Novel therapeutic targets for arenavirus hemorrhagic fevers

Autores
Garcia, Cybele; Sepúlveda, Claudia Soledad; Damonte, Elsa Beatriz
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Several members of the family Arenaviridae can cause severe hemorrhagic fevers in humans, representing a serious public health problem in endemic areas of Africa and South America. The Lassa virus is the most prevalent and dangerous arenavirus, causing over 300,000 infections per year and several thousand deaths. Furthermore, pathogenic arenaviruses are considered as category A potential agents for bioterrorism. Based on the danger of arenaviruses for human health, the increased emergence of new viral species in recent years and the lack of effective tools for their control or prevention, the search for novel antiviral compounds effective against these pathogenic agents is a continuous demanding effort. This article focuses on novel strategies to identify inhibitors for arenavirus therapy, analyzing viral and host proteins essential for virus infection as potential targets for antiviral development. © 2011 Future Medicine Ltd.
Fil: Garcia, Cybele. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina
Fil: Sepúlveda, Claudia Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina
Fil: Damonte, Elsa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina
Materia
Antiviral Agent
Arenavirus
Junin Virus
Lassa Virus
Therapeutic Target
Viral Hemorrhagic Fevers
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/66763
Acceder
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spelling Novel therapeutic targets for arenavirus hemorrhagic feversGarcia, CybeleSepúlveda, Claudia SoledadDamonte, Elsa BeatrizAntiviral AgentArenavirusJunin VirusLassa VirusTherapeutic TargetViral Hemorrhagic Fevershttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Several members of the family Arenaviridae can cause severe hemorrhagic fevers in humans, representing a serious public health problem in endemic areas of Africa and South America. The Lassa virus is the most prevalent and dangerous arenavirus, causing over 300,000 infections per year and several thousand deaths. Furthermore, pathogenic arenaviruses are considered as category A potential agents for bioterrorism. Based on the danger of arenaviruses for human health, the increased emergence of new viral species in recent years and the lack of effective tools for their control or prevention, the search for novel antiviral compounds effective against these pathogenic agents is a continuous demanding effort. This article focuses on novel strategies to identify inhibitors for arenavirus therapy, analyzing viral and host proteins essential for virus infection as potential targets for antiviral development. © 2011 Future Medicine Ltd.Fil: Garcia, Cybele. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; ArgentinaFil: Sepúlveda, Claudia Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; ArgentinaFil: Damonte, Elsa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; ArgentinaFuture Medicine2011-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/66763Garcia, Cybele; Sepúlveda, Claudia Soledad; Damonte, Elsa Beatriz; Novel therapeutic targets for arenavirus hemorrhagic fevers; Future Medicine; Future Virology; 6; 1; 1-2011; 27-441746-0794CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.futuremedicine.com/doi/10.2217/fvl.10.65info:eu-repo/semantics/altIdentifier/doi/10.2217/fvl.10.65info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:21:48Zoai:ri.conicet.gov.ar:11336/66763instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:21:48.704CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Novel therapeutic targets for arenavirus hemorrhagic fevers
title Novel therapeutic targets for arenavirus hemorrhagic fevers
spellingShingle Novel therapeutic targets for arenavirus hemorrhagic fevers
Garcia, Cybele
Antiviral Agent
Arenavirus
Junin Virus
Lassa Virus
Therapeutic Target
Viral Hemorrhagic Fevers
title_short Novel therapeutic targets for arenavirus hemorrhagic fevers
title_full Novel therapeutic targets for arenavirus hemorrhagic fevers
title_fullStr Novel therapeutic targets for arenavirus hemorrhagic fevers
title_full_unstemmed Novel therapeutic targets for arenavirus hemorrhagic fevers
title_sort Novel therapeutic targets for arenavirus hemorrhagic fevers
dc.creator.none.fl_str_mv Garcia, Cybele
Sepúlveda, Claudia Soledad
Damonte, Elsa Beatriz
author Garcia, Cybele
author_facet Garcia, Cybele
Sepúlveda, Claudia Soledad
Damonte, Elsa Beatriz
author_role author
author2 Sepúlveda, Claudia Soledad
Damonte, Elsa Beatriz
author2_role author
author
dc.subject.none.fl_str_mv Antiviral Agent
Arenavirus
Junin Virus
Lassa Virus
Therapeutic Target
Viral Hemorrhagic Fevers
topic Antiviral Agent
Arenavirus
Junin Virus
Lassa Virus
Therapeutic Target
Viral Hemorrhagic Fevers
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Several members of the family Arenaviridae can cause severe hemorrhagic fevers in humans, representing a serious public health problem in endemic areas of Africa and South America. The Lassa virus is the most prevalent and dangerous arenavirus, causing over 300,000 infections per year and several thousand deaths. Furthermore, pathogenic arenaviruses are considered as category A potential agents for bioterrorism. Based on the danger of arenaviruses for human health, the increased emergence of new viral species in recent years and the lack of effective tools for their control or prevention, the search for novel antiviral compounds effective against these pathogenic agents is a continuous demanding effort. This article focuses on novel strategies to identify inhibitors for arenavirus therapy, analyzing viral and host proteins essential for virus infection as potential targets for antiviral development. © 2011 Future Medicine Ltd.
Fil: Garcia, Cybele. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina
Fil: Sepúlveda, Claudia Soledad. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina
Fil: Damonte, Elsa Beatriz. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Departamento de Química Biológica. Laboratorio de Virología; Argentina
description Several members of the family Arenaviridae can cause severe hemorrhagic fevers in humans, representing a serious public health problem in endemic areas of Africa and South America. The Lassa virus is the most prevalent and dangerous arenavirus, causing over 300,000 infections per year and several thousand deaths. Furthermore, pathogenic arenaviruses are considered as category A potential agents for bioterrorism. Based on the danger of arenaviruses for human health, the increased emergence of new viral species in recent years and the lack of effective tools for their control or prevention, the search for novel antiviral compounds effective against these pathogenic agents is a continuous demanding effort. This article focuses on novel strategies to identify inhibitors for arenavirus therapy, analyzing viral and host proteins essential for virus infection as potential targets for antiviral development. © 2011 Future Medicine Ltd.
publishDate 2011
dc.date.none.fl_str_mv 2011-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/66763
Garcia, Cybele; Sepúlveda, Claudia Soledad; Damonte, Elsa Beatriz; Novel therapeutic targets for arenavirus hemorrhagic fevers; Future Medicine; Future Virology; 6; 1; 1-2011; 27-44
1746-0794
CONICET Digital
CONICET
url http://hdl.handle.net/11336/66763
identifier_str_mv Garcia, Cybele; Sepúlveda, Claudia Soledad; Damonte, Elsa Beatriz; Novel therapeutic targets for arenavirus hemorrhagic fevers; Future Medicine; Future Virology; 6; 1; 1-2011; 27-44
1746-0794
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.futuremedicine.com/doi/10.2217/fvl.10.65
info:eu-repo/semantics/altIdentifier/doi/10.2217/fvl.10.65
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Future Medicine
publisher.none.fl_str_mv Future Medicine
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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