Surviving nebulization-induced stress: dexamethasone in pH-sensitive archaeosomes

Autores
Altube, María Julia; Selzer, Solange Mailen; de Farias, Marcelo Alexandre; Portugal, Rodrigo Villares; Morilla, María José; Romero, Eder Lilia
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Aim: To increase the subcellular delivery of dexamethasone phosphate (DP) and stability to nebulization stress, pH-sensitive nanoliposomes (LpH) exhibiting archaeolipids, acting as ligands for scavenger receptors (pH-sensitive archaeosomes [ApH]), were prepared. Materials & methods: The anti-inflammatory effect of 0.18 mg DP/mg total lipid, 100–150 nm DP-containing ApH (dioleylphosphatidylethanolamine: Halorubrum tebenquichense total polar archaeolipids:cholesteryl hemisuccinate 4.2:2.8:3 w:w) was tested on different cell lines. Size and HPTS retention of ApH and conventional LpH (dioleylphosphatidylethanolamine:cholesteryl hemisuccinate 7:3 w:w) before and after nebulization were determined. Results & conclusion: DP-ApH suppressed IL-6 and TNF-α on phagocytic cells. Nebulized after 6-month storage, LpH increased size and completely lost its HPTS while ApH3 conserved size and polydispersity, fully retaining its original HPTS content.
Fil: Altube, María Julia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Selzer, Solange Mailen. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: de Farias, Marcelo Alexandre. Brazilian Nanotechnology National Laboratory; Brasil
Fil: Portugal, Rodrigo Villares. Brazilian Nanotechnology National Laboratory; Brasil
Fil: Morilla, María José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Romero, Eder Lilia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Materia
Lung
Nebulization
Subcellular Delivery
Macrophages Targeting
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/46701
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Surviving nebulization-induced stress: dexamethasone in pH-sensitive archaeosomesAltube, María JuliaSelzer, Solange Mailende Farias, Marcelo AlexandrePortugal, Rodrigo VillaresMorilla, María JoséRomero, Eder LiliaLungNebulizationSubcellular DeliveryMacrophages Targetinghttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2Aim: To increase the subcellular delivery of dexamethasone phosphate (DP) and stability to nebulization stress, pH-sensitive nanoliposomes (LpH) exhibiting archaeolipids, acting as ligands for scavenger receptors (pH-sensitive archaeosomes [ApH]), were prepared. Materials & methods: The anti-inflammatory effect of 0.18 mg DP/mg total lipid, 100–150 nm DP-containing ApH (dioleylphosphatidylethanolamine: Halorubrum tebenquichense total polar archaeolipids:cholesteryl hemisuccinate 4.2:2.8:3 w:w) was tested on different cell lines. Size and HPTS retention of ApH and conventional LpH (dioleylphosphatidylethanolamine:cholesteryl hemisuccinate 7:3 w:w) before and after nebulization were determined. Results & conclusion: DP-ApH suppressed IL-6 and TNF-α on phagocytic cells. Nebulized after 6-month storage, LpH increased size and completely lost its HPTS while ApH3 conserved size and polydispersity, fully retaining its original HPTS content.Fil: Altube, María Julia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Selzer, Solange Mailen. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; ArgentinaFil: de Farias, Marcelo Alexandre. Brazilian Nanotechnology National Laboratory; BrasilFil: Portugal, Rodrigo Villares. Brazilian Nanotechnology National Laboratory; BrasilFil: Morilla, María José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; ArgentinaFil: Romero, Eder Lilia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; ArgentinaFuture Medicine2016-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/46701Altube, María Julia; Selzer, Solange Mailen; de Farias, Marcelo Alexandre; Portugal, Rodrigo Villares; Morilla, María José; et al.; Surviving nebulization-induced stress: dexamethasone in pH-sensitive archaeosomes; Future Medicine; Nanomedicine; 11; 16; 8-2016; 2103-21171743-5889CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.2217/nnm-2016-0165info:eu-repo/semantics/altIdentifier/url/https://www.futuremedicine.com/doi/10.2217/nnm-2016-0165info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:42:51Zoai:ri.conicet.gov.ar:11336/46701instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:42:52.289CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Surviving nebulization-induced stress: dexamethasone in pH-sensitive archaeosomes
title Surviving nebulization-induced stress: dexamethasone in pH-sensitive archaeosomes
spellingShingle Surviving nebulization-induced stress: dexamethasone in pH-sensitive archaeosomes
Altube, María Julia
Lung
Nebulization
Subcellular Delivery
Macrophages Targeting
title_short Surviving nebulization-induced stress: dexamethasone in pH-sensitive archaeosomes
title_full Surviving nebulization-induced stress: dexamethasone in pH-sensitive archaeosomes
title_fullStr Surviving nebulization-induced stress: dexamethasone in pH-sensitive archaeosomes
title_full_unstemmed Surviving nebulization-induced stress: dexamethasone in pH-sensitive archaeosomes
title_sort Surviving nebulization-induced stress: dexamethasone in pH-sensitive archaeosomes
dc.creator.none.fl_str_mv Altube, María Julia
Selzer, Solange Mailen
de Farias, Marcelo Alexandre
Portugal, Rodrigo Villares
Morilla, María José
Romero, Eder Lilia
author Altube, María Julia
author_facet Altube, María Julia
Selzer, Solange Mailen
de Farias, Marcelo Alexandre
Portugal, Rodrigo Villares
Morilla, María José
Romero, Eder Lilia
author_role author
author2 Selzer, Solange Mailen
de Farias, Marcelo Alexandre
Portugal, Rodrigo Villares
Morilla, María José
Romero, Eder Lilia
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Lung
Nebulization
Subcellular Delivery
Macrophages Targeting
topic Lung
Nebulization
Subcellular Delivery
Macrophages Targeting
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Aim: To increase the subcellular delivery of dexamethasone phosphate (DP) and stability to nebulization stress, pH-sensitive nanoliposomes (LpH) exhibiting archaeolipids, acting as ligands for scavenger receptors (pH-sensitive archaeosomes [ApH]), were prepared. Materials & methods: The anti-inflammatory effect of 0.18 mg DP/mg total lipid, 100–150 nm DP-containing ApH (dioleylphosphatidylethanolamine: Halorubrum tebenquichense total polar archaeolipids:cholesteryl hemisuccinate 4.2:2.8:3 w:w) was tested on different cell lines. Size and HPTS retention of ApH and conventional LpH (dioleylphosphatidylethanolamine:cholesteryl hemisuccinate 7:3 w:w) before and after nebulization were determined. Results & conclusion: DP-ApH suppressed IL-6 and TNF-α on phagocytic cells. Nebulized after 6-month storage, LpH increased size and completely lost its HPTS while ApH3 conserved size and polydispersity, fully retaining its original HPTS content.
Fil: Altube, María Julia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Selzer, Solange Mailen. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: de Farias, Marcelo Alexandre. Brazilian Nanotechnology National Laboratory; Brasil
Fil: Portugal, Rodrigo Villares. Brazilian Nanotechnology National Laboratory; Brasil
Fil: Morilla, María José. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
Fil: Romero, Eder Lilia. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina. Universidad Nacional de Quilmes. Departamento de Ciencia y Tecnología; Argentina
description Aim: To increase the subcellular delivery of dexamethasone phosphate (DP) and stability to nebulization stress, pH-sensitive nanoliposomes (LpH) exhibiting archaeolipids, acting as ligands for scavenger receptors (pH-sensitive archaeosomes [ApH]), were prepared. Materials & methods: The anti-inflammatory effect of 0.18 mg DP/mg total lipid, 100–150 nm DP-containing ApH (dioleylphosphatidylethanolamine: Halorubrum tebenquichense total polar archaeolipids:cholesteryl hemisuccinate 4.2:2.8:3 w:w) was tested on different cell lines. Size and HPTS retention of ApH and conventional LpH (dioleylphosphatidylethanolamine:cholesteryl hemisuccinate 7:3 w:w) before and after nebulization were determined. Results & conclusion: DP-ApH suppressed IL-6 and TNF-α on phagocytic cells. Nebulized after 6-month storage, LpH increased size and completely lost its HPTS while ApH3 conserved size and polydispersity, fully retaining its original HPTS content.
publishDate 2016
dc.date.none.fl_str_mv 2016-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/46701
Altube, María Julia; Selzer, Solange Mailen; de Farias, Marcelo Alexandre; Portugal, Rodrigo Villares; Morilla, María José; et al.; Surviving nebulization-induced stress: dexamethasone in pH-sensitive archaeosomes; Future Medicine; Nanomedicine; 11; 16; 8-2016; 2103-2117
1743-5889
CONICET Digital
CONICET
url http://hdl.handle.net/11336/46701
identifier_str_mv Altube, María Julia; Selzer, Solange Mailen; de Farias, Marcelo Alexandre; Portugal, Rodrigo Villares; Morilla, María José; et al.; Surviving nebulization-induced stress: dexamethasone in pH-sensitive archaeosomes; Future Medicine; Nanomedicine; 11; 16; 8-2016; 2103-2117
1743-5889
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.2217/nnm-2016-0165
info:eu-repo/semantics/altIdentifier/url/https://www.futuremedicine.com/doi/10.2217/nnm-2016-0165
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Future Medicine
publisher.none.fl_str_mv Future Medicine
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083535870361600
score 13.22299

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