Zn finger containing proteins as targets for the control of viral infections

Autores
García, C. C.; Damonte, Elsa Beatriz
Año de publicación
2007
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The zinc finger proteins have fascinated many research groups because of their modular assembly, broad range of biological functions and more recently because they are attractive targets for antiviral therapy. The zinc finger domain is a very stable structural element whose hallmark is the coordination of a zinc ion by several amino acid residues, usually cysteines and histidines. These structural motifs are associated with protein-nucleic acid recognition as well as protein-protein interactions. The biological function of the zinc finger proteins is strongly dependent on the zinc ion, which assure integrity and stability. Thus, the disruption of critical zinc finger viral proteins represents a fundamentally new approach to inhibit viral replication in the absence of mutations leading to drug resistance phenotypes. This review summarizes the drug design and potential therapeutic applications of viral zinc fingers disrupting agents for the control of viral diseases.
Fil: García, C. C.. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina
Fil: Damonte, Elsa Beatriz. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Materia
Antiviral
Arenavirus
Human Immunodeficiency Virus
Oxiding Compounds
Structural Domains
Zinc Fingers
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/83870
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Zn finger containing proteins as targets for the control of viral infectionsGarcía, C. C.Damonte, Elsa BeatrizAntiviralArenavirusHuman Immunodeficiency VirusOxiding CompoundsStructural DomainsZinc Fingershttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The zinc finger proteins have fascinated many research groups because of their modular assembly, broad range of biological functions and more recently because they are attractive targets for antiviral therapy. The zinc finger domain is a very stable structural element whose hallmark is the coordination of a zinc ion by several amino acid residues, usually cysteines and histidines. These structural motifs are associated with protein-nucleic acid recognition as well as protein-protein interactions. The biological function of the zinc finger proteins is strongly dependent on the zinc ion, which assure integrity and stability. Thus, the disruption of critical zinc finger viral proteins represents a fundamentally new approach to inhibit viral replication in the absence of mutations leading to drug resistance phenotypes. This review summarizes the drug design and potential therapeutic applications of viral zinc fingers disrupting agents for the control of viral diseases.Fil: García, C. C.. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; ArgentinaFil: Damonte, Elsa Beatriz. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaBentham Science Publishers2007-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/83870García, C. C.; Damonte, Elsa Beatriz; Zn finger containing proteins as targets for the control of viral infections; Bentham Science Publishers; Infectious Disorders - Drug Targets; 7; 3; 9-2007; 204-2121871-5265CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/78866/articleinfo:eu-repo/semantics/altIdentifier/doi/10.2174/187152607782110004info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:04:46Zoai:ri.conicet.gov.ar:11336/83870instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:04:46.427CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Zn finger containing proteins as targets for the control of viral infections
title Zn finger containing proteins as targets for the control of viral infections
spellingShingle Zn finger containing proteins as targets for the control of viral infections
García, C. C.
Antiviral
Arenavirus
Human Immunodeficiency Virus
Oxiding Compounds
Structural Domains
Zinc Fingers
title_short Zn finger containing proteins as targets for the control of viral infections
title_full Zn finger containing proteins as targets for the control of viral infections
title_fullStr Zn finger containing proteins as targets for the control of viral infections
title_full_unstemmed Zn finger containing proteins as targets for the control of viral infections
title_sort Zn finger containing proteins as targets for the control of viral infections
dc.creator.none.fl_str_mv García, C. C.
Damonte, Elsa Beatriz
author García, C. C.
author_facet García, C. C.
Damonte, Elsa Beatriz
author_role author
author2 Damonte, Elsa Beatriz
author2_role author
dc.subject.none.fl_str_mv Antiviral
Arenavirus
Human Immunodeficiency Virus
Oxiding Compounds
Structural Domains
Zinc Fingers
topic Antiviral
Arenavirus
Human Immunodeficiency Virus
Oxiding Compounds
Structural Domains
Zinc Fingers
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The zinc finger proteins have fascinated many research groups because of their modular assembly, broad range of biological functions and more recently because they are attractive targets for antiviral therapy. The zinc finger domain is a very stable structural element whose hallmark is the coordination of a zinc ion by several amino acid residues, usually cysteines and histidines. These structural motifs are associated with protein-nucleic acid recognition as well as protein-protein interactions. The biological function of the zinc finger proteins is strongly dependent on the zinc ion, which assure integrity and stability. Thus, the disruption of critical zinc finger viral proteins represents a fundamentally new approach to inhibit viral replication in the absence of mutations leading to drug resistance phenotypes. This review summarizes the drug design and potential therapeutic applications of viral zinc fingers disrupting agents for the control of viral diseases.
Fil: García, C. C.. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina
Fil: Damonte, Elsa Beatriz. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
description The zinc finger proteins have fascinated many research groups because of their modular assembly, broad range of biological functions and more recently because they are attractive targets for antiviral therapy. The zinc finger domain is a very stable structural element whose hallmark is the coordination of a zinc ion by several amino acid residues, usually cysteines and histidines. These structural motifs are associated with protein-nucleic acid recognition as well as protein-protein interactions. The biological function of the zinc finger proteins is strongly dependent on the zinc ion, which assure integrity and stability. Thus, the disruption of critical zinc finger viral proteins represents a fundamentally new approach to inhibit viral replication in the absence of mutations leading to drug resistance phenotypes. This review summarizes the drug design and potential therapeutic applications of viral zinc fingers disrupting agents for the control of viral diseases.
publishDate 2007
dc.date.none.fl_str_mv 2007-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/83870
García, C. C.; Damonte, Elsa Beatriz; Zn finger containing proteins as targets for the control of viral infections; Bentham Science Publishers; Infectious Disorders - Drug Targets; 7; 3; 9-2007; 204-212
1871-5265
CONICET Digital
CONICET
url http://hdl.handle.net/11336/83870
identifier_str_mv García, C. C.; Damonte, Elsa Beatriz; Zn finger containing proteins as targets for the control of viral infections; Bentham Science Publishers; Infectious Disorders - Drug Targets; 7; 3; 9-2007; 204-212
1871-5265
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.eurekaselect.com/78866/article
info:eu-repo/semantics/altIdentifier/doi/10.2174/187152607782110004
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Bentham Science Publishers
publisher.none.fl_str_mv Bentham Science Publishers
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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