Photodegradation of prednisolone under UVB solar irradiation. Role of photogenerated ROS in the degradation mechanism

Autores
Cacciari, Rodolfo Daniel; Reynoso, Eugenia; Montejano, Hernan Alfredo; Biasutti, Maria Alicia
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The use of biologically active substances with anti-inflammatory properties such as corticosteroids has increased considerably in the last few decades. Particularly, the compound we are interested in, prednisolone (Predn), is a glucocorticoid with high biological activity. This compound absorbs UV radiation and may participate in photochemical processes, which can result in its own decomposition. These processes could result in the formation of free radicals or reactive oxygen species (ROS). On these grounds, the kinetic and mechanistic aspects of the direct photodegradation of Predn have been studied in aqueous medium under different atmospheric conditions by stationary and time-resolved techniques. The mechanism involved in the photodegradation has been elucidated. Predn is capable of generating the excited triplet state 3 Predn∗ as a result of UVB light absorption. In the presence of oxygen, 3 Predn∗ allows the formation of ROS, of which O 2 ( 1 Δ g ) (Φ Δ = 0.014), H 2 O 2 and the radical OH stand out. The latter is generated from the spontaneous dismutation of O 2 - and subsequent homolytic cleavage, photochemically promoted, of H 2 O 2 . Predn undergoes unimolecular photodegradation reactions under an inert argon atmosphere. In this study we found that in the presence of oxygen, the Predn photo-consumption is improved. This implies that the attack by ROS involves a very important additional contribution to the photodegradation of Predn under aerobic conditions.
Fil: Cacciari, Rodolfo Daniel. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Reynoso, Eugenia. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Montejano, Hernan Alfredo. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Biasutti, Maria Alicia. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
PREDNISOLONE
CORTICOSTEROIDS
PHOTODEGRADATION MECHANISMS
REACTIVE OXYGEN SPECIES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/72780
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Photodegradation of prednisolone under UVB solar irradiation. Role of photogenerated ROS in the degradation mechanismCacciari, Rodolfo DanielReynoso, EugeniaMontejano, Hernan AlfredoBiasutti, Maria AliciaPREDNISOLONECORTICOSTEROIDSPHOTODEGRADATION MECHANISMSREACTIVE OXYGEN SPECIEShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1The use of biologically active substances with anti-inflammatory properties such as corticosteroids has increased considerably in the last few decades. Particularly, the compound we are interested in, prednisolone (Predn), is a glucocorticoid with high biological activity. This compound absorbs UV radiation and may participate in photochemical processes, which can result in its own decomposition. These processes could result in the formation of free radicals or reactive oxygen species (ROS). On these grounds, the kinetic and mechanistic aspects of the direct photodegradation of Predn have been studied in aqueous medium under different atmospheric conditions by stationary and time-resolved techniques. The mechanism involved in the photodegradation has been elucidated. Predn is capable of generating the excited triplet state 3 Predn∗ as a result of UVB light absorption. In the presence of oxygen, 3 Predn∗ allows the formation of ROS, of which O 2 ( 1 Δ g ) (Φ Δ = 0.014), H 2 O 2 and the radical OH stand out. The latter is generated from the spontaneous dismutation of O 2 - and subsequent homolytic cleavage, photochemically promoted, of H 2 O 2 . Predn undergoes unimolecular photodegradation reactions under an inert argon atmosphere. In this study we found that in the presence of oxygen, the Predn photo-consumption is improved. This implies that the attack by ROS involves a very important additional contribution to the photodegradation of Predn under aerobic conditions.Fil: Cacciari, Rodolfo Daniel. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Reynoso, Eugenia. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Montejano, Hernan Alfredo. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Biasutti, Maria Alicia. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaRoyal Society of Chemistry2017-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/72780Cacciari, Rodolfo Daniel; Reynoso, Eugenia; Montejano, Hernan Alfredo; Biasutti, Maria Alicia; Photodegradation of prednisolone under UVB solar irradiation. Role of photogenerated ROS in the degradation mechanism; Royal Society of Chemistry; Photochemical and Photobiological Sciences; 16; 11; 11-2017; 1717-17261474-905XCONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1039/c7pp00200ainfo:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/Content/ArticleLanding/2017/PP/C7PP00200Ainfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:21:10Zoai:ri.conicet.gov.ar:11336/72780instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:21:11.026CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Photodegradation of prednisolone under UVB solar irradiation. Role of photogenerated ROS in the degradation mechanism
title Photodegradation of prednisolone under UVB solar irradiation. Role of photogenerated ROS in the degradation mechanism
spellingShingle Photodegradation of prednisolone under UVB solar irradiation. Role of photogenerated ROS in the degradation mechanism
Cacciari, Rodolfo Daniel
PREDNISOLONE
CORTICOSTEROIDS
PHOTODEGRADATION MECHANISMS
REACTIVE OXYGEN SPECIES
title_short Photodegradation of prednisolone under UVB solar irradiation. Role of photogenerated ROS in the degradation mechanism
title_full Photodegradation of prednisolone under UVB solar irradiation. Role of photogenerated ROS in the degradation mechanism
title_fullStr Photodegradation of prednisolone under UVB solar irradiation. Role of photogenerated ROS in the degradation mechanism
title_full_unstemmed Photodegradation of prednisolone under UVB solar irradiation. Role of photogenerated ROS in the degradation mechanism
title_sort Photodegradation of prednisolone under UVB solar irradiation. Role of photogenerated ROS in the degradation mechanism
dc.creator.none.fl_str_mv Cacciari, Rodolfo Daniel
Reynoso, Eugenia
Montejano, Hernan Alfredo
Biasutti, Maria Alicia
author Cacciari, Rodolfo Daniel
author_facet Cacciari, Rodolfo Daniel
Reynoso, Eugenia
Montejano, Hernan Alfredo
Biasutti, Maria Alicia
author_role author
author2 Reynoso, Eugenia
Montejano, Hernan Alfredo
Biasutti, Maria Alicia
author2_role author
author
author
dc.subject.none.fl_str_mv PREDNISOLONE
CORTICOSTEROIDS
PHOTODEGRADATION MECHANISMS
REACTIVE OXYGEN SPECIES
topic PREDNISOLONE
CORTICOSTEROIDS
PHOTODEGRADATION MECHANISMS
REACTIVE OXYGEN SPECIES
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv The use of biologically active substances with anti-inflammatory properties such as corticosteroids has increased considerably in the last few decades. Particularly, the compound we are interested in, prednisolone (Predn), is a glucocorticoid with high biological activity. This compound absorbs UV radiation and may participate in photochemical processes, which can result in its own decomposition. These processes could result in the formation of free radicals or reactive oxygen species (ROS). On these grounds, the kinetic and mechanistic aspects of the direct photodegradation of Predn have been studied in aqueous medium under different atmospheric conditions by stationary and time-resolved techniques. The mechanism involved in the photodegradation has been elucidated. Predn is capable of generating the excited triplet state 3 Predn∗ as a result of UVB light absorption. In the presence of oxygen, 3 Predn∗ allows the formation of ROS, of which O 2 ( 1 Δ g ) (Φ Δ = 0.014), H 2 O 2 and the radical OH stand out. The latter is generated from the spontaneous dismutation of O 2 - and subsequent homolytic cleavage, photochemically promoted, of H 2 O 2 . Predn undergoes unimolecular photodegradation reactions under an inert argon atmosphere. In this study we found that in the presence of oxygen, the Predn photo-consumption is improved. This implies that the attack by ROS involves a very important additional contribution to the photodegradation of Predn under aerobic conditions.
Fil: Cacciari, Rodolfo Daniel. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Reynoso, Eugenia. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Montejano, Hernan Alfredo. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Biasutti, Maria Alicia. Universidad Nacional de Río Cuarto. Facultad de Ciencias Exactas Fisicoquímicas y Naturales. Departamento de Química; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description The use of biologically active substances with anti-inflammatory properties such as corticosteroids has increased considerably in the last few decades. Particularly, the compound we are interested in, prednisolone (Predn), is a glucocorticoid with high biological activity. This compound absorbs UV radiation and may participate in photochemical processes, which can result in its own decomposition. These processes could result in the formation of free radicals or reactive oxygen species (ROS). On these grounds, the kinetic and mechanistic aspects of the direct photodegradation of Predn have been studied in aqueous medium under different atmospheric conditions by stationary and time-resolved techniques. The mechanism involved in the photodegradation has been elucidated. Predn is capable of generating the excited triplet state 3 Predn∗ as a result of UVB light absorption. In the presence of oxygen, 3 Predn∗ allows the formation of ROS, of which O 2 ( 1 Δ g ) (Φ Δ = 0.014), H 2 O 2 and the radical OH stand out. The latter is generated from the spontaneous dismutation of O 2 - and subsequent homolytic cleavage, photochemically promoted, of H 2 O 2 . Predn undergoes unimolecular photodegradation reactions under an inert argon atmosphere. In this study we found that in the presence of oxygen, the Predn photo-consumption is improved. This implies that the attack by ROS involves a very important additional contribution to the photodegradation of Predn under aerobic conditions.
publishDate 2017
dc.date.none.fl_str_mv 2017-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/72780
Cacciari, Rodolfo Daniel; Reynoso, Eugenia; Montejano, Hernan Alfredo; Biasutti, Maria Alicia; Photodegradation of prednisolone under UVB solar irradiation. Role of photogenerated ROS in the degradation mechanism; Royal Society of Chemistry; Photochemical and Photobiological Sciences; 16; 11; 11-2017; 1717-1726
1474-905X
CONICET Digital
CONICET
url http://hdl.handle.net/11336/72780
identifier_str_mv Cacciari, Rodolfo Daniel; Reynoso, Eugenia; Montejano, Hernan Alfredo; Biasutti, Maria Alicia; Photodegradation of prednisolone under UVB solar irradiation. Role of photogenerated ROS in the degradation mechanism; Royal Society of Chemistry; Photochemical and Photobiological Sciences; 16; 11; 11-2017; 1717-1726
1474-905X
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1039/c7pp00200a
info:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/Content/ArticleLanding/2017/PP/C7PP00200A
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.069144

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