Antiviral and Virucidal Activities against Arenaviruses of Zinc-Finger Active Compounds
- Autores
- Garcia, Cybele; Candurra, Nélida Alicia; Damonte, Elsa Beatriz
- Año de publicación
- 2016
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Fifteen antiretroviral Zn-finger active compounds with diverse chemical structures, including azoic compounds, hydrazide derivatives, disulfide-based reagents and others, were screened in vitro against Junin virus (JUNV), the etiological agent of Argentine hemorrhagic fever, by a virus yield inhibition assay in Vero cells. Cytotoxicity was evaluated simultaneously by the MTT method. From the total of compounds, three were totally inactive as antivirals, nine presented moderate anti JUNV-activity and three were truly active with EC50 (effective concentration 50%) values in the range 6.5-9.3 µM and selectivity indices greater than 10. The most active inhibitors, named NSC20625, 3-7 and 2-71, demonstrated a broad range of action against arenaviruses, including several attenuated and pathogenic strains of JUNV as well as the antigenically related Tacaribe virus (TACV) and Pichinde virus (PICV). The direct treatment of JUNV and TACV virions with the compounds has shown two types of behavior: the aromatic disulfide NSC20625 was a very potent virucidal agent, whereas the other two compounds exhibited moderate or negligible virus inactivating properties.
Fil: Garcia, Cybele. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina
Fil: Candurra, Nélida Alicia. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina
Fil: Damonte, Elsa Beatriz. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina - Materia
-
antiviral
virucidal
arenavirus
zinc finger - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/103290
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Antiviral and Virucidal Activities against Arenaviruses of Zinc-Finger Active CompoundsGarcia, CybeleCandurra, Nélida AliciaDamonte, Elsa Beatrizantiviralvirucidalarenaviruszinc fingerhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Fifteen antiretroviral Zn-finger active compounds with diverse chemical structures, including azoic compounds, hydrazide derivatives, disulfide-based reagents and others, were screened in vitro against Junin virus (JUNV), the etiological agent of Argentine hemorrhagic fever, by a virus yield inhibition assay in Vero cells. Cytotoxicity was evaluated simultaneously by the MTT method. From the total of compounds, three were totally inactive as antivirals, nine presented moderate anti JUNV-activity and three were truly active with EC50 (effective concentration 50%) values in the range 6.5-9.3 µM and selectivity indices greater than 10. The most active inhibitors, named NSC20625, 3-7 and 2-71, demonstrated a broad range of action against arenaviruses, including several attenuated and pathogenic strains of JUNV as well as the antigenically related Tacaribe virus (TACV) and Pichinde virus (PICV). The direct treatment of JUNV and TACV virions with the compounds has shown two types of behavior: the aromatic disulfide NSC20625 was a very potent virucidal agent, whereas the other two compounds exhibited moderate or negligible virus inactivating properties.Fil: Garcia, Cybele. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; ArgentinaFil: Candurra, Nélida Alicia. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; ArgentinaFil: Damonte, Elsa Beatriz. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaInternational Medical Press2016-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/103290Garcia, Cybele; Candurra, Nélida Alicia; Damonte, Elsa Beatriz; Antiviral and Virucidal Activities against Arenaviruses of Zinc-Finger Active Compounds; International Medical Press; Antiviral Chemistry and Chemotherapy; 11; 3; 6-2016; 231-2370956-32022040-2066CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/abs/10.1177/095632020001100306info:eu-repo/semantics/altIdentifier/doi/10.1177/095632020001100306info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:56:42Zoai:ri.conicet.gov.ar:11336/103290instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:56:43.139CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Antiviral and Virucidal Activities against Arenaviruses of Zinc-Finger Active Compounds |
title |
Antiviral and Virucidal Activities against Arenaviruses of Zinc-Finger Active Compounds |
spellingShingle |
Antiviral and Virucidal Activities against Arenaviruses of Zinc-Finger Active Compounds Garcia, Cybele antiviral virucidal arenavirus zinc finger |
title_short |
Antiviral and Virucidal Activities against Arenaviruses of Zinc-Finger Active Compounds |
title_full |
Antiviral and Virucidal Activities against Arenaviruses of Zinc-Finger Active Compounds |
title_fullStr |
Antiviral and Virucidal Activities against Arenaviruses of Zinc-Finger Active Compounds |
title_full_unstemmed |
Antiviral and Virucidal Activities against Arenaviruses of Zinc-Finger Active Compounds |
title_sort |
Antiviral and Virucidal Activities against Arenaviruses of Zinc-Finger Active Compounds |
dc.creator.none.fl_str_mv |
Garcia, Cybele Candurra, Nélida Alicia Damonte, Elsa Beatriz |
author |
Garcia, Cybele |
author_facet |
Garcia, Cybele Candurra, Nélida Alicia Damonte, Elsa Beatriz |
author_role |
author |
author2 |
Candurra, Nélida Alicia Damonte, Elsa Beatriz |
author2_role |
author author |
dc.subject.none.fl_str_mv |
antiviral virucidal arenavirus zinc finger |
topic |
antiviral virucidal arenavirus zinc finger |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Fifteen antiretroviral Zn-finger active compounds with diverse chemical structures, including azoic compounds, hydrazide derivatives, disulfide-based reagents and others, were screened in vitro against Junin virus (JUNV), the etiological agent of Argentine hemorrhagic fever, by a virus yield inhibition assay in Vero cells. Cytotoxicity was evaluated simultaneously by the MTT method. From the total of compounds, three were totally inactive as antivirals, nine presented moderate anti JUNV-activity and three were truly active with EC50 (effective concentration 50%) values in the range 6.5-9.3 µM and selectivity indices greater than 10. The most active inhibitors, named NSC20625, 3-7 and 2-71, demonstrated a broad range of action against arenaviruses, including several attenuated and pathogenic strains of JUNV as well as the antigenically related Tacaribe virus (TACV) and Pichinde virus (PICV). The direct treatment of JUNV and TACV virions with the compounds has shown two types of behavior: the aromatic disulfide NSC20625 was a very potent virucidal agent, whereas the other two compounds exhibited moderate or negligible virus inactivating properties. Fil: Garcia, Cybele. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina Fil: Candurra, Nélida Alicia. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina Fil: Damonte, Elsa Beatriz. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina |
description |
Fifteen antiretroviral Zn-finger active compounds with diverse chemical structures, including azoic compounds, hydrazide derivatives, disulfide-based reagents and others, were screened in vitro against Junin virus (JUNV), the etiological agent of Argentine hemorrhagic fever, by a virus yield inhibition assay in Vero cells. Cytotoxicity was evaluated simultaneously by the MTT method. From the total of compounds, three were totally inactive as antivirals, nine presented moderate anti JUNV-activity and three were truly active with EC50 (effective concentration 50%) values in the range 6.5-9.3 µM and selectivity indices greater than 10. The most active inhibitors, named NSC20625, 3-7 and 2-71, demonstrated a broad range of action against arenaviruses, including several attenuated and pathogenic strains of JUNV as well as the antigenically related Tacaribe virus (TACV) and Pichinde virus (PICV). The direct treatment of JUNV and TACV virions with the compounds has shown two types of behavior: the aromatic disulfide NSC20625 was a very potent virucidal agent, whereas the other two compounds exhibited moderate or negligible virus inactivating properties. |
publishDate |
2016 |
dc.date.none.fl_str_mv |
2016-06 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/103290 Garcia, Cybele; Candurra, Nélida Alicia; Damonte, Elsa Beatriz; Antiviral and Virucidal Activities against Arenaviruses of Zinc-Finger Active Compounds; International Medical Press; Antiviral Chemistry and Chemotherapy; 11; 3; 6-2016; 231-237 0956-3202 2040-2066 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/103290 |
identifier_str_mv |
Garcia, Cybele; Candurra, Nélida Alicia; Damonte, Elsa Beatriz; Antiviral and Virucidal Activities against Arenaviruses of Zinc-Finger Active Compounds; International Medical Press; Antiviral Chemistry and Chemotherapy; 11; 3; 6-2016; 231-237 0956-3202 2040-2066 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://journals.sagepub.com/doi/abs/10.1177/095632020001100306 info:eu-repo/semantics/altIdentifier/doi/10.1177/095632020001100306 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
International Medical Press |
publisher.none.fl_str_mv |
International Medical Press |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842269419620794368 |
score |
13.13397 |