Simultaneous Determination of Amoxicillin and Diclofenac in Pharmaceutical Formulations Using UV Spectral Data and the PLS Chemometric Method

Autores
Cantarelli, Miguel Angel; Pellerano, Roberto Gerardo; Marchevsky, Eduardo Jorge; Camiña, José Manuel
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A new method for the simultaneous determination of amoxicillin trihydrate (AMT) and sodium diclofenac (DIC) in pharmaceutical formulations is proposed. The resolution of binary mixtures of these drugs has been accomplished by using partial least squares (PLS) regression analysis. The model was obtained from UV spectral data, validated by internal cross-validation and was used to find the concentration of analytes in the commercial samples. The method was applied in the concentration ranges of 0 -120.0 mg L-1 for AMT and 0 - 16.0 mg L-1 for DIC, allowing a rapid, accurate and precise simultaneous estimation of the concentration of both analytes of interest in the presence of small amounts of different, unmodelled, absorbing excipients, in spite of their important spectral overlapping. The accuracy, precision and figures of merit (FOM) for AMT and DIC were calculated. This new method proved to be useful for a fast and simultaneous determination of AMT and DIC in pharmaceutical formulations.
Fil: Cantarelli, Miguel Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Pellerano, Roberto Gerardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Química Básica y Aplicada del Nordeste Argentino. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Instituto de Química Básica y Aplicada del Nordeste Argentino; Argentina
Fil: Marchevsky, Eduardo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Camiña, José Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Materia
AMOXICILLIN
DICLOFENAC
PLS-1
MULTIVARIATE
CALIBRATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/43381
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Simultaneous Determination of Amoxicillin and Diclofenac in Pharmaceutical Formulations Using UV Spectral Data and the PLS Chemometric MethodCantarelli, Miguel AngelPellerano, Roberto GerardoMarchevsky, Eduardo JorgeCamiña, José ManuelAMOXICILLINDICLOFENACPLS-1MULTIVARIATECALIBRATIONhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1A new method for the simultaneous determination of amoxicillin trihydrate (AMT) and sodium diclofenac (DIC) in pharmaceutical formulations is proposed. The resolution of binary mixtures of these drugs has been accomplished by using partial least squares (PLS) regression analysis. The model was obtained from UV spectral data, validated by internal cross-validation and was used to find the concentration of analytes in the commercial samples. The method was applied in the concentration ranges of 0 -120.0 mg L-1 for AMT and 0 - 16.0 mg L-1 for DIC, allowing a rapid, accurate and precise simultaneous estimation of the concentration of both analytes of interest in the presence of small amounts of different, unmodelled, absorbing excipients, in spite of their important spectral overlapping. The accuracy, precision and figures of merit (FOM) for AMT and DIC were calculated. This new method proved to be useful for a fast and simultaneous determination of AMT and DIC in pharmaceutical formulations.Fil: Cantarelli, Miguel Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaFil: Pellerano, Roberto Gerardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Química Básica y Aplicada del Nordeste Argentino. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Instituto de Química Básica y Aplicada del Nordeste Argentino; ArgentinaFil: Marchevsky, Eduardo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaFil: Camiña, José Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; ArgentinaJapan Society for Analytical Chemistry2011-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/43381Cantarelli, Miguel Angel; Pellerano, Roberto Gerardo; Marchevsky, Eduardo Jorge; Camiña, José Manuel; Simultaneous Determination of Amoxicillin and Diclofenac in Pharmaceutical Formulations Using UV Spectral Data and the PLS Chemometric Method; Japan Society for Analytical Chemistry; Analytical Sciences; 27; 1-2011; 73-780910-63401348-2246CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.2116/analsci.27.73info:eu-repo/semantics/altIdentifier/url/https://www.jstage.jst.go.jp/article/analsci/27/1/27_1_73/_articleinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:46:03Zoai:ri.conicet.gov.ar:11336/43381instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:46:03.4CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Simultaneous Determination of Amoxicillin and Diclofenac in Pharmaceutical Formulations Using UV Spectral Data and the PLS Chemometric Method
title Simultaneous Determination of Amoxicillin and Diclofenac in Pharmaceutical Formulations Using UV Spectral Data and the PLS Chemometric Method
spellingShingle Simultaneous Determination of Amoxicillin and Diclofenac in Pharmaceutical Formulations Using UV Spectral Data and the PLS Chemometric Method
Cantarelli, Miguel Angel
AMOXICILLIN
DICLOFENAC
PLS-1
MULTIVARIATE
CALIBRATION
title_short Simultaneous Determination of Amoxicillin and Diclofenac in Pharmaceutical Formulations Using UV Spectral Data and the PLS Chemometric Method
title_full Simultaneous Determination of Amoxicillin and Diclofenac in Pharmaceutical Formulations Using UV Spectral Data and the PLS Chemometric Method
title_fullStr Simultaneous Determination of Amoxicillin and Diclofenac in Pharmaceutical Formulations Using UV Spectral Data and the PLS Chemometric Method
title_full_unstemmed Simultaneous Determination of Amoxicillin and Diclofenac in Pharmaceutical Formulations Using UV Spectral Data and the PLS Chemometric Method
title_sort Simultaneous Determination of Amoxicillin and Diclofenac in Pharmaceutical Formulations Using UV Spectral Data and the PLS Chemometric Method
dc.creator.none.fl_str_mv Cantarelli, Miguel Angel
Pellerano, Roberto Gerardo
Marchevsky, Eduardo Jorge
Camiña, José Manuel
author Cantarelli, Miguel Angel
author_facet Cantarelli, Miguel Angel
Pellerano, Roberto Gerardo
Marchevsky, Eduardo Jorge
Camiña, José Manuel
author_role author
author2 Pellerano, Roberto Gerardo
Marchevsky, Eduardo Jorge
Camiña, José Manuel
author2_role author
author
author
dc.subject.none.fl_str_mv AMOXICILLIN
DICLOFENAC
PLS-1
MULTIVARIATE
CALIBRATION
topic AMOXICILLIN
DICLOFENAC
PLS-1
MULTIVARIATE
CALIBRATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv A new method for the simultaneous determination of amoxicillin trihydrate (AMT) and sodium diclofenac (DIC) in pharmaceutical formulations is proposed. The resolution of binary mixtures of these drugs has been accomplished by using partial least squares (PLS) regression analysis. The model was obtained from UV spectral data, validated by internal cross-validation and was used to find the concentration of analytes in the commercial samples. The method was applied in the concentration ranges of 0 -120.0 mg L-1 for AMT and 0 - 16.0 mg L-1 for DIC, allowing a rapid, accurate and precise simultaneous estimation of the concentration of both analytes of interest in the presence of small amounts of different, unmodelled, absorbing excipients, in spite of their important spectral overlapping. The accuracy, precision and figures of merit (FOM) for AMT and DIC were calculated. This new method proved to be useful for a fast and simultaneous determination of AMT and DIC in pharmaceutical formulations.
Fil: Cantarelli, Miguel Angel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Pellerano, Roberto Gerardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste. Instituto de Química Básica y Aplicada del Nordeste Argentino. Universidad Nacional del Nordeste. Facultad de Ciencias Exactas Naturales y Agrimensura. Instituto de Química Básica y Aplicada del Nordeste Argentino; Argentina
Fil: Marchevsky, Eduardo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
Fil: Camiña, José Manuel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina
description A new method for the simultaneous determination of amoxicillin trihydrate (AMT) and sodium diclofenac (DIC) in pharmaceutical formulations is proposed. The resolution of binary mixtures of these drugs has been accomplished by using partial least squares (PLS) regression analysis. The model was obtained from UV spectral data, validated by internal cross-validation and was used to find the concentration of analytes in the commercial samples. The method was applied in the concentration ranges of 0 -120.0 mg L-1 for AMT and 0 - 16.0 mg L-1 for DIC, allowing a rapid, accurate and precise simultaneous estimation of the concentration of both analytes of interest in the presence of small amounts of different, unmodelled, absorbing excipients, in spite of their important spectral overlapping. The accuracy, precision and figures of merit (FOM) for AMT and DIC were calculated. This new method proved to be useful for a fast and simultaneous determination of AMT and DIC in pharmaceutical formulations.
publishDate 2011
dc.date.none.fl_str_mv 2011-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/43381
Cantarelli, Miguel Angel; Pellerano, Roberto Gerardo; Marchevsky, Eduardo Jorge; Camiña, José Manuel; Simultaneous Determination of Amoxicillin and Diclofenac in Pharmaceutical Formulations Using UV Spectral Data and the PLS Chemometric Method; Japan Society for Analytical Chemistry; Analytical Sciences; 27; 1-2011; 73-78
0910-6340
1348-2246
CONICET Digital
CONICET
url http://hdl.handle.net/11336/43381
identifier_str_mv Cantarelli, Miguel Angel; Pellerano, Roberto Gerardo; Marchevsky, Eduardo Jorge; Camiña, José Manuel; Simultaneous Determination of Amoxicillin and Diclofenac in Pharmaceutical Formulations Using UV Spectral Data and the PLS Chemometric Method; Japan Society for Analytical Chemistry; Analytical Sciences; 27; 1-2011; 73-78
0910-6340
1348-2246
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.2116/analsci.27.73
info:eu-repo/semantics/altIdentifier/url/https://www.jstage.jst.go.jp/article/analsci/27/1/27_1_73/_article
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Japan Society for Analytical Chemistry
publisher.none.fl_str_mv Japan Society for Analytical Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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