Glucose metabolism regulates T cell activation, differentiation, and functions

Autores
Palmer, Clovis; Ostrowski, Matias; Balderson, Brad; Christian, Nicole; Crowe, Suzanne
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The adaptive immune system is equipped to eliminate both tumors and pathogenic microorganisms. It requires a series of complex and coordinated signals to drive the activation, proliferation, and differentiation of appropriate T cell subsets. It is now established that changes in cellular activation are coupled to profound changes in cellular metabolism. In addition, emerging evidence now suggest that specific metabolic alterations associated with distinct T cell subsets may be ancillary to their differentiation and influential in their immune functions. The "Warburg effect" originally used to describe a phenomenon in which most cancer cells relied on aerobic glycolysis for their growth is a key process that sustain T cell activation and differentiation. Here, we review how different aspects of metabolism in T cells influence their functions, focusing on the emerging role of key regulators of glucose metabolism such as HIF-1a. A thorough understanding of the role of metabolism in T cell function could provide insights into mechanisms involved in inflammatory-mediated conditions, with the potential for developing novel therapeutic approaches to treat these diseases.
Fil: Palmer, Clovis. Burnet Institute; Australia
Fil: Ostrowski, Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Balderson, Brad. Burnet Institute; Australia
Fil: Christian, Nicole. The University of the West Indies; Jamaica
Fil: Crowe, Suzanne. Burnet Institute; Australia
Materia
GLUCOSE TRANSPORTER 1
HIF-1A
HIV
IMMUNE ACTIVATION
INFLAMMATION
METABOLISM
MTOR
PI3K
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/97087
Acceder
id CONICETDig_7a7993a798cab111e5227ced44e0e1e5
oai_identifier_str oai:ri.conicet.gov.ar:11336/97087
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Glucose metabolism regulates T cell activation, differentiation, and functionsPalmer, ClovisOstrowski, MatiasBalderson, BradChristian, NicoleCrowe, SuzanneGLUCOSE TRANSPORTER 1HIF-1AHIVIMMUNE ACTIVATIONINFLAMMATIONMETABOLISMMTORPI3Khttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3The adaptive immune system is equipped to eliminate both tumors and pathogenic microorganisms. It requires a series of complex and coordinated signals to drive the activation, proliferation, and differentiation of appropriate T cell subsets. It is now established that changes in cellular activation are coupled to profound changes in cellular metabolism. In addition, emerging evidence now suggest that specific metabolic alterations associated with distinct T cell subsets may be ancillary to their differentiation and influential in their immune functions. The "Warburg effect" originally used to describe a phenomenon in which most cancer cells relied on aerobic glycolysis for their growth is a key process that sustain T cell activation and differentiation. Here, we review how different aspects of metabolism in T cells influence their functions, focusing on the emerging role of key regulators of glucose metabolism such as HIF-1a. A thorough understanding of the role of metabolism in T cell function could provide insights into mechanisms involved in inflammatory-mediated conditions, with the potential for developing novel therapeutic approaches to treat these diseases.Fil: Palmer, Clovis. Burnet Institute; AustraliaFil: Ostrowski, Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Balderson, Brad. Burnet Institute; AustraliaFil: Christian, Nicole. The University of the West Indies; JamaicaFil: Crowe, Suzanne. Burnet Institute; AustraliaFrontiers Research Foundation2015-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/97087Palmer, Clovis; Ostrowski, Matias; Balderson, Brad; Christian, Nicole; Crowe, Suzanne; Glucose metabolism regulates T cell activation, differentiation, and functions; Frontiers Research Foundation; Frontiers in Immunology; 6; JAN; 1-2015; 1-61664-3224CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2015.00001info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fimmu.2015.00001/fullinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:33:40Zoai:ri.conicet.gov.ar:11336/97087instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:33:41.125CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Glucose metabolism regulates T cell activation, differentiation, and functions
title Glucose metabolism regulates T cell activation, differentiation, and functions
spellingShingle Glucose metabolism regulates T cell activation, differentiation, and functions
Palmer, Clovis
GLUCOSE TRANSPORTER 1
HIF-1A
HIV
IMMUNE ACTIVATION
INFLAMMATION
METABOLISM
MTOR
PI3K
title_short Glucose metabolism regulates T cell activation, differentiation, and functions
title_full Glucose metabolism regulates T cell activation, differentiation, and functions
title_fullStr Glucose metabolism regulates T cell activation, differentiation, and functions
title_full_unstemmed Glucose metabolism regulates T cell activation, differentiation, and functions
title_sort Glucose metabolism regulates T cell activation, differentiation, and functions
dc.creator.none.fl_str_mv Palmer, Clovis
Ostrowski, Matias
Balderson, Brad
Christian, Nicole
Crowe, Suzanne
author Palmer, Clovis
author_facet Palmer, Clovis
Ostrowski, Matias
Balderson, Brad
Christian, Nicole
Crowe, Suzanne
author_role author
author2 Ostrowski, Matias
Balderson, Brad
Christian, Nicole
Crowe, Suzanne
author2_role author
author
author
author
dc.subject.none.fl_str_mv GLUCOSE TRANSPORTER 1
HIF-1A
HIV
IMMUNE ACTIVATION
INFLAMMATION
METABOLISM
MTOR
PI3K
topic GLUCOSE TRANSPORTER 1
HIF-1A
HIV
IMMUNE ACTIVATION
INFLAMMATION
METABOLISM
MTOR
PI3K
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The adaptive immune system is equipped to eliminate both tumors and pathogenic microorganisms. It requires a series of complex and coordinated signals to drive the activation, proliferation, and differentiation of appropriate T cell subsets. It is now established that changes in cellular activation are coupled to profound changes in cellular metabolism. In addition, emerging evidence now suggest that specific metabolic alterations associated with distinct T cell subsets may be ancillary to their differentiation and influential in their immune functions. The "Warburg effect" originally used to describe a phenomenon in which most cancer cells relied on aerobic glycolysis for their growth is a key process that sustain T cell activation and differentiation. Here, we review how different aspects of metabolism in T cells influence their functions, focusing on the emerging role of key regulators of glucose metabolism such as HIF-1a. A thorough understanding of the role of metabolism in T cell function could provide insights into mechanisms involved in inflammatory-mediated conditions, with the potential for developing novel therapeutic approaches to treat these diseases.
Fil: Palmer, Clovis. Burnet Institute; Australia
Fil: Ostrowski, Matias. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Balderson, Brad. Burnet Institute; Australia
Fil: Christian, Nicole. The University of the West Indies; Jamaica
Fil: Crowe, Suzanne. Burnet Institute; Australia
description The adaptive immune system is equipped to eliminate both tumors and pathogenic microorganisms. It requires a series of complex and coordinated signals to drive the activation, proliferation, and differentiation of appropriate T cell subsets. It is now established that changes in cellular activation are coupled to profound changes in cellular metabolism. In addition, emerging evidence now suggest that specific metabolic alterations associated with distinct T cell subsets may be ancillary to their differentiation and influential in their immune functions. The "Warburg effect" originally used to describe a phenomenon in which most cancer cells relied on aerobic glycolysis for their growth is a key process that sustain T cell activation and differentiation. Here, we review how different aspects of metabolism in T cells influence their functions, focusing on the emerging role of key regulators of glucose metabolism such as HIF-1a. A thorough understanding of the role of metabolism in T cell function could provide insights into mechanisms involved in inflammatory-mediated conditions, with the potential for developing novel therapeutic approaches to treat these diseases.
publishDate 2015
dc.date.none.fl_str_mv 2015-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/97087
Palmer, Clovis; Ostrowski, Matias; Balderson, Brad; Christian, Nicole; Crowe, Suzanne; Glucose metabolism regulates T cell activation, differentiation, and functions; Frontiers Research Foundation; Frontiers in Immunology; 6; JAN; 1-2015; 1-6
1664-3224
CONICET Digital
CONICET
url http://hdl.handle.net/11336/97087
identifier_str_mv Palmer, Clovis; Ostrowski, Matias; Balderson, Brad; Christian, Nicole; Crowe, Suzanne; Glucose metabolism regulates T cell activation, differentiation, and functions; Frontiers Research Foundation; Frontiers in Immunology; 6; JAN; 1-2015; 1-6
1664-3224
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.3389/fimmu.2015.00001
info:eu-repo/semantics/altIdentifier/url/https://www.frontiersin.org/articles/10.3389/fimmu.2015.00001/full
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Frontiers Research Foundation
publisher.none.fl_str_mv Frontiers Research Foundation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1844613036805980160
score 13.070432

Publicaciones similares