value to decipher key biochemical and mechanical factors regulating cell fate. The combination of material science and surface chemistry aided in the creation of controllable environments to study cell mechanosensing and mechanotransduction. Biologically inspired materials tailored with specific bioactive molecules, desired physical properties and tunable topography have emerged as suitable tools to study cell behavior. Among these materials, synthetic cell interfaces with built-in sensing capabilities are highly advantageous to measure biophysical and biochemical interaction between cells and their environment. In this review, we discuss the design of micro and nanostructured biomaterials engineered not only to mimic the structure, properties, and function of the cellular microenvironment, but also to obtain quantitative information on how cells sense and probe specific adhesive cues from the extracellular domain. This type of responsive biointerfaces provides a readout of mechanics, biochemistry, and electrical activity in real time allowing observation of cellular processes with molecular specificity. Specifically designed sensors based on advanced optical and electrochemical readout are discussed. We further provide an insight into the emerging role of multifunctional micro and nanosensors to control and monitor cell functions by means of material design.
publishDate 2020
dc.date.none.fl_str_mv 2020-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/169108
Saffioti, Nicolas Andres; Cavalcanti Adam, Elisabetta Ada; Pallarola, Diego Andres; Biosensors for studies on adhesion-mediated cellular responses to their microenvironment; Frontiers Media; Frontiers in Bioengineering and Biotechnology; 8; 10-2020; 1-21
2296-4185
CONICET Digital
CONICET
url http://hdl.handle.net/11336/169108
identifier_str_mv Saffioti, Nicolas Andres; Cavalcanti Adam, Elisabetta Ada; Pallarola, Diego Andres; Biosensors for studies on adhesion-mediated cellular responses to their microenvironment; Frontiers Media; Frontiers in Bioengineering and Biotechnology; 8; 10-2020; 1-21
2296-4185
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fbioe.2020.597950/full
info:eu-repo/semantics/altIdentifier/doi/10.3389/fbioe.2020.597950
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Media
publisher.none.fl_str_mv Frontiers Media
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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