Goal-directed Design of Dynamic Experiments for Cybernetic Models of Bioreactors

Autores
Luna, Martín Francisco; Martínez, Ernesto Carlos
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The distinctive feature of cybernetic models of bioreactors is their capacity to account for regulatory mechanisms in a cell metabolism by modeling the synthesis of enzymes and their activities. From a process engineering viewpoint, to guarantee its predictive capabilities regarding one or more process objective or goals (e.g. optimization, controllability, etc.), experimental data used to fit a cybernetic model parameters should be the most informative bearing in mind the adequacy of the resulting model to describe the specific objective of interest. To excite the most relevant metabolic modes in the cybernetic model, a dynamic experiment is optimally designed by accounting for the sensitivity of the chosen objective to operating conditions. The bioreactor feeding profile and sampling times are selected to maximize a global sensitivity index. As a case study, biomass production or fermentation to ethanol conversion in the fed-batch cultivation of Saccharomyces Cerevisiae are considered as alternative objectives.
Fil: Luna, Martín Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo y Diseño. Universidad Tecnológica Nacional. Facultad Regional Santa Fe. Instituto de Desarrollo y Diseño; Argentina
Fil: Martínez, Ernesto Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo y Diseño. Universidad Tecnológica Nacional. Facultad Regional Santa Fe. Instituto de Desarrollo y Diseño; Argentina
Materia
BIOREACTOR
CYBERNETIC MODEL
DESIGN OF EXPERIMENTS
OPTIMIZATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/87043
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Goal-directed Design of Dynamic Experiments for Cybernetic Models of BioreactorsLuna, Martín FranciscoMartínez, Ernesto CarlosBIOREACTORCYBERNETIC MODELDESIGN OF EXPERIMENTSOPTIMIZATIONhttps://purl.org/becyt/ford/2.4https://purl.org/becyt/ford/2The distinctive feature of cybernetic models of bioreactors is their capacity to account for regulatory mechanisms in a cell metabolism by modeling the synthesis of enzymes and their activities. From a process engineering viewpoint, to guarantee its predictive capabilities regarding one or more process objective or goals (e.g. optimization, controllability, etc.), experimental data used to fit a cybernetic model parameters should be the most informative bearing in mind the adequacy of the resulting model to describe the specific objective of interest. To excite the most relevant metabolic modes in the cybernetic model, a dynamic experiment is optimally designed by accounting for the sensitivity of the chosen objective to operating conditions. The bioreactor feeding profile and sampling times are selected to maximize a global sensitivity index. As a case study, biomass production or fermentation to ethanol conversion in the fed-batch cultivation of Saccharomyces Cerevisiae are considered as alternative objectives.Fil: Luna, Martín Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo y Diseño. Universidad Tecnológica Nacional. Facultad Regional Santa Fe. Instituto de Desarrollo y Diseño; ArgentinaFil: Martínez, Ernesto Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo y Diseño. Universidad Tecnológica Nacional. Facultad Regional Santa Fe. Instituto de Desarrollo y Diseño; ArgentinaElsevier B.V.2018-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/vnd.openxmlformats-officedocument.wordprocessingml.documentapplication/pdfhttp://hdl.handle.net/11336/87043Luna, Martín Francisco; Martínez, Ernesto Carlos; Goal-directed Design of Dynamic Experiments for Cybernetic Models of Bioreactors; Elsevier B.V.; Computer Aided Chemical Engineering; 44; 1-2018; 2479-24841570-7946CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/B978-0-444-64241-7.50408-0info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:33:03Zoai:ri.conicet.gov.ar:11336/87043instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:33:03.564CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Goal-directed Design of Dynamic Experiments for Cybernetic Models of Bioreactors
title Goal-directed Design of Dynamic Experiments for Cybernetic Models of Bioreactors
spellingShingle Goal-directed Design of Dynamic Experiments for Cybernetic Models of Bioreactors
Luna, Martín Francisco
BIOREACTOR
CYBERNETIC MODEL
DESIGN OF EXPERIMENTS
OPTIMIZATION
title_short Goal-directed Design of Dynamic Experiments for Cybernetic Models of Bioreactors
title_full Goal-directed Design of Dynamic Experiments for Cybernetic Models of Bioreactors
title_fullStr Goal-directed Design of Dynamic Experiments for Cybernetic Models of Bioreactors
title_full_unstemmed Goal-directed Design of Dynamic Experiments for Cybernetic Models of Bioreactors
title_sort Goal-directed Design of Dynamic Experiments for Cybernetic Models of Bioreactors
dc.creator.none.fl_str_mv Luna, Martín Francisco
Martínez, Ernesto Carlos
author Luna, Martín Francisco
author_facet Luna, Martín Francisco
Martínez, Ernesto Carlos
author_role author
author2 Martínez, Ernesto Carlos
author2_role author
dc.subject.none.fl_str_mv BIOREACTOR
CYBERNETIC MODEL
DESIGN OF EXPERIMENTS
OPTIMIZATION
topic BIOREACTOR
CYBERNETIC MODEL
DESIGN OF EXPERIMENTS
OPTIMIZATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.4
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The distinctive feature of cybernetic models of bioreactors is their capacity to account for regulatory mechanisms in a cell metabolism by modeling the synthesis of enzymes and their activities. From a process engineering viewpoint, to guarantee its predictive capabilities regarding one or more process objective or goals (e.g. optimization, controllability, etc.), experimental data used to fit a cybernetic model parameters should be the most informative bearing in mind the adequacy of the resulting model to describe the specific objective of interest. To excite the most relevant metabolic modes in the cybernetic model, a dynamic experiment is optimally designed by accounting for the sensitivity of the chosen objective to operating conditions. The bioreactor feeding profile and sampling times are selected to maximize a global sensitivity index. As a case study, biomass production or fermentation to ethanol conversion in the fed-batch cultivation of Saccharomyces Cerevisiae are considered as alternative objectives.
Fil: Luna, Martín Francisco. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo y Diseño. Universidad Tecnológica Nacional. Facultad Regional Santa Fe. Instituto de Desarrollo y Diseño; Argentina
Fil: Martínez, Ernesto Carlos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Santa Fe. Instituto de Desarrollo y Diseño. Universidad Tecnológica Nacional. Facultad Regional Santa Fe. Instituto de Desarrollo y Diseño; Argentina
description The distinctive feature of cybernetic models of bioreactors is their capacity to account for regulatory mechanisms in a cell metabolism by modeling the synthesis of enzymes and their activities. From a process engineering viewpoint, to guarantee its predictive capabilities regarding one or more process objective or goals (e.g. optimization, controllability, etc.), experimental data used to fit a cybernetic model parameters should be the most informative bearing in mind the adequacy of the resulting model to describe the specific objective of interest. To excite the most relevant metabolic modes in the cybernetic model, a dynamic experiment is optimally designed by accounting for the sensitivity of the chosen objective to operating conditions. The bioreactor feeding profile and sampling times are selected to maximize a global sensitivity index. As a case study, biomass production or fermentation to ethanol conversion in the fed-batch cultivation of Saccharomyces Cerevisiae are considered as alternative objectives.
publishDate 2018
dc.date.none.fl_str_mv 2018-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/87043
Luna, Martín Francisco; Martínez, Ernesto Carlos; Goal-directed Design of Dynamic Experiments for Cybernetic Models of Bioreactors; Elsevier B.V.; Computer Aided Chemical Engineering; 44; 1-2018; 2479-2484
1570-7946
CONICET Digital
CONICET
url http://hdl.handle.net/11336/87043
identifier_str_mv Luna, Martín Francisco; Martínez, Ernesto Carlos; Goal-directed Design of Dynamic Experiments for Cybernetic Models of Bioreactors; Elsevier B.V.; Computer Aided Chemical Engineering; 44; 1-2018; 2479-2484
1570-7946
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/B978-0-444-64241-7.50408-0
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/vnd.openxmlformats-officedocument.wordprocessingml.document
application/pdf
dc.publisher.none.fl_str_mv Elsevier B.V.
publisher.none.fl_str_mv Elsevier B.V.
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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