Baroreflex Impairment Precedes Cardiometabolic Dysfunction in an Experimental Model of Metabolic Syndrome: Role of Inflammation and Oxidative Stress

Autores
Bernardes, Nathalia; Da Silva Dias, Danielle; Fernandes Stoyell Conti, Filipe; De Oliveira Brito Monzani, Janaina; Malfitano, Christiane; Garcia Caldini, Elia; Ulloa, Luis; Llesuy, Susana Francisca; Irigoyen, Maria Cláudia; De Angelis, Kátia
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This study analyzes whether autonomic dysfunction precedes cardiometabolic alterations in spontaneously hypertensive rats (SHR) with fructose overload. Animals were randomly distributed into three groups: control, hypertensive and hypertensive with fructose overload. Fructose overload (100 g/L) was initiated at 30 days old, and the animals (n = 6/group/time) were evaluated after 7, 15, 30 and 60 days of fructose consumption. Fructose consumption reduced baroreflex sensitivity by day 7, and still induced a progressive reduction in baroreflex sensitivity over the time. Fructose consumption also increased TNFα and IL-6 levels in the adipose tissue and IL-1β levels in the spleen at days 15 and 30. Fructose consumption also reduced plasmatic nitrites (day 15 and 30) and superoxide dismutase activity (day 15 and 60), but increased hydrogen peroxide (day 30 and 60), lipid peroxidation and protein oxidation (day 60). Fructose consumption increased arterial pressure at day 30 (8%) and 60 (11%). Fructose consumption also induced a late insulin resistance at day 60, but did not affect glucose levels. In conclusion, the results show that baroreflex sensitivity impairment precedes inflammatory and oxidative stress disorders, probably by inducing hemodynamic and metabolic dysfunctions observed in metabolic syndrome.
Fil: Bernardes, Nathalia. Universidade de Sao Paulo; Brasil
Fil: Da Silva Dias, Danielle. Universidade Nove de Julho; Brasil
Fil: Fernandes Stoyell Conti, Filipe. Universidade de Sao Paulo; Brasil
Fil: De Oliveira Brito Monzani, Janaina. Universidade Nove de Julho; Brasil
Fil: Malfitano, Christiane. Universidade Nove de Julho; Brasil
Fil: Garcia Caldini, Elia. Universidade de Sao Paulo; Brasil
Fil: Ulloa, Luis. Universidade Nove de Julho; Brasil
Fil: Llesuy, Susana Francisca. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Irigoyen, Maria Cláudia. Universidade de Sao Paulo; Brasil
Fil: De Angelis, Kátia. Universidade Nove de Julho; Brasil
Materia
Baroreflex imparmente
cardiometabolica disfunction
inflammation
oxdiative stress
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/224601
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/224601
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Baroreflex Impairment Precedes Cardiometabolic Dysfunction in an Experimental Model of Metabolic Syndrome: Role of Inflammation and Oxidative StressBernardes, NathaliaDa Silva Dias, DanielleFernandes Stoyell Conti, FilipeDe Oliveira Brito Monzani, JanainaMalfitano, ChristianeGarcia Caldini, EliaUlloa, LuisLlesuy, Susana FranciscaIrigoyen, Maria CláudiaDe Angelis, KátiaBaroreflex imparmentecardiometabolica disfunctioninflammationoxdiative stresshttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1This study analyzes whether autonomic dysfunction precedes cardiometabolic alterations in spontaneously hypertensive rats (SHR) with fructose overload. Animals were randomly distributed into three groups: control, hypertensive and hypertensive with fructose overload. Fructose overload (100 g/L) was initiated at 30 days old, and the animals (n = 6/group/time) were evaluated after 7, 15, 30 and 60 days of fructose consumption. Fructose consumption reduced baroreflex sensitivity by day 7, and still induced a progressive reduction in baroreflex sensitivity over the time. Fructose consumption also increased TNFα and IL-6 levels in the adipose tissue and IL-1β levels in the spleen at days 15 and 30. Fructose consumption also reduced plasmatic nitrites (day 15 and 30) and superoxide dismutase activity (day 15 and 60), but increased hydrogen peroxide (day 30 and 60), lipid peroxidation and protein oxidation (day 60). Fructose consumption increased arterial pressure at day 30 (8%) and 60 (11%). Fructose consumption also induced a late insulin resistance at day 60, but did not affect glucose levels. In conclusion, the results show that baroreflex sensitivity impairment precedes inflammatory and oxidative stress disorders, probably by inducing hemodynamic and metabolic dysfunctions observed in metabolic syndrome.Fil: Bernardes, Nathalia. Universidade de Sao Paulo; BrasilFil: Da Silva Dias, Danielle. Universidade Nove de Julho; BrasilFil: Fernandes Stoyell Conti, Filipe. Universidade de Sao Paulo; BrasilFil: De Oliveira Brito Monzani, Janaina. Universidade Nove de Julho; BrasilFil: Malfitano, Christiane. Universidade Nove de Julho; BrasilFil: Garcia Caldini, Elia. Universidade de Sao Paulo; BrasilFil: Ulloa, Luis. Universidade Nove de Julho; BrasilFil: Llesuy, Susana Francisca. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; ArgentinaFil: Irigoyen, Maria Cláudia. Universidade de Sao Paulo; BrasilFil: De Angelis, Kátia. Universidade Nove de Julho; BrasilNature2018-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/224601Bernardes, Nathalia; Da Silva Dias, Danielle; Fernandes Stoyell Conti, Filipe; De Oliveira Brito Monzani, Janaina; Malfitano, Christiane; et al.; Baroreflex Impairment Precedes Cardiometabolic Dysfunction in an Experimental Model of Metabolic Syndrome: Role of Inflammation and Oxidative Stress; Nature; Scientific Reports; 8; 1; 6-2018; 1-102045-2322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-018-26816-4info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-018-26816-4info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:30:52Zoai:ri.conicet.gov.ar:11336/224601instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:30:52.554CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Baroreflex Impairment Precedes Cardiometabolic Dysfunction in an Experimental Model of Metabolic Syndrome: Role of Inflammation and Oxidative Stress
title Baroreflex Impairment Precedes Cardiometabolic Dysfunction in an Experimental Model of Metabolic Syndrome: Role of Inflammation and Oxidative Stress
spellingShingle Baroreflex Impairment Precedes Cardiometabolic Dysfunction in an Experimental Model of Metabolic Syndrome: Role of Inflammation and Oxidative Stress
Bernardes, Nathalia
Baroreflex imparmente
cardiometabolica disfunction
inflammation
oxdiative stress
title_short Baroreflex Impairment Precedes Cardiometabolic Dysfunction in an Experimental Model of Metabolic Syndrome: Role of Inflammation and Oxidative Stress
title_full Baroreflex Impairment Precedes Cardiometabolic Dysfunction in an Experimental Model of Metabolic Syndrome: Role of Inflammation and Oxidative Stress
title_fullStr Baroreflex Impairment Precedes Cardiometabolic Dysfunction in an Experimental Model of Metabolic Syndrome: Role of Inflammation and Oxidative Stress
title_full_unstemmed Baroreflex Impairment Precedes Cardiometabolic Dysfunction in an Experimental Model of Metabolic Syndrome: Role of Inflammation and Oxidative Stress
title_sort Baroreflex Impairment Precedes Cardiometabolic Dysfunction in an Experimental Model of Metabolic Syndrome: Role of Inflammation and Oxidative Stress
dc.creator.none.fl_str_mv Bernardes, Nathalia
Da Silva Dias, Danielle
Fernandes Stoyell Conti, Filipe
De Oliveira Brito Monzani, Janaina
Malfitano, Christiane
Garcia Caldini, Elia
Ulloa, Luis
Llesuy, Susana Francisca
Irigoyen, Maria Cláudia
De Angelis, Kátia
author Bernardes, Nathalia
author_facet Bernardes, Nathalia
Da Silva Dias, Danielle
Fernandes Stoyell Conti, Filipe
De Oliveira Brito Monzani, Janaina
Malfitano, Christiane
Garcia Caldini, Elia
Ulloa, Luis
Llesuy, Susana Francisca
Irigoyen, Maria Cláudia
De Angelis, Kátia
author_role author
author2 Da Silva Dias, Danielle
Fernandes Stoyell Conti, Filipe
De Oliveira Brito Monzani, Janaina
Malfitano, Christiane
Garcia Caldini, Elia
Ulloa, Luis
Llesuy, Susana Francisca
Irigoyen, Maria Cláudia
De Angelis, Kátia
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Baroreflex imparmente
cardiometabolica disfunction
inflammation
oxdiative stress
topic Baroreflex imparmente
cardiometabolica disfunction
inflammation
oxdiative stress
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.6
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv This study analyzes whether autonomic dysfunction precedes cardiometabolic alterations in spontaneously hypertensive rats (SHR) with fructose overload. Animals were randomly distributed into three groups: control, hypertensive and hypertensive with fructose overload. Fructose overload (100 g/L) was initiated at 30 days old, and the animals (n = 6/group/time) were evaluated after 7, 15, 30 and 60 days of fructose consumption. Fructose consumption reduced baroreflex sensitivity by day 7, and still induced a progressive reduction in baroreflex sensitivity over the time. Fructose consumption also increased TNFα and IL-6 levels in the adipose tissue and IL-1β levels in the spleen at days 15 and 30. Fructose consumption also reduced plasmatic nitrites (day 15 and 30) and superoxide dismutase activity (day 15 and 60), but increased hydrogen peroxide (day 30 and 60), lipid peroxidation and protein oxidation (day 60). Fructose consumption increased arterial pressure at day 30 (8%) and 60 (11%). Fructose consumption also induced a late insulin resistance at day 60, but did not affect glucose levels. In conclusion, the results show that baroreflex sensitivity impairment precedes inflammatory and oxidative stress disorders, probably by inducing hemodynamic and metabolic dysfunctions observed in metabolic syndrome.
Fil: Bernardes, Nathalia. Universidade de Sao Paulo; Brasil
Fil: Da Silva Dias, Danielle. Universidade Nove de Julho; Brasil
Fil: Fernandes Stoyell Conti, Filipe. Universidade de Sao Paulo; Brasil
Fil: De Oliveira Brito Monzani, Janaina. Universidade Nove de Julho; Brasil
Fil: Malfitano, Christiane. Universidade Nove de Julho; Brasil
Fil: Garcia Caldini, Elia. Universidade de Sao Paulo; Brasil
Fil: Ulloa, Luis. Universidade Nove de Julho; Brasil
Fil: Llesuy, Susana Francisca. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Química Analítica y Fisicoquímica. Cátedra de Química General e Inorgánica; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Bioquímica y Medicina Molecular. Universidad de Buenos Aires. Facultad Medicina. Instituto de Bioquímica y Medicina Molecular; Argentina
Fil: Irigoyen, Maria Cláudia. Universidade de Sao Paulo; Brasil
Fil: De Angelis, Kátia. Universidade Nove de Julho; Brasil
description This study analyzes whether autonomic dysfunction precedes cardiometabolic alterations in spontaneously hypertensive rats (SHR) with fructose overload. Animals were randomly distributed into three groups: control, hypertensive and hypertensive with fructose overload. Fructose overload (100 g/L) was initiated at 30 days old, and the animals (n = 6/group/time) were evaluated after 7, 15, 30 and 60 days of fructose consumption. Fructose consumption reduced baroreflex sensitivity by day 7, and still induced a progressive reduction in baroreflex sensitivity over the time. Fructose consumption also increased TNFα and IL-6 levels in the adipose tissue and IL-1β levels in the spleen at days 15 and 30. Fructose consumption also reduced plasmatic nitrites (day 15 and 30) and superoxide dismutase activity (day 15 and 60), but increased hydrogen peroxide (day 30 and 60), lipid peroxidation and protein oxidation (day 60). Fructose consumption increased arterial pressure at day 30 (8%) and 60 (11%). Fructose consumption also induced a late insulin resistance at day 60, but did not affect glucose levels. In conclusion, the results show that baroreflex sensitivity impairment precedes inflammatory and oxidative stress disorders, probably by inducing hemodynamic and metabolic dysfunctions observed in metabolic syndrome.
publishDate 2018
dc.date.none.fl_str_mv 2018-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/224601
Bernardes, Nathalia; Da Silva Dias, Danielle; Fernandes Stoyell Conti, Filipe; De Oliveira Brito Monzani, Janaina; Malfitano, Christiane; et al.; Baroreflex Impairment Precedes Cardiometabolic Dysfunction in an Experimental Model of Metabolic Syndrome: Role of Inflammation and Oxidative Stress; Nature; Scientific Reports; 8; 1; 6-2018; 1-10
2045-2322
CONICET Digital
CONICET
url http://hdl.handle.net/11336/224601
identifier_str_mv Bernardes, Nathalia; Da Silva Dias, Danielle; Fernandes Stoyell Conti, Filipe; De Oliveira Brito Monzani, Janaina; Malfitano, Christiane; et al.; Baroreflex Impairment Precedes Cardiometabolic Dysfunction in an Experimental Model of Metabolic Syndrome: Role of Inflammation and Oxidative Stress; Nature; Scientific Reports; 8; 1; 6-2018; 1-10
2045-2322
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/s41598-018-26816-4
info:eu-repo/semantics/altIdentifier/doi/10.1038/s41598-018-26816-4
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature
publisher.none.fl_str_mv Nature
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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