Metabolically active CD4+ T cells expressing Glut1 and OX40 preferentially harbor HIV during in vitro infection
- Autores
- Palmer, Clovis S.; Duette, Gabriel; Wagner, Marc C. E.; Henstridge, Darren C.; Saleh, Suah; Pereira, Candida; Zhou, Jingling; Simar, David; Lewin, Sharon R.; Ostrowski, Matias; McCune, Joseph M.; Crowe, Suzanne M.
- Año de publicación
- 2017
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- High glucose transporter 1 (Glut1) surface expression is associated with increased glycolytic activity in activated CD4+ T cells. Phosphatidylinositide 3-kinases (PI3K) activation measured by p-Akt and OX40 is elevated in CD4+Glut1+ T cells from HIV+ subjects. TCR engagement of CD4+Glut1+ T cells from HIV+ subjects demonstrates hyperresponsive PI3K-mammalian target of rapamycin signaling. High basal Glut1 and OX40 on CD4+ T cells from combination antiretroviral therapy (cART)-treated HIV+ patients represent a sufficiently metabolically active state permissive for HIV infection in vitro without external stimuli. The majority of CD4+OX40+ T cells express Glut1, thus OX40 rather than Glut1 itself may facilitate HIV infection. Furthermore, infection of CD4+ T cells is limited by p110γ PI3K inhibition. Modulating glucose metabolism may limit cellular activation and prevent residual HIV replication in ‘virologically suppressed’ cART-treated HIV+ persons.
Fil: Palmer, Clovis S.. Burnet Institute; Australia. Monash University; Australia. University of Melbourne; Australia
Fil: Duette, Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Wagner, Marc C. E.. No especifíca;
Fil: Henstridge, Darren C.. Baker IDI Heart and Diabetes Institute; Australia
Fil: Saleh, Suah. Burnet Institute; Australia. University of Melbourne; Australia
Fil: Pereira, Candida. Burnet Institute; Australia. University of Melbourne; Australia. Monash University; Australia
Fil: Zhou, Jingling. Burnet Institute; Australia
Fil: Simar, David. University of New South Wales; Australia
Fil: Lewin, Sharon R.. Monash University; Australia. University of Melbourne; Australia
Fil: Ostrowski, Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: McCune, Joseph M.. University of California; Estados Unidos
Fil: Crowe, Suzanne M.. Burnet Institute; Australia. Monash University; Australia - Materia
-
CANCER
CD4 T CELLS
GLUT1
HIV
IMMUNOMETABOLISM
MTOR
PI3K - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/66268
Ver los metadatos del registro completo
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oai:ri.conicet.gov.ar:11336/66268 |
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3498 |
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CONICET Digital (CONICET) |
spelling |
Metabolically active CD4+ T cells expressing Glut1 and OX40 preferentially harbor HIV during in vitro infectionPalmer, Clovis S.Duette, GabrielWagner, Marc C. E.Henstridge, Darren C.Saleh, SuahPereira, CandidaZhou, JinglingSimar, DavidLewin, Sharon R.Ostrowski, MatiasMcCune, Joseph M.Crowe, Suzanne M.CANCERCD4 T CELLSGLUT1HIVIMMUNOMETABOLISMMTORPI3Khttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3High glucose transporter 1 (Glut1) surface expression is associated with increased glycolytic activity in activated CD4+ T cells. Phosphatidylinositide 3-kinases (PI3K) activation measured by p-Akt and OX40 is elevated in CD4+Glut1+ T cells from HIV+ subjects. TCR engagement of CD4+Glut1+ T cells from HIV+ subjects demonstrates hyperresponsive PI3K-mammalian target of rapamycin signaling. High basal Glut1 and OX40 on CD4+ T cells from combination antiretroviral therapy (cART)-treated HIV+ patients represent a sufficiently metabolically active state permissive for HIV infection in vitro without external stimuli. The majority of CD4+OX40+ T cells express Glut1, thus OX40 rather than Glut1 itself may facilitate HIV infection. Furthermore, infection of CD4+ T cells is limited by p110γ PI3K inhibition. Modulating glucose metabolism may limit cellular activation and prevent residual HIV replication in ‘virologically suppressed’ cART-treated HIV+ persons.Fil: Palmer, Clovis S.. Burnet Institute; Australia. Monash University; Australia. University of Melbourne; AustraliaFil: Duette, Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Wagner, Marc C. E.. No especifíca;Fil: Henstridge, Darren C.. Baker IDI Heart and Diabetes Institute; AustraliaFil: Saleh, Suah. Burnet Institute; Australia. University of Melbourne; AustraliaFil: Pereira, Candida. Burnet Institute; Australia. University of Melbourne; Australia. Monash University; AustraliaFil: Zhou, Jingling. Burnet Institute; AustraliaFil: Simar, David. University of New South Wales; AustraliaFil: Lewin, Sharon R.. Monash University; Australia. University of Melbourne; AustraliaFil: Ostrowski, Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: McCune, Joseph M.. University of California; Estados UnidosFil: Crowe, Suzanne M.. Burnet Institute; Australia. Monash University; AustraliaElsevier Science2017-10info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/66268Palmer, Clovis S.; Duette, Gabriel; Wagner, Marc C. E.; Henstridge, Darren C.; Saleh, Suah; et al.; Metabolically active CD4+ T cells expressing Glut1 and OX40 preferentially harbor HIV during in vitro infection; Elsevier Science; FEBS Letters; 591; 20; 10-2017; 3319-33320014-5793CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/1873-3468.12843info:eu-repo/semantics/altIdentifier/url/https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.12843info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:07:10Zoai:ri.conicet.gov.ar:11336/66268instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:07:10.736CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Metabolically active CD4+ T cells expressing Glut1 and OX40 preferentially harbor HIV during in vitro infection |
title |
Metabolically active CD4+ T cells expressing Glut1 and OX40 preferentially harbor HIV during in vitro infection |
spellingShingle |
Metabolically active CD4+ T cells expressing Glut1 and OX40 preferentially harbor HIV during in vitro infection Palmer, Clovis S. CANCER CD4 T CELLS GLUT1 HIV IMMUNOMETABOLISM MTOR PI3K |
title_short |
Metabolically active CD4+ T cells expressing Glut1 and OX40 preferentially harbor HIV during in vitro infection |
title_full |
Metabolically active CD4+ T cells expressing Glut1 and OX40 preferentially harbor HIV during in vitro infection |
title_fullStr |
Metabolically active CD4+ T cells expressing Glut1 and OX40 preferentially harbor HIV during in vitro infection |
title_full_unstemmed |
Metabolically active CD4+ T cells expressing Glut1 and OX40 preferentially harbor HIV during in vitro infection |
title_sort |
Metabolically active CD4+ T cells expressing Glut1 and OX40 preferentially harbor HIV during in vitro infection |
dc.creator.none.fl_str_mv |
Palmer, Clovis S. Duette, Gabriel Wagner, Marc C. E. Henstridge, Darren C. Saleh, Suah Pereira, Candida Zhou, Jingling Simar, David Lewin, Sharon R. Ostrowski, Matias McCune, Joseph M. Crowe, Suzanne M. |
author |
Palmer, Clovis S. |
author_facet |
Palmer, Clovis S. Duette, Gabriel Wagner, Marc C. E. Henstridge, Darren C. Saleh, Suah Pereira, Candida Zhou, Jingling Simar, David Lewin, Sharon R. Ostrowski, Matias McCune, Joseph M. Crowe, Suzanne M. |
author_role |
author |
author2 |
Duette, Gabriel Wagner, Marc C. E. Henstridge, Darren C. Saleh, Suah Pereira, Candida Zhou, Jingling Simar, David Lewin, Sharon R. Ostrowski, Matias McCune, Joseph M. Crowe, Suzanne M. |
author2_role |
author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
CANCER CD4 T CELLS GLUT1 HIV IMMUNOMETABOLISM MTOR PI3K |
topic |
CANCER CD4 T CELLS GLUT1 HIV IMMUNOMETABOLISM MTOR PI3K |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/3.3 https://purl.org/becyt/ford/3 |
dc.description.none.fl_txt_mv |
High glucose transporter 1 (Glut1) surface expression is associated with increased glycolytic activity in activated CD4+ T cells. Phosphatidylinositide 3-kinases (PI3K) activation measured by p-Akt and OX40 is elevated in CD4+Glut1+ T cells from HIV+ subjects. TCR engagement of CD4+Glut1+ T cells from HIV+ subjects demonstrates hyperresponsive PI3K-mammalian target of rapamycin signaling. High basal Glut1 and OX40 on CD4+ T cells from combination antiretroviral therapy (cART)-treated HIV+ patients represent a sufficiently metabolically active state permissive for HIV infection in vitro without external stimuli. The majority of CD4+OX40+ T cells express Glut1, thus OX40 rather than Glut1 itself may facilitate HIV infection. Furthermore, infection of CD4+ T cells is limited by p110γ PI3K inhibition. Modulating glucose metabolism may limit cellular activation and prevent residual HIV replication in ‘virologically suppressed’ cART-treated HIV+ persons. Fil: Palmer, Clovis S.. Burnet Institute; Australia. Monash University; Australia. University of Melbourne; Australia Fil: Duette, Gabriel. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina Fil: Wagner, Marc C. E.. No especifíca; Fil: Henstridge, Darren C.. Baker IDI Heart and Diabetes Institute; Australia Fil: Saleh, Suah. Burnet Institute; Australia. University of Melbourne; Australia Fil: Pereira, Candida. Burnet Institute; Australia. University of Melbourne; Australia. Monash University; Australia Fil: Zhou, Jingling. Burnet Institute; Australia Fil: Simar, David. University of New South Wales; Australia Fil: Lewin, Sharon R.. Monash University; Australia. University of Melbourne; Australia Fil: Ostrowski, Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina Fil: McCune, Joseph M.. University of California; Estados Unidos Fil: Crowe, Suzanne M.. Burnet Institute; Australia. Monash University; Australia |
description |
High glucose transporter 1 (Glut1) surface expression is associated with increased glycolytic activity in activated CD4+ T cells. Phosphatidylinositide 3-kinases (PI3K) activation measured by p-Akt and OX40 is elevated in CD4+Glut1+ T cells from HIV+ subjects. TCR engagement of CD4+Glut1+ T cells from HIV+ subjects demonstrates hyperresponsive PI3K-mammalian target of rapamycin signaling. High basal Glut1 and OX40 on CD4+ T cells from combination antiretroviral therapy (cART)-treated HIV+ patients represent a sufficiently metabolically active state permissive for HIV infection in vitro without external stimuli. The majority of CD4+OX40+ T cells express Glut1, thus OX40 rather than Glut1 itself may facilitate HIV infection. Furthermore, infection of CD4+ T cells is limited by p110γ PI3K inhibition. Modulating glucose metabolism may limit cellular activation and prevent residual HIV replication in ‘virologically suppressed’ cART-treated HIV+ persons. |
publishDate |
2017 |
dc.date.none.fl_str_mv |
2017-10 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/66268 Palmer, Clovis S.; Duette, Gabriel; Wagner, Marc C. E.; Henstridge, Darren C.; Saleh, Suah; et al.; Metabolically active CD4+ T cells expressing Glut1 and OX40 preferentially harbor HIV during in vitro infection; Elsevier Science; FEBS Letters; 591; 20; 10-2017; 3319-3332 0014-5793 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/66268 |
identifier_str_mv |
Palmer, Clovis S.; Duette, Gabriel; Wagner, Marc C. E.; Henstridge, Darren C.; Saleh, Suah; et al.; Metabolically active CD4+ T cells expressing Glut1 and OX40 preferentially harbor HIV during in vitro infection; Elsevier Science; FEBS Letters; 591; 20; 10-2017; 3319-3332 0014-5793 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/doi/10.1002/1873-3468.12843 info:eu-repo/semantics/altIdentifier/url/https://febs.onlinelibrary.wiley.com/doi/full/10.1002/1873-3468.12843 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science |
publisher.none.fl_str_mv |
Elsevier Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
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Consejo Nacional de Investigaciones Científicas y Técnicas |
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CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844613928394424320 |
score |
13.070432 |