Pharmacokinetic behavior of marbofloxacin in plasma from chickens at different seasons

Autores
Urzúa Pizarro, Natala Francisca; Errecalde, Carlos; Prieto, Guillermo Fermín; Lüders, Carlos Fernando; Tonini, María Paula; Picco, Eduardo Jesús
Año de publicación
2017
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The purpose of this study was to evaluate the differences in the disposition and plasma pharmacokinetic behavior of marbofloxacin (MAR) in broiler chickens at different seasons. Chicken broilers (n = 345) were used, in lots of 5 individuals, divided into 6 groups depending on the way of administration, intravenous or oral (dose 2 mg/kg) and the test period. Post-administration plasma samples were obtained at different times, intravenously (0.08 to 24 hours) and orally (0.25 to 120 hours). A liquid-liquid extraction of MAR was performed by high-performance liquid chromatography (HPLC) with a fluorescent detector. The plasma concentrations obtained at the different sampling times of each season, were analyzed with ANOVA and pharmacokinetic analysis was conducted with the PK Solution 2.0 software. The concentration of marbofloxacin in plasma was significantly lower in winter and summer than in spring, with MAR being detected in winter up to 72 hours post-application, coinciding with the differences in MAR pharmacokinetics parameters with increase in the average residence time (MRT) is 9.4 hours in winter. Increased clearance MAR in summer (7.5 ml/min/kg) coincides with MRT 6.3 hours. Finally, the oral bioavailability of MAR is lower in summer and winter (86 ± 1.7% and 78 ± 3.1%) than in spring (94 ± 5.2 %). There are differences in the disposition and plasma pharmacokinetic behavior of MAR applied orally in broiler chickens, coinciding with the physiological changes in the thermoregulation of birds, considering its correct therapeutic management and contributing to provide safe food for human consumption.
Fil: Urzúa Pizarro, Natala Francisca. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Clínica Animal; Argentina
Fil: Errecalde, Carlos. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Clínica Animal; Argentina
Fil: Prieto, Guillermo Fermín. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Clínica Animal; Argentina
Fil: Lüders, Carlos Fernando. Universidad Catolica de Temuco; Chile
Fil: Tonini, María Paula. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
Fil: Picco, Eduardo Jesús. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina
Materia
MARBOFLOXACIN
PHARMACOKINETICS
POULTRY
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/79531
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Pharmacokinetic behavior of marbofloxacin in plasma from chickens at different seasonsUrzúa Pizarro, Natala FranciscaErrecalde, CarlosPrieto, Guillermo FermínLüders, Carlos FernandoTonini, María PaulaPicco, Eduardo JesúsMARBOFLOXACINPHARMACOKINETICSPOULTRYhttps://purl.org/becyt/ford/4.3https://purl.org/becyt/ford/4https://purl.org/becyt/ford/4.2https://purl.org/becyt/ford/4The purpose of this study was to evaluate the differences in the disposition and plasma pharmacokinetic behavior of marbofloxacin (MAR) in broiler chickens at different seasons. Chicken broilers (n = 345) were used, in lots of 5 individuals, divided into 6 groups depending on the way of administration, intravenous or oral (dose 2 mg/kg) and the test period. Post-administration plasma samples were obtained at different times, intravenously (0.08 to 24 hours) and orally (0.25 to 120 hours). A liquid-liquid extraction of MAR was performed by high-performance liquid chromatography (HPLC) with a fluorescent detector. The plasma concentrations obtained at the different sampling times of each season, were analyzed with ANOVA and pharmacokinetic analysis was conducted with the PK Solution 2.0 software. The concentration of marbofloxacin in plasma was significantly lower in winter and summer than in spring, with MAR being detected in winter up to 72 hours post-application, coinciding with the differences in MAR pharmacokinetics parameters with increase in the average residence time (MRT) is 9.4 hours in winter. Increased clearance MAR in summer (7.5 ml/min/kg) coincides with MRT 6.3 hours. Finally, the oral bioavailability of MAR is lower in summer and winter (86 ± 1.7% and 78 ± 3.1%) than in spring (94 ± 5.2 %). There are differences in the disposition and plasma pharmacokinetic behavior of MAR applied orally in broiler chickens, coinciding with the physiological changes in the thermoregulation of birds, considering its correct therapeutic management and contributing to provide safe food for human consumption.Fil: Urzúa Pizarro, Natala Francisca. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Clínica Animal; ArgentinaFil: Errecalde, Carlos. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Clínica Animal; ArgentinaFil: Prieto, Guillermo Fermín. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Clínica Animal; ArgentinaFil: Lüders, Carlos Fernando. Universidad Catolica de Temuco; ChileFil: Tonini, María Paula. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; ArgentinaFil: Picco, Eduardo Jesús. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; ArgentinaMethodius University. Faculty of Veterinary Medicin2017-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/79531Urzúa Pizarro, Natala Francisca; Errecalde, Carlos; Prieto, Guillermo Fermín; Lüders, Carlos Fernando; Tonini, María Paula; et al.; Pharmacokinetic behavior of marbofloxacin in plasma from chickens at different seasons; Methodius University. Faculty of Veterinary Medicin; Macedonian Veterinary Review; 40; 2; 6-2017; 1-51409-76211857-7415CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://content.sciendo.com/view/journals/macvetrev/40/2/article-p143.xmlinfo:eu-repo/semantics/altIdentifier/doi/10.1515/macvetrev-2017-0019info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:12:33Zoai:ri.conicet.gov.ar:11336/79531instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:12:34.146CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Pharmacokinetic behavior of marbofloxacin in plasma from chickens at different seasons
title Pharmacokinetic behavior of marbofloxacin in plasma from chickens at different seasons
spellingShingle Pharmacokinetic behavior of marbofloxacin in plasma from chickens at different seasons
Urzúa Pizarro, Natala Francisca
MARBOFLOXACIN
PHARMACOKINETICS
POULTRY
title_short Pharmacokinetic behavior of marbofloxacin in plasma from chickens at different seasons
title_full Pharmacokinetic behavior of marbofloxacin in plasma from chickens at different seasons
title_fullStr Pharmacokinetic behavior of marbofloxacin in plasma from chickens at different seasons
title_full_unstemmed Pharmacokinetic behavior of marbofloxacin in plasma from chickens at different seasons
title_sort Pharmacokinetic behavior of marbofloxacin in plasma from chickens at different seasons
dc.creator.none.fl_str_mv Urzúa Pizarro, Natala Francisca
Errecalde, Carlos
Prieto, Guillermo Fermín
Lüders, Carlos Fernando
Tonini, María Paula
Picco, Eduardo Jesús
author Urzúa Pizarro, Natala Francisca
author_facet Urzúa Pizarro, Natala Francisca
Errecalde, Carlos
Prieto, Guillermo Fermín
Lüders, Carlos Fernando
Tonini, María Paula
Picco, Eduardo Jesús
author_role author
author2 Errecalde, Carlos
Prieto, Guillermo Fermín
Lüders, Carlos Fernando
Tonini, María Paula
Picco, Eduardo Jesús
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv MARBOFLOXACIN
PHARMACOKINETICS
POULTRY
topic MARBOFLOXACIN
PHARMACOKINETICS
POULTRY
purl_subject.fl_str_mv https://purl.org/becyt/ford/4.3
https://purl.org/becyt/ford/4
https://purl.org/becyt/ford/4.2
https://purl.org/becyt/ford/4
dc.description.none.fl_txt_mv The purpose of this study was to evaluate the differences in the disposition and plasma pharmacokinetic behavior of marbofloxacin (MAR) in broiler chickens at different seasons. Chicken broilers (n = 345) were used, in lots of 5 individuals, divided into 6 groups depending on the way of administration, intravenous or oral (dose 2 mg/kg) and the test period. Post-administration plasma samples were obtained at different times, intravenously (0.08 to 24 hours) and orally (0.25 to 120 hours). A liquid-liquid extraction of MAR was performed by high-performance liquid chromatography (HPLC) with a fluorescent detector. The plasma concentrations obtained at the different sampling times of each season, were analyzed with ANOVA and pharmacokinetic analysis was conducted with the PK Solution 2.0 software. The concentration of marbofloxacin in plasma was significantly lower in winter and summer than in spring, with MAR being detected in winter up to 72 hours post-application, coinciding with the differences in MAR pharmacokinetics parameters with increase in the average residence time (MRT) is 9.4 hours in winter. Increased clearance MAR in summer (7.5 ml/min/kg) coincides with MRT 6.3 hours. Finally, the oral bioavailability of MAR is lower in summer and winter (86 ± 1.7% and 78 ± 3.1%) than in spring (94 ± 5.2 %). There are differences in the disposition and plasma pharmacokinetic behavior of MAR applied orally in broiler chickens, coinciding with the physiological changes in the thermoregulation of birds, considering its correct therapeutic management and contributing to provide safe food for human consumption.
Fil: Urzúa Pizarro, Natala Francisca. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Clínica Animal; Argentina
Fil: Errecalde, Carlos. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Clínica Animal; Argentina
Fil: Prieto, Guillermo Fermín. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria. Departamento de Clínica Animal; Argentina
Fil: Lüders, Carlos Fernando. Universidad Catolica de Temuco; Chile
Fil: Tonini, María Paula. Universidad Nacional de Río Cuarto. Facultad de Agronomía y Veterinaria; Argentina
Fil: Picco, Eduardo Jesús. Universidad Nacional del Litoral. Facultad de Ciencias Veterinarias; Argentina
description The purpose of this study was to evaluate the differences in the disposition and plasma pharmacokinetic behavior of marbofloxacin (MAR) in broiler chickens at different seasons. Chicken broilers (n = 345) were used, in lots of 5 individuals, divided into 6 groups depending on the way of administration, intravenous or oral (dose 2 mg/kg) and the test period. Post-administration plasma samples were obtained at different times, intravenously (0.08 to 24 hours) and orally (0.25 to 120 hours). A liquid-liquid extraction of MAR was performed by high-performance liquid chromatography (HPLC) with a fluorescent detector. The plasma concentrations obtained at the different sampling times of each season, were analyzed with ANOVA and pharmacokinetic analysis was conducted with the PK Solution 2.0 software. The concentration of marbofloxacin in plasma was significantly lower in winter and summer than in spring, with MAR being detected in winter up to 72 hours post-application, coinciding with the differences in MAR pharmacokinetics parameters with increase in the average residence time (MRT) is 9.4 hours in winter. Increased clearance MAR in summer (7.5 ml/min/kg) coincides with MRT 6.3 hours. Finally, the oral bioavailability of MAR is lower in summer and winter (86 ± 1.7% and 78 ± 3.1%) than in spring (94 ± 5.2 %). There are differences in the disposition and plasma pharmacokinetic behavior of MAR applied orally in broiler chickens, coinciding with the physiological changes in the thermoregulation of birds, considering its correct therapeutic management and contributing to provide safe food for human consumption.
publishDate 2017
dc.date.none.fl_str_mv 2017-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/79531
Urzúa Pizarro, Natala Francisca; Errecalde, Carlos; Prieto, Guillermo Fermín; Lüders, Carlos Fernando; Tonini, María Paula; et al.; Pharmacokinetic behavior of marbofloxacin in plasma from chickens at different seasons; Methodius University. Faculty of Veterinary Medicin; Macedonian Veterinary Review; 40; 2; 6-2017; 1-5
1409-7621
1857-7415
CONICET Digital
CONICET
url http://hdl.handle.net/11336/79531
identifier_str_mv Urzúa Pizarro, Natala Francisca; Errecalde, Carlos; Prieto, Guillermo Fermín; Lüders, Carlos Fernando; Tonini, María Paula; et al.; Pharmacokinetic behavior of marbofloxacin in plasma from chickens at different seasons; Methodius University. Faculty of Veterinary Medicin; Macedonian Veterinary Review; 40; 2; 6-2017; 1-5
1409-7621
1857-7415
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://content.sciendo.com/view/journals/macvetrev/40/2/article-p143.xml
info:eu-repo/semantics/altIdentifier/doi/10.1515/macvetrev-2017-0019
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Methodius University. Faculty of Veterinary Medicin
publisher.none.fl_str_mv Methodius University. Faculty of Veterinary Medicin
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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