The immunosuppressive tuberculosis-associated microenvironment inhibits viral replication and promotes HIV-1 latency in CD4+ T cells

Autores
Cronin, Samantha; de Vries Egan, Anneke; Vahlas, Zoï; Czernikier, Alejandro; Melucci Ganzarain, Claudia del Carmen; Pereyra Gerber, Federico Pehuén; O’Neil, Thomas; Gloss, Brian; Sharabas, Mayssa; Turk, Gabriela Julia Ana; Verollet, Christel; Balboa, Luciana; Palmer, Sarah; Duette, Gabriel
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is the most common coinfection among people living with HIV-1. This coinfection is associated with accelerated HIV-1 disease progression and reduced survival. However, the impact of the HIV-1/TB coinfection on HIV-1 replication and latency in CD4+ T cells remains poorly studied. Using the acellular fraction of tuberculous pleural effusion (TB-PE), we investigated whether viral replication and HIV-1 latency in CD4+ T cells are affected by a TB-associated microenvironment. Our results revealed that TB-PE impaired T cell receptor-dependent cell activation and decreased HIV-1 replication in CD4+ T cells. Moreover, this immunosuppressive TB microenvironment promoted viral latency and inhibited HIV-1 reactivation. This study indicates that the TB-induced immune response may contribute to the persistence of the viral reservoir by silencing HIV-1 expression, allowing the virus to persist undetected by the immune system, and increasing the size of the latent HIV-1 reservoir.
Fil: Cronin, Samantha. The Westmead Institute For Medical Research; Australia. University of Sydney; Australia
Fil: de Vries Egan, Anneke. The Westmead Institute For Medical Research; Australia
Fil: Vahlas, Zoï. Université de Toulouse; Francia
Fil: Czernikier, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Melucci Ganzarain, Claudia del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Pereyra Gerber, Federico Pehuén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina. Cambridge Institute For Therapeutic Immunology; Estados Unidos
Fil: O’Neil, Thomas. The Westmead Institute For Medical Research; Australia. University of Sydney; Australia
Fil: Gloss, Brian. The Westmead Institute For Medical Research; Australia
Fil: Sharabas, Mayssa. The Westmead Institute For Medical Research; Australia
Fil: Turk, Gabriela Julia Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Verollet, Christel. Université de Toulouse; Francia
Fil: Balboa, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Palmer, Sarah. The Westmead Institute For Medical Research; Australia
Fil: Duette, Gabriel. The Westmead Institute For Medical Research; Australia. University of Sydney; Australia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Materia
Mycobacterium tuberculosis
Latency
HIV
CD4
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/266743
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/266743
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The immunosuppressive tuberculosis-associated microenvironment inhibits viral replication and promotes HIV-1 latency in CD4+ T cellsCronin, Samanthade Vries Egan, AnnekeVahlas, ZoïCzernikier, AlejandroMelucci Ganzarain, Claudia del CarmenPereyra Gerber, Federico PehuénO’Neil, ThomasGloss, BrianSharabas, MayssaTurk, Gabriela Julia AnaVerollet, ChristelBalboa, LucianaPalmer, SarahDuette, GabrielMycobacterium tuberculosisLatencyHIVCD4https://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is the most common coinfection among people living with HIV-1. This coinfection is associated with accelerated HIV-1 disease progression and reduced survival. However, the impact of the HIV-1/TB coinfection on HIV-1 replication and latency in CD4+ T cells remains poorly studied. Using the acellular fraction of tuberculous pleural effusion (TB-PE), we investigated whether viral replication and HIV-1 latency in CD4+ T cells are affected by a TB-associated microenvironment. Our results revealed that TB-PE impaired T cell receptor-dependent cell activation and decreased HIV-1 replication in CD4+ T cells. Moreover, this immunosuppressive TB microenvironment promoted viral latency and inhibited HIV-1 reactivation. This study indicates that the TB-induced immune response may contribute to the persistence of the viral reservoir by silencing HIV-1 expression, allowing the virus to persist undetected by the immune system, and increasing the size of the latent HIV-1 reservoir.Fil: Cronin, Samantha. The Westmead Institute For Medical Research; Australia. University of Sydney; AustraliaFil: de Vries Egan, Anneke. The Westmead Institute For Medical Research; AustraliaFil: Vahlas, Zoï. Université de Toulouse; FranciaFil: Czernikier, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Melucci Ganzarain, Claudia del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Pereyra Gerber, Federico Pehuén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina. Cambridge Institute For Therapeutic Immunology; Estados UnidosFil: O’Neil, Thomas. The Westmead Institute For Medical Research; Australia. University of Sydney; AustraliaFil: Gloss, Brian. The Westmead Institute For Medical Research; AustraliaFil: Sharabas, Mayssa. The Westmead Institute For Medical Research; AustraliaFil: Turk, Gabriela Julia Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Verollet, Christel. Université de Toulouse; FranciaFil: Balboa, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Palmer, Sarah. The Westmead Institute For Medical Research; AustraliaFil: Duette, Gabriel. The Westmead Institute For Medical Research; Australia. University of Sydney; Australia. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaCell Press2024-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/266743Cronin, Samantha; de Vries Egan, Anneke; Vahlas, Zoï; Czernikier, Alejandro; Melucci Ganzarain, Claudia del Carmen; et al.; The immunosuppressive tuberculosis-associated microenvironment inhibits viral replication and promotes HIV-1 latency in CD4+ T cells; Cell Press; iScience; 27; 7; 7-2024; 1-192589-0042CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S2589004224015499info:eu-repo/semantics/altIdentifier/doi/10.1016/j.isci.2024.110324info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:53:48Zoai:ri.conicet.gov.ar:11336/266743instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:53:48.361CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The immunosuppressive tuberculosis-associated microenvironment inhibits viral replication and promotes HIV-1 latency in CD4+ T cells
title The immunosuppressive tuberculosis-associated microenvironment inhibits viral replication and promotes HIV-1 latency in CD4+ T cells
spellingShingle The immunosuppressive tuberculosis-associated microenvironment inhibits viral replication and promotes HIV-1 latency in CD4+ T cells
Cronin, Samantha
Mycobacterium tuberculosis
Latency
HIV
CD4
title_short The immunosuppressive tuberculosis-associated microenvironment inhibits viral replication and promotes HIV-1 latency in CD4+ T cells
title_full The immunosuppressive tuberculosis-associated microenvironment inhibits viral replication and promotes HIV-1 latency in CD4+ T cells
title_fullStr The immunosuppressive tuberculosis-associated microenvironment inhibits viral replication and promotes HIV-1 latency in CD4+ T cells
title_full_unstemmed The immunosuppressive tuberculosis-associated microenvironment inhibits viral replication and promotes HIV-1 latency in CD4+ T cells
title_sort The immunosuppressive tuberculosis-associated microenvironment inhibits viral replication and promotes HIV-1 latency in CD4+ T cells
dc.creator.none.fl_str_mv Cronin, Samantha
de Vries Egan, Anneke
Vahlas, Zoï
Czernikier, Alejandro
Melucci Ganzarain, Claudia del Carmen
Pereyra Gerber, Federico Pehuén
O’Neil, Thomas
Gloss, Brian
Sharabas, Mayssa
Turk, Gabriela Julia Ana
Verollet, Christel
Balboa, Luciana
Palmer, Sarah
Duette, Gabriel
author Cronin, Samantha
author_facet Cronin, Samantha
de Vries Egan, Anneke
Vahlas, Zoï
Czernikier, Alejandro
Melucci Ganzarain, Claudia del Carmen
Pereyra Gerber, Federico Pehuén
O’Neil, Thomas
Gloss, Brian
Sharabas, Mayssa
Turk, Gabriela Julia Ana
Verollet, Christel
Balboa, Luciana
Palmer, Sarah
Duette, Gabriel
author_role author
author2 de Vries Egan, Anneke
Vahlas, Zoï
Czernikier, Alejandro
Melucci Ganzarain, Claudia del Carmen
Pereyra Gerber, Federico Pehuén
O’Neil, Thomas
Gloss, Brian
Sharabas, Mayssa
Turk, Gabriela Julia Ana
Verollet, Christel
Balboa, Luciana
Palmer, Sarah
Duette, Gabriel
author2_role author
author
author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Mycobacterium tuberculosis
Latency
HIV
CD4
topic Mycobacterium tuberculosis
Latency
HIV
CD4
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is the most common coinfection among people living with HIV-1. This coinfection is associated with accelerated HIV-1 disease progression and reduced survival. However, the impact of the HIV-1/TB coinfection on HIV-1 replication and latency in CD4+ T cells remains poorly studied. Using the acellular fraction of tuberculous pleural effusion (TB-PE), we investigated whether viral replication and HIV-1 latency in CD4+ T cells are affected by a TB-associated microenvironment. Our results revealed that TB-PE impaired T cell receptor-dependent cell activation and decreased HIV-1 replication in CD4+ T cells. Moreover, this immunosuppressive TB microenvironment promoted viral latency and inhibited HIV-1 reactivation. This study indicates that the TB-induced immune response may contribute to the persistence of the viral reservoir by silencing HIV-1 expression, allowing the virus to persist undetected by the immune system, and increasing the size of the latent HIV-1 reservoir.
Fil: Cronin, Samantha. The Westmead Institute For Medical Research; Australia. University of Sydney; Australia
Fil: de Vries Egan, Anneke. The Westmead Institute For Medical Research; Australia
Fil: Vahlas, Zoï. Université de Toulouse; Francia
Fil: Czernikier, Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Melucci Ganzarain, Claudia del Carmen. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Pereyra Gerber, Federico Pehuén. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina. Cambridge Institute For Therapeutic Immunology; Estados Unidos
Fil: O’Neil, Thomas. The Westmead Institute For Medical Research; Australia. University of Sydney; Australia
Fil: Gloss, Brian. The Westmead Institute For Medical Research; Australia
Fil: Sharabas, Mayssa. The Westmead Institute For Medical Research; Australia
Fil: Turk, Gabriela Julia Ana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Verollet, Christel. Université de Toulouse; Francia
Fil: Balboa, Luciana. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Palmer, Sarah. The Westmead Institute For Medical Research; Australia
Fil: Duette, Gabriel. The Westmead Institute For Medical Research; Australia. University of Sydney; Australia. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
description Mycobacterium tuberculosis (Mtb), the causative agent of tuberculosis (TB), is the most common coinfection among people living with HIV-1. This coinfection is associated with accelerated HIV-1 disease progression and reduced survival. However, the impact of the HIV-1/TB coinfection on HIV-1 replication and latency in CD4+ T cells remains poorly studied. Using the acellular fraction of tuberculous pleural effusion (TB-PE), we investigated whether viral replication and HIV-1 latency in CD4+ T cells are affected by a TB-associated microenvironment. Our results revealed that TB-PE impaired T cell receptor-dependent cell activation and decreased HIV-1 replication in CD4+ T cells. Moreover, this immunosuppressive TB microenvironment promoted viral latency and inhibited HIV-1 reactivation. This study indicates that the TB-induced immune response may contribute to the persistence of the viral reservoir by silencing HIV-1 expression, allowing the virus to persist undetected by the immune system, and increasing the size of the latent HIV-1 reservoir.
publishDate 2024
dc.date.none.fl_str_mv 2024-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/266743
Cronin, Samantha; de Vries Egan, Anneke; Vahlas, Zoï; Czernikier, Alejandro; Melucci Ganzarain, Claudia del Carmen; et al.; The immunosuppressive tuberculosis-associated microenvironment inhibits viral replication and promotes HIV-1 latency in CD4+ T cells; Cell Press; iScience; 27; 7; 7-2024; 1-19
2589-0042
CONICET Digital
CONICET
url http://hdl.handle.net/11336/266743
identifier_str_mv Cronin, Samantha; de Vries Egan, Anneke; Vahlas, Zoï; Czernikier, Alejandro; Melucci Ganzarain, Claudia del Carmen; et al.; The immunosuppressive tuberculosis-associated microenvironment inhibits viral replication and promotes HIV-1 latency in CD4+ T cells; Cell Press; iScience; 27; 7; 7-2024; 1-19
2589-0042
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S2589004224015499
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.isci.2024.110324
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Cell Press
publisher.none.fl_str_mv Cell Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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