Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats

Autores
Ruiz, Paul; Calliari, Aldo; Genovese, Patricia; Scorza, Cecilia; Pautassi, Ricardo Marcos
Año de publicación
2018
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Introduction: There has been an increasing interest in analyzing the interactions between stimulants and ethanol during childhood and adolescence. Stimulants are used to treat attention-deficit hyperactivity disorder (ADHD) in these developmental stages, during which ethanol initiation and escalation often occur. Methods: This study assessed the effects of repeated d-amphetamine (AMPH) or methylphenidate (MPH) treatment during adolescence [male and female Wistar rats, between postnatal day (PD) 28 to PD34, approximately] on the initiation of ethanol intake during a later section of adolescence (PD35 to PD40). Results: Amphetamine and MPH exerted reliable acute motor stimulant effects, but there was no indication of sensitized motor or anxiety responses. MPH did not affect dopamine (DA) levels, whereas AMPH significantly reduced insular levels of DA in both sexes and norepinephrine levels in females only. Repeated treatment with AMPH, but not with MPH, enhanced ethanol intake during late adolescence in male, but not in female, rats. Conclusion: A short treatment with AMPH during adolescence significantly altered DA levels in the insula, both in male and females, and significantly enhanced ethanol intake in males. The present results suggest that, in adolescent males, a very brief history of AMPH exposure can facilitate the initiation of ethanol intake.
Fil: Ruiz, Paul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad de la República; Uruguay
Fil: Calliari, Aldo. Universidad de la República; Uruguay
Fil: Genovese, Patricia. Universidad de la República; Uruguay
Fil: Scorza, Cecilia. Instituto de Investigaciones Biológicas "Clemente Estable"; Uruguay
Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina
Materia
ADOLESCENCE
AMPHETAMINE
ETHANOL
METHYLPHENIDATE
MOTOR BEHAVIOR
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/96867
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/96867
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, ratsRuiz, PaulCalliari, AldoGenovese, PatriciaScorza, CeciliaPautassi, Ricardo MarcosADOLESCENCEAMPHETAMINEETHANOLMETHYLPHENIDATEMOTOR BEHAVIORhttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Introduction: There has been an increasing interest in analyzing the interactions between stimulants and ethanol during childhood and adolescence. Stimulants are used to treat attention-deficit hyperactivity disorder (ADHD) in these developmental stages, during which ethanol initiation and escalation often occur. Methods: This study assessed the effects of repeated d-amphetamine (AMPH) or methylphenidate (MPH) treatment during adolescence [male and female Wistar rats, between postnatal day (PD) 28 to PD34, approximately] on the initiation of ethanol intake during a later section of adolescence (PD35 to PD40). Results: Amphetamine and MPH exerted reliable acute motor stimulant effects, but there was no indication of sensitized motor or anxiety responses. MPH did not affect dopamine (DA) levels, whereas AMPH significantly reduced insular levels of DA in both sexes and norepinephrine levels in females only. Repeated treatment with AMPH, but not with MPH, enhanced ethanol intake during late adolescence in male, but not in female, rats. Conclusion: A short treatment with AMPH during adolescence significantly altered DA levels in the insula, both in male and females, and significantly enhanced ethanol intake in males. The present results suggest that, in adolescent males, a very brief history of AMPH exposure can facilitate the initiation of ethanol intake.Fil: Ruiz, Paul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad de la República; UruguayFil: Calliari, Aldo. Universidad de la República; UruguayFil: Genovese, Patricia. Universidad de la República; UruguayFil: Scorza, Cecilia. Instituto de Investigaciones Biológicas "Clemente Estable"; UruguayFil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; ArgentinaJohn Wiley & Sons Ltd2018-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/96867Ruiz, Paul; Calliari, Aldo; Genovese, Patricia; Scorza, Cecilia; Pautassi, Ricardo Marcos; Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats; John Wiley & Sons Ltd; Brain and Behavior; 8; 4; 4-2018; 1-132162-3279CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1002/brb3.939info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/brb3.939info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:18Zoai:ri.conicet.gov.ar:11336/96867instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:18.888CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats
title Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats
spellingShingle Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats
Ruiz, Paul
ADOLESCENCE
AMPHETAMINE
ETHANOL
METHYLPHENIDATE
MOTOR BEHAVIOR
title_short Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats
title_full Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats
title_fullStr Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats
title_full_unstemmed Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats
title_sort Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats
dc.creator.none.fl_str_mv Ruiz, Paul
Calliari, Aldo
Genovese, Patricia
Scorza, Cecilia
Pautassi, Ricardo Marcos
author Ruiz, Paul
author_facet Ruiz, Paul
Calliari, Aldo
Genovese, Patricia
Scorza, Cecilia
Pautassi, Ricardo Marcos
author_role author
author2 Calliari, Aldo
Genovese, Patricia
Scorza, Cecilia
Pautassi, Ricardo Marcos
author2_role author
author
author
author
dc.subject.none.fl_str_mv ADOLESCENCE
AMPHETAMINE
ETHANOL
METHYLPHENIDATE
MOTOR BEHAVIOR
topic ADOLESCENCE
AMPHETAMINE
ETHANOL
METHYLPHENIDATE
MOTOR BEHAVIOR
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Introduction: There has been an increasing interest in analyzing the interactions between stimulants and ethanol during childhood and adolescence. Stimulants are used to treat attention-deficit hyperactivity disorder (ADHD) in these developmental stages, during which ethanol initiation and escalation often occur. Methods: This study assessed the effects of repeated d-amphetamine (AMPH) or methylphenidate (MPH) treatment during adolescence [male and female Wistar rats, between postnatal day (PD) 28 to PD34, approximately] on the initiation of ethanol intake during a later section of adolescence (PD35 to PD40). Results: Amphetamine and MPH exerted reliable acute motor stimulant effects, but there was no indication of sensitized motor or anxiety responses. MPH did not affect dopamine (DA) levels, whereas AMPH significantly reduced insular levels of DA in both sexes and norepinephrine levels in females only. Repeated treatment with AMPH, but not with MPH, enhanced ethanol intake during late adolescence in male, but not in female, rats. Conclusion: A short treatment with AMPH during adolescence significantly altered DA levels in the insula, both in male and females, and significantly enhanced ethanol intake in males. The present results suggest that, in adolescent males, a very brief history of AMPH exposure can facilitate the initiation of ethanol intake.
Fil: Ruiz, Paul. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad de la República; Uruguay
Fil: Calliari, Aldo. Universidad de la República; Uruguay
Fil: Genovese, Patricia. Universidad de la República; Uruguay
Fil: Scorza, Cecilia. Instituto de Investigaciones Biológicas "Clemente Estable"; Uruguay
Fil: Pautassi, Ricardo Marcos. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra. Universidad Nacional de Córdoba. Instituto de Investigación Médica Mercedes y Martín Ferreyra; Argentina. Universidad Nacional de Córdoba. Facultad de Psicología; Argentina
description Introduction: There has been an increasing interest in analyzing the interactions between stimulants and ethanol during childhood and adolescence. Stimulants are used to treat attention-deficit hyperactivity disorder (ADHD) in these developmental stages, during which ethanol initiation and escalation often occur. Methods: This study assessed the effects of repeated d-amphetamine (AMPH) or methylphenidate (MPH) treatment during adolescence [male and female Wistar rats, between postnatal day (PD) 28 to PD34, approximately] on the initiation of ethanol intake during a later section of adolescence (PD35 to PD40). Results: Amphetamine and MPH exerted reliable acute motor stimulant effects, but there was no indication of sensitized motor or anxiety responses. MPH did not affect dopamine (DA) levels, whereas AMPH significantly reduced insular levels of DA in both sexes and norepinephrine levels in females only. Repeated treatment with AMPH, but not with MPH, enhanced ethanol intake during late adolescence in male, but not in female, rats. Conclusion: A short treatment with AMPH during adolescence significantly altered DA levels in the insula, both in male and females, and significantly enhanced ethanol intake in males. The present results suggest that, in adolescent males, a very brief history of AMPH exposure can facilitate the initiation of ethanol intake.
publishDate 2018
dc.date.none.fl_str_mv 2018-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/96867
Ruiz, Paul; Calliari, Aldo; Genovese, Patricia; Scorza, Cecilia; Pautassi, Ricardo Marcos; Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats; John Wiley & Sons Ltd; Brain and Behavior; 8; 4; 4-2018; 1-13
2162-3279
CONICET Digital
CONICET
url http://hdl.handle.net/11336/96867
identifier_str_mv Ruiz, Paul; Calliari, Aldo; Genovese, Patricia; Scorza, Cecilia; Pautassi, Ricardo Marcos; Amphetamine, but not methylphenidate, increases ethanol intake in adolescent male, but not in female, rats; John Wiley & Sons Ltd; Brain and Behavior; 8; 4; 4-2018; 1-13
2162-3279
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1002/brb3.939
info:eu-repo/semantics/altIdentifier/url/https://onlinelibrary.wiley.com/doi/full/10.1002/brb3.939
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv John Wiley & Sons Ltd
publisher.none.fl_str_mv John Wiley & Sons Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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