Genomic diversity of the human pathogen Paracoccidioides across the South American continent
- Autores
- Teixeira, Marcus de Melo; Cattana, Maria Emilia; Matute, Daniel R.; Muñoz, José F.; Arechavala, Alicia; Isbell, Kristin; Schipper, Rafael; Santiso, Gabriela Maria; Tracogna, Fernanda; Sosa, María de los Ángeles; Cech, Norma; Alvarado, Primavera; Barreto, Laura; Chacón, Yone; Ortellado, Juana; Lima, Cleoni Mendes de; Chang, Marilene Rodrigues; Niño Vega, Gustavo; Yasuda, Maria Aparecida Shikanai; Felipe, Maria Sueli Soares; Negroni, Ricardo; Cuomo, Christina A.; Barker, Bridget; Giusiano, Gustavo Emilio
- Año de publicación
- 2020
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Paracoccidioidomycosis (PCM) is a life-threatening systemic mycosis widely reported in the Gran Chaco ecosystem. The disease is caused by different species from the genus Paracoccidioides, which are all endemic to South and Central America. Here, we sequenced and analyzed 31 isolates of Paracoccidioides across South America, with particular focus on isolates from Argentina and Paraguay. The de novo sequenced isolates were compared with publicly available genomes. Phylogenetics and population genomics revealed that PCM in Argentina and Paraguay is caused by three distinct Paracoccidioides genotypes, P. brasiliensis (S1a and S1b) and P. restrepiensis (PS3). P. brasiliensis S1a isolates from Argentina are frequently associated with chronic forms of the disease. Our results suggest the existence of extensive molecular polymorphism among Paracoccidioides species, and provide a framework to begin to dissect the connection between genotypic differences in the pathogen and the clinical outcomes of the disease.
Fil: Teixeira, Marcus de Melo. Universidade do Brasília; Brasil
Fil: Cattana, Maria Emilia. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina
Fil: Matute, Daniel R.. University of North Carolina; Estados Unidos
Fil: Muñoz, José F.. Broad Institute Of Mit And Harvard; Estados Unidos
Fil: Arechavala, Alicia. Hospital Francisco J Muñiz; Argentina
Fil: Isbell, Kristin. University of North Carolina; Estados Unidos
Fil: Schipper, Rafael. Universidade do Brasília; Brasil
Fil: Santiso, Gabriela Maria. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
Fil: Tracogna, Fernanda. Gobierno de la Provincia de Chaco. Hospital Julio Cecilio Perrando.; Argentina
Fil: Sosa, María de los Ángeles. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina
Fil: Cech, Norma. Hospital 4 de Junio; Argentina
Fil: Alvarado, Primavera. Instituto de Biomedicina Dr. Jacinto Convit; Venezuela
Fil: Barreto, Laura. Instituto Superior de Formación Docente Salome Ureña; República Dominicana
Fil: Chacón, Yone. Provincia de Salta. Ministerio de Salud Pública. Hospital del Milagro; Argentina
Fil: Ortellado, Juana. Universidad Nacional de Asunción; Paraguay
Fil: Lima, Cleoni Mendes de. Universidade Federal de Rondonia; Brasil
Fil: Chang, Marilene Rodrigues. Universidade Federal do Mato Grosso do Sul; Brasil
Fil: Niño Vega, Gustavo. Universidad de Guanajuato; México
Fil: Yasuda, Maria Aparecida Shikanai. Universidade de Sao Paulo; Brasil
Fil: Felipe, Maria Sueli Soares. Universidade Catolica de Brasilia; Brasil
Fil: Negroni, Ricardo. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina
Fil: Cuomo, Christina A.. Broad Institute of MIT And Harvard; Estados Unidos
Fil: Barker, Bridget. Tgen Northern Arizona University; Estados Unidos
Fil: Giusiano, Gustavo Emilio. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina - Materia
-
GRAN CHACO
PARACOCCIDIOIDES
PHYLOGENOMICS
POPULATION GENETICS - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
.jpg)
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/114626
Ver los metadatos del registro completo
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Genomic diversity of the human pathogen Paracoccidioides across the South American continentTeixeira, Marcus de MeloCattana, Maria EmiliaMatute, Daniel R.Muñoz, José F.Arechavala, AliciaIsbell, KristinSchipper, RafaelSantiso, Gabriela MariaTracogna, FernandaSosa, María de los ÁngelesCech, NormaAlvarado, PrimaveraBarreto, LauraChacón, YoneOrtellado, JuanaLima, Cleoni Mendes deChang, Marilene RodriguesNiño Vega, GustavoYasuda, Maria Aparecida ShikanaiFelipe, Maria Sueli SoaresNegroni, RicardoCuomo, Christina A.Barker, BridgetGiusiano, Gustavo EmilioGRAN CHACOPARACOCCIDIOIDESPHYLOGENOMICSPOPULATION GENETICShttps://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1Paracoccidioidomycosis (PCM) is a life-threatening systemic mycosis widely reported in the Gran Chaco ecosystem. The disease is caused by different species from the genus Paracoccidioides, which are all endemic to South and Central America. Here, we sequenced and analyzed 31 isolates of Paracoccidioides across South America, with particular focus on isolates from Argentina and Paraguay. The de novo sequenced isolates were compared with publicly available genomes. Phylogenetics and population genomics revealed that PCM in Argentina and Paraguay is caused by three distinct Paracoccidioides genotypes, P. brasiliensis (S1a and S1b) and P. restrepiensis (PS3). P. brasiliensis S1a isolates from Argentina are frequently associated with chronic forms of the disease. Our results suggest the existence of extensive molecular polymorphism among Paracoccidioides species, and provide a framework to begin to dissect the connection between genotypic differences in the pathogen and the clinical outcomes of the disease.Fil: Teixeira, Marcus de Melo. Universidade do Brasília; BrasilFil: Cattana, Maria Emilia. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; ArgentinaFil: Matute, Daniel R.. University of North Carolina; Estados UnidosFil: Muñoz, José F.. Broad Institute Of Mit And Harvard; Estados UnidosFil: Arechavala, Alicia. Hospital Francisco J Muñiz; ArgentinaFil: Isbell, Kristin. University of North Carolina; Estados UnidosFil: Schipper, Rafael. Universidade do Brasília; BrasilFil: Santiso, Gabriela Maria. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; ArgentinaFil: Tracogna, Fernanda. Gobierno de la Provincia de Chaco. Hospital Julio Cecilio Perrando.; ArgentinaFil: Sosa, María de los Ángeles. Universidad Nacional del Nordeste. Instituto de Medicina Regional; ArgentinaFil: Cech, Norma. Hospital 4 de Junio; ArgentinaFil: Alvarado, Primavera. Instituto de Biomedicina Dr. Jacinto Convit; VenezuelaFil: Barreto, Laura. Instituto Superior de Formación Docente Salome Ureña; República DominicanaFil: Chacón, Yone. Provincia de Salta. Ministerio de Salud Pública. Hospital del Milagro; ArgentinaFil: Ortellado, Juana. Universidad Nacional de Asunción; ParaguayFil: Lima, Cleoni Mendes de. Universidade Federal de Rondonia; BrasilFil: Chang, Marilene Rodrigues. Universidade Federal do Mato Grosso do Sul; BrasilFil: Niño Vega, Gustavo. Universidad de Guanajuato; MéxicoFil: Yasuda, Maria Aparecida Shikanai. Universidade de Sao Paulo; BrasilFil: Felipe, Maria Sueli Soares. Universidade Catolica de Brasilia; BrasilFil: Negroni, Ricardo. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; ArgentinaFil: Cuomo, Christina A.. Broad Institute of MIT And Harvard; Estados UnidosFil: Barker, Bridget. Tgen Northern Arizona University; Estados UnidosFil: Giusiano, Gustavo Emilio. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; ArgentinaAcademic Press Inc Elsevier Science2020-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/114626Teixeira, Marcus de Melo; Cattana, Maria Emilia; Matute, Daniel R.; Muñoz, José F.; Arechavala, Alicia; et al.; Genomic diversity of the human pathogen Paracoccidioides across the South American continent; Academic Press Inc Elsevier Science; Fungal Genetics And Biology; 140; 7-2020; 1033951087-1845CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://linkinghub.elsevier.com/retrieve/pii/S1087184520300864info:eu-repo/semantics/altIdentifier/doi/10.1016/j.fgb.2020.103395info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T14:28:26Zoai:ri.conicet.gov.ar:11336/114626instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 14:28:27.176CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
| dc.title.none.fl_str_mv |
Genomic diversity of the human pathogen Paracoccidioides across the South American continent |
| title |
Genomic diversity of the human pathogen Paracoccidioides across the South American continent |
| spellingShingle |
Genomic diversity of the human pathogen Paracoccidioides across the South American continent Teixeira, Marcus de Melo GRAN CHACO PARACOCCIDIOIDES PHYLOGENOMICS POPULATION GENETICS |
| title_short |
Genomic diversity of the human pathogen Paracoccidioides across the South American continent |
| title_full |
Genomic diversity of the human pathogen Paracoccidioides across the South American continent |
| title_fullStr |
Genomic diversity of the human pathogen Paracoccidioides across the South American continent |
| title_full_unstemmed |
Genomic diversity of the human pathogen Paracoccidioides across the South American continent |
| title_sort |
Genomic diversity of the human pathogen Paracoccidioides across the South American continent |
| dc.creator.none.fl_str_mv |
Teixeira, Marcus de Melo Cattana, Maria Emilia Matute, Daniel R. Muñoz, José F. Arechavala, Alicia Isbell, Kristin Schipper, Rafael Santiso, Gabriela Maria Tracogna, Fernanda Sosa, María de los Ángeles Cech, Norma Alvarado, Primavera Barreto, Laura Chacón, Yone Ortellado, Juana Lima, Cleoni Mendes de Chang, Marilene Rodrigues Niño Vega, Gustavo Yasuda, Maria Aparecida Shikanai Felipe, Maria Sueli Soares Negroni, Ricardo Cuomo, Christina A. Barker, Bridget Giusiano, Gustavo Emilio |
| author |
Teixeira, Marcus de Melo |
| author_facet |
Teixeira, Marcus de Melo Cattana, Maria Emilia Matute, Daniel R. Muñoz, José F. Arechavala, Alicia Isbell, Kristin Schipper, Rafael Santiso, Gabriela Maria Tracogna, Fernanda Sosa, María de los Ángeles Cech, Norma Alvarado, Primavera Barreto, Laura Chacón, Yone Ortellado, Juana Lima, Cleoni Mendes de Chang, Marilene Rodrigues Niño Vega, Gustavo Yasuda, Maria Aparecida Shikanai Felipe, Maria Sueli Soares Negroni, Ricardo Cuomo, Christina A. Barker, Bridget Giusiano, Gustavo Emilio |
| author_role |
author |
| author2 |
Cattana, Maria Emilia Matute, Daniel R. Muñoz, José F. Arechavala, Alicia Isbell, Kristin Schipper, Rafael Santiso, Gabriela Maria Tracogna, Fernanda Sosa, María de los Ángeles Cech, Norma Alvarado, Primavera Barreto, Laura Chacón, Yone Ortellado, Juana Lima, Cleoni Mendes de Chang, Marilene Rodrigues Niño Vega, Gustavo Yasuda, Maria Aparecida Shikanai Felipe, Maria Sueli Soares Negroni, Ricardo Cuomo, Christina A. Barker, Bridget Giusiano, Gustavo Emilio |
| author2_role |
author author author author author author author author author author author author author author author author author author author author author author author |
| dc.subject.none.fl_str_mv |
GRAN CHACO PARACOCCIDIOIDES PHYLOGENOMICS POPULATION GENETICS |
| topic |
GRAN CHACO PARACOCCIDIOIDES PHYLOGENOMICS POPULATION GENETICS |
| purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
| dc.description.none.fl_txt_mv |
Paracoccidioidomycosis (PCM) is a life-threatening systemic mycosis widely reported in the Gran Chaco ecosystem. The disease is caused by different species from the genus Paracoccidioides, which are all endemic to South and Central America. Here, we sequenced and analyzed 31 isolates of Paracoccidioides across South America, with particular focus on isolates from Argentina and Paraguay. The de novo sequenced isolates were compared with publicly available genomes. Phylogenetics and population genomics revealed that PCM in Argentina and Paraguay is caused by three distinct Paracoccidioides genotypes, P. brasiliensis (S1a and S1b) and P. restrepiensis (PS3). P. brasiliensis S1a isolates from Argentina are frequently associated with chronic forms of the disease. Our results suggest the existence of extensive molecular polymorphism among Paracoccidioides species, and provide a framework to begin to dissect the connection between genotypic differences in the pathogen and the clinical outcomes of the disease. Fil: Teixeira, Marcus de Melo. Universidade do Brasília; Brasil Fil: Cattana, Maria Emilia. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina Fil: Matute, Daniel R.. University of North Carolina; Estados Unidos Fil: Muñoz, José F.. Broad Institute Of Mit And Harvard; Estados Unidos Fil: Arechavala, Alicia. Hospital Francisco J Muñiz; Argentina Fil: Isbell, Kristin. University of North Carolina; Estados Unidos Fil: Schipper, Rafael. Universidade do Brasília; Brasil Fil: Santiso, Gabriela Maria. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina Fil: Tracogna, Fernanda. Gobierno de la Provincia de Chaco. Hospital Julio Cecilio Perrando.; Argentina Fil: Sosa, María de los Ángeles. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina Fil: Cech, Norma. Hospital 4 de Junio; Argentina Fil: Alvarado, Primavera. Instituto de Biomedicina Dr. Jacinto Convit; Venezuela Fil: Barreto, Laura. Instituto Superior de Formación Docente Salome Ureña; República Dominicana Fil: Chacón, Yone. Provincia de Salta. Ministerio de Salud Pública. Hospital del Milagro; Argentina Fil: Ortellado, Juana. Universidad Nacional de Asunción; Paraguay Fil: Lima, Cleoni Mendes de. Universidade Federal de Rondonia; Brasil Fil: Chang, Marilene Rodrigues. Universidade Federal do Mato Grosso do Sul; Brasil Fil: Niño Vega, Gustavo. Universidad de Guanajuato; México Fil: Yasuda, Maria Aparecida Shikanai. Universidade de Sao Paulo; Brasil Fil: Felipe, Maria Sueli Soares. Universidade Catolica de Brasilia; Brasil Fil: Negroni, Ricardo. Gobierno de la Ciudad de Buenos Aires. Hospital de Infecciosas "Dr. Francisco Javier Muñiz"; Argentina Fil: Cuomo, Christina A.. Broad Institute of MIT And Harvard; Estados Unidos Fil: Barker, Bridget. Tgen Northern Arizona University; Estados Unidos Fil: Giusiano, Gustavo Emilio. Universidad Nacional del Nordeste. Instituto de Medicina Regional; Argentina. Universidad Nacional del Nordeste. Facultad de Medicina; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Nordeste; Argentina |
| description |
Paracoccidioidomycosis (PCM) is a life-threatening systemic mycosis widely reported in the Gran Chaco ecosystem. The disease is caused by different species from the genus Paracoccidioides, which are all endemic to South and Central America. Here, we sequenced and analyzed 31 isolates of Paracoccidioides across South America, with particular focus on isolates from Argentina and Paraguay. The de novo sequenced isolates were compared with publicly available genomes. Phylogenetics and population genomics revealed that PCM in Argentina and Paraguay is caused by three distinct Paracoccidioides genotypes, P. brasiliensis (S1a and S1b) and P. restrepiensis (PS3). P. brasiliensis S1a isolates from Argentina are frequently associated with chronic forms of the disease. Our results suggest the existence of extensive molecular polymorphism among Paracoccidioides species, and provide a framework to begin to dissect the connection between genotypic differences in the pathogen and the clinical outcomes of the disease. |
| publishDate |
2020 |
| dc.date.none.fl_str_mv |
2020-07 |
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info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
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article |
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publishedVersion |
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http://hdl.handle.net/11336/114626 Teixeira, Marcus de Melo; Cattana, Maria Emilia; Matute, Daniel R.; Muñoz, José F.; Arechavala, Alicia; et al.; Genomic diversity of the human pathogen Paracoccidioides across the South American continent; Academic Press Inc Elsevier Science; Fungal Genetics And Biology; 140; 7-2020; 103395 1087-1845 CONICET Digital CONICET |
| url |
http://hdl.handle.net/11336/114626 |
| identifier_str_mv |
Teixeira, Marcus de Melo; Cattana, Maria Emilia; Matute, Daniel R.; Muñoz, José F.; Arechavala, Alicia; et al.; Genomic diversity of the human pathogen Paracoccidioides across the South American continent; Academic Press Inc Elsevier Science; Fungal Genetics And Biology; 140; 7-2020; 103395 1087-1845 CONICET Digital CONICET |
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eng |
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eng |
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Academic Press Inc Elsevier Science |
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Academic Press Inc Elsevier Science |
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