Functional diversity for body actions in the mesencephalic locomotor region

Autores
Ferreira Pinto, Manuel J.; Kanodia, Harsh; Falasconi, Antonio; Sigrist, Markus; Esposito, Maria Soledad; Arber, Silvia
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The mesencephalic locomotor region (MLR) is a key midbrain center with roles in locomotion. Despite extensive studies and clinical trials aimed at therapy-resistant Parkinson’s disease (PD), debate on its function remains. Here, we reveal the existence of functionally diverse neuronal populations with distinct roles in control of body movements. We identify two spatially intermingled glutamatergic populations separable by axonal projections, mouse genetics, neuronal activity profiles, and motor functions. Most spinally projecting MLR neurons encoded the full-body behavior rearing. Loss- and gain-of-function optogenetic perturbation experiments establish a function for these neurons in controlling body extension. In contrast, Rbp4-transgene-positive MLR neurons project in an ascending direction to basal ganglia, preferentially encode the forelimb behaviors handling and grooming, and exhibit a role in modulating movement. Thus, the MLR contains glutamatergic neuronal subpopulations stratified by projection target exhibiting roles in action control not restricted to locomotion.
Fil: Ferreira Pinto, Manuel J.. Friedrich Miescher Institute for Biomedical Research; Suiza. Universidad de Basilea; Suiza
Fil: Kanodia, Harsh. Friedrich Miescher Institute for Biomedical Research; Suiza. Universidad de Basilea; Suiza
Fil: Falasconi, Antonio. Friedrich Miescher Institute for Biomedical Research; Suiza. Universidad de Basilea; Suiza
Fil: Sigrist, Markus. Universidad de Basilea; Suiza. Friedrich Miescher Institute for Biomedical Research; Suiza
Fil: Esposito, Maria Soledad. Universidad de Basilea; Suiza. Friedrich Miescher Institute for Biomedical Research; Suiza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
Fil: Arber, Silvia. Universidad de Basilea; Suiza. Friedrich Miescher Institute for Biomedical Research; Suiza
Materia
Calcium imaging
Locomotion
Motor Control
Posture
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/157386
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Functional diversity for body actions in the mesencephalic locomotor regionFerreira Pinto, Manuel J.Kanodia, HarshFalasconi, AntonioSigrist, MarkusEsposito, Maria SoledadArber, SilviaCalcium imagingLocomotionMotor ControlPosturehttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3The mesencephalic locomotor region (MLR) is a key midbrain center with roles in locomotion. Despite extensive studies and clinical trials aimed at therapy-resistant Parkinson’s disease (PD), debate on its function remains. Here, we reveal the existence of functionally diverse neuronal populations with distinct roles in control of body movements. We identify two spatially intermingled glutamatergic populations separable by axonal projections, mouse genetics, neuronal activity profiles, and motor functions. Most spinally projecting MLR neurons encoded the full-body behavior rearing. Loss- and gain-of-function optogenetic perturbation experiments establish a function for these neurons in controlling body extension. In contrast, Rbp4-transgene-positive MLR neurons project in an ascending direction to basal ganglia, preferentially encode the forelimb behaviors handling and grooming, and exhibit a role in modulating movement. Thus, the MLR contains glutamatergic neuronal subpopulations stratified by projection target exhibiting roles in action control not restricted to locomotion.Fil: Ferreira Pinto, Manuel J.. Friedrich Miescher Institute for Biomedical Research; Suiza. Universidad de Basilea; SuizaFil: Kanodia, Harsh. Friedrich Miescher Institute for Biomedical Research; Suiza. Universidad de Basilea; SuizaFil: Falasconi, Antonio. Friedrich Miescher Institute for Biomedical Research; Suiza. Universidad de Basilea; SuizaFil: Sigrist, Markus. Universidad de Basilea; Suiza. Friedrich Miescher Institute for Biomedical Research; SuizaFil: Esposito, Maria Soledad. Universidad de Basilea; Suiza. Friedrich Miescher Institute for Biomedical Research; Suiza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; ArgentinaFil: Arber, Silvia. Universidad de Basilea; Suiza. Friedrich Miescher Institute for Biomedical Research; SuizaCell Press2021-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/zipapplication/pdfhttp://hdl.handle.net/11336/157386Ferreira Pinto, Manuel J.; Kanodia, Harsh; Falasconi, Antonio; Sigrist, Markus; Esposito, Maria Soledad; et al.; Functional diversity for body actions in the mesencephalic locomotor region; Cell Press; Cell; 184; 17; 7-2021; 4564-45780092-8674CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.cell.com/cell/fulltext/S0092-8674(21)00828-Xinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.cell.2021.07.002info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:34:51Zoai:ri.conicet.gov.ar:11336/157386instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:34:51.765CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Functional diversity for body actions in the mesencephalic locomotor region
title Functional diversity for body actions in the mesencephalic locomotor region
spellingShingle Functional diversity for body actions in the mesencephalic locomotor region
Ferreira Pinto, Manuel J.
Calcium imaging
Locomotion
Motor Control
Posture
title_short Functional diversity for body actions in the mesencephalic locomotor region
title_full Functional diversity for body actions in the mesencephalic locomotor region
title_fullStr Functional diversity for body actions in the mesencephalic locomotor region
title_full_unstemmed Functional diversity for body actions in the mesencephalic locomotor region
title_sort Functional diversity for body actions in the mesencephalic locomotor region
dc.creator.none.fl_str_mv Ferreira Pinto, Manuel J.
Kanodia, Harsh
Falasconi, Antonio
Sigrist, Markus
Esposito, Maria Soledad
Arber, Silvia
author Ferreira Pinto, Manuel J.
author_facet Ferreira Pinto, Manuel J.
Kanodia, Harsh
Falasconi, Antonio
Sigrist, Markus
Esposito, Maria Soledad
Arber, Silvia
author_role author
author2 Kanodia, Harsh
Falasconi, Antonio
Sigrist, Markus
Esposito, Maria Soledad
Arber, Silvia
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Calcium imaging
Locomotion
Motor Control
Posture
topic Calcium imaging
Locomotion
Motor Control
Posture
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.5
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The mesencephalic locomotor region (MLR) is a key midbrain center with roles in locomotion. Despite extensive studies and clinical trials aimed at therapy-resistant Parkinson’s disease (PD), debate on its function remains. Here, we reveal the existence of functionally diverse neuronal populations with distinct roles in control of body movements. We identify two spatially intermingled glutamatergic populations separable by axonal projections, mouse genetics, neuronal activity profiles, and motor functions. Most spinally projecting MLR neurons encoded the full-body behavior rearing. Loss- and gain-of-function optogenetic perturbation experiments establish a function for these neurons in controlling body extension. In contrast, Rbp4-transgene-positive MLR neurons project in an ascending direction to basal ganglia, preferentially encode the forelimb behaviors handling and grooming, and exhibit a role in modulating movement. Thus, the MLR contains glutamatergic neuronal subpopulations stratified by projection target exhibiting roles in action control not restricted to locomotion.
Fil: Ferreira Pinto, Manuel J.. Friedrich Miescher Institute for Biomedical Research; Suiza. Universidad de Basilea; Suiza
Fil: Kanodia, Harsh. Friedrich Miescher Institute for Biomedical Research; Suiza. Universidad de Basilea; Suiza
Fil: Falasconi, Antonio. Friedrich Miescher Institute for Biomedical Research; Suiza. Universidad de Basilea; Suiza
Fil: Sigrist, Markus. Universidad de Basilea; Suiza. Friedrich Miescher Institute for Biomedical Research; Suiza
Fil: Esposito, Maria Soledad. Universidad de Basilea; Suiza. Friedrich Miescher Institute for Biomedical Research; Suiza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
Fil: Arber, Silvia. Universidad de Basilea; Suiza. Friedrich Miescher Institute for Biomedical Research; Suiza
description The mesencephalic locomotor region (MLR) is a key midbrain center with roles in locomotion. Despite extensive studies and clinical trials aimed at therapy-resistant Parkinson’s disease (PD), debate on its function remains. Here, we reveal the existence of functionally diverse neuronal populations with distinct roles in control of body movements. We identify two spatially intermingled glutamatergic populations separable by axonal projections, mouse genetics, neuronal activity profiles, and motor functions. Most spinally projecting MLR neurons encoded the full-body behavior rearing. Loss- and gain-of-function optogenetic perturbation experiments establish a function for these neurons in controlling body extension. In contrast, Rbp4-transgene-positive MLR neurons project in an ascending direction to basal ganglia, preferentially encode the forelimb behaviors handling and grooming, and exhibit a role in modulating movement. Thus, the MLR contains glutamatergic neuronal subpopulations stratified by projection target exhibiting roles in action control not restricted to locomotion.
publishDate 2021
dc.date.none.fl_str_mv 2021-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/157386
Ferreira Pinto, Manuel J.; Kanodia, Harsh; Falasconi, Antonio; Sigrist, Markus; Esposito, Maria Soledad; et al.; Functional diversity for body actions in the mesencephalic locomotor region; Cell Press; Cell; 184; 17; 7-2021; 4564-4578
0092-8674
CONICET Digital
CONICET
url http://hdl.handle.net/11336/157386
identifier_str_mv Ferreira Pinto, Manuel J.; Kanodia, Harsh; Falasconi, Antonio; Sigrist, Markus; Esposito, Maria Soledad; et al.; Functional diversity for body actions in the mesencephalic locomotor region; Cell Press; Cell; 184; 17; 7-2021; 4564-4578
0092-8674
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.cell.com/cell/fulltext/S0092-8674(21)00828-X
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cell.2021.07.002
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/zip
application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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