Progesterone has a neuroprotective effect and prevents depression sings in a male rat depression like model

Autores
Villegas, Vanina Anabel; Mulle Bernedo, María Belén; García, Sebastián; Cáceres Gimenez, Antonella Rosario Ramona; Yunes, Roberto Miguel Federico; Cabrera Kreiker, Ricardo Jorge
Año de publicación
2016
Idioma
español castellano
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Depression is one of the psychiatric disorders with the highest incidence in recent decades. It has been recently related to different neurodegenerative diseases such as Parkinson. These pathologies often appear associated with a premotor sign such as depression and decreased cognitive performance. The objective was to study and evaluate if the treatment with the neuroactive steroid progesterone could prevent the development of premotor early signs of neurodegenerative diseases in a model of catecholaminergic depletion by reserpine. Sprague-Dawley male rats (250-350 g), between 60 and 90 days old were used. The experimental groups were: C (saline), R (reserpine 0.1 mg/kg/sc, 10 injection over the course of 20 days), P (progesterone 4 mg/kg/sc) alone, 5 days after de experiments andPP + R (reserpine 5 days after a previous dose of progesterone). During the course of reserpine treatment, the animals were evaluated in the catalepsy test. Forced swimming and novel object recognition were tested before the appearance of the motor signs. Data were analyzed by ANOVA-1 and Tukey`s post hoc. A significant decrease (p<0.05) was observed between the R vs C groups in all evaluated behavioral parameters. There were no significant differences in the catalepsy time in the PP+R vs C. Although PP+R vs R showed a significant increase in the time spent swimming in the forced swimming test (p <0.05) and in the discrimination index (p <0.05) in novel object recognition. We conclude that a previous progesterone treatment can avoid depression-like behavior and improves short time memory and the on/ off effect on locomotor activity. Progesterone exerts a neuroprotective effect against the reserpine treatment, preventing cognitive and depression premotor disorders induced by catecholamine depletion.
Fil: Villegas, Vanina Anabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Mulle Bernedo, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: García, Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Cáceres Gimenez, Antonella Rosario Ramona. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Yunes, Roberto Miguel Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Cabrera Kreiker, Ricardo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Materia
Reserpina
Enfermedades Neurodegenerativas
Depresión
Ratas
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/107181
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/107181
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Progesterone has a neuroprotective effect and prevents depression sings in a male rat depression like modelVillegas, Vanina AnabelMulle Bernedo, María BelénGarcía, SebastiánCáceres Gimenez, Antonella Rosario RamonaYunes, Roberto Miguel FedericoCabrera Kreiker, Ricardo JorgeReserpinaEnfermedades NeurodegenerativasDepresiónRatashttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Depression is one of the psychiatric disorders with the highest incidence in recent decades. It has been recently related to different neurodegenerative diseases such as Parkinson. These pathologies often appear associated with a premotor sign such as depression and decreased cognitive performance. The objective was to study and evaluate if the treatment with the neuroactive steroid progesterone could prevent the development of premotor early signs of neurodegenerative diseases in a model of catecholaminergic depletion by reserpine. Sprague-Dawley male rats (250-350 g), between 60 and 90 days old were used. The experimental groups were: C (saline), R (reserpine 0.1 mg/kg/sc, 10 injection over the course of 20 days), P (progesterone 4 mg/kg/sc) alone, 5 days after de experiments andPP + R (reserpine 5 days after a previous dose of progesterone). During the course of reserpine treatment, the animals were evaluated in the catalepsy test. Forced swimming and novel object recognition were tested before the appearance of the motor signs. Data were analyzed by ANOVA-1 and Tukey`s post hoc. A significant decrease (p<0.05) was observed between the R vs C groups in all evaluated behavioral parameters. There were no significant differences in the catalepsy time in the PP+R vs C. Although PP+R vs R showed a significant increase in the time spent swimming in the forced swimming test (p <0.05) and in the discrimination index (p <0.05) in novel object recognition. We conclude that a previous progesterone treatment can avoid depression-like behavior and improves short time memory and the on/ off effect on locomotor activity. Progesterone exerts a neuroprotective effect against the reserpine treatment, preventing cognitive and depression premotor disorders induced by catecholamine depletion.Fil: Villegas, Vanina Anabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Mulle Bernedo, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: García, Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Cáceres Gimenez, Antonella Rosario Ramona. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Yunes, Roberto Miguel Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Cabrera Kreiker, Ricardo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaMedicina (Buenos Aires)2016-11info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/107181Villegas, Vanina Anabel; Mulle Bernedo, María Belén; García, Sebastián; Cáceres Gimenez, Antonella Rosario Ramona; Yunes, Roberto Miguel Federico; et al.; Progesterone has a neuroprotective effect and prevents depression sings in a male rat depression like model; Medicina (Buenos Aires); Medicina (Buenos Aires); 76; Supl. 1; 11-2016; 20-210025-76801669-9106CONICET DigitalCONICETspainfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:43:26Zoai:ri.conicet.gov.ar:11336/107181instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:43:26.889CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Progesterone has a neuroprotective effect and prevents depression sings in a male rat depression like model
title Progesterone has a neuroprotective effect and prevents depression sings in a male rat depression like model
spellingShingle Progesterone has a neuroprotective effect and prevents depression sings in a male rat depression like model
Villegas, Vanina Anabel
Reserpina
Enfermedades Neurodegenerativas
Depresión
Ratas
title_short Progesterone has a neuroprotective effect and prevents depression sings in a male rat depression like model
title_full Progesterone has a neuroprotective effect and prevents depression sings in a male rat depression like model
title_fullStr Progesterone has a neuroprotective effect and prevents depression sings in a male rat depression like model
title_full_unstemmed Progesterone has a neuroprotective effect and prevents depression sings in a male rat depression like model
title_sort Progesterone has a neuroprotective effect and prevents depression sings in a male rat depression like model
dc.creator.none.fl_str_mv Villegas, Vanina Anabel
Mulle Bernedo, María Belén
García, Sebastián
Cáceres Gimenez, Antonella Rosario Ramona
Yunes, Roberto Miguel Federico
Cabrera Kreiker, Ricardo Jorge
author Villegas, Vanina Anabel
author_facet Villegas, Vanina Anabel
Mulle Bernedo, María Belén
García, Sebastián
Cáceres Gimenez, Antonella Rosario Ramona
Yunes, Roberto Miguel Federico
Cabrera Kreiker, Ricardo Jorge
author_role author
author2 Mulle Bernedo, María Belén
García, Sebastián
Cáceres Gimenez, Antonella Rosario Ramona
Yunes, Roberto Miguel Federico
Cabrera Kreiker, Ricardo Jorge
author2_role author
author
author
author
author
dc.subject.none.fl_str_mv Reserpina
Enfermedades Neurodegenerativas
Depresión
Ratas
topic Reserpina
Enfermedades Neurodegenerativas
Depresión
Ratas
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Depression is one of the psychiatric disorders with the highest incidence in recent decades. It has been recently related to different neurodegenerative diseases such as Parkinson. These pathologies often appear associated with a premotor sign such as depression and decreased cognitive performance. The objective was to study and evaluate if the treatment with the neuroactive steroid progesterone could prevent the development of premotor early signs of neurodegenerative diseases in a model of catecholaminergic depletion by reserpine. Sprague-Dawley male rats (250-350 g), between 60 and 90 days old were used. The experimental groups were: C (saline), R (reserpine 0.1 mg/kg/sc, 10 injection over the course of 20 days), P (progesterone 4 mg/kg/sc) alone, 5 days after de experiments andPP + R (reserpine 5 days after a previous dose of progesterone). During the course of reserpine treatment, the animals were evaluated in the catalepsy test. Forced swimming and novel object recognition were tested before the appearance of the motor signs. Data were analyzed by ANOVA-1 and Tukey`s post hoc. A significant decrease (p<0.05) was observed between the R vs C groups in all evaluated behavioral parameters. There were no significant differences in the catalepsy time in the PP+R vs C. Although PP+R vs R showed a significant increase in the time spent swimming in the forced swimming test (p <0.05) and in the discrimination index (p <0.05) in novel object recognition. We conclude that a previous progesterone treatment can avoid depression-like behavior and improves short time memory and the on/ off effect on locomotor activity. Progesterone exerts a neuroprotective effect against the reserpine treatment, preventing cognitive and depression premotor disorders induced by catecholamine depletion.
Fil: Villegas, Vanina Anabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Mulle Bernedo, María Belén. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: García, Sebastián. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Cáceres Gimenez, Antonella Rosario Ramona. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Yunes, Roberto Miguel Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Cabrera Kreiker, Ricardo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
description Depression is one of the psychiatric disorders with the highest incidence in recent decades. It has been recently related to different neurodegenerative diseases such as Parkinson. These pathologies often appear associated with a premotor sign such as depression and decreased cognitive performance. The objective was to study and evaluate if the treatment with the neuroactive steroid progesterone could prevent the development of premotor early signs of neurodegenerative diseases in a model of catecholaminergic depletion by reserpine. Sprague-Dawley male rats (250-350 g), between 60 and 90 days old were used. The experimental groups were: C (saline), R (reserpine 0.1 mg/kg/sc, 10 injection over the course of 20 days), P (progesterone 4 mg/kg/sc) alone, 5 days after de experiments andPP + R (reserpine 5 days after a previous dose of progesterone). During the course of reserpine treatment, the animals were evaluated in the catalepsy test. Forced swimming and novel object recognition were tested before the appearance of the motor signs. Data were analyzed by ANOVA-1 and Tukey`s post hoc. A significant decrease (p<0.05) was observed between the R vs C groups in all evaluated behavioral parameters. There were no significant differences in the catalepsy time in the PP+R vs C. Although PP+R vs R showed a significant increase in the time spent swimming in the forced swimming test (p <0.05) and in the discrimination index (p <0.05) in novel object recognition. We conclude that a previous progesterone treatment can avoid depression-like behavior and improves short time memory and the on/ off effect on locomotor activity. Progesterone exerts a neuroprotective effect against the reserpine treatment, preventing cognitive and depression premotor disorders induced by catecholamine depletion.
publishDate 2016
dc.date.none.fl_str_mv 2016-11
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/107181
Villegas, Vanina Anabel; Mulle Bernedo, María Belén; García, Sebastián; Cáceres Gimenez, Antonella Rosario Ramona; Yunes, Roberto Miguel Federico; et al.; Progesterone has a neuroprotective effect and prevents depression sings in a male rat depression like model; Medicina (Buenos Aires); Medicina (Buenos Aires); 76; Supl. 1; 11-2016; 20-21
0025-7680
1669-9106
CONICET Digital
CONICET
url http://hdl.handle.net/11336/107181
identifier_str_mv Villegas, Vanina Anabel; Mulle Bernedo, María Belén; García, Sebastián; Cáceres Gimenez, Antonella Rosario Ramona; Yunes, Roberto Miguel Federico; et al.; Progesterone has a neuroprotective effect and prevents depression sings in a male rat depression like model; Medicina (Buenos Aires); Medicina (Buenos Aires); 76; Supl. 1; 11-2016; 20-21
0025-7680
1669-9106
CONICET Digital
CONICET
dc.language.none.fl_str_mv spa
language spa
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Medicina (Buenos Aires)
publisher.none.fl_str_mv Medicina (Buenos Aires)
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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