Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast

Autores
Ortega, Francisco Gabriel; Fernández Baldo, Martín Alejandro; Fernández, Jorge Gastón; Serrano, Maria J.; Sanz Ferramola, Maria Isabel; Diaz Mochón, Juan J.; Lorente, José Antonio; Raba, Julio
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In the present article, we describe a study of antitumor activity in breast cell lines using silver nanoparticles (Ag NPs) synthesized by a microbiological method. These Ag NPs were tested for their antitumor activity against MCF7 and T47D cancer cells and MCF10-A normal breast cell line. We analyzed cell viability, apoptosis induction and endocytosis activity of those cell lines and we observed that the effects of the biosynthesized Ag NPs were directly related with the endocytosis activity. Moreover, Ag NPs had higher inhibition efficacy in tumor lines than in normal lines of breast, which is due to the higher endocytic activity of tumor cells comparing to normal cells. In this way, we are demonstrating that biosynthesized Ag NPs can be an alternative for the treatment of tumors.
Fil: Ortega, Francisco Gabriel. Universidad de Granada. Centro de Genómica e Investigación Oncológica; España
Fil: Fernández Baldo, Martín Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; Argentina
Fil: Fernández, Jorge Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; Argentina
Fil: Serrano, Maria J.. Universidad de Granada. Centro de Genómica e Investigación Oncológica; España
Fil: Sanz Ferramola, Maria Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; Argentina
Fil: Diaz Mochón, Juan J.. Universidad de Granada. Centro de Genómica e Investigación Oncológica; España
Fil: Lorente, José Antonio. Universidad de Granada. Centro de Genómica e Investigación Oncológica; España
Fil: Raba, Julio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; Argentina
Materia
APOPTOSIS
BREAST CANCER
SILVER NANOPARTICLES
NANOTECHNOLOGY
CANCER
MICROBIOLOGICAL SYNTHESIS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/5780
Acceder
id CONICETDig_196d4e38796ade4fe9cacf6daa01323b
oai_identifier_str oai:ri.conicet.gov.ar:11336/5780
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeastOrtega, Francisco GabrielFernández Baldo, Martín AlejandroFernández, Jorge GastónSerrano, Maria J.Sanz Ferramola, Maria IsabelDiaz Mochón, Juan J.Lorente, José AntonioRaba, JulioAPOPTOSISBREAST CANCERSILVER NANOPARTICLESNANOTECHNOLOGYCANCERMICROBIOLOGICAL SYNTHESIShttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2In the present article, we describe a study of antitumor activity in breast cell lines using silver nanoparticles (Ag NPs) synthesized by a microbiological method. These Ag NPs were tested for their antitumor activity against MCF7 and T47D cancer cells and MCF10-A normal breast cell line. We analyzed cell viability, apoptosis induction and endocytosis activity of those cell lines and we observed that the effects of the biosynthesized Ag NPs were directly related with the endocytosis activity. Moreover, Ag NPs had higher inhibition efficacy in tumor lines than in normal lines of breast, which is due to the higher endocytic activity of tumor cells comparing to normal cells. In this way, we are demonstrating that biosynthesized Ag NPs can be an alternative for the treatment of tumors.Fil: Ortega, Francisco Gabriel. Universidad de Granada. Centro de Genómica e Investigación Oncológica; EspañaFil: Fernández Baldo, Martín Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; ArgentinaFil: Fernández, Jorge Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; ArgentinaFil: Serrano, Maria J.. Universidad de Granada. Centro de Genómica e Investigación Oncológica; EspañaFil: Sanz Ferramola, Maria Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; ArgentinaFil: Diaz Mochón, Juan J.. Universidad de Granada. Centro de Genómica e Investigación Oncológica; EspañaFil: Lorente, José Antonio. Universidad de Granada. Centro de Genómica e Investigación Oncológica; EspañaFil: Raba, Julio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; ArgentinaDove Press2015-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/5780Ortega, Francisco Gabriel; Fernández Baldo, Martín Alejandro; Fernández, Jorge Gastón; Serrano, Maria J.; Sanz Ferramola, Maria Isabel; et al.; Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast; Dove Press; International Journal of Nanomedicine; 10; 1; 3-2015; 2021-20311176-91141178-2013enginfo:eu-repo/semantics/altIdentifier/url/https://www.dovepress.com/study-of-antitumor-activity-in-breast-cell-lines-using-silver-nanopart-peer-reviewed-article-IJNinfo:eu-repo/semantics/altIdentifier/pmid/PMC4368032info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368032/info:eu-repo/semantics/altIdentifier/doi/10.2147%2FIJN.S75835info:eu-repo/semantics/altIdentifier/doi/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:33:19Zoai:ri.conicet.gov.ar:11336/5780instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:33:20.056CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast
title Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast
spellingShingle Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast
Ortega, Francisco Gabriel
APOPTOSIS
BREAST CANCER
SILVER NANOPARTICLES
NANOTECHNOLOGY
CANCER
MICROBIOLOGICAL SYNTHESIS
title_short Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast
title_full Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast
title_fullStr Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast
title_full_unstemmed Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast
title_sort Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast
dc.creator.none.fl_str_mv Ortega, Francisco Gabriel
Fernández Baldo, Martín Alejandro
Fernández, Jorge Gastón
Serrano, Maria J.
Sanz Ferramola, Maria Isabel
Diaz Mochón, Juan J.
Lorente, José Antonio
Raba, Julio
author Ortega, Francisco Gabriel
author_facet Ortega, Francisco Gabriel
Fernández Baldo, Martín Alejandro
Fernández, Jorge Gastón
Serrano, Maria J.
Sanz Ferramola, Maria Isabel
Diaz Mochón, Juan J.
Lorente, José Antonio
Raba, Julio
author_role author
author2 Fernández Baldo, Martín Alejandro
Fernández, Jorge Gastón
Serrano, Maria J.
Sanz Ferramola, Maria Isabel
Diaz Mochón, Juan J.
Lorente, José Antonio
Raba, Julio
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv APOPTOSIS
BREAST CANCER
SILVER NANOPARTICLES
NANOTECHNOLOGY
CANCER
MICROBIOLOGICAL SYNTHESIS
topic APOPTOSIS
BREAST CANCER
SILVER NANOPARTICLES
NANOTECHNOLOGY
CANCER
MICROBIOLOGICAL SYNTHESIS
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv In the present article, we describe a study of antitumor activity in breast cell lines using silver nanoparticles (Ag NPs) synthesized by a microbiological method. These Ag NPs were tested for their antitumor activity against MCF7 and T47D cancer cells and MCF10-A normal breast cell line. We analyzed cell viability, apoptosis induction and endocytosis activity of those cell lines and we observed that the effects of the biosynthesized Ag NPs were directly related with the endocytosis activity. Moreover, Ag NPs had higher inhibition efficacy in tumor lines than in normal lines of breast, which is due to the higher endocytic activity of tumor cells comparing to normal cells. In this way, we are demonstrating that biosynthesized Ag NPs can be an alternative for the treatment of tumors.
Fil: Ortega, Francisco Gabriel. Universidad de Granada. Centro de Genómica e Investigación Oncológica; España
Fil: Fernández Baldo, Martín Alejandro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; Argentina
Fil: Fernández, Jorge Gastón. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; Argentina
Fil: Serrano, Maria J.. Universidad de Granada. Centro de Genómica e Investigación Oncológica; España
Fil: Sanz Ferramola, Maria Isabel. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; Argentina
Fil: Diaz Mochón, Juan J.. Universidad de Granada. Centro de Genómica e Investigación Oncológica; España
Fil: Lorente, José Antonio. Universidad de Granada. Centro de Genómica e Investigación Oncológica; España
Fil: Raba, Julio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico San Luis. Instituto de Química de San Luis; Argentina
description In the present article, we describe a study of antitumor activity in breast cell lines using silver nanoparticles (Ag NPs) synthesized by a microbiological method. These Ag NPs were tested for their antitumor activity against MCF7 and T47D cancer cells and MCF10-A normal breast cell line. We analyzed cell viability, apoptosis induction and endocytosis activity of those cell lines and we observed that the effects of the biosynthesized Ag NPs were directly related with the endocytosis activity. Moreover, Ag NPs had higher inhibition efficacy in tumor lines than in normal lines of breast, which is due to the higher endocytic activity of tumor cells comparing to normal cells. In this way, we are demonstrating that biosynthesized Ag NPs can be an alternative for the treatment of tumors.
publishDate 2015
dc.date.none.fl_str_mv 2015-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/5780
Ortega, Francisco Gabriel; Fernández Baldo, Martín Alejandro; Fernández, Jorge Gastón; Serrano, Maria J.; Sanz Ferramola, Maria Isabel; et al.; Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast; Dove Press; International Journal of Nanomedicine; 10; 1; 3-2015; 2021-2031
1176-9114
1178-2013
url http://hdl.handle.net/11336/5780
identifier_str_mv Ortega, Francisco Gabriel; Fernández Baldo, Martín Alejandro; Fernández, Jorge Gastón; Serrano, Maria J.; Sanz Ferramola, Maria Isabel; et al.; Study of antitumor activity in breast cell lines using silver nanoparticles produced by yeast; Dove Press; International Journal of Nanomedicine; 10; 1; 3-2015; 2021-2031
1176-9114
1178-2013
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.dovepress.com/study-of-antitumor-activity-in-breast-cell-lines-using-silver-nanopart-peer-reviewed-article-IJN
info:eu-repo/semantics/altIdentifier/pmid/PMC4368032
info:eu-repo/semantics/altIdentifier/url/http://www.ncbi.nlm.nih.gov/pmc/articles/PMC4368032/
info:eu-repo/semantics/altIdentifier/doi/10.2147%2FIJN.S75835
info:eu-repo/semantics/altIdentifier/doi/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Dove Press
publisher.none.fl_str_mv Dove Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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