The gut-lung axis and asthma susceptibility in early life

Autores
Kahhaleh, Fariz G.; Barrientos, Gabriela Laura; Conrad, Melanie L.
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Asthma is the most common chronic disease among children, with more than 300million cases worldwide. Over the past several decades, asthma incidence has grown, and epidemiological studies identify the modernized lifestyle as playing a strong contributing role in this phenomenon. In particular, lifestyle factors that modify the maternal gut microbiome during pregnancy, or the infant microbiome in early life, can act as developmental programming events which determine health or disease susceptibility later in life. Microbial colonization of the gut begins at birth, and factors such as delivery mode, breastfeeding, diet, antibiotic use, and exposure to environmental bacteria influence the development of the infant microbiome. Colonization of the gut microbiome is crucial for proper immune system development and disruptions to this process can predispose a child to asthma development. Here, we describe the importance of early-life events for shaping immune responses along the gut-lung axis and why they may provide a window of opportunity for asthma prevention.
Fil: Kahhaleh, Fariz G.. Humboldt-Universität zu Berlin; Alemania
Fil: Barrientos, Gabriela Laura. Hospital Alemán; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Conrad, Melanie L.. Humboldt-Universität zu Berlin; Alemania
Materia
ANTIBIOTIC
ASTHMA
DOHAD
EARLY LIFE
GUT-LUNG AXIS
HYGIENE HYPOTHESIS
MICROBIOME
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/236579
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/236579
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The gut-lung axis and asthma susceptibility in early lifeKahhaleh, Fariz G.Barrientos, Gabriela LauraConrad, Melanie L.ANTIBIOTICASTHMADOHADEARLY LIFEGUT-LUNG AXISHYGIENE HYPOTHESISMICROBIOMEhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Asthma is the most common chronic disease among children, with more than 300million cases worldwide. Over the past several decades, asthma incidence has grown, and epidemiological studies identify the modernized lifestyle as playing a strong contributing role in this phenomenon. In particular, lifestyle factors that modify the maternal gut microbiome during pregnancy, or the infant microbiome in early life, can act as developmental programming events which determine health or disease susceptibility later in life. Microbial colonization of the gut begins at birth, and factors such as delivery mode, breastfeeding, diet, antibiotic use, and exposure to environmental bacteria influence the development of the infant microbiome. Colonization of the gut microbiome is crucial for proper immune system development and disruptions to this process can predispose a child to asthma development. Here, we describe the importance of early-life events for shaping immune responses along the gut-lung axis and why they may provide a window of opportunity for asthma prevention.Fil: Kahhaleh, Fariz G.. Humboldt-Universität zu Berlin; AlemaniaFil: Barrientos, Gabriela Laura. Hospital Alemán; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Conrad, Melanie L.. Humboldt-Universität zu Berlin; AlemaniaJohn Wiley & Sons Ltd2024-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/236579Kahhaleh, Fariz G.; Barrientos, Gabriela Laura; Conrad, Melanie L.; The gut-lung axis and asthma susceptibility in early life; John Wiley & Sons Ltd; Acta Physiologica; 240; 3; 1-2024; 1-151748-1716CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1111/apha.14092info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/apha.14092info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:29:56Zoai:ri.conicet.gov.ar:11336/236579instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:29:56.528CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The gut-lung axis and asthma susceptibility in early life
title The gut-lung axis and asthma susceptibility in early life
spellingShingle The gut-lung axis and asthma susceptibility in early life
Kahhaleh, Fariz G.
ANTIBIOTIC
ASTHMA
DOHAD
EARLY LIFE
GUT-LUNG AXIS
HYGIENE HYPOTHESIS
MICROBIOME
title_short The gut-lung axis and asthma susceptibility in early life
title_full The gut-lung axis and asthma susceptibility in early life
title_fullStr The gut-lung axis and asthma susceptibility in early life
title_full_unstemmed The gut-lung axis and asthma susceptibility in early life
title_sort The gut-lung axis and asthma susceptibility in early life
dc.creator.none.fl_str_mv Kahhaleh, Fariz G.
Barrientos, Gabriela Laura
Conrad, Melanie L.
author Kahhaleh, Fariz G.
author_facet Kahhaleh, Fariz G.
Barrientos, Gabriela Laura
Conrad, Melanie L.
author_role author
author2 Barrientos, Gabriela Laura
Conrad, Melanie L.
author2_role author
author
dc.subject.none.fl_str_mv ANTIBIOTIC
ASTHMA
DOHAD
EARLY LIFE
GUT-LUNG AXIS
HYGIENE HYPOTHESIS
MICROBIOME
topic ANTIBIOTIC
ASTHMA
DOHAD
EARLY LIFE
GUT-LUNG AXIS
HYGIENE HYPOTHESIS
MICROBIOME
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Asthma is the most common chronic disease among children, with more than 300million cases worldwide. Over the past several decades, asthma incidence has grown, and epidemiological studies identify the modernized lifestyle as playing a strong contributing role in this phenomenon. In particular, lifestyle factors that modify the maternal gut microbiome during pregnancy, or the infant microbiome in early life, can act as developmental programming events which determine health or disease susceptibility later in life. Microbial colonization of the gut begins at birth, and factors such as delivery mode, breastfeeding, diet, antibiotic use, and exposure to environmental bacteria influence the development of the infant microbiome. Colonization of the gut microbiome is crucial for proper immune system development and disruptions to this process can predispose a child to asthma development. Here, we describe the importance of early-life events for shaping immune responses along the gut-lung axis and why they may provide a window of opportunity for asthma prevention.
Fil: Kahhaleh, Fariz G.. Humboldt-Universität zu Berlin; Alemania
Fil: Barrientos, Gabriela Laura. Hospital Alemán; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Conrad, Melanie L.. Humboldt-Universität zu Berlin; Alemania
description Asthma is the most common chronic disease among children, with more than 300million cases worldwide. Over the past several decades, asthma incidence has grown, and epidemiological studies identify the modernized lifestyle as playing a strong contributing role in this phenomenon. In particular, lifestyle factors that modify the maternal gut microbiome during pregnancy, or the infant microbiome in early life, can act as developmental programming events which determine health or disease susceptibility later in life. Microbial colonization of the gut begins at birth, and factors such as delivery mode, breastfeeding, diet, antibiotic use, and exposure to environmental bacteria influence the development of the infant microbiome. Colonization of the gut microbiome is crucial for proper immune system development and disruptions to this process can predispose a child to asthma development. Here, we describe the importance of early-life events for shaping immune responses along the gut-lung axis and why they may provide a window of opportunity for asthma prevention.
publishDate 2024
dc.date.none.fl_str_mv 2024-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/236579
Kahhaleh, Fariz G.; Barrientos, Gabriela Laura; Conrad, Melanie L.; The gut-lung axis and asthma susceptibility in early life; John Wiley & Sons Ltd; Acta Physiologica; 240; 3; 1-2024; 1-15
1748-1716
CONICET Digital
CONICET
url http://hdl.handle.net/11336/236579
identifier_str_mv Kahhaleh, Fariz G.; Barrientos, Gabriela Laura; Conrad, Melanie L.; The gut-lung axis and asthma susceptibility in early life; John Wiley & Sons Ltd; Acta Physiologica; 240; 3; 1-2024; 1-15
1748-1716
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1111/apha.14092
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/10.1111/apha.14092
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons Ltd
publisher.none.fl_str_mv John Wiley & Sons Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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