Dexamethasone-Loaded Chitosan Beads Coated with a pH-Dependent Interpolymer Complex for Colon-Specific Drug Delivery

Autores
García Couce, Jomarien; Bada Rivero, Nancy; López Hernández, Orestes D.; Nogueira, Antonio; Caracciolo, Pablo Christian; Abraham, Gustavo Abel; Ramón Hernández, José A.; Peniche, Carlos
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Chitosan (CS) microparticles loaded with dexamethasone were prepared by spray drying, followed by coating with a pH-dependentinterpolymer complex based on poly(acrylic acid)/poly(vinyl pyrrolidone) using an water-in-oil emulsion technique. The aim ofthis research was to evaluate the influence of PAA/PVP coating on the release of dexamethasone from loaded chitosanmicroparticles, in simulated gastric fluid (SGF, pH = 1 2) and simulated intestinal fluid (SIF, pH = 6 8). The release ofdexamethasone from uncoated loaded CS microparticles was similar in both fluids, and almost complete release of the drug wasachieved in 5 hours. In the coated loaded CS microparticles, the release of dexamethasone in SGF was reduced considerably,very close to zero, due to the interpolymer complex formation at low pH, demonstrating that this system applied aspH-dependent coating has a potential as a site-specific delivery system.
Fil: García Couce, Jomarien. Universidad de La Habana; Cuba
Fil: Bada Rivero, Nancy. Universidad de La Habana; Cuba
Fil: López Hernández, Orestes D.. Universidad Técnica de Ambato; Ecuador
Fil: Nogueira, Antonio. Centro de Investigacion y Desarrollo de Drogas; Cuba
Fil: Caracciolo, Pablo Christian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Ramón Hernández, José A.. Universidade Federal do Rio de Janeiro; Brasil
Fil: Peniche, Carlos. Universidad de La Habana; Cuba
Materia
DRUG DELIVERY SYSTEMS
PH-DEPENDENT
MICROPARTICLES
CHITOSAN
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/119401
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/119401
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Dexamethasone-Loaded Chitosan Beads Coated with a pH-Dependent Interpolymer Complex for Colon-Specific Drug DeliveryGarcía Couce, JomarienBada Rivero, NancyLópez Hernández, Orestes D.Nogueira, AntonioCaracciolo, Pablo ChristianAbraham, Gustavo AbelRamón Hernández, José A.Peniche, CarlosDRUG DELIVERY SYSTEMSPH-DEPENDENTMICROPARTICLESCHITOSANhttps://purl.org/becyt/ford/2.9https://purl.org/becyt/ford/2Chitosan (CS) microparticles loaded with dexamethasone were prepared by spray drying, followed by coating with a pH-dependentinterpolymer complex based on poly(acrylic acid)/poly(vinyl pyrrolidone) using an water-in-oil emulsion technique. The aim ofthis research was to evaluate the influence of PAA/PVP coating on the release of dexamethasone from loaded chitosanmicroparticles, in simulated gastric fluid (SGF, pH = 1 2) and simulated intestinal fluid (SIF, pH = 6 8). The release ofdexamethasone from uncoated loaded CS microparticles was similar in both fluids, and almost complete release of the drug wasachieved in 5 hours. In the coated loaded CS microparticles, the release of dexamethasone in SGF was reduced considerably,very close to zero, due to the interpolymer complex formation at low pH, demonstrating that this system applied aspH-dependent coating has a potential as a site-specific delivery system.Fil: García Couce, Jomarien. Universidad de La Habana; CubaFil: Bada Rivero, Nancy. Universidad de La Habana; CubaFil: López Hernández, Orestes D.. Universidad Técnica de Ambato; EcuadorFil: Nogueira, Antonio. Centro de Investigacion y Desarrollo de Drogas; CubaFil: Caracciolo, Pablo Christian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; ArgentinaFil: Ramón Hernández, José A.. Universidade Federal do Rio de Janeiro; BrasilFil: Peniche, Carlos. Universidad de La Habana; CubaHindawi Publishing Corporation2019-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/119401García Couce, Jomarien; Bada Rivero, Nancy; López Hernández, Orestes D.; Nogueira, Antonio; Caracciolo, Pablo Christian; et al.; Dexamethasone-Loaded Chitosan Beads Coated with a pH-Dependent Interpolymer Complex for Colon-Specific Drug Delivery; Hindawi Publishing Corporation; International Journal of Polymer Science; 2019; 3-2019; 1-91687-9430CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/ijps/2019/4204375/info:eu-repo/semantics/altIdentifier/doi/10.1155/2019/4204375info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:04:14Zoai:ri.conicet.gov.ar:11336/119401instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:04:14.34CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Dexamethasone-Loaded Chitosan Beads Coated with a pH-Dependent Interpolymer Complex for Colon-Specific Drug Delivery
title Dexamethasone-Loaded Chitosan Beads Coated with a pH-Dependent Interpolymer Complex for Colon-Specific Drug Delivery
spellingShingle Dexamethasone-Loaded Chitosan Beads Coated with a pH-Dependent Interpolymer Complex for Colon-Specific Drug Delivery
García Couce, Jomarien
DRUG DELIVERY SYSTEMS
PH-DEPENDENT
MICROPARTICLES
CHITOSAN
title_short Dexamethasone-Loaded Chitosan Beads Coated with a pH-Dependent Interpolymer Complex for Colon-Specific Drug Delivery
title_full Dexamethasone-Loaded Chitosan Beads Coated with a pH-Dependent Interpolymer Complex for Colon-Specific Drug Delivery
title_fullStr Dexamethasone-Loaded Chitosan Beads Coated with a pH-Dependent Interpolymer Complex for Colon-Specific Drug Delivery
title_full_unstemmed Dexamethasone-Loaded Chitosan Beads Coated with a pH-Dependent Interpolymer Complex for Colon-Specific Drug Delivery
title_sort Dexamethasone-Loaded Chitosan Beads Coated with a pH-Dependent Interpolymer Complex for Colon-Specific Drug Delivery
dc.creator.none.fl_str_mv García Couce, Jomarien
Bada Rivero, Nancy
López Hernández, Orestes D.
Nogueira, Antonio
Caracciolo, Pablo Christian
Abraham, Gustavo Abel
Ramón Hernández, José A.
Peniche, Carlos
author García Couce, Jomarien
author_facet García Couce, Jomarien
Bada Rivero, Nancy
López Hernández, Orestes D.
Nogueira, Antonio
Caracciolo, Pablo Christian
Abraham, Gustavo Abel
Ramón Hernández, José A.
Peniche, Carlos
author_role author
author2 Bada Rivero, Nancy
López Hernández, Orestes D.
Nogueira, Antonio
Caracciolo, Pablo Christian
Abraham, Gustavo Abel
Ramón Hernández, José A.
Peniche, Carlos
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv DRUG DELIVERY SYSTEMS
PH-DEPENDENT
MICROPARTICLES
CHITOSAN
topic DRUG DELIVERY SYSTEMS
PH-DEPENDENT
MICROPARTICLES
CHITOSAN
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.9
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv Chitosan (CS) microparticles loaded with dexamethasone were prepared by spray drying, followed by coating with a pH-dependentinterpolymer complex based on poly(acrylic acid)/poly(vinyl pyrrolidone) using an water-in-oil emulsion technique. The aim ofthis research was to evaluate the influence of PAA/PVP coating on the release of dexamethasone from loaded chitosanmicroparticles, in simulated gastric fluid (SGF, pH = 1 2) and simulated intestinal fluid (SIF, pH = 6 8). The release ofdexamethasone from uncoated loaded CS microparticles was similar in both fluids, and almost complete release of the drug wasachieved in 5 hours. In the coated loaded CS microparticles, the release of dexamethasone in SGF was reduced considerably,very close to zero, due to the interpolymer complex formation at low pH, demonstrating that this system applied aspH-dependent coating has a potential as a site-specific delivery system.
Fil: García Couce, Jomarien. Universidad de La Habana; Cuba
Fil: Bada Rivero, Nancy. Universidad de La Habana; Cuba
Fil: López Hernández, Orestes D.. Universidad Técnica de Ambato; Ecuador
Fil: Nogueira, Antonio. Centro de Investigacion y Desarrollo de Drogas; Cuba
Fil: Caracciolo, Pablo Christian. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Abraham, Gustavo Abel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mar del Plata. Instituto de Investigaciones en Ciencia y Tecnología de Materiales. Universidad Nacional de Mar del Plata. Facultad de Ingeniería. Instituto de Investigaciones en Ciencia y Tecnología de Materiales; Argentina
Fil: Ramón Hernández, José A.. Universidade Federal do Rio de Janeiro; Brasil
Fil: Peniche, Carlos. Universidad de La Habana; Cuba
description Chitosan (CS) microparticles loaded with dexamethasone were prepared by spray drying, followed by coating with a pH-dependentinterpolymer complex based on poly(acrylic acid)/poly(vinyl pyrrolidone) using an water-in-oil emulsion technique. The aim ofthis research was to evaluate the influence of PAA/PVP coating on the release of dexamethasone from loaded chitosanmicroparticles, in simulated gastric fluid (SGF, pH = 1 2) and simulated intestinal fluid (SIF, pH = 6 8). The release ofdexamethasone from uncoated loaded CS microparticles was similar in both fluids, and almost complete release of the drug wasachieved in 5 hours. In the coated loaded CS microparticles, the release of dexamethasone in SGF was reduced considerably,very close to zero, due to the interpolymer complex formation at low pH, demonstrating that this system applied aspH-dependent coating has a potential as a site-specific delivery system.
publishDate 2019
dc.date.none.fl_str_mv 2019-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/119401
García Couce, Jomarien; Bada Rivero, Nancy; López Hernández, Orestes D.; Nogueira, Antonio; Caracciolo, Pablo Christian; et al.; Dexamethasone-Loaded Chitosan Beads Coated with a pH-Dependent Interpolymer Complex for Colon-Specific Drug Delivery; Hindawi Publishing Corporation; International Journal of Polymer Science; 2019; 3-2019; 1-9
1687-9430
CONICET Digital
CONICET
url http://hdl.handle.net/11336/119401
identifier_str_mv García Couce, Jomarien; Bada Rivero, Nancy; López Hernández, Orestes D.; Nogueira, Antonio; Caracciolo, Pablo Christian; et al.; Dexamethasone-Loaded Chitosan Beads Coated with a pH-Dependent Interpolymer Complex for Colon-Specific Drug Delivery; Hindawi Publishing Corporation; International Journal of Polymer Science; 2019; 3-2019; 1-9
1687-9430
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.hindawi.com/journals/ijps/2019/4204375/
info:eu-repo/semantics/altIdentifier/doi/10.1155/2019/4204375
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Hindawi Publishing Corporation
publisher.none.fl_str_mv Hindawi Publishing Corporation
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269845060583424
score 13.13397

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