Cannabinoid content in inflorescences and in based on cannabis home-made products used for therapeutic purposes in Argentina

Autores
Sedan, Daniela Yazmine; Vaccarini, Cristian Adrián; Demetrio, Pablo Martin; Morante, Dario Marcelo; Montiel, Romina; Sauri, Alvaro; Andrinolo, Dario
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
SummaryIntroduction A recent law (DCTO-2020-883-APN-PTE - Law No. 27,350. Regulation) passed in Argentina put an end to the ban imposed for the last 60 years on cannabis cultivation within the country. The law permits restricted access to cannabis derivatives for medicinal, therapeutic and palliative use by individuals and communities, allowing self- and community-based cannabis production. This is cause for concern in view of the lack of quality controls for cannabis derivatives. The several varieties of cannabis grown in Argentina have different chemical profiles and are processed in a variety of ways ―mostly by alcohol extraction or maceration at different temperatures and for different amounts of times― making the cannabinoid content of these preparations highly variable. Determining the characteristics of home- and community-grown cannabis products will facilitate the implementation of public policies conducive to their safety and improvement. Objective. The aim of the present study was to determine the cannabinoid chemotypes used for therapeutic purposes in Argentina and evaluate whether the cannabinoids present in home-made derivatives are comparable to those in commercially available products.Methods HPLC/UV-DAD analysis of 436 samples (oils, resins and inflorescences) was carried out to determine the identity and concentration of five cannabinoids: THCA, THC, CBDA, CBD and CBN. From three different sources, the samples represent the type of medical cannabis preparations to which patients have access.Results The results indicate that the medium-to-low cannabinoid concentration in a significant number of home-made oil samples is similar to that found in commercial products. Most of the samples have a THC/CBD ratio ˃ 1 or only contain THC. Acidic cannabinoids were detected in home-made preparations but were not reported in package inserts of commercial products.Conclusions Our results indicate that despite their considerable variability, home-made preparations as a whole show cannabinoid levels and profiles equivalent to the commercially available products commonly used for medicinal, therapeutic and palliative purposes in Argentina.
Fil: Sedan, Daniela Yazmine. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; Argentina
Fil: Vaccarini, Cristian Adrián. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; Argentina
Fil: Demetrio, Pablo Martin. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; Argentina
Fil: Morante, Dario Marcelo. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentina
Fil: Montiel, Romina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Fil: Sauri, Alvaro. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Fil: Andrinolo, Dario. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; Argentina
Materia
CANNABIS OIL
INFLORESCENCES
RESINS
CANNABINOIDS
HOME-MADE HERBAL PRODUCTS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/172152
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/172152
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Cannabinoid content in inflorescences and in based on cannabis home-made products used for therapeutic purposes in ArgentinaSedan, Daniela YazmineVaccarini, Cristian AdriánDemetrio, Pablo MartinMorante, Dario MarceloMontiel, RominaSauri, AlvaroAndrinolo, DarioCANNABIS OILINFLORESCENCESRESINSCANNABINOIDSHOME-MADE HERBAL PRODUCTShttps://purl.org/becyt/ford/1.7https://purl.org/becyt/ford/1SummaryIntroduction A recent law (DCTO-2020-883-APN-PTE - Law No. 27,350. Regulation) passed in Argentina put an end to the ban imposed for the last 60 years on cannabis cultivation within the country. The law permits restricted access to cannabis derivatives for medicinal, therapeutic and palliative use by individuals and communities, allowing self- and community-based cannabis production. This is cause for concern in view of the lack of quality controls for cannabis derivatives. The several varieties of cannabis grown in Argentina have different chemical profiles and are processed in a variety of ways ―mostly by alcohol extraction or maceration at different temperatures and for different amounts of times― making the cannabinoid content of these preparations highly variable. Determining the characteristics of home- and community-grown cannabis products will facilitate the implementation of public policies conducive to their safety and improvement. Objective. The aim of the present study was to determine the cannabinoid chemotypes used for therapeutic purposes in Argentina and evaluate whether the cannabinoids present in home-made derivatives are comparable to those in commercially available products.Methods HPLC/UV-DAD analysis of 436 samples (oils, resins and inflorescences) was carried out to determine the identity and concentration of five cannabinoids: THCA, THC, CBDA, CBD and CBN. From three different sources, the samples represent the type of medical cannabis preparations to which patients have access.Results The results indicate that the medium-to-low cannabinoid concentration in a significant number of home-made oil samples is similar to that found in commercial products. Most of the samples have a THC/CBD ratio ˃ 1 or only contain THC. Acidic cannabinoids were detected in home-made preparations but were not reported in package inserts of commercial products.Conclusions Our results indicate that despite their considerable variability, home-made preparations as a whole show cannabinoid levels and profiles equivalent to the commercially available products commonly used for medicinal, therapeutic and palliative purposes in Argentina.Fil: Sedan, Daniela Yazmine. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; ArgentinaFil: Vaccarini, Cristian Adrián. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; ArgentinaFil: Demetrio, Pablo Martin. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; ArgentinaFil: Morante, Dario Marcelo. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; ArgentinaFil: Montiel, Romina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; ArgentinaFil: Sauri, Alvaro. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; ArgentinaFil: Andrinolo, Dario. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; ArgentinaMary Ann Liebert2021-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/172152Sedan, Daniela Yazmine; Vaccarini, Cristian Adrián; Demetrio, Pablo Martin; Morante, Dario Marcelo; Montiel, Romina; et al.; Cannabinoid content in inflorescences and in based on cannabis home-made products used for therapeutic purposes in Argentina; Mary Ann Liebert; Cannabis and Cannabinoid Research; 2021; 3-2021; 1-102578-51252378-8763CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1089/can.2020.0117info:eu-repo/semantics/altIdentifier/url/https://www.liebertpub.com/doi/10.1089/can.2020.0117info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-11-12T09:49:12Zoai:ri.conicet.gov.ar:11336/172152instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-11-12 09:49:12.931CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Cannabinoid content in inflorescences and in based on cannabis home-made products used for therapeutic purposes in Argentina
title Cannabinoid content in inflorescences and in based on cannabis home-made products used for therapeutic purposes in Argentina
spellingShingle Cannabinoid content in inflorescences and in based on cannabis home-made products used for therapeutic purposes in Argentina
Sedan, Daniela Yazmine
CANNABIS OIL
INFLORESCENCES
RESINS
CANNABINOIDS
HOME-MADE HERBAL PRODUCTS
title_short Cannabinoid content in inflorescences and in based on cannabis home-made products used for therapeutic purposes in Argentina
title_full Cannabinoid content in inflorescences and in based on cannabis home-made products used for therapeutic purposes in Argentina
title_fullStr Cannabinoid content in inflorescences and in based on cannabis home-made products used for therapeutic purposes in Argentina
title_full_unstemmed Cannabinoid content in inflorescences and in based on cannabis home-made products used for therapeutic purposes in Argentina
title_sort Cannabinoid content in inflorescences and in based on cannabis home-made products used for therapeutic purposes in Argentina
dc.creator.none.fl_str_mv Sedan, Daniela Yazmine
Vaccarini, Cristian Adrián
Demetrio, Pablo Martin
Morante, Dario Marcelo
Montiel, Romina
Sauri, Alvaro
Andrinolo, Dario
author Sedan, Daniela Yazmine
author_facet Sedan, Daniela Yazmine
Vaccarini, Cristian Adrián
Demetrio, Pablo Martin
Morante, Dario Marcelo
Montiel, Romina
Sauri, Alvaro
Andrinolo, Dario
author_role author
author2 Vaccarini, Cristian Adrián
Demetrio, Pablo Martin
Morante, Dario Marcelo
Montiel, Romina
Sauri, Alvaro
Andrinolo, Dario
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv CANNABIS OIL
INFLORESCENCES
RESINS
CANNABINOIDS
HOME-MADE HERBAL PRODUCTS
topic CANNABIS OIL
INFLORESCENCES
RESINS
CANNABINOIDS
HOME-MADE HERBAL PRODUCTS
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.7
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv SummaryIntroduction A recent law (DCTO-2020-883-APN-PTE - Law No. 27,350. Regulation) passed in Argentina put an end to the ban imposed for the last 60 years on cannabis cultivation within the country. The law permits restricted access to cannabis derivatives for medicinal, therapeutic and palliative use by individuals and communities, allowing self- and community-based cannabis production. This is cause for concern in view of the lack of quality controls for cannabis derivatives. The several varieties of cannabis grown in Argentina have different chemical profiles and are processed in a variety of ways ―mostly by alcohol extraction or maceration at different temperatures and for different amounts of times― making the cannabinoid content of these preparations highly variable. Determining the characteristics of home- and community-grown cannabis products will facilitate the implementation of public policies conducive to their safety and improvement. Objective. The aim of the present study was to determine the cannabinoid chemotypes used for therapeutic purposes in Argentina and evaluate whether the cannabinoids present in home-made derivatives are comparable to those in commercially available products.Methods HPLC/UV-DAD analysis of 436 samples (oils, resins and inflorescences) was carried out to determine the identity and concentration of five cannabinoids: THCA, THC, CBDA, CBD and CBN. From three different sources, the samples represent the type of medical cannabis preparations to which patients have access.Results The results indicate that the medium-to-low cannabinoid concentration in a significant number of home-made oil samples is similar to that found in commercial products. Most of the samples have a THC/CBD ratio ˃ 1 or only contain THC. Acidic cannabinoids were detected in home-made preparations but were not reported in package inserts of commercial products.Conclusions Our results indicate that despite their considerable variability, home-made preparations as a whole show cannabinoid levels and profiles equivalent to the commercially available products commonly used for medicinal, therapeutic and palliative purposes in Argentina.
Fil: Sedan, Daniela Yazmine. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; Argentina
Fil: Vaccarini, Cristian Adrián. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; Argentina
Fil: Demetrio, Pablo Martin. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; Argentina
Fil: Morante, Dario Marcelo. Universidad Nacional de La Plata. Facultad de Ciencias Médicas; Argentina
Fil: Montiel, Romina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Fil: Sauri, Alvaro. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Oncología "Ángel H. Roffo"; Argentina
Fil: Andrinolo, Dario. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Investigaciones del Medio Ambiente - Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones del Medio Ambiente; Argentina
description SummaryIntroduction A recent law (DCTO-2020-883-APN-PTE - Law No. 27,350. Regulation) passed in Argentina put an end to the ban imposed for the last 60 years on cannabis cultivation within the country. The law permits restricted access to cannabis derivatives for medicinal, therapeutic and palliative use by individuals and communities, allowing self- and community-based cannabis production. This is cause for concern in view of the lack of quality controls for cannabis derivatives. The several varieties of cannabis grown in Argentina have different chemical profiles and are processed in a variety of ways ―mostly by alcohol extraction or maceration at different temperatures and for different amounts of times― making the cannabinoid content of these preparations highly variable. Determining the characteristics of home- and community-grown cannabis products will facilitate the implementation of public policies conducive to their safety and improvement. Objective. The aim of the present study was to determine the cannabinoid chemotypes used for therapeutic purposes in Argentina and evaluate whether the cannabinoids present in home-made derivatives are comparable to those in commercially available products.Methods HPLC/UV-DAD analysis of 436 samples (oils, resins and inflorescences) was carried out to determine the identity and concentration of five cannabinoids: THCA, THC, CBDA, CBD and CBN. From three different sources, the samples represent the type of medical cannabis preparations to which patients have access.Results The results indicate that the medium-to-low cannabinoid concentration in a significant number of home-made oil samples is similar to that found in commercial products. Most of the samples have a THC/CBD ratio ˃ 1 or only contain THC. Acidic cannabinoids were detected in home-made preparations but were not reported in package inserts of commercial products.Conclusions Our results indicate that despite their considerable variability, home-made preparations as a whole show cannabinoid levels and profiles equivalent to the commercially available products commonly used for medicinal, therapeutic and palliative purposes in Argentina.
publishDate 2021
dc.date.none.fl_str_mv 2021-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
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info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/172152
Sedan, Daniela Yazmine; Vaccarini, Cristian Adrián; Demetrio, Pablo Martin; Morante, Dario Marcelo; Montiel, Romina; et al.; Cannabinoid content in inflorescences and in based on cannabis home-made products used for therapeutic purposes in Argentina; Mary Ann Liebert; Cannabis and Cannabinoid Research; 2021; 3-2021; 1-10
2578-5125
2378-8763
CONICET Digital
CONICET
url http://hdl.handle.net/11336/172152
identifier_str_mv Sedan, Daniela Yazmine; Vaccarini, Cristian Adrián; Demetrio, Pablo Martin; Morante, Dario Marcelo; Montiel, Romina; et al.; Cannabinoid content in inflorescences and in based on cannabis home-made products used for therapeutic purposes in Argentina; Mary Ann Liebert; Cannabis and Cannabinoid Research; 2021; 3-2021; 1-10
2578-5125
2378-8763
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1089/can.2020.0117
info:eu-repo/semantics/altIdentifier/url/https://www.liebertpub.com/doi/10.1089/can.2020.0117
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Mary Ann Liebert
publisher.none.fl_str_mv Mary Ann Liebert
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.24909

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