Inverse expression of estrogen receptor alpha and apolipoprotein B in coronary intimal hyperplasia of surgically repaired congenital heart disease: A pre-atherosclerotic condition?
- Autores
- Castilla Lozano, Maria del Rocio; Cao, Gabriel Fernando; Kolliker Frers, Rodolfo Alberto; Muller, Angelica del Carmen; Ambrosio, Giuseppe; Milei, Jose
- Año de publicación
- 2014
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Congenital heart diseases (CHD) or the process of their repair leads to an increased risk for adult cardiovascular disease compared with the general population. The proliferation of intimal smooth muscle cells (SMCs), which causes intimal thickenings prior to any evidence of visible lipid deposition, was proposed to be the initial lesion of coronary atherosclerosis. The increasing trend to consider intimal thickenings as possible pre-atherosclerotic lesions is based on the distribution of intimal hyperplasia in children and the localization of characteristic atherosclerotic lesions observed in adult humans. Early coronary artery lesions may range from focal areas with mild myointimal thickenings in prenatal life to early soft plaques in infants, which may also present as intermingled lesions with components of both categories, more frequently observed with increasing age. Also,we proposed that TGF-β1 expressionmight be considered another possible predisposing factor to develop atherosclerotic coronary artery disease in CHD patients. On the other hand, estrogen receptor-α (ERα) appears to be responsible for the protective effects of estrogens against atherosclerotic vascular disease. The aim of this paper was to analyze the immunohistochemical expression of ERα, TGF-β1 and apolipoprotein B in coronary intimal hyperplasia in children with CHD and the possible increased risk for the development pre-atherosclerotic lesions.
Fil: Castilla Lozano, Maria del Rocio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina
Fil: Cao, Gabriel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina
Fil: Kolliker Frers, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina
Fil: Muller, Angelica del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina
Fil: Ambrosio, Giuseppe. Universita Di Perugia; Italia
Fil: Milei, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina - Materia
-
Coronary Intimal Hyperplasia
Congenital Heart Disease
Er Alpha
Apo B
Atherogenesis - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/7869
Ver los metadatos del registro completo
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Inverse expression of estrogen receptor alpha and apolipoprotein B in coronary intimal hyperplasia of surgically repaired congenital heart disease: A pre-atherosclerotic condition?Castilla Lozano, Maria del RocioCao, Gabriel FernandoKolliker Frers, Rodolfo AlbertoMuller, Angelica del CarmenAmbrosio, GiuseppeMilei, JoseCoronary Intimal HyperplasiaCongenital Heart DiseaseEr AlphaApo BAtherogenesishttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Congenital heart diseases (CHD) or the process of their repair leads to an increased risk for adult cardiovascular disease compared with the general population. The proliferation of intimal smooth muscle cells (SMCs), which causes intimal thickenings prior to any evidence of visible lipid deposition, was proposed to be the initial lesion of coronary atherosclerosis. The increasing trend to consider intimal thickenings as possible pre-atherosclerotic lesions is based on the distribution of intimal hyperplasia in children and the localization of characteristic atherosclerotic lesions observed in adult humans. Early coronary artery lesions may range from focal areas with mild myointimal thickenings in prenatal life to early soft plaques in infants, which may also present as intermingled lesions with components of both categories, more frequently observed with increasing age. Also,we proposed that TGF-β1 expressionmight be considered another possible predisposing factor to develop atherosclerotic coronary artery disease in CHD patients. On the other hand, estrogen receptor-α (ERα) appears to be responsible for the protective effects of estrogens against atherosclerotic vascular disease. The aim of this paper was to analyze the immunohistochemical expression of ERα, TGF-β1 and apolipoprotein B in coronary intimal hyperplasia in children with CHD and the possible increased risk for the development pre-atherosclerotic lesions.Fil: Castilla Lozano, Maria del Rocio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); ArgentinaFil: Cao, Gabriel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); ArgentinaFil: Kolliker Frers, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); ArgentinaFil: Muller, Angelica del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); ArgentinaFil: Ambrosio, Giuseppe. Universita Di Perugia; ItaliaFil: Milei, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); ArgentinaElsevier2014-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/7869Castilla Lozano, Maria del Rocio; Cao, Gabriel Fernando; Kolliker Frers, Rodolfo Alberto; Muller, Angelica del Carmen; Ambrosio, Giuseppe; et al.; Inverse expression of estrogen receptor alpha and apolipoprotein B in coronary intimal hyperplasia of surgically repaired congenital heart disease: A pre-atherosclerotic condition?; Elsevier; International Journal Of Cardiology; 177; 2; 8-2014; 548-5500167-5273enginfo:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0167527314016453info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijcard.2014.08.100info:eu-repo/semantics/altIdentifier/url/http://www.internationaljournalofcardiology.com/article/S0167-5273(14)01645-3/abstractinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:50:44Zoai:ri.conicet.gov.ar:11336/7869instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:50:45.241CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Inverse expression of estrogen receptor alpha and apolipoprotein B in coronary intimal hyperplasia of surgically repaired congenital heart disease: A pre-atherosclerotic condition? |
title |
Inverse expression of estrogen receptor alpha and apolipoprotein B in coronary intimal hyperplasia of surgically repaired congenital heart disease: A pre-atherosclerotic condition? |
spellingShingle |
Inverse expression of estrogen receptor alpha and apolipoprotein B in coronary intimal hyperplasia of surgically repaired congenital heart disease: A pre-atherosclerotic condition? Castilla Lozano, Maria del Rocio Coronary Intimal Hyperplasia Congenital Heart Disease Er Alpha Apo B Atherogenesis |
title_short |
Inverse expression of estrogen receptor alpha and apolipoprotein B in coronary intimal hyperplasia of surgically repaired congenital heart disease: A pre-atherosclerotic condition? |
title_full |
Inverse expression of estrogen receptor alpha and apolipoprotein B in coronary intimal hyperplasia of surgically repaired congenital heart disease: A pre-atherosclerotic condition? |
title_fullStr |
Inverse expression of estrogen receptor alpha and apolipoprotein B in coronary intimal hyperplasia of surgically repaired congenital heart disease: A pre-atherosclerotic condition? |
title_full_unstemmed |
Inverse expression of estrogen receptor alpha and apolipoprotein B in coronary intimal hyperplasia of surgically repaired congenital heart disease: A pre-atherosclerotic condition? |
title_sort |
Inverse expression of estrogen receptor alpha and apolipoprotein B in coronary intimal hyperplasia of surgically repaired congenital heart disease: A pre-atherosclerotic condition? |
dc.creator.none.fl_str_mv |
Castilla Lozano, Maria del Rocio Cao, Gabriel Fernando Kolliker Frers, Rodolfo Alberto Muller, Angelica del Carmen Ambrosio, Giuseppe Milei, Jose |
author |
Castilla Lozano, Maria del Rocio |
author_facet |
Castilla Lozano, Maria del Rocio Cao, Gabriel Fernando Kolliker Frers, Rodolfo Alberto Muller, Angelica del Carmen Ambrosio, Giuseppe Milei, Jose |
author_role |
author |
author2 |
Cao, Gabriel Fernando Kolliker Frers, Rodolfo Alberto Muller, Angelica del Carmen Ambrosio, Giuseppe Milei, Jose |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
Coronary Intimal Hyperplasia Congenital Heart Disease Er Alpha Apo B Atherogenesis |
topic |
Coronary Intimal Hyperplasia Congenital Heart Disease Er Alpha Apo B Atherogenesis |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.1 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
Congenital heart diseases (CHD) or the process of their repair leads to an increased risk for adult cardiovascular disease compared with the general population. The proliferation of intimal smooth muscle cells (SMCs), which causes intimal thickenings prior to any evidence of visible lipid deposition, was proposed to be the initial lesion of coronary atherosclerosis. The increasing trend to consider intimal thickenings as possible pre-atherosclerotic lesions is based on the distribution of intimal hyperplasia in children and the localization of characteristic atherosclerotic lesions observed in adult humans. Early coronary artery lesions may range from focal areas with mild myointimal thickenings in prenatal life to early soft plaques in infants, which may also present as intermingled lesions with components of both categories, more frequently observed with increasing age. Also,we proposed that TGF-β1 expressionmight be considered another possible predisposing factor to develop atherosclerotic coronary artery disease in CHD patients. On the other hand, estrogen receptor-α (ERα) appears to be responsible for the protective effects of estrogens against atherosclerotic vascular disease. The aim of this paper was to analyze the immunohistochemical expression of ERα, TGF-β1 and apolipoprotein B in coronary intimal hyperplasia in children with CHD and the possible increased risk for the development pre-atherosclerotic lesions. Fil: Castilla Lozano, Maria del Rocio. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina Fil: Cao, Gabriel Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina Fil: Kolliker Frers, Rodolfo Alberto. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina Fil: Muller, Angelica del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina Fil: Ambrosio, Giuseppe. Universita Di Perugia; Italia Fil: Milei, Jose. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Cardiológicas (i); Argentina |
description |
Congenital heart diseases (CHD) or the process of their repair leads to an increased risk for adult cardiovascular disease compared with the general population. The proliferation of intimal smooth muscle cells (SMCs), which causes intimal thickenings prior to any evidence of visible lipid deposition, was proposed to be the initial lesion of coronary atherosclerosis. The increasing trend to consider intimal thickenings as possible pre-atherosclerotic lesions is based on the distribution of intimal hyperplasia in children and the localization of characteristic atherosclerotic lesions observed in adult humans. Early coronary artery lesions may range from focal areas with mild myointimal thickenings in prenatal life to early soft plaques in infants, which may also present as intermingled lesions with components of both categories, more frequently observed with increasing age. Also,we proposed that TGF-β1 expressionmight be considered another possible predisposing factor to develop atherosclerotic coronary artery disease in CHD patients. On the other hand, estrogen receptor-α (ERα) appears to be responsible for the protective effects of estrogens against atherosclerotic vascular disease. The aim of this paper was to analyze the immunohistochemical expression of ERα, TGF-β1 and apolipoprotein B in coronary intimal hyperplasia in children with CHD and the possible increased risk for the development pre-atherosclerotic lesions. |
publishDate |
2014 |
dc.date.none.fl_str_mv |
2014-08 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/7869 Castilla Lozano, Maria del Rocio; Cao, Gabriel Fernando; Kolliker Frers, Rodolfo Alberto; Muller, Angelica del Carmen; Ambrosio, Giuseppe; et al.; Inverse expression of estrogen receptor alpha and apolipoprotein B in coronary intimal hyperplasia of surgically repaired congenital heart disease: A pre-atherosclerotic condition?; Elsevier; International Journal Of Cardiology; 177; 2; 8-2014; 548-550 0167-5273 |
url |
http://hdl.handle.net/11336/7869 |
identifier_str_mv |
Castilla Lozano, Maria del Rocio; Cao, Gabriel Fernando; Kolliker Frers, Rodolfo Alberto; Muller, Angelica del Carmen; Ambrosio, Giuseppe; et al.; Inverse expression of estrogen receptor alpha and apolipoprotein B in coronary intimal hyperplasia of surgically repaired congenital heart disease: A pre-atherosclerotic condition?; Elsevier; International Journal Of Cardiology; 177; 2; 8-2014; 548-550 0167-5273 |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.sciencedirect.com/science/article/pii/S0167527314016453 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.ijcard.2014.08.100 info:eu-repo/semantics/altIdentifier/url/http://www.internationaljournalofcardiology.com/article/S0167-5273(14)01645-3/abstract |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier |
publisher.none.fl_str_mv |
Elsevier |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613563412381696 |
score |
13.070432 |