Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesion

Autores
Zhang, Haolan; Wang, Danyu; Lin, Xue; Politakos, Nikolaos; Tuninetti, Jimena Soledad; Moya, Sergio Enrique; Gao, Changyou
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Multilayers incorporated with stimuli-responsive substances by means of layer-by-layer (LbL) self-assembly are much attractive due to the advantages of stimuli-responsiveness and potential applications in different fields. In this study, pyrenemethyl acrylate (PA) was synthesized, and was copolymerized with acrylic acid (AA) to obtain the amphiphilic and photodegradable P(PA-co-AA) polymers with a PA:AA molar ratio of 1.3:3, and an average molecular weight of 6.9 kDa and polydispersity index of 1.04. They formed micelles spontaneously when dispersed in aqueous solution with a size of 27.5 nm in a dry state and 136.6 nm in a wet state. The micelles were readily decomposed to form aggregates as a result of the cleavage of the pyrenemethyl ester bonds under UV-irradiation. UV-responsive micelles-containing multilayers were prepared by LbL self-assembly of the UV-responsive micelles and polyallylamine hydrochloride (PAH). UV-irradiation of the multilayers resulted in the decomposition of micelles, leading to larger surface roughness, and enhanced swelling ratio and wettability of the multilayers. In vitro culture of A549 and HepG2 cells showed significantly better adhesion at 4 h on the UV-illuminated multilayers, whereas the cell proliferation was not affected until 5 d.
Fil: Zhang, Haolan. Zhejiang University; China
Fil: Wang, Danyu. Zhejiang University; China
Fil: Lin, Xue. Zhejiang University; China
Fil: Politakos, Nikolaos. Centro de Investigación Cooperativa en Biomateriales; España
Fil: Tuninetti, Jimena Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Centro de Investigación Cooperativa en Biomateriales; España
Fil: Moya, Sergio Enrique. Centro de Investigación Cooperativa en Biomateriales; España
Fil: Gao, Changyou. Zhejiang University; China
Materia
BIOMATERIALS
CELL ADHESION
MULTILAYERS
PHOTO-RESPONSIVE
SURFACES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/100859
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/100859
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesionZhang, HaolanWang, DanyuLin, XuePolitakos, NikolaosTuninetti, Jimena SoledadMoya, Sergio EnriqueGao, ChangyouBIOMATERIALSCELL ADHESIONMULTILAYERSPHOTO-RESPONSIVESURFACEShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Multilayers incorporated with stimuli-responsive substances by means of layer-by-layer (LbL) self-assembly are much attractive due to the advantages of stimuli-responsiveness and potential applications in different fields. In this study, pyrenemethyl acrylate (PA) was synthesized, and was copolymerized with acrylic acid (AA) to obtain the amphiphilic and photodegradable P(PA-co-AA) polymers with a PA:AA molar ratio of 1.3:3, and an average molecular weight of 6.9 kDa and polydispersity index of 1.04. They formed micelles spontaneously when dispersed in aqueous solution with a size of 27.5 nm in a dry state and 136.6 nm in a wet state. The micelles were readily decomposed to form aggregates as a result of the cleavage of the pyrenemethyl ester bonds under UV-irradiation. UV-responsive micelles-containing multilayers were prepared by LbL self-assembly of the UV-responsive micelles and polyallylamine hydrochloride (PAH). UV-irradiation of the multilayers resulted in the decomposition of micelles, leading to larger surface roughness, and enhanced swelling ratio and wettability of the multilayers. In vitro culture of A549 and HepG2 cells showed significantly better adhesion at 4 h on the UV-illuminated multilayers, whereas the cell proliferation was not affected until 5 d.Fil: Zhang, Haolan. Zhejiang University; ChinaFil: Wang, Danyu. Zhejiang University; ChinaFil: Lin, Xue. Zhejiang University; ChinaFil: Politakos, Nikolaos. Centro de Investigación Cooperativa en Biomateriales; EspañaFil: Tuninetti, Jimena Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Centro de Investigación Cooperativa en Biomateriales; EspañaFil: Moya, Sergio Enrique. Centro de Investigación Cooperativa en Biomateriales; EspañaFil: Gao, Changyou. Zhejiang University; ChinaScience in China Press2018-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/100859Zhang, Haolan; Wang, Danyu; Lin, Xue; Politakos, Nikolaos; Tuninetti, Jimena Soledad; et al.; Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesion; Science in China Press; Science China Chemistry; 61; 1; 1-2018; 54-631869-18701674-7291CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s11426-017-9143-yinfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs11426-017-9143-yinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:14:15Zoai:ri.conicet.gov.ar:11336/100859instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:14:16.177CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesion
title Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesion
spellingShingle Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesion
Zhang, Haolan
BIOMATERIALS
CELL ADHESION
MULTILAYERS
PHOTO-RESPONSIVE
SURFACES
title_short Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesion
title_full Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesion
title_fullStr Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesion
title_full_unstemmed Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesion
title_sort Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesion
dc.creator.none.fl_str_mv Zhang, Haolan
Wang, Danyu
Lin, Xue
Politakos, Nikolaos
Tuninetti, Jimena Soledad
Moya, Sergio Enrique
Gao, Changyou
author Zhang, Haolan
author_facet Zhang, Haolan
Wang, Danyu
Lin, Xue
Politakos, Nikolaos
Tuninetti, Jimena Soledad
Moya, Sergio Enrique
Gao, Changyou
author_role author
author2 Wang, Danyu
Lin, Xue
Politakos, Nikolaos
Tuninetti, Jimena Soledad
Moya, Sergio Enrique
Gao, Changyou
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv BIOMATERIALS
CELL ADHESION
MULTILAYERS
PHOTO-RESPONSIVE
SURFACES
topic BIOMATERIALS
CELL ADHESION
MULTILAYERS
PHOTO-RESPONSIVE
SURFACES
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Multilayers incorporated with stimuli-responsive substances by means of layer-by-layer (LbL) self-assembly are much attractive due to the advantages of stimuli-responsiveness and potential applications in different fields. In this study, pyrenemethyl acrylate (PA) was synthesized, and was copolymerized with acrylic acid (AA) to obtain the amphiphilic and photodegradable P(PA-co-AA) polymers with a PA:AA molar ratio of 1.3:3, and an average molecular weight of 6.9 kDa and polydispersity index of 1.04. They formed micelles spontaneously when dispersed in aqueous solution with a size of 27.5 nm in a dry state and 136.6 nm in a wet state. The micelles were readily decomposed to form aggregates as a result of the cleavage of the pyrenemethyl ester bonds under UV-irradiation. UV-responsive micelles-containing multilayers were prepared by LbL self-assembly of the UV-responsive micelles and polyallylamine hydrochloride (PAH). UV-irradiation of the multilayers resulted in the decomposition of micelles, leading to larger surface roughness, and enhanced swelling ratio and wettability of the multilayers. In vitro culture of A549 and HepG2 cells showed significantly better adhesion at 4 h on the UV-illuminated multilayers, whereas the cell proliferation was not affected until 5 d.
Fil: Zhang, Haolan. Zhejiang University; China
Fil: Wang, Danyu. Zhejiang University; China
Fil: Lin, Xue. Zhejiang University; China
Fil: Politakos, Nikolaos. Centro de Investigación Cooperativa en Biomateriales; España
Fil: Tuninetti, Jimena Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Centro de Investigación Cooperativa en Biomateriales; España
Fil: Moya, Sergio Enrique. Centro de Investigación Cooperativa en Biomateriales; España
Fil: Gao, Changyou. Zhejiang University; China
description Multilayers incorporated with stimuli-responsive substances by means of layer-by-layer (LbL) self-assembly are much attractive due to the advantages of stimuli-responsiveness and potential applications in different fields. In this study, pyrenemethyl acrylate (PA) was synthesized, and was copolymerized with acrylic acid (AA) to obtain the amphiphilic and photodegradable P(PA-co-AA) polymers with a PA:AA molar ratio of 1.3:3, and an average molecular weight of 6.9 kDa and polydispersity index of 1.04. They formed micelles spontaneously when dispersed in aqueous solution with a size of 27.5 nm in a dry state and 136.6 nm in a wet state. The micelles were readily decomposed to form aggregates as a result of the cleavage of the pyrenemethyl ester bonds under UV-irradiation. UV-responsive micelles-containing multilayers were prepared by LbL self-assembly of the UV-responsive micelles and polyallylamine hydrochloride (PAH). UV-irradiation of the multilayers resulted in the decomposition of micelles, leading to larger surface roughness, and enhanced swelling ratio and wettability of the multilayers. In vitro culture of A549 and HepG2 cells showed significantly better adhesion at 4 h on the UV-illuminated multilayers, whereas the cell proliferation was not affected until 5 d.
publishDate 2018
dc.date.none.fl_str_mv 2018-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/100859
Zhang, Haolan; Wang, Danyu; Lin, Xue; Politakos, Nikolaos; Tuninetti, Jimena Soledad; et al.; Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesion; Science in China Press; Science China Chemistry; 61; 1; 1-2018; 54-63
1869-1870
1674-7291
CONICET Digital
CONICET
url http://hdl.handle.net/11336/100859
identifier_str_mv Zhang, Haolan; Wang, Danyu; Lin, Xue; Politakos, Nikolaos; Tuninetti, Jimena Soledad; et al.; Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesion; Science in China Press; Science China Chemistry; 61; 1; 1-2018; 54-63
1869-1870
1674-7291
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1007/s11426-017-9143-y
info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs11426-017-9143-y
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Science in China Press
publisher.none.fl_str_mv Science in China Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846781560751128576
score 12.982451

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