Reserpine-induced depression is associated in female, but not in male, adolescent rats with heightened, fluoxetine-sensitive, ethanol consumption

Autores
Ruiz, Paul; Calliari, Aldo; Pautassi, Ricardo Marcos
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Depression usually emerges during adolescence, is significantly more frequent in women, and exhibits comorbidity with alcohol (ethanol) use disorders. Most of the pre-clinical studies assessing the link between depression and ethanol intake, however, have employed only males or relied on stress-induced depression, or induced the experimentally-induced, depressive-like phenotype, during adolescence yet measured ethanol intake at adulthood. This study assessed, in Wistar male and female adolescent rats, the effects of inducing experimental depression (via administration of 1.0 mg/kg reserpine [RES], a monoamine depleting drug, between postnatal day [PD] 30 to PD33) on the acquisition of voluntary ethanol drinking during PD38 to PD42), and the modulation of these effects by fluoxetine (FLUOX, 10.0 mg/kg) on PDs 34–37. RES-treated rats exhibited a significant reduction of dopamine levels at the insula, no significant changes in circulating levels of thyroxine T4, and reduced distance travelled in an open field. Repeated treatment with RES heightened ethanol intake in female, but not in male, rats; and effect that was inhibited by FLUOX. Similarly, RES significantly increased, and FLUOX reversed, risk-taking behaviors in a concentric square field (CSF) test. FLUOX significantly increased shelter-seeking in the CSF and reduced insular dopamine levels. These results indicate that depression, in females, can kindle the initiation of voluntary ethanol drinking in adolescence (one of the most reliable predictors of being diagnosed with an AUD), and pinpoint alterations in risk-taking as potential mechanisms underlying this effect. Adolescent women afflicted by mood disorders should be specifically targeted for interventions directed towards delaying initiation of alcohol consumption.
Fil: Ruiz, Paul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad de la República; Uruguay
Fil: Calliari, Aldo. Universidad de la República; Uruguay
Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
Materia
ETHANOL
EXPERIMENTAL DEPRESSION
FLUOXETINE, ADOLESCENTS
RESERPINE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/96467
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/96467
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Reserpine-induced depression is associated in female, but not in male, adolescent rats with heightened, fluoxetine-sensitive, ethanol consumptionRuiz, PaulCalliari, AldoPautassi, Ricardo MarcosETHANOLEXPERIMENTAL DEPRESSIONFLUOXETINE, ADOLESCENTSRESERPINEhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Depression usually emerges during adolescence, is significantly more frequent in women, and exhibits comorbidity with alcohol (ethanol) use disorders. Most of the pre-clinical studies assessing the link between depression and ethanol intake, however, have employed only males or relied on stress-induced depression, or induced the experimentally-induced, depressive-like phenotype, during adolescence yet measured ethanol intake at adulthood. This study assessed, in Wistar male and female adolescent rats, the effects of inducing experimental depression (via administration of 1.0 mg/kg reserpine [RES], a monoamine depleting drug, between postnatal day [PD] 30 to PD33) on the acquisition of voluntary ethanol drinking during PD38 to PD42), and the modulation of these effects by fluoxetine (FLUOX, 10.0 mg/kg) on PDs 34–37. RES-treated rats exhibited a significant reduction of dopamine levels at the insula, no significant changes in circulating levels of thyroxine T4, and reduced distance travelled in an open field. Repeated treatment with RES heightened ethanol intake in female, but not in male, rats; and effect that was inhibited by FLUOX. Similarly, RES significantly increased, and FLUOX reversed, risk-taking behaviors in a concentric square field (CSF) test. FLUOX significantly increased shelter-seeking in the CSF and reduced insular dopamine levels. These results indicate that depression, in females, can kindle the initiation of voluntary ethanol drinking in adolescence (one of the most reliable predictors of being diagnosed with an AUD), and pinpoint alterations in risk-taking as potential mechanisms underlying this effect. Adolescent women afflicted by mood disorders should be specifically targeted for interventions directed towards delaying initiation of alcohol consumption.Fil: Ruiz, Paul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad de la República; UruguayFil: Calliari, Aldo. Universidad de la República; UruguayFil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; ArgentinaElsevier Science2018-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/96467Ruiz, Paul; Calliari, Aldo; Pautassi, Ricardo Marcos; Reserpine-induced depression is associated in female, but not in male, adolescent rats with heightened, fluoxetine-sensitive, ethanol consumption; Elsevier Science; Behavioural Brain Research; 348; 8-2018; 160-1700166-4328CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbr.2018.04.011info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0166432818302821info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:03:48Zoai:ri.conicet.gov.ar:11336/96467instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:03:48.405CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Reserpine-induced depression is associated in female, but not in male, adolescent rats with heightened, fluoxetine-sensitive, ethanol consumption
title Reserpine-induced depression is associated in female, but not in male, adolescent rats with heightened, fluoxetine-sensitive, ethanol consumption
spellingShingle Reserpine-induced depression is associated in female, but not in male, adolescent rats with heightened, fluoxetine-sensitive, ethanol consumption
Ruiz, Paul
ETHANOL
EXPERIMENTAL DEPRESSION
FLUOXETINE, ADOLESCENTS
RESERPINE
title_short Reserpine-induced depression is associated in female, but not in male, adolescent rats with heightened, fluoxetine-sensitive, ethanol consumption
title_full Reserpine-induced depression is associated in female, but not in male, adolescent rats with heightened, fluoxetine-sensitive, ethanol consumption
title_fullStr Reserpine-induced depression is associated in female, but not in male, adolescent rats with heightened, fluoxetine-sensitive, ethanol consumption
title_full_unstemmed Reserpine-induced depression is associated in female, but not in male, adolescent rats with heightened, fluoxetine-sensitive, ethanol consumption
title_sort Reserpine-induced depression is associated in female, but not in male, adolescent rats with heightened, fluoxetine-sensitive, ethanol consumption
dc.creator.none.fl_str_mv Ruiz, Paul
Calliari, Aldo
Pautassi, Ricardo Marcos
author Ruiz, Paul
author_facet Ruiz, Paul
Calliari, Aldo
Pautassi, Ricardo Marcos
author_role author
author2 Calliari, Aldo
Pautassi, Ricardo Marcos
author2_role author
author
dc.subject.none.fl_str_mv ETHANOL
EXPERIMENTAL DEPRESSION
FLUOXETINE, ADOLESCENTS
RESERPINE
topic ETHANOL
EXPERIMENTAL DEPRESSION
FLUOXETINE, ADOLESCENTS
RESERPINE
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Depression usually emerges during adolescence, is significantly more frequent in women, and exhibits comorbidity with alcohol (ethanol) use disorders. Most of the pre-clinical studies assessing the link between depression and ethanol intake, however, have employed only males or relied on stress-induced depression, or induced the experimentally-induced, depressive-like phenotype, during adolescence yet measured ethanol intake at adulthood. This study assessed, in Wistar male and female adolescent rats, the effects of inducing experimental depression (via administration of 1.0 mg/kg reserpine [RES], a monoamine depleting drug, between postnatal day [PD] 30 to PD33) on the acquisition of voluntary ethanol drinking during PD38 to PD42), and the modulation of these effects by fluoxetine (FLUOX, 10.0 mg/kg) on PDs 34–37. RES-treated rats exhibited a significant reduction of dopamine levels at the insula, no significant changes in circulating levels of thyroxine T4, and reduced distance travelled in an open field. Repeated treatment with RES heightened ethanol intake in female, but not in male, rats; and effect that was inhibited by FLUOX. Similarly, RES significantly increased, and FLUOX reversed, risk-taking behaviors in a concentric square field (CSF) test. FLUOX significantly increased shelter-seeking in the CSF and reduced insular dopamine levels. These results indicate that depression, in females, can kindle the initiation of voluntary ethanol drinking in adolescence (one of the most reliable predictors of being diagnosed with an AUD), and pinpoint alterations in risk-taking as potential mechanisms underlying this effect. Adolescent women afflicted by mood disorders should be specifically targeted for interventions directed towards delaying initiation of alcohol consumption.
Fil: Ruiz, Paul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad de la República; Uruguay
Fil: Calliari, Aldo. Universidad de la República; Uruguay
Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina
description Depression usually emerges during adolescence, is significantly more frequent in women, and exhibits comorbidity with alcohol (ethanol) use disorders. Most of the pre-clinical studies assessing the link between depression and ethanol intake, however, have employed only males or relied on stress-induced depression, or induced the experimentally-induced, depressive-like phenotype, during adolescence yet measured ethanol intake at adulthood. This study assessed, in Wistar male and female adolescent rats, the effects of inducing experimental depression (via administration of 1.0 mg/kg reserpine [RES], a monoamine depleting drug, between postnatal day [PD] 30 to PD33) on the acquisition of voluntary ethanol drinking during PD38 to PD42), and the modulation of these effects by fluoxetine (FLUOX, 10.0 mg/kg) on PDs 34–37. RES-treated rats exhibited a significant reduction of dopamine levels at the insula, no significant changes in circulating levels of thyroxine T4, and reduced distance travelled in an open field. Repeated treatment with RES heightened ethanol intake in female, but not in male, rats; and effect that was inhibited by FLUOX. Similarly, RES significantly increased, and FLUOX reversed, risk-taking behaviors in a concentric square field (CSF) test. FLUOX significantly increased shelter-seeking in the CSF and reduced insular dopamine levels. These results indicate that depression, in females, can kindle the initiation of voluntary ethanol drinking in adolescence (one of the most reliable predictors of being diagnosed with an AUD), and pinpoint alterations in risk-taking as potential mechanisms underlying this effect. Adolescent women afflicted by mood disorders should be specifically targeted for interventions directed towards delaying initiation of alcohol consumption.
publishDate 2018
dc.date.none.fl_str_mv 2018-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/96467
Ruiz, Paul; Calliari, Aldo; Pautassi, Ricardo Marcos; Reserpine-induced depression is associated in female, but not in male, adolescent rats with heightened, fluoxetine-sensitive, ethanol consumption; Elsevier Science; Behavioural Brain Research; 348; 8-2018; 160-170
0166-4328
CONICET Digital
CONICET
url http://hdl.handle.net/11336/96467
identifier_str_mv Ruiz, Paul; Calliari, Aldo; Pautassi, Ricardo Marcos; Reserpine-induced depression is associated in female, but not in male, adolescent rats with heightened, fluoxetine-sensitive, ethanol consumption; Elsevier Science; Behavioural Brain Research; 348; 8-2018; 160-170
0166-4328
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.bbr.2018.04.011
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0166432818302821
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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