p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage
- Autores
- Gironella, Meritxell; Malicet, Cedric; Cano, Carla; Sandi, Maria Jose; Hamidi, Tewfic; Neme Tauil, Ricardo Martin; Baston, Mariela; Valacco, Maria Pia; Moreno, Silvia Margarita; Lopez, Frederic; Neira, Jose Luis; Dagorn, Juan Charles; Iovanna, Juan Lucio
- Año de publicación
- 2009
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- The stress protein p8 is a small, highly basic, unfolded, and multifunctional protein. We have previously shown that most of its functions are exerted through interactions with other proteins, whose activities are thereby enhanced or repressed. In this work we describe another example of such mechanism, by which p8 binds and negatively regulates MSL1, a histone acetyl transferase (HAT)-associated protein, which in turn binds the DNA-damage-associated 53BP1 protein to facilitate DNA repair following DNA gamma-irradiation. Contrary to the HAT-associated activity, MSL1-dependent DNA-repair activity is almost completely dependent on 53BP1 expression. The picture that has emerged from our findings is that 53BP1 could be a scaffold that gets the HAT MSL1-dependent DNA-repair activity to the sites of DNA damage. Finally, we also found that, although p8 expression is transiently activated after gamma-irradiation, it is eventually submitted to sustained down-regulation, presumably to allow development of MSL1-associated DNA-repair activity. We conclude that interaction of MSL1 with 53BP1 brings MSL1-dependent HAT activity to the vicinity of damaged DNA. MSL1-dependent HAT activity, which is negatively regulated by the stress protein p8, induces chromatin remodeling and relaxation allowing access to DNA of the repair machinery
Fil: Gironella, Meritxell. Inserm; Francia. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas; España
Fil: Malicet, Cedric. Inserm; Francia
Fil: Cano, Carla. Inserm; Francia
Fil: Sandi, Maria Jose. Inserm; Francia
Fil: Hamidi, Tewfic. Inserm; Francia
Fil: Neme Tauil, Ricardo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Baston, Mariela. Inserm; Francia
Fil: Valacco, Maria Pia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Moreno, Silvia Margarita. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina
Fil: Lopez, Frederic. Inserm; Francia
Fil: Neira, Jose Luis. Universidad Miguel Hernandez; España
Fil: Dagorn, Juan Charles. Inserm; Francia
Fil: Iovanna, Juan Lucio. Inserm; Francia - Materia
-
P8
Msl1
Dna Repair
Hat
Yeast Two-Hybrid Screening
Tp53bp1 - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/28429
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p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damageGironella, MeritxellMalicet, CedricCano, CarlaSandi, Maria JoseHamidi, TewficNeme Tauil, Ricardo MartinBaston, MarielaValacco, Maria PiaMoreno, Silvia MargaritaLopez, FredericNeira, Jose LuisDagorn, Juan CharlesIovanna, Juan LucioP8Msl1Dna RepairHatYeast Two-Hybrid ScreeningTp53bp1https://purl.org/becyt/ford/1.6https://purl.org/becyt/ford/1The stress protein p8 is a small, highly basic, unfolded, and multifunctional protein. We have previously shown that most of its functions are exerted through interactions with other proteins, whose activities are thereby enhanced or repressed. In this work we describe another example of such mechanism, by which p8 binds and negatively regulates MSL1, a histone acetyl transferase (HAT)-associated protein, which in turn binds the DNA-damage-associated 53BP1 protein to facilitate DNA repair following DNA gamma-irradiation. Contrary to the HAT-associated activity, MSL1-dependent DNA-repair activity is almost completely dependent on 53BP1 expression. The picture that has emerged from our findings is that 53BP1 could be a scaffold that gets the HAT MSL1-dependent DNA-repair activity to the sites of DNA damage. Finally, we also found that, although p8 expression is transiently activated after gamma-irradiation, it is eventually submitted to sustained down-regulation, presumably to allow development of MSL1-associated DNA-repair activity. We conclude that interaction of MSL1 with 53BP1 brings MSL1-dependent HAT activity to the vicinity of damaged DNA. MSL1-dependent HAT activity, which is negatively regulated by the stress protein p8, induces chromatin remodeling and relaxation allowing access to DNA of the repair machineryFil: Gironella, Meritxell. Inserm; Francia. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas; EspañaFil: Malicet, Cedric. Inserm; FranciaFil: Cano, Carla. Inserm; FranciaFil: Sandi, Maria Jose. Inserm; FranciaFil: Hamidi, Tewfic. Inserm; FranciaFil: Neme Tauil, Ricardo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Baston, Mariela. Inserm; FranciaFil: Valacco, Maria Pia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Moreno, Silvia Margarita. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; ArgentinaFil: Lopez, Frederic. Inserm; FranciaFil: Neira, Jose Luis. Universidad Miguel Hernandez; EspañaFil: Dagorn, Juan Charles. Inserm; FranciaFil: Iovanna, Juan Lucio. Inserm; FranciaWiley2009-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/28429Gironella, Meritxell; Malicet, Cedric; Cano, Carla; Sandi, Maria Jose; Hamidi, Tewfic; et al.; p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage; Wiley; Journal of Cellular Physiology; 221; 3; 12-2009; 594-6020021-95411097-4652CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/jcp.21889info:eu-repo/semantics/altIdentifier/doi/10.1002/jcp.21889info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-22T11:03:13Zoai:ri.conicet.gov.ar:11336/28429instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-22 11:03:14.119CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage |
title |
p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage |
spellingShingle |
p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage Gironella, Meritxell P8 Msl1 Dna Repair Hat Yeast Two-Hybrid Screening Tp53bp1 |
title_short |
p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage |
title_full |
p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage |
title_fullStr |
p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage |
title_full_unstemmed |
p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage |
title_sort |
p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage |
dc.creator.none.fl_str_mv |
Gironella, Meritxell Malicet, Cedric Cano, Carla Sandi, Maria Jose Hamidi, Tewfic Neme Tauil, Ricardo Martin Baston, Mariela Valacco, Maria Pia Moreno, Silvia Margarita Lopez, Frederic Neira, Jose Luis Dagorn, Juan Charles Iovanna, Juan Lucio |
author |
Gironella, Meritxell |
author_facet |
Gironella, Meritxell Malicet, Cedric Cano, Carla Sandi, Maria Jose Hamidi, Tewfic Neme Tauil, Ricardo Martin Baston, Mariela Valacco, Maria Pia Moreno, Silvia Margarita Lopez, Frederic Neira, Jose Luis Dagorn, Juan Charles Iovanna, Juan Lucio |
author_role |
author |
author2 |
Malicet, Cedric Cano, Carla Sandi, Maria Jose Hamidi, Tewfic Neme Tauil, Ricardo Martin Baston, Mariela Valacco, Maria Pia Moreno, Silvia Margarita Lopez, Frederic Neira, Jose Luis Dagorn, Juan Charles Iovanna, Juan Lucio |
author2_role |
author author author author author author author author author author author author |
dc.subject.none.fl_str_mv |
P8 Msl1 Dna Repair Hat Yeast Two-Hybrid Screening Tp53bp1 |
topic |
P8 Msl1 Dna Repair Hat Yeast Two-Hybrid Screening Tp53bp1 |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.6 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
The stress protein p8 is a small, highly basic, unfolded, and multifunctional protein. We have previously shown that most of its functions are exerted through interactions with other proteins, whose activities are thereby enhanced or repressed. In this work we describe another example of such mechanism, by which p8 binds and negatively regulates MSL1, a histone acetyl transferase (HAT)-associated protein, which in turn binds the DNA-damage-associated 53BP1 protein to facilitate DNA repair following DNA gamma-irradiation. Contrary to the HAT-associated activity, MSL1-dependent DNA-repair activity is almost completely dependent on 53BP1 expression. The picture that has emerged from our findings is that 53BP1 could be a scaffold that gets the HAT MSL1-dependent DNA-repair activity to the sites of DNA damage. Finally, we also found that, although p8 expression is transiently activated after gamma-irradiation, it is eventually submitted to sustained down-regulation, presumably to allow development of MSL1-associated DNA-repair activity. We conclude that interaction of MSL1 with 53BP1 brings MSL1-dependent HAT activity to the vicinity of damaged DNA. MSL1-dependent HAT activity, which is negatively regulated by the stress protein p8, induces chromatin remodeling and relaxation allowing access to DNA of the repair machinery Fil: Gironella, Meritxell. Inserm; Francia. Centro de Investigación Biomédica en Red de Enfermedades Hepáticas y Digestivas; España Fil: Malicet, Cedric. Inserm; Francia Fil: Cano, Carla. Inserm; Francia Fil: Sandi, Maria Jose. Inserm; Francia Fil: Hamidi, Tewfic. Inserm; Francia Fil: Neme Tauil, Ricardo Martin. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina Fil: Baston, Mariela. Inserm; Francia Fil: Valacco, Maria Pia. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina Fil: Moreno, Silvia Margarita. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Ciudad Universitaria. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales. Universidad de Buenos Aires. Facultad de Ciencias Exactas y Naturales. Instituto de Química Biológica de la Facultad de Ciencias Exactas y Naturales; Argentina Fil: Lopez, Frederic. Inserm; Francia Fil: Neira, Jose Luis. Universidad Miguel Hernandez; España Fil: Dagorn, Juan Charles. Inserm; Francia Fil: Iovanna, Juan Lucio. Inserm; Francia |
description |
The stress protein p8 is a small, highly basic, unfolded, and multifunctional protein. We have previously shown that most of its functions are exerted through interactions with other proteins, whose activities are thereby enhanced or repressed. In this work we describe another example of such mechanism, by which p8 binds and negatively regulates MSL1, a histone acetyl transferase (HAT)-associated protein, which in turn binds the DNA-damage-associated 53BP1 protein to facilitate DNA repair following DNA gamma-irradiation. Contrary to the HAT-associated activity, MSL1-dependent DNA-repair activity is almost completely dependent on 53BP1 expression. The picture that has emerged from our findings is that 53BP1 could be a scaffold that gets the HAT MSL1-dependent DNA-repair activity to the sites of DNA damage. Finally, we also found that, although p8 expression is transiently activated after gamma-irradiation, it is eventually submitted to sustained down-regulation, presumably to allow development of MSL1-associated DNA-repair activity. We conclude that interaction of MSL1 with 53BP1 brings MSL1-dependent HAT activity to the vicinity of damaged DNA. MSL1-dependent HAT activity, which is negatively regulated by the stress protein p8, induces chromatin remodeling and relaxation allowing access to DNA of the repair machinery |
publishDate |
2009 |
dc.date.none.fl_str_mv |
2009-12 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/28429 Gironella, Meritxell; Malicet, Cedric; Cano, Carla; Sandi, Maria Jose; Hamidi, Tewfic; et al.; p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage; Wiley; Journal of Cellular Physiology; 221; 3; 12-2009; 594-602 0021-9541 1097-4652 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/28429 |
identifier_str_mv |
Gironella, Meritxell; Malicet, Cedric; Cano, Carla; Sandi, Maria Jose; Hamidi, Tewfic; et al.; p8/nupr1 regulates DNA-repair activity after double-strand gamma irradiation-induced DNA damage; Wiley; Journal of Cellular Physiology; 221; 3; 12-2009; 594-602 0021-9541 1097-4652 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://onlinelibrary.wiley.com/doi/10.1002/jcp.21889 info:eu-repo/semantics/altIdentifier/doi/10.1002/jcp.21889 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Wiley |
publisher.none.fl_str_mv |
Wiley |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1846781260294258688 |
score |
13.199325 |