Reduced cardio-respiratory coupling indicates suppression of vagal activity in healthy relatives of patients with schizophrenia

Autores
Berger, Sandy; Boettger, Michael Karl; Tancer, Manuel; Guinjoan, Salvador Martín; Yeragani, Vikram K.; Bär, Karl-Jürgen
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Previous studies have observed reduced vagal modulation in patients with acute schizophrenia and their first-degree relatives, thus suggesting a genetic predisposition. To investigate vagal modulation, we analyzed the coupling between heart rate and breathing as a putative measure of central autonomic function in 19 patients, 19 of their relatives and 19 matched control subjects. The interaction of heart rate and breathing was investigated in all groups applying the non-linear parameter cross-ApEn, indicating the asynchrony between both time series. In addition, measures of the time and frequency domain of heart rate variability (HRV) were obtained. The main finding of our study is a significantly increased cross-ApEn value, indicating reduced central vagal modulation both in relatives and patients suffering from schizophrenia. Non-linear measures of HRV proved to more sensitively differentiate relatives from control subjects. Furthermore, we observed a correlation between psychopathology and breathing, indicating that positive symptoms are associated with a higher degree of regularity in the breathing pattern. Our results suggest that autonomic dysfunction previously described for patients suffering from schizophrenia is also present in first-degree relatives. This might relate to changes of brainstem activity in patients and relatives, and a common genetic background in patients and their family members can be assumed.
Fil: Berger, Sandy. Universitat Jena; Alemania
Fil: Boettger, Michael Karl. Universitat Jena; Alemania
Fil: Tancer, Manuel. Wayne State University School of Medicine; Estados Unidos
Fil: Guinjoan, Salvador Martín. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Yeragani, Vikram K.. Wayne State University School of Medicine; Estados Unidos. University of Alberta; Canadá
Fil: Bär, Karl-Jürgen . Universitat Jena; Alemania. Ruhr-universität Bochum; Alemania
Materia
Autonomic Function
Bbreathing Rate
Ccardio-Respiratory Coupling
Schizophrenia
Vagal Tone
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/14304
Acceder
id CONICETDig_2acdbbc35f0455f2c92270e1bfdedb0f
oai_identifier_str oai:ri.conicet.gov.ar:11336/14304
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Reduced cardio-respiratory coupling indicates suppression of vagal activity in healthy relatives of patients with schizophreniaBerger, SandyBoettger, Michael KarlTancer, ManuelGuinjoan, Salvador MartínYeragani, Vikram K.Bär, Karl-Jürgen Autonomic FunctionBbreathing RateCcardio-Respiratory CouplingSchizophreniaVagal Tonehttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Previous studies have observed reduced vagal modulation in patients with acute schizophrenia and their first-degree relatives, thus suggesting a genetic predisposition. To investigate vagal modulation, we analyzed the coupling between heart rate and breathing as a putative measure of central autonomic function in 19 patients, 19 of their relatives and 19 matched control subjects. The interaction of heart rate and breathing was investigated in all groups applying the non-linear parameter cross-ApEn, indicating the asynchrony between both time series. In addition, measures of the time and frequency domain of heart rate variability (HRV) were obtained. The main finding of our study is a significantly increased cross-ApEn value, indicating reduced central vagal modulation both in relatives and patients suffering from schizophrenia. Non-linear measures of HRV proved to more sensitively differentiate relatives from control subjects. Furthermore, we observed a correlation between psychopathology and breathing, indicating that positive symptoms are associated with a higher degree of regularity in the breathing pattern. Our results suggest that autonomic dysfunction previously described for patients suffering from schizophrenia is also present in first-degree relatives. This might relate to changes of brainstem activity in patients and relatives, and a common genetic background in patients and their family members can be assumed.Fil: Berger, Sandy. Universitat Jena; AlemaniaFil: Boettger, Michael Karl. Universitat Jena; AlemaniaFil: Tancer, Manuel. Wayne State University School of Medicine; Estados UnidosFil: Guinjoan, Salvador Martín. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Yeragani, Vikram K.. Wayne State University School of Medicine; Estados Unidos. University of Alberta; CanadáFil: Bär, Karl-Jürgen . Universitat Jena; Alemania. Ruhr-universität Bochum; AlemaniaElsevier Inc2010-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/14304Berger, Sandy; Boettger, Michael Karl; Tancer, Manuel; Guinjoan, Salvador Martín; Yeragani, Vikram K.; et al.; Reduced cardio-respiratory coupling indicates suppression of vagal activity in healthy relatives of patients with schizophrenia; Elsevier Inc; Progress of Neuro-psychopharmacology and Biological Psychiatry; 34; 2; 3-2010; 406-4110278-5846enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0278584610000175info:eu-repo/semantics/altIdentifier/doi/10.1016/j.pnpbp.2010.01.009info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:46:34Zoai:ri.conicet.gov.ar:11336/14304instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:46:34.914CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Reduced cardio-respiratory coupling indicates suppression of vagal activity in healthy relatives of patients with schizophrenia
title Reduced cardio-respiratory coupling indicates suppression of vagal activity in healthy relatives of patients with schizophrenia
spellingShingle Reduced cardio-respiratory coupling indicates suppression of vagal activity in healthy relatives of patients with schizophrenia
Berger, Sandy
Autonomic Function
Bbreathing Rate
Ccardio-Respiratory Coupling
Schizophrenia
Vagal Tone
title_short Reduced cardio-respiratory coupling indicates suppression of vagal activity in healthy relatives of patients with schizophrenia
title_full Reduced cardio-respiratory coupling indicates suppression of vagal activity in healthy relatives of patients with schizophrenia
title_fullStr Reduced cardio-respiratory coupling indicates suppression of vagal activity in healthy relatives of patients with schizophrenia
title_full_unstemmed Reduced cardio-respiratory coupling indicates suppression of vagal activity in healthy relatives of patients with schizophrenia
title_sort Reduced cardio-respiratory coupling indicates suppression of vagal activity in healthy relatives of patients with schizophrenia
dc.creator.none.fl_str_mv Berger, Sandy
Boettger, Michael Karl
Tancer, Manuel
Guinjoan, Salvador Martín
Yeragani, Vikram K.
Bär, Karl-Jürgen
author Berger, Sandy
author_facet Berger, Sandy
Boettger, Michael Karl
Tancer, Manuel
Guinjoan, Salvador Martín
Yeragani, Vikram K.
Bär, Karl-Jürgen
author_role author
author2 Boettger, Michael Karl
Tancer, Manuel
Guinjoan, Salvador Martín
Yeragani, Vikram K.
Bär, Karl-Jürgen
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Autonomic Function
Bbreathing Rate
Ccardio-Respiratory Coupling
Schizophrenia
Vagal Tone
topic Autonomic Function
Bbreathing Rate
Ccardio-Respiratory Coupling
Schizophrenia
Vagal Tone
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Previous studies have observed reduced vagal modulation in patients with acute schizophrenia and their first-degree relatives, thus suggesting a genetic predisposition. To investigate vagal modulation, we analyzed the coupling between heart rate and breathing as a putative measure of central autonomic function in 19 patients, 19 of their relatives and 19 matched control subjects. The interaction of heart rate and breathing was investigated in all groups applying the non-linear parameter cross-ApEn, indicating the asynchrony between both time series. In addition, measures of the time and frequency domain of heart rate variability (HRV) were obtained. The main finding of our study is a significantly increased cross-ApEn value, indicating reduced central vagal modulation both in relatives and patients suffering from schizophrenia. Non-linear measures of HRV proved to more sensitively differentiate relatives from control subjects. Furthermore, we observed a correlation between psychopathology and breathing, indicating that positive symptoms are associated with a higher degree of regularity in the breathing pattern. Our results suggest that autonomic dysfunction previously described for patients suffering from schizophrenia is also present in first-degree relatives. This might relate to changes of brainstem activity in patients and relatives, and a common genetic background in patients and their family members can be assumed.
Fil: Berger, Sandy. Universitat Jena; Alemania
Fil: Boettger, Michael Karl. Universitat Jena; Alemania
Fil: Tancer, Manuel. Wayne State University School of Medicine; Estados Unidos
Fil: Guinjoan, Salvador Martín. Universidad de Buenos Aires. Facultad de Medicina. Departamento de Ciencias Fisiológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Yeragani, Vikram K.. Wayne State University School of Medicine; Estados Unidos. University of Alberta; Canadá
Fil: Bär, Karl-Jürgen . Universitat Jena; Alemania. Ruhr-universität Bochum; Alemania
description Previous studies have observed reduced vagal modulation in patients with acute schizophrenia and their first-degree relatives, thus suggesting a genetic predisposition. To investigate vagal modulation, we analyzed the coupling between heart rate and breathing as a putative measure of central autonomic function in 19 patients, 19 of their relatives and 19 matched control subjects. The interaction of heart rate and breathing was investigated in all groups applying the non-linear parameter cross-ApEn, indicating the asynchrony between both time series. In addition, measures of the time and frequency domain of heart rate variability (HRV) were obtained. The main finding of our study is a significantly increased cross-ApEn value, indicating reduced central vagal modulation both in relatives and patients suffering from schizophrenia. Non-linear measures of HRV proved to more sensitively differentiate relatives from control subjects. Furthermore, we observed a correlation between psychopathology and breathing, indicating that positive symptoms are associated with a higher degree of regularity in the breathing pattern. Our results suggest that autonomic dysfunction previously described for patients suffering from schizophrenia is also present in first-degree relatives. This might relate to changes of brainstem activity in patients and relatives, and a common genetic background in patients and their family members can be assumed.
publishDate 2010
dc.date.none.fl_str_mv 2010-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/14304
Berger, Sandy; Boettger, Michael Karl; Tancer, Manuel; Guinjoan, Salvador Martín; Yeragani, Vikram K.; et al.; Reduced cardio-respiratory coupling indicates suppression of vagal activity in healthy relatives of patients with schizophrenia; Elsevier Inc; Progress of Neuro-psychopharmacology and Biological Psychiatry; 34; 2; 3-2010; 406-411
0278-5846
url http://hdl.handle.net/11336/14304
identifier_str_mv Berger, Sandy; Boettger, Michael Karl; Tancer, Manuel; Guinjoan, Salvador Martín; Yeragani, Vikram K.; et al.; Reduced cardio-respiratory coupling indicates suppression of vagal activity in healthy relatives of patients with schizophrenia; Elsevier Inc; Progress of Neuro-psychopharmacology and Biological Psychiatry; 34; 2; 3-2010; 406-411
0278-5846
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0278584610000175
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.pnpbp.2010.01.009
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Inc
publisher.none.fl_str_mv Elsevier Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083562404577280
score 13.22299

Publicaciones similares