V3 spinal neurons establish a robust and balanced locomotor rhythm during walking

Autores
Zhang, Ying; Narajan, Sujatha; Geiman, Eric; Lanuza, Guillermo Marcos; Velasquez, Tomoko; Shanks, Bayle; Akay, Turgay; Dyck, Jason; Pearson, Keir; Gosgnach, Simon; Fan, Chen-Ming; Goulding, Martyn
Año de publicación
2008
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
A robust and well-organized rhythm is a key feature of many neuronal networks, including those that regulate essential behaviors such as circadian rhythmogenesis, breathing, and locomotion. Here we show that excitatory V3-derived neurons are necessary for a robust and organized locomotor rhythm during walking. When V3-mediated neurotransmission is selectively blocked by the expression of the tetanus toxin light chain subunit (TeNT), the regularity and robustness of the locomotor rhythm is severely perturbed. A similar degeneration in the locomotor rhythm occurs when the excitability of V3-derived neurons is reduced acutely by ligand-induced activation of the allatostatin receptor. The V3-derived neurons additionally function to balance the locomotor output between both halves of the spinal cord, thereby ensuring a symmetrical pattern of locomotor activity during walking. We propose that the V3 neurons establish a regular and balanced motor rhythm by distributing excitatory drive between both halves of the spinal cord.
Fil: Zhang, Ying. Salk Institute for Biological Studies; Estados Unidos
Fil: Narajan, Sujatha. Salk Institute for Biological Studies; Estados Unidos
Fil: Geiman, Eric. Salk Institute for Biological Studies; Estados Unidos
Fil: Lanuza, Guillermo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Salk Institute for Biological Studies; Estados Unidos
Fil: Velasquez, Tomoko. Salk Institute for Biological Studies; Estados Unidos
Fil: Shanks, Bayle. Salk Institute for Biological Studies; Estados Unidos
Fil: Akay, Turgay. University of Alberta; Canadá
Fil: Dyck, Jason. University of Alberta; Canadá
Fil: Pearson, Keir. University of Alberta; Canadá
Fil: Gosgnach, Simon. University of Alberta; Canadá
Fil: Fan, Chen-Ming. University Of Carnegie Mellon; Estados Unidos
Fil: Goulding, Martyn. Salk Institute for Biological Studies; Estados Unidos
Materia
Interneuron
Locomotion
Cpg
Spinal Cord
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/21116
Acceder
id CONICETDig_939097e78c5ca5ec86736184914bf503
oai_identifier_str oai:ri.conicet.gov.ar:11336/21116
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling V3 spinal neurons establish a robust and balanced locomotor rhythm during walkingZhang, YingNarajan, SujathaGeiman, EricLanuza, Guillermo MarcosVelasquez, TomokoShanks, BayleAkay, TurgayDyck, JasonPearson, KeirGosgnach, SimonFan, Chen-MingGoulding, MartynInterneuronLocomotionCpgSpinal Cordhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3A robust and well-organized rhythm is a key feature of many neuronal networks, including those that regulate essential behaviors such as circadian rhythmogenesis, breathing, and locomotion. Here we show that excitatory V3-derived neurons are necessary for a robust and organized locomotor rhythm during walking. When V3-mediated neurotransmission is selectively blocked by the expression of the tetanus toxin light chain subunit (TeNT), the regularity and robustness of the locomotor rhythm is severely perturbed. A similar degeneration in the locomotor rhythm occurs when the excitability of V3-derived neurons is reduced acutely by ligand-induced activation of the allatostatin receptor. The V3-derived neurons additionally function to balance the locomotor output between both halves of the spinal cord, thereby ensuring a symmetrical pattern of locomotor activity during walking. We propose that the V3 neurons establish a regular and balanced motor rhythm by distributing excitatory drive between both halves of the spinal cord.Fil: Zhang, Ying. Salk Institute for Biological Studies; Estados UnidosFil: Narajan, Sujatha. Salk Institute for Biological Studies; Estados UnidosFil: Geiman, Eric. Salk Institute for Biological Studies; Estados UnidosFil: Lanuza, Guillermo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Salk Institute for Biological Studies; Estados UnidosFil: Velasquez, Tomoko. Salk Institute for Biological Studies; Estados UnidosFil: Shanks, Bayle. Salk Institute for Biological Studies; Estados UnidosFil: Akay, Turgay. University of Alberta; CanadáFil: Dyck, Jason. University of Alberta; CanadáFil: Pearson, Keir. University of Alberta; CanadáFil: Gosgnach, Simon. University of Alberta; CanadáFil: Fan, Chen-Ming. University Of Carnegie Mellon; Estados UnidosFil: Goulding, Martyn. Salk Institute for Biological Studies; Estados UnidosCell Press2008-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/21116Zhang, Ying; Narajan, Sujatha; Geiman, Eric; Lanuza, Guillermo Marcos; Velasquez, Tomoko; et al.; V3 spinal neurons establish a robust and balanced locomotor rhythm during walking; Cell Press; Neuron; 60; 1; 10-2008; 84-960896-62731097-4199CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0896627308008064info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuron.2008.09.027info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:08:51Zoai:ri.conicet.gov.ar:11336/21116instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:08:51.984CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv V3 spinal neurons establish a robust and balanced locomotor rhythm during walking
title V3 spinal neurons establish a robust and balanced locomotor rhythm during walking
spellingShingle V3 spinal neurons establish a robust and balanced locomotor rhythm during walking
Zhang, Ying
Interneuron
Locomotion
Cpg
Spinal Cord
title_short V3 spinal neurons establish a robust and balanced locomotor rhythm during walking
title_full V3 spinal neurons establish a robust and balanced locomotor rhythm during walking
title_fullStr V3 spinal neurons establish a robust and balanced locomotor rhythm during walking
title_full_unstemmed V3 spinal neurons establish a robust and balanced locomotor rhythm during walking
title_sort V3 spinal neurons establish a robust and balanced locomotor rhythm during walking
dc.creator.none.fl_str_mv Zhang, Ying
Narajan, Sujatha
Geiman, Eric
Lanuza, Guillermo Marcos
Velasquez, Tomoko
Shanks, Bayle
Akay, Turgay
Dyck, Jason
Pearson, Keir
Gosgnach, Simon
Fan, Chen-Ming
Goulding, Martyn
author Zhang, Ying
author_facet Zhang, Ying
Narajan, Sujatha
Geiman, Eric
Lanuza, Guillermo Marcos
Velasquez, Tomoko
Shanks, Bayle
Akay, Turgay
Dyck, Jason
Pearson, Keir
Gosgnach, Simon
Fan, Chen-Ming
Goulding, Martyn
author_role author
author2 Narajan, Sujatha
Geiman, Eric
Lanuza, Guillermo Marcos
Velasquez, Tomoko
Shanks, Bayle
Akay, Turgay
Dyck, Jason
Pearson, Keir
Gosgnach, Simon
Fan, Chen-Ming
Goulding, Martyn
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Interneuron
Locomotion
Cpg
Spinal Cord
topic Interneuron
Locomotion
Cpg
Spinal Cord
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv A robust and well-organized rhythm is a key feature of many neuronal networks, including those that regulate essential behaviors such as circadian rhythmogenesis, breathing, and locomotion. Here we show that excitatory V3-derived neurons are necessary for a robust and organized locomotor rhythm during walking. When V3-mediated neurotransmission is selectively blocked by the expression of the tetanus toxin light chain subunit (TeNT), the regularity and robustness of the locomotor rhythm is severely perturbed. A similar degeneration in the locomotor rhythm occurs when the excitability of V3-derived neurons is reduced acutely by ligand-induced activation of the allatostatin receptor. The V3-derived neurons additionally function to balance the locomotor output between both halves of the spinal cord, thereby ensuring a symmetrical pattern of locomotor activity during walking. We propose that the V3 neurons establish a regular and balanced motor rhythm by distributing excitatory drive between both halves of the spinal cord.
Fil: Zhang, Ying. Salk Institute for Biological Studies; Estados Unidos
Fil: Narajan, Sujatha. Salk Institute for Biological Studies; Estados Unidos
Fil: Geiman, Eric. Salk Institute for Biological Studies; Estados Unidos
Fil: Lanuza, Guillermo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Parque Centenario. Instituto de Investigaciones Bioquímicas de Buenos Aires. Fundación Instituto Leloir. Instituto de Investigaciones Bioquímicas de Buenos Aires; Argentina. Salk Institute for Biological Studies; Estados Unidos
Fil: Velasquez, Tomoko. Salk Institute for Biological Studies; Estados Unidos
Fil: Shanks, Bayle. Salk Institute for Biological Studies; Estados Unidos
Fil: Akay, Turgay. University of Alberta; Canadá
Fil: Dyck, Jason. University of Alberta; Canadá
Fil: Pearson, Keir. University of Alberta; Canadá
Fil: Gosgnach, Simon. University of Alberta; Canadá
Fil: Fan, Chen-Ming. University Of Carnegie Mellon; Estados Unidos
Fil: Goulding, Martyn. Salk Institute for Biological Studies; Estados Unidos
description A robust and well-organized rhythm is a key feature of many neuronal networks, including those that regulate essential behaviors such as circadian rhythmogenesis, breathing, and locomotion. Here we show that excitatory V3-derived neurons are necessary for a robust and organized locomotor rhythm during walking. When V3-mediated neurotransmission is selectively blocked by the expression of the tetanus toxin light chain subunit (TeNT), the regularity and robustness of the locomotor rhythm is severely perturbed. A similar degeneration in the locomotor rhythm occurs when the excitability of V3-derived neurons is reduced acutely by ligand-induced activation of the allatostatin receptor. The V3-derived neurons additionally function to balance the locomotor output between both halves of the spinal cord, thereby ensuring a symmetrical pattern of locomotor activity during walking. We propose that the V3 neurons establish a regular and balanced motor rhythm by distributing excitatory drive between both halves of the spinal cord.
publishDate 2008
dc.date.none.fl_str_mv 2008-10
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/21116
Zhang, Ying; Narajan, Sujatha; Geiman, Eric; Lanuza, Guillermo Marcos; Velasquez, Tomoko; et al.; V3 spinal neurons establish a robust and balanced locomotor rhythm during walking; Cell Press; Neuron; 60; 1; 10-2008; 84-96
0896-6273
1097-4199
CONICET Digital
CONICET
url http://hdl.handle.net/11336/21116
identifier_str_mv Zhang, Ying; Narajan, Sujatha; Geiman, Eric; Lanuza, Guillermo Marcos; Velasquez, Tomoko; et al.; V3 spinal neurons establish a robust and balanced locomotor rhythm during walking; Cell Press; Neuron; 60; 1; 10-2008; 84-96
0896-6273
1097-4199
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0896627308008064
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.neuron.2008.09.027
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842270060319604736
score 13.13397

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