Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesion
- Autores
- Zhang, Haolan; Wang, Danyu; Lin, Xue; Politakos, Nikolaos; Tuninetti, Jimena Soledad; Moya, Sergio Enrique; Gao, Changyou
- Año de publicación
- 2018
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Multilayers incorporated with stimuli-responsive substances by means of layer-by-layer (LbL) self-assembly are much attractive due to the advantages of stimuli-responsiveness and potential applications in different fields. In this study, pyrenemethyl acrylate (PA) was synthesized, and was copolymerized with acrylic acid (AA) to obtain the amphiphilic and photodegradable P(PA-co-AA) polymers with a PA:AA molar ratio of 1.3:3, and an average molecular weight of 6.9 kDa and polydispersity index of 1.04. They formed micelles spontaneously when dispersed in aqueous solution with a size of 27.5 nm in a dry state and 136.6 nm in a wet state. The micelles were readily decomposed to form aggregates as a result of the cleavage of the pyrenemethyl ester bonds under UV-irradiation. UV-responsive micelles-containing multilayers were prepared by LbL self-assembly of the UV-responsive micelles and polyallylamine hydrochloride (PAH). UV-irradiation of the multilayers resulted in the decomposition of micelles, leading to larger surface roughness, and enhanced swelling ratio and wettability of the multilayers. In vitro culture of A549 and HepG2 cells showed significantly better adhesion at 4 h on the UV-illuminated multilayers, whereas the cell proliferation was not affected until 5 d.
Fil: Zhang, Haolan. Zhejiang University; China
Fil: Wang, Danyu. Zhejiang University; China
Fil: Lin, Xue. Zhejiang University; China
Fil: Politakos, Nikolaos. Centro de Investigación Cooperativa en Biomateriales; España
Fil: Tuninetti, Jimena Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Centro de Investigación Cooperativa en Biomateriales; España
Fil: Moya, Sergio Enrique. Centro de Investigación Cooperativa en Biomateriales; España
Fil: Gao, Changyou. Zhejiang University; China - Materia
-
BIOMATERIALS
CELL ADHESION
MULTILAYERS
PHOTO-RESPONSIVE
SURFACES - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/100859
Ver los metadatos del registro completo
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Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesionZhang, HaolanWang, DanyuLin, XuePolitakos, NikolaosTuninetti, Jimena SoledadMoya, Sergio EnriqueGao, ChangyouBIOMATERIALSCELL ADHESIONMULTILAYERSPHOTO-RESPONSIVESURFACEShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Multilayers incorporated with stimuli-responsive substances by means of layer-by-layer (LbL) self-assembly are much attractive due to the advantages of stimuli-responsiveness and potential applications in different fields. In this study, pyrenemethyl acrylate (PA) was synthesized, and was copolymerized with acrylic acid (AA) to obtain the amphiphilic and photodegradable P(PA-co-AA) polymers with a PA:AA molar ratio of 1.3:3, and an average molecular weight of 6.9 kDa and polydispersity index of 1.04. They formed micelles spontaneously when dispersed in aqueous solution with a size of 27.5 nm in a dry state and 136.6 nm in a wet state. The micelles were readily decomposed to form aggregates as a result of the cleavage of the pyrenemethyl ester bonds under UV-irradiation. UV-responsive micelles-containing multilayers were prepared by LbL self-assembly of the UV-responsive micelles and polyallylamine hydrochloride (PAH). UV-irradiation of the multilayers resulted in the decomposition of micelles, leading to larger surface roughness, and enhanced swelling ratio and wettability of the multilayers. In vitro culture of A549 and HepG2 cells showed significantly better adhesion at 4 h on the UV-illuminated multilayers, whereas the cell proliferation was not affected until 5 d.Fil: Zhang, Haolan. Zhejiang University; ChinaFil: Wang, Danyu. Zhejiang University; ChinaFil: Lin, Xue. Zhejiang University; ChinaFil: Politakos, Nikolaos. Centro de Investigación Cooperativa en Biomateriales; EspañaFil: Tuninetti, Jimena Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Centro de Investigación Cooperativa en Biomateriales; EspañaFil: Moya, Sergio Enrique. Centro de Investigación Cooperativa en Biomateriales; EspañaFil: Gao, Changyou. Zhejiang University; ChinaScience in China Press2018-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/100859Zhang, Haolan; Wang, Danyu; Lin, Xue; Politakos, Nikolaos; Tuninetti, Jimena Soledad; et al.; Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesion; Science in China Press; Science China Chemistry; 61; 1; 1-2018; 54-631869-18701674-7291CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1007/s11426-017-9143-yinfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs11426-017-9143-yinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:45:24Zoai:ri.conicet.gov.ar:11336/100859instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:45:24.521CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesion |
title |
Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesion |
spellingShingle |
Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesion Zhang, Haolan BIOMATERIALS CELL ADHESION MULTILAYERS PHOTO-RESPONSIVE SURFACES |
title_short |
Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesion |
title_full |
Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesion |
title_fullStr |
Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesion |
title_full_unstemmed |
Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesion |
title_sort |
Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesion |
dc.creator.none.fl_str_mv |
Zhang, Haolan Wang, Danyu Lin, Xue Politakos, Nikolaos Tuninetti, Jimena Soledad Moya, Sergio Enrique Gao, Changyou |
author |
Zhang, Haolan |
author_facet |
Zhang, Haolan Wang, Danyu Lin, Xue Politakos, Nikolaos Tuninetti, Jimena Soledad Moya, Sergio Enrique Gao, Changyou |
author_role |
author |
author2 |
Wang, Danyu Lin, Xue Politakos, Nikolaos Tuninetti, Jimena Soledad Moya, Sergio Enrique Gao, Changyou |
author2_role |
author author author author author author |
dc.subject.none.fl_str_mv |
BIOMATERIALS CELL ADHESION MULTILAYERS PHOTO-RESPONSIVE SURFACES |
topic |
BIOMATERIALS CELL ADHESION MULTILAYERS PHOTO-RESPONSIVE SURFACES |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Multilayers incorporated with stimuli-responsive substances by means of layer-by-layer (LbL) self-assembly are much attractive due to the advantages of stimuli-responsiveness and potential applications in different fields. In this study, pyrenemethyl acrylate (PA) was synthesized, and was copolymerized with acrylic acid (AA) to obtain the amphiphilic and photodegradable P(PA-co-AA) polymers with a PA:AA molar ratio of 1.3:3, and an average molecular weight of 6.9 kDa and polydispersity index of 1.04. They formed micelles spontaneously when dispersed in aqueous solution with a size of 27.5 nm in a dry state and 136.6 nm in a wet state. The micelles were readily decomposed to form aggregates as a result of the cleavage of the pyrenemethyl ester bonds under UV-irradiation. UV-responsive micelles-containing multilayers were prepared by LbL self-assembly of the UV-responsive micelles and polyallylamine hydrochloride (PAH). UV-irradiation of the multilayers resulted in the decomposition of micelles, leading to larger surface roughness, and enhanced swelling ratio and wettability of the multilayers. In vitro culture of A549 and HepG2 cells showed significantly better adhesion at 4 h on the UV-illuminated multilayers, whereas the cell proliferation was not affected until 5 d. Fil: Zhang, Haolan. Zhejiang University; China Fil: Wang, Danyu. Zhejiang University; China Fil: Lin, Xue. Zhejiang University; China Fil: Politakos, Nikolaos. Centro de Investigación Cooperativa en Biomateriales; España Fil: Tuninetti, Jimena Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Centro de Investigación Cooperativa en Biomateriales; España Fil: Moya, Sergio Enrique. Centro de Investigación Cooperativa en Biomateriales; España Fil: Gao, Changyou. Zhejiang University; China |
description |
Multilayers incorporated with stimuli-responsive substances by means of layer-by-layer (LbL) self-assembly are much attractive due to the advantages of stimuli-responsiveness and potential applications in different fields. In this study, pyrenemethyl acrylate (PA) was synthesized, and was copolymerized with acrylic acid (AA) to obtain the amphiphilic and photodegradable P(PA-co-AA) polymers with a PA:AA molar ratio of 1.3:3, and an average molecular weight of 6.9 kDa and polydispersity index of 1.04. They formed micelles spontaneously when dispersed in aqueous solution with a size of 27.5 nm in a dry state and 136.6 nm in a wet state. The micelles were readily decomposed to form aggregates as a result of the cleavage of the pyrenemethyl ester bonds under UV-irradiation. UV-responsive micelles-containing multilayers were prepared by LbL self-assembly of the UV-responsive micelles and polyallylamine hydrochloride (PAH). UV-irradiation of the multilayers resulted in the decomposition of micelles, leading to larger surface roughness, and enhanced swelling ratio and wettability of the multilayers. In vitro culture of A549 and HepG2 cells showed significantly better adhesion at 4 h on the UV-illuminated multilayers, whereas the cell proliferation was not affected until 5 d. |
publishDate |
2018 |
dc.date.none.fl_str_mv |
2018-01 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/100859 Zhang, Haolan; Wang, Danyu; Lin, Xue; Politakos, Nikolaos; Tuninetti, Jimena Soledad; et al.; Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesion; Science in China Press; Science China Chemistry; 61; 1; 1-2018; 54-63 1869-1870 1674-7291 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/100859 |
identifier_str_mv |
Zhang, Haolan; Wang, Danyu; Lin, Xue; Politakos, Nikolaos; Tuninetti, Jimena Soledad; et al.; Fabrication of UV responsive micelles-containing multilayers and their influence on cell adhesion; Science in China Press; Science China Chemistry; 61; 1; 1-2018; 54-63 1869-1870 1674-7291 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1007/s11426-017-9143-y info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007%2Fs11426-017-9143-y |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Science in China Press |
publisher.none.fl_str_mv |
Science in China Press |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613424876617728 |
score |
13.070432 |