Functional diversity for body actions in the mesencephalic locomotor region
- Autores
- Ferreira Pinto, Manuel J.; Kanodia, Harsh; Falasconi, Antonio; Sigrist, Markus; Esposito, Maria Soledad; Arber, Silvia
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The mesencephalic locomotor region (MLR) is a key midbrain center with roles in locomotion. Despite extensive studies and clinical trials aimed at therapy-resistant Parkinson’s disease (PD), debate on its function remains. Here, we reveal the existence of functionally diverse neuronal populations with distinct roles in control of body movements. We identify two spatially intermingled glutamatergic populations separable by axonal projections, mouse genetics, neuronal activity profiles, and motor functions. Most spinally projecting MLR neurons encoded the full-body behavior rearing. Loss- and gain-of-function optogenetic perturbation experiments establish a function for these neurons in controlling body extension. In contrast, Rbp4-transgene-positive MLR neurons project in an ascending direction to basal ganglia, preferentially encode the forelimb behaviors handling and grooming, and exhibit a role in modulating movement. Thus, the MLR contains glutamatergic neuronal subpopulations stratified by projection target exhibiting roles in action control not restricted to locomotion.
Fil: Ferreira Pinto, Manuel J.. Friedrich Miescher Institute for Biomedical Research; Suiza. Universidad de Basilea; Suiza
Fil: Kanodia, Harsh. Friedrich Miescher Institute for Biomedical Research; Suiza. Universidad de Basilea; Suiza
Fil: Falasconi, Antonio. Friedrich Miescher Institute for Biomedical Research; Suiza. Universidad de Basilea; Suiza
Fil: Sigrist, Markus. Universidad de Basilea; Suiza. Friedrich Miescher Institute for Biomedical Research; Suiza
Fil: Esposito, Maria Soledad. Universidad de Basilea; Suiza. Friedrich Miescher Institute for Biomedical Research; Suiza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
Fil: Arber, Silvia. Universidad de Basilea; Suiza. Friedrich Miescher Institute for Biomedical Research; Suiza - Materia
-
Calcium imaging
Locomotion
Motor Control
Posture - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/157386
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Functional diversity for body actions in the mesencephalic locomotor regionFerreira Pinto, Manuel J.Kanodia, HarshFalasconi, AntonioSigrist, MarkusEsposito, Maria SoledadArber, SilviaCalcium imagingLocomotionMotor ControlPosturehttps://purl.org/becyt/ford/3.5https://purl.org/becyt/ford/3The mesencephalic locomotor region (MLR) is a key midbrain center with roles in locomotion. Despite extensive studies and clinical trials aimed at therapy-resistant Parkinson’s disease (PD), debate on its function remains. Here, we reveal the existence of functionally diverse neuronal populations with distinct roles in control of body movements. We identify two spatially intermingled glutamatergic populations separable by axonal projections, mouse genetics, neuronal activity profiles, and motor functions. Most spinally projecting MLR neurons encoded the full-body behavior rearing. Loss- and gain-of-function optogenetic perturbation experiments establish a function for these neurons in controlling body extension. In contrast, Rbp4-transgene-positive MLR neurons project in an ascending direction to basal ganglia, preferentially encode the forelimb behaviors handling and grooming, and exhibit a role in modulating movement. Thus, the MLR contains glutamatergic neuronal subpopulations stratified by projection target exhibiting roles in action control not restricted to locomotion.Fil: Ferreira Pinto, Manuel J.. Friedrich Miescher Institute for Biomedical Research; Suiza. Universidad de Basilea; SuizaFil: Kanodia, Harsh. Friedrich Miescher Institute for Biomedical Research; Suiza. Universidad de Basilea; SuizaFil: Falasconi, Antonio. Friedrich Miescher Institute for Biomedical Research; Suiza. Universidad de Basilea; SuizaFil: Sigrist, Markus. Universidad de Basilea; Suiza. Friedrich Miescher Institute for Biomedical Research; SuizaFil: Esposito, Maria Soledad. Universidad de Basilea; Suiza. Friedrich Miescher Institute for Biomedical Research; Suiza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; ArgentinaFil: Arber, Silvia. Universidad de Basilea; Suiza. Friedrich Miescher Institute for Biomedical Research; SuizaCell Press2021-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/zipapplication/pdfhttp://hdl.handle.net/11336/157386Ferreira Pinto, Manuel J.; Kanodia, Harsh; Falasconi, Antonio; Sigrist, Markus; Esposito, Maria Soledad; et al.; Functional diversity for body actions in the mesencephalic locomotor region; Cell Press; Cell; 184; 17; 7-2021; 4564-45780092-8674CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.cell.com/cell/fulltext/S0092-8674(21)00828-Xinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.cell.2021.07.002info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:46Zoai:ri.conicet.gov.ar:11336/157386instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:46.764CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Functional diversity for body actions in the mesencephalic locomotor region |
title |
Functional diversity for body actions in the mesencephalic locomotor region |
spellingShingle |
Functional diversity for body actions in the mesencephalic locomotor region Ferreira Pinto, Manuel J. Calcium imaging Locomotion Motor Control Posture |
title_short |
Functional diversity for body actions in the mesencephalic locomotor region |
title_full |
Functional diversity for body actions in the mesencephalic locomotor region |
title_fullStr |
Functional diversity for body actions in the mesencephalic locomotor region |
title_full_unstemmed |
Functional diversity for body actions in the mesencephalic locomotor region |
title_sort |
Functional diversity for body actions in the mesencephalic locomotor region |
dc.creator.none.fl_str_mv |
Ferreira Pinto, Manuel J. Kanodia, Harsh Falasconi, Antonio Sigrist, Markus Esposito, Maria Soledad Arber, Silvia |
author |
Ferreira Pinto, Manuel J. |
author_facet |
Ferreira Pinto, Manuel J. Kanodia, Harsh Falasconi, Antonio Sigrist, Markus Esposito, Maria Soledad Arber, Silvia |
author_role |
author |
author2 |
Kanodia, Harsh Falasconi, Antonio Sigrist, Markus Esposito, Maria Soledad Arber, Silvia |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
Calcium imaging Locomotion Motor Control Posture |
topic |
Calcium imaging Locomotion Motor Control Posture |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.5 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
The mesencephalic locomotor region (MLR) is a key midbrain center with roles in locomotion. Despite extensive studies and clinical trials aimed at therapy-resistant Parkinson’s disease (PD), debate on its function remains. Here, we reveal the existence of functionally diverse neuronal populations with distinct roles in control of body movements. We identify two spatially intermingled glutamatergic populations separable by axonal projections, mouse genetics, neuronal activity profiles, and motor functions. Most spinally projecting MLR neurons encoded the full-body behavior rearing. Loss- and gain-of-function optogenetic perturbation experiments establish a function for these neurons in controlling body extension. In contrast, Rbp4-transgene-positive MLR neurons project in an ascending direction to basal ganglia, preferentially encode the forelimb behaviors handling and grooming, and exhibit a role in modulating movement. Thus, the MLR contains glutamatergic neuronal subpopulations stratified by projection target exhibiting roles in action control not restricted to locomotion. Fil: Ferreira Pinto, Manuel J.. Friedrich Miescher Institute for Biomedical Research; Suiza. Universidad de Basilea; Suiza Fil: Kanodia, Harsh. Friedrich Miescher Institute for Biomedical Research; Suiza. Universidad de Basilea; Suiza Fil: Falasconi, Antonio. Friedrich Miescher Institute for Biomedical Research; Suiza. Universidad de Basilea; Suiza Fil: Sigrist, Markus. Universidad de Basilea; Suiza. Friedrich Miescher Institute for Biomedical Research; Suiza Fil: Esposito, Maria Soledad. Universidad de Basilea; Suiza. Friedrich Miescher Institute for Biomedical Research; Suiza. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina Fil: Arber, Silvia. Universidad de Basilea; Suiza. Friedrich Miescher Institute for Biomedical Research; Suiza |
description |
The mesencephalic locomotor region (MLR) is a key midbrain center with roles in locomotion. Despite extensive studies and clinical trials aimed at therapy-resistant Parkinson’s disease (PD), debate on its function remains. Here, we reveal the existence of functionally diverse neuronal populations with distinct roles in control of body movements. We identify two spatially intermingled glutamatergic populations separable by axonal projections, mouse genetics, neuronal activity profiles, and motor functions. Most spinally projecting MLR neurons encoded the full-body behavior rearing. Loss- and gain-of-function optogenetic perturbation experiments establish a function for these neurons in controlling body extension. In contrast, Rbp4-transgene-positive MLR neurons project in an ascending direction to basal ganglia, preferentially encode the forelimb behaviors handling and grooming, and exhibit a role in modulating movement. Thus, the MLR contains glutamatergic neuronal subpopulations stratified by projection target exhibiting roles in action control not restricted to locomotion. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-07 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/157386 Ferreira Pinto, Manuel J.; Kanodia, Harsh; Falasconi, Antonio; Sigrist, Markus; Esposito, Maria Soledad; et al.; Functional diversity for body actions in the mesencephalic locomotor region; Cell Press; Cell; 184; 17; 7-2021; 4564-4578 0092-8674 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/157386 |
identifier_str_mv |
Ferreira Pinto, Manuel J.; Kanodia, Harsh; Falasconi, Antonio; Sigrist, Markus; Esposito, Maria Soledad; et al.; Functional diversity for body actions in the mesencephalic locomotor region; Cell Press; Cell; 184; 17; 7-2021; 4564-4578 0092-8674 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.cell.com/cell/fulltext/S0092-8674(21)00828-X info:eu-repo/semantics/altIdentifier/doi/10.1016/j.cell.2021.07.002 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/zip application/pdf |
dc.publisher.none.fl_str_mv |
Cell Press |
publisher.none.fl_str_mv |
Cell Press |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842268688210722816 |
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13.13397 |