The role of heparan sulfates in protein aggregation and their potential impact on neurodegeneration

Autores
Maïza, Auriane; Chantepie, Sandrine; Vera, Claudia Cecilia; Fifre, Alexandre; Huynh, Minh Bao; Stettler, Olivier; Ouidja, Mohand Ouidir; Papy Garcia, Dulce
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Neurodegenerative disorders, such as Alzheimer´s, Parkinson´s, and prion diseases, are directly linked to the formation and accumulation of protein aggregates in the brain. These aggregates, principally made of proteins or peptides that clamp together after acquisition of β-folded structures, also contain heparan sulfates. Several lines of evidence suggest that heparan sulfates centrally participate in the protein aggregation process. In vitro, they trigger misfolding, oligomerization, and fibrillation of amyloidogenic proteins, such as Aβ, tau, α-synuclein, prion protein, etc. They participate in the stabilization of protein aggregates, protect them from proteolysis, and act as cell-surface receptors for the cellular uptake of proteopathic seeds during their spreading. This review focuses attention on the importance of heparan sulfates in protein aggregation in brain disorders including Alzheimer´s, Parkinson´s, and prion diseases. The presence of these sulfated polysaccharides in protein inclusions in vivo and their capacity to trigger protein aggregation in vitro strongly suggest that they might play critical roles in the neurodegenerative process. Further advances in glyco-neurobiology will improve our understanding of the molecular and cellular mechanisms leading to protein aggregation and neurodegeneration.
Fil: Maïza, Auriane. Universite de Paris; Francia
Fil: Chantepie, Sandrine. Universite de Paris; Francia
Fil: Vera, Claudia Cecilia. Universite de Paris; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Fifre, Alexandre. Universite de Paris; Francia
Fil: Huynh, Minh Bao. Universite de Paris; Francia
Fil: Stettler, Olivier. Universite de Paris; Francia
Fil: Ouidja, Mohand Ouidir. Universite de Paris; Francia
Fil: Papy Garcia, Dulce. Universite de Paris; Francia
Materia
ALZHEIMER'S DISEASE
PARKINSON'S DISEASE
HEPARAN SULFATES
NEURODEGENERATION
PRION DISEASES
PROTEIN AGGREGATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/101926
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The role of heparan sulfates in protein aggregation and their potential impact on neurodegenerationMaïza, AurianeChantepie, SandrineVera, Claudia CeciliaFifre, AlexandreHuynh, Minh BaoStettler, OlivierOuidja, Mohand OuidirPapy Garcia, DulceALZHEIMER'S DISEASEPARKINSON'S DISEASEHEPARAN SULFATESNEURODEGENERATIONPRION DISEASESPROTEIN AGGREGATIONhttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Neurodegenerative disorders, such as Alzheimer´s, Parkinson´s, and prion diseases, are directly linked to the formation and accumulation of protein aggregates in the brain. These aggregates, principally made of proteins or peptides that clamp together after acquisition of β-folded structures, also contain heparan sulfates. Several lines of evidence suggest that heparan sulfates centrally participate in the protein aggregation process. In vitro, they trigger misfolding, oligomerization, and fibrillation of amyloidogenic proteins, such as Aβ, tau, α-synuclein, prion protein, etc. They participate in the stabilization of protein aggregates, protect them from proteolysis, and act as cell-surface receptors for the cellular uptake of proteopathic seeds during their spreading. This review focuses attention on the importance of heparan sulfates in protein aggregation in brain disorders including Alzheimer´s, Parkinson´s, and prion diseases. The presence of these sulfated polysaccharides in protein inclusions in vivo and their capacity to trigger protein aggregation in vitro strongly suggest that they might play critical roles in the neurodegenerative process. Further advances in glyco-neurobiology will improve our understanding of the molecular and cellular mechanisms leading to protein aggregation and neurodegeneration.Fil: Maïza, Auriane. Universite de Paris; FranciaFil: Chantepie, Sandrine. Universite de Paris; FranciaFil: Vera, Claudia Cecilia. Universite de Paris; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; ArgentinaFil: Fifre, Alexandre. Universite de Paris; FranciaFil: Huynh, Minh Bao. Universite de Paris; FranciaFil: Stettler, Olivier. Universite de Paris; FranciaFil: Ouidja, Mohand Ouidir. Universite de Paris; FranciaFil: Papy Garcia, Dulce. Universite de Paris; FranciaWiley2018-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/101926Maïza, Auriane; Chantepie, Sandrine; Vera, Claudia Cecilia; Fifre, Alexandre; Huynh, Minh Bao; et al.; The role of heparan sulfates in protein aggregation and their potential impact on neurodegeneration; Wiley; FEBS Letters; 592; 23; 6-2018; 3806-38180014-57931873-3468CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/1873-3468.13082info:eu-repo/semantics/altIdentifier/url/https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.13082info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:46:13Zoai:ri.conicet.gov.ar:11336/101926instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:46:13.981CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The role of heparan sulfates in protein aggregation and their potential impact on neurodegeneration
title The role of heparan sulfates in protein aggregation and their potential impact on neurodegeneration
spellingShingle The role of heparan sulfates in protein aggregation and their potential impact on neurodegeneration
Maïza, Auriane
ALZHEIMER'S DISEASE
PARKINSON'S DISEASE
HEPARAN SULFATES
NEURODEGENERATION
PRION DISEASES
PROTEIN AGGREGATION
title_short The role of heparan sulfates in protein aggregation and their potential impact on neurodegeneration
title_full The role of heparan sulfates in protein aggregation and their potential impact on neurodegeneration
title_fullStr The role of heparan sulfates in protein aggregation and their potential impact on neurodegeneration
title_full_unstemmed The role of heparan sulfates in protein aggregation and their potential impact on neurodegeneration
title_sort The role of heparan sulfates in protein aggregation and their potential impact on neurodegeneration
dc.creator.none.fl_str_mv Maïza, Auriane
Chantepie, Sandrine
Vera, Claudia Cecilia
Fifre, Alexandre
Huynh, Minh Bao
Stettler, Olivier
Ouidja, Mohand Ouidir
Papy Garcia, Dulce
author Maïza, Auriane
author_facet Maïza, Auriane
Chantepie, Sandrine
Vera, Claudia Cecilia
Fifre, Alexandre
Huynh, Minh Bao
Stettler, Olivier
Ouidja, Mohand Ouidir
Papy Garcia, Dulce
author_role author
author2 Chantepie, Sandrine
Vera, Claudia Cecilia
Fifre, Alexandre
Huynh, Minh Bao
Stettler, Olivier
Ouidja, Mohand Ouidir
Papy Garcia, Dulce
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv ALZHEIMER'S DISEASE
PARKINSON'S DISEASE
HEPARAN SULFATES
NEURODEGENERATION
PRION DISEASES
PROTEIN AGGREGATION
topic ALZHEIMER'S DISEASE
PARKINSON'S DISEASE
HEPARAN SULFATES
NEURODEGENERATION
PRION DISEASES
PROTEIN AGGREGATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Neurodegenerative disorders, such as Alzheimer´s, Parkinson´s, and prion diseases, are directly linked to the formation and accumulation of protein aggregates in the brain. These aggregates, principally made of proteins or peptides that clamp together after acquisition of β-folded structures, also contain heparan sulfates. Several lines of evidence suggest that heparan sulfates centrally participate in the protein aggregation process. In vitro, they trigger misfolding, oligomerization, and fibrillation of amyloidogenic proteins, such as Aβ, tau, α-synuclein, prion protein, etc. They participate in the stabilization of protein aggregates, protect them from proteolysis, and act as cell-surface receptors for the cellular uptake of proteopathic seeds during their spreading. This review focuses attention on the importance of heparan sulfates in protein aggregation in brain disorders including Alzheimer´s, Parkinson´s, and prion diseases. The presence of these sulfated polysaccharides in protein inclusions in vivo and their capacity to trigger protein aggregation in vitro strongly suggest that they might play critical roles in the neurodegenerative process. Further advances in glyco-neurobiology will improve our understanding of the molecular and cellular mechanisms leading to protein aggregation and neurodegeneration.
Fil: Maïza, Auriane. Universite de Paris; Francia
Fil: Chantepie, Sandrine. Universite de Paris; Francia
Fil: Vera, Claudia Cecilia. Universite de Paris; Francia. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Instituto Superior de Investigaciones Biológicas. Universidad Nacional de Tucumán. Instituto Superior de Investigaciones Biológicas; Argentina
Fil: Fifre, Alexandre. Universite de Paris; Francia
Fil: Huynh, Minh Bao. Universite de Paris; Francia
Fil: Stettler, Olivier. Universite de Paris; Francia
Fil: Ouidja, Mohand Ouidir. Universite de Paris; Francia
Fil: Papy Garcia, Dulce. Universite de Paris; Francia
description Neurodegenerative disorders, such as Alzheimer´s, Parkinson´s, and prion diseases, are directly linked to the formation and accumulation of protein aggregates in the brain. These aggregates, principally made of proteins or peptides that clamp together after acquisition of β-folded structures, also contain heparan sulfates. Several lines of evidence suggest that heparan sulfates centrally participate in the protein aggregation process. In vitro, they trigger misfolding, oligomerization, and fibrillation of amyloidogenic proteins, such as Aβ, tau, α-synuclein, prion protein, etc. They participate in the stabilization of protein aggregates, protect them from proteolysis, and act as cell-surface receptors for the cellular uptake of proteopathic seeds during their spreading. This review focuses attention on the importance of heparan sulfates in protein aggregation in brain disorders including Alzheimer´s, Parkinson´s, and prion diseases. The presence of these sulfated polysaccharides in protein inclusions in vivo and their capacity to trigger protein aggregation in vitro strongly suggest that they might play critical roles in the neurodegenerative process. Further advances in glyco-neurobiology will improve our understanding of the molecular and cellular mechanisms leading to protein aggregation and neurodegeneration.
publishDate 2018
dc.date.none.fl_str_mv 2018-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/101926
Maïza, Auriane; Chantepie, Sandrine; Vera, Claudia Cecilia; Fifre, Alexandre; Huynh, Minh Bao; et al.; The role of heparan sulfates in protein aggregation and their potential impact on neurodegeneration; Wiley; FEBS Letters; 592; 23; 6-2018; 3806-3818
0014-5793
1873-3468
CONICET Digital
CONICET
url http://hdl.handle.net/11336/101926
identifier_str_mv Maïza, Auriane; Chantepie, Sandrine; Vera, Claudia Cecilia; Fifre, Alexandre; Huynh, Minh Bao; et al.; The role of heparan sulfates in protein aggregation and their potential impact on neurodegeneration; Wiley; FEBS Letters; 592; 23; 6-2018; 3806-3818
0014-5793
1873-3468
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/1873-3468.13082
info:eu-repo/semantics/altIdentifier/url/https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.13082
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Wiley
publisher.none.fl_str_mv Wiley
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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