Eliminating artificial trans fatty acids in Argentina: estimated effects on the burden of coronary heart disease and costs

Autores
Rubinstein, Adolfo Luis; Elorriaga, Natalia; Garay, Ulises; Poggio, Rosana; Caporale, Joaquin; Matta, Maria Gabriela; Augustovski, Federico Ariel; Pichón-Riviere, Andrés; Mozaffarian, Dariush
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Objective: To estimate the impact of Argentine policies to reduce trans fatty acids (TFA) on coronary heart disease (CHD), disability-adjusted life years (DALYs) and associated health-care costs. Methods: We estimated the baseline intake of TFA before 2004 to be 1.5% of total energy intake. We built a policy model including baseline intake of TFA, the oils and fats used to replace artificial TFAs, the clinical effect of reducing artificial TFAs and the costs and DALYs saved due to averted CHD events. To calculate the percentage of reduction of CHD, we calculated CHD risks on a population-based sample before and after implementation. The effect of the policies was modelled in three ways, based on projected changes: (i) in plasma lipid profiles; (ii) in lipid and inflammatory biomarkers; and (iii) the results of prospective cohort studies. We also estimated the present economic value of DALYs and associated health-care costs of coronary heart disease averted. Findings: We estimated that projected changes in lipid profile would avert 301 deaths, 1066 acute CHD events, 5237 DALYs and 17 million United States dollars (US$) in health-care costs annually. Based on the adverse effects of TFA intake reported in prospective cohort studies, 1517 deaths, 5373 acute CHD events, 26 394 DALYs and US$ 87 million would be averted annually. Conclusion: Even under the most conservative scenario, reduction of TFA intake had a substantial effect on public health. These findings will help inform decision-makers in Argentina and other countries on the potential public health and economic impact of this policy.
Fil: Rubinstein, Adolfo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Elorriaga, Natalia. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Garay, Ulises. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Poggio, Rosana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Caporale, Joaquin. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Matta, Maria Gabriela. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Augustovski, Federico Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Pichón-Riviere, Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Mozaffarian, Dariush. Tufts University; Estados Unidos
Materia
TRANS FATTY ACIDS
ARGENTINA
BURDEN OF CORONARY HEART DISEASE
COSTS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/42859
Acceder
id CONICETDig_06c91c55d3cd7bdfbad900286088bcb5
oai_identifier_str oai:ri.conicet.gov.ar:11336/42859
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Eliminating artificial trans fatty acids in Argentina: estimated effects on the burden of coronary heart disease and costsRubinstein, Adolfo LuisElorriaga, NataliaGaray, UlisesPoggio, RosanaCaporale, JoaquinMatta, Maria GabrielaAugustovski, Federico ArielPichón-Riviere, AndrésMozaffarian, DariushTRANS FATTY ACIDSARGENTINABURDEN OF CORONARY HEART DISEASECOSTShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Objective: To estimate the impact of Argentine policies to reduce trans fatty acids (TFA) on coronary heart disease (CHD), disability-adjusted life years (DALYs) and associated health-care costs. Methods: We estimated the baseline intake of TFA before 2004 to be 1.5% of total energy intake. We built a policy model including baseline intake of TFA, the oils and fats used to replace artificial TFAs, the clinical effect of reducing artificial TFAs and the costs and DALYs saved due to averted CHD events. To calculate the percentage of reduction of CHD, we calculated CHD risks on a population-based sample before and after implementation. The effect of the policies was modelled in three ways, based on projected changes: (i) in plasma lipid profiles; (ii) in lipid and inflammatory biomarkers; and (iii) the results of prospective cohort studies. We also estimated the present economic value of DALYs and associated health-care costs of coronary heart disease averted. Findings: We estimated that projected changes in lipid profile would avert 301 deaths, 1066 acute CHD events, 5237 DALYs and 17 million United States dollars (US$) in health-care costs annually. Based on the adverse effects of TFA intake reported in prospective cohort studies, 1517 deaths, 5373 acute CHD events, 26 394 DALYs and US$ 87 million would be averted annually. Conclusion: Even under the most conservative scenario, reduction of TFA intake had a substantial effect on public health. These findings will help inform decision-makers in Argentina and other countries on the potential public health and economic impact of this policy.Fil: Rubinstein, Adolfo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Elorriaga, Natalia. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Garay, Ulises. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Poggio, Rosana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Caporale, Joaquin. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Matta, Maria Gabriela. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Augustovski, Federico Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Pichón-Riviere, Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Efectividad Clínica y Sanitaria; ArgentinaFil: Mozaffarian, Dariush. Tufts University; Estados UnidosWorld Health Organization2015-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/42859Rubinstein, Adolfo Luis; Elorriaga, Natalia; Garay, Ulises; Poggio, Rosana; Caporale, Joaquin; et al.; Eliminating artificial trans fatty acids in Argentina: estimated effects on the burden of coronary heart disease and costs; World Health Organization; Bulletin of the World Health Organization; 93; 9; 9-2015; 614-6220042-9686CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.2471/BLT.14.150516info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581646/info:eu-repo/semantics/altIdentifier/url/http://www.who.int/bulletin/volumes/93/9/14-150516-ab/en/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:49:13Zoai:ri.conicet.gov.ar:11336/42859instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:49:13.368CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Eliminating artificial trans fatty acids in Argentina: estimated effects on the burden of coronary heart disease and costs
title Eliminating artificial trans fatty acids in Argentina: estimated effects on the burden of coronary heart disease and costs
spellingShingle Eliminating artificial trans fatty acids in Argentina: estimated effects on the burden of coronary heart disease and costs
Rubinstein, Adolfo Luis
TRANS FATTY ACIDS
ARGENTINA
BURDEN OF CORONARY HEART DISEASE
COSTS
title_short Eliminating artificial trans fatty acids in Argentina: estimated effects on the burden of coronary heart disease and costs
title_full Eliminating artificial trans fatty acids in Argentina: estimated effects on the burden of coronary heart disease and costs
title_fullStr Eliminating artificial trans fatty acids in Argentina: estimated effects on the burden of coronary heart disease and costs
title_full_unstemmed Eliminating artificial trans fatty acids in Argentina: estimated effects on the burden of coronary heart disease and costs
title_sort Eliminating artificial trans fatty acids in Argentina: estimated effects on the burden of coronary heart disease and costs
dc.creator.none.fl_str_mv Rubinstein, Adolfo Luis
Elorriaga, Natalia
Garay, Ulises
Poggio, Rosana
Caporale, Joaquin
Matta, Maria Gabriela
Augustovski, Federico Ariel
Pichón-Riviere, Andrés
Mozaffarian, Dariush
author Rubinstein, Adolfo Luis
author_facet Rubinstein, Adolfo Luis
Elorriaga, Natalia
Garay, Ulises
Poggio, Rosana
Caporale, Joaquin
Matta, Maria Gabriela
Augustovski, Federico Ariel
Pichón-Riviere, Andrés
Mozaffarian, Dariush
author_role author
author2 Elorriaga, Natalia
Garay, Ulises
Poggio, Rosana
Caporale, Joaquin
Matta, Maria Gabriela
Augustovski, Federico Ariel
Pichón-Riviere, Andrés
Mozaffarian, Dariush
author2_role author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv TRANS FATTY ACIDS
ARGENTINA
BURDEN OF CORONARY HEART DISEASE
COSTS
topic TRANS FATTY ACIDS
ARGENTINA
BURDEN OF CORONARY HEART DISEASE
COSTS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Objective: To estimate the impact of Argentine policies to reduce trans fatty acids (TFA) on coronary heart disease (CHD), disability-adjusted life years (DALYs) and associated health-care costs. Methods: We estimated the baseline intake of TFA before 2004 to be 1.5% of total energy intake. We built a policy model including baseline intake of TFA, the oils and fats used to replace artificial TFAs, the clinical effect of reducing artificial TFAs and the costs and DALYs saved due to averted CHD events. To calculate the percentage of reduction of CHD, we calculated CHD risks on a population-based sample before and after implementation. The effect of the policies was modelled in three ways, based on projected changes: (i) in plasma lipid profiles; (ii) in lipid and inflammatory biomarkers; and (iii) the results of prospective cohort studies. We also estimated the present economic value of DALYs and associated health-care costs of coronary heart disease averted. Findings: We estimated that projected changes in lipid profile would avert 301 deaths, 1066 acute CHD events, 5237 DALYs and 17 million United States dollars (US$) in health-care costs annually. Based on the adverse effects of TFA intake reported in prospective cohort studies, 1517 deaths, 5373 acute CHD events, 26 394 DALYs and US$ 87 million would be averted annually. Conclusion: Even under the most conservative scenario, reduction of TFA intake had a substantial effect on public health. These findings will help inform decision-makers in Argentina and other countries on the potential public health and economic impact of this policy.
Fil: Rubinstein, Adolfo Luis. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Elorriaga, Natalia. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Garay, Ulises. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Poggio, Rosana. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Caporale, Joaquin. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Matta, Maria Gabriela. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Augustovski, Federico Ariel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Pichón-Riviere, Andrés. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Instituto de Efectividad Clínica y Sanitaria; Argentina
Fil: Mozaffarian, Dariush. Tufts University; Estados Unidos
description Objective: To estimate the impact of Argentine policies to reduce trans fatty acids (TFA) on coronary heart disease (CHD), disability-adjusted life years (DALYs) and associated health-care costs. Methods: We estimated the baseline intake of TFA before 2004 to be 1.5% of total energy intake. We built a policy model including baseline intake of TFA, the oils and fats used to replace artificial TFAs, the clinical effect of reducing artificial TFAs and the costs and DALYs saved due to averted CHD events. To calculate the percentage of reduction of CHD, we calculated CHD risks on a population-based sample before and after implementation. The effect of the policies was modelled in three ways, based on projected changes: (i) in plasma lipid profiles; (ii) in lipid and inflammatory biomarkers; and (iii) the results of prospective cohort studies. We also estimated the present economic value of DALYs and associated health-care costs of coronary heart disease averted. Findings: We estimated that projected changes in lipid profile would avert 301 deaths, 1066 acute CHD events, 5237 DALYs and 17 million United States dollars (US$) in health-care costs annually. Based on the adverse effects of TFA intake reported in prospective cohort studies, 1517 deaths, 5373 acute CHD events, 26 394 DALYs and US$ 87 million would be averted annually. Conclusion: Even under the most conservative scenario, reduction of TFA intake had a substantial effect on public health. These findings will help inform decision-makers in Argentina and other countries on the potential public health and economic impact of this policy.
publishDate 2015
dc.date.none.fl_str_mv 2015-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/42859
Rubinstein, Adolfo Luis; Elorriaga, Natalia; Garay, Ulises; Poggio, Rosana; Caporale, Joaquin; et al.; Eliminating artificial trans fatty acids in Argentina: estimated effects on the burden of coronary heart disease and costs; World Health Organization; Bulletin of the World Health Organization; 93; 9; 9-2015; 614-622
0042-9686
CONICET Digital
CONICET
url http://hdl.handle.net/11336/42859
identifier_str_mv Rubinstein, Adolfo Luis; Elorriaga, Natalia; Garay, Ulises; Poggio, Rosana; Caporale, Joaquin; et al.; Eliminating artificial trans fatty acids in Argentina: estimated effects on the burden of coronary heart disease and costs; World Health Organization; Bulletin of the World Health Organization; 93; 9; 9-2015; 614-622
0042-9686
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.2471/BLT.14.150516
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC4581646/
info:eu-repo/semantics/altIdentifier/url/http://www.who.int/bulletin/volumes/93/9/14-150516-ab/en/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv World Health Organization
publisher.none.fl_str_mv World Health Organization
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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