Tp53 polymorfhism codon 72 in oral cancer and oral potentially malignant disorders in argentinean patients
- Autores
- Zárate, Ana María; Secchi, Dante Gustavo; Carrica, Victoriano Andrés; Barra, José Luis; Brunotto, Mabel
- Año de publicación
- 2013
- Idioma
- inglés
- Tipo de recurso
- documento de conferencia
- Estado
- versión publicada
- Descripción
- Fil: Zárate, Ana María. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Biología Celular A; Argentina.
Fil: Secchi, Dante Gustavo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina.
Fil: Carrica, Victoriano Andrés. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina.
Fil: Barra, José Luis. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento Química Biológica; Argentina.
Fil: Brunotto, Mabel. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Biología Celular A; Argentina.
The tumor suppressor gene presents a common polymorphism at codon 72, encoding proline or arginine. These variants could modify biological functions and are related to geographic latitude. Purpose: Our purpose was to evaluate the prevalence and possible relationship to both alleles with oral carcinoma (Ca), oral potentially malignant disorders (OPMD) or other stomatological (Con) lesions in adult patients. Material and Methods: Cross-sectional study was designed, the 43 patients, both genders, aged 36 to 80 years were recruited at Dentistry Faculty of Córdoba, Universidad Nacional de Córdoba-Argentina. The detection of polymorphism at codon 72 was performed with the allele specific PCR. Results: We observed 33% of OPMD, 28% of Ca and 39% of Con; and the male was presented higher percentage of Ca (35%) in relation to female with Ca (25%), however the inverse relationship was observed with patients diagnosed with OPMD. The homozygous or heterozygous status are high significant (p=0.000) associated with study lesions. The only patients with Ca (36%) and OPMD (30%) lesions are presented heterozygous status. And the presence of R72 allele was higher in Con patients (80%). Conclusions: therefore, evidence of association among homozygosity / heterozygosity for p53 arginine or proline and premalignant and malignant lesions in our population sample. It is known that the accumulated number of variants on the same chromosome could be additive or multiplicative for changes in function of p53 gene and leading to increase the malignity risk.
http://www.oraloncology.com
Fil: Zárate, Ana María. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Biología Celular A; Argentina.
Fil: Secchi, Dante Gustavo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina.
Fil: Carrica, Victoriano Andrés. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina.
Fil: Barra, José Luis. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento Química Biológica; Argentina.
Fil: Brunotto, Mabel. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Biología Celular A; Argentina.
Otras Ciencias de la Salud - Materia
-
Tp53
Polymorphism
Oral lesions - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- Repositorio
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- Institución
- Universidad Nacional de Córdoba
- OAI Identificador
- oai:rdu.unc.edu.ar:11086/558356
Ver los metadatos del registro completo
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Tp53 polymorfhism codon 72 in oral cancer and oral potentially malignant disorders in argentinean patientsZárate, Ana MaríaSecchi, Dante GustavoCarrica, Victoriano AndrésBarra, José LuisBrunotto, MabelTp53PolymorphismOral lesionsFil: Zárate, Ana María. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Biología Celular A; Argentina.Fil: Secchi, Dante Gustavo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina.Fil: Carrica, Victoriano Andrés. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina.Fil: Barra, José Luis. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento Química Biológica; Argentina.Fil: Brunotto, Mabel. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Biología Celular A; Argentina.The tumor suppressor gene presents a common polymorphism at codon 72, encoding proline or arginine. These variants could modify biological functions and are related to geographic latitude. Purpose: Our purpose was to evaluate the prevalence and possible relationship to both alleles with oral carcinoma (Ca), oral potentially malignant disorders (OPMD) or other stomatological (Con) lesions in adult patients. Material and Methods: Cross-sectional study was designed, the 43 patients, both genders, aged 36 to 80 years were recruited at Dentistry Faculty of Córdoba, Universidad Nacional de Córdoba-Argentina. The detection of polymorphism at codon 72 was performed with the allele specific PCR. Results: We observed 33% of OPMD, 28% of Ca and 39% of Con; and the male was presented higher percentage of Ca (35%) in relation to female with Ca (25%), however the inverse relationship was observed with patients diagnosed with OPMD. The homozygous or heterozygous status are high significant (p=0.000) associated with study lesions. The only patients with Ca (36%) and OPMD (30%) lesions are presented heterozygous status. And the presence of R72 allele was higher in Con patients (80%). Conclusions: therefore, evidence of association among homozygosity / heterozygosity for p53 arginine or proline and premalignant and malignant lesions in our population sample. It is known that the accumulated number of variants on the same chromosome could be additive or multiplicative for changes in function of p53 gene and leading to increase the malignity risk.http://www.oraloncology.comFil: Zárate, Ana María. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Biología Celular A; Argentina.Fil: Secchi, Dante Gustavo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina.Fil: Carrica, Victoriano Andrés. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina.Fil: Barra, José Luis. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento Química Biológica; Argentina.Fil: Brunotto, Mabel. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Biología Celular A; Argentina.Otras Ciencias de la Salud2013info:eu-repo/semantics/conferenceObjectinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_5794info:ar-repo/semantics/documentoDeConferenciaapplication/pdfhttp://hdl.handle.net/11086/558356enginfo:eu-repo/semantics/openAccessreponame:Repositorio Digital Universitario (UNC)instname:Universidad Nacional de Córdobainstacron:UNC2025-10-16T09:29:56Zoai:rdu.unc.edu.ar:11086/558356Institucionalhttps://rdu.unc.edu.ar/Universidad públicaNo correspondehttp://rdu.unc.edu.ar/oai/snrdoca.unc@gmail.comArgentinaNo correspondeNo correspondeNo correspondeopendoar:25722025-10-16 09:29:56.461Repositorio Digital Universitario (UNC) - Universidad Nacional de Córdobafalse |
| dc.title.none.fl_str_mv |
Tp53 polymorfhism codon 72 in oral cancer and oral potentially malignant disorders in argentinean patients |
| title |
Tp53 polymorfhism codon 72 in oral cancer and oral potentially malignant disorders in argentinean patients |
| spellingShingle |
Tp53 polymorfhism codon 72 in oral cancer and oral potentially malignant disorders in argentinean patients Zárate, Ana María Tp53 Polymorphism Oral lesions |
| title_short |
Tp53 polymorfhism codon 72 in oral cancer and oral potentially malignant disorders in argentinean patients |
| title_full |
Tp53 polymorfhism codon 72 in oral cancer and oral potentially malignant disorders in argentinean patients |
| title_fullStr |
Tp53 polymorfhism codon 72 in oral cancer and oral potentially malignant disorders in argentinean patients |
| title_full_unstemmed |
Tp53 polymorfhism codon 72 in oral cancer and oral potentially malignant disorders in argentinean patients |
| title_sort |
Tp53 polymorfhism codon 72 in oral cancer and oral potentially malignant disorders in argentinean patients |
| dc.creator.none.fl_str_mv |
Zárate, Ana María Secchi, Dante Gustavo Carrica, Victoriano Andrés Barra, José Luis Brunotto, Mabel |
| author |
Zárate, Ana María |
| author_facet |
Zárate, Ana María Secchi, Dante Gustavo Carrica, Victoriano Andrés Barra, José Luis Brunotto, Mabel |
| author_role |
author |
| author2 |
Secchi, Dante Gustavo Carrica, Victoriano Andrés Barra, José Luis Brunotto, Mabel |
| author2_role |
author author author author |
| dc.subject.none.fl_str_mv |
Tp53 Polymorphism Oral lesions |
| topic |
Tp53 Polymorphism Oral lesions |
| dc.description.none.fl_txt_mv |
Fil: Zárate, Ana María. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Biología Celular A; Argentina. Fil: Secchi, Dante Gustavo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina. Fil: Carrica, Victoriano Andrés. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina. Fil: Barra, José Luis. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento Química Biológica; Argentina. Fil: Brunotto, Mabel. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Biología Celular A; Argentina. The tumor suppressor gene presents a common polymorphism at codon 72, encoding proline or arginine. These variants could modify biological functions and are related to geographic latitude. Purpose: Our purpose was to evaluate the prevalence and possible relationship to both alleles with oral carcinoma (Ca), oral potentially malignant disorders (OPMD) or other stomatological (Con) lesions in adult patients. Material and Methods: Cross-sectional study was designed, the 43 patients, both genders, aged 36 to 80 years were recruited at Dentistry Faculty of Córdoba, Universidad Nacional de Córdoba-Argentina. The detection of polymorphism at codon 72 was performed with the allele specific PCR. Results: We observed 33% of OPMD, 28% of Ca and 39% of Con; and the male was presented higher percentage of Ca (35%) in relation to female with Ca (25%), however the inverse relationship was observed with patients diagnosed with OPMD. The homozygous or heterozygous status are high significant (p=0.000) associated with study lesions. The only patients with Ca (36%) and OPMD (30%) lesions are presented heterozygous status. And the presence of R72 allele was higher in Con patients (80%). Conclusions: therefore, evidence of association among homozygosity / heterozygosity for p53 arginine or proline and premalignant and malignant lesions in our population sample. It is known that the accumulated number of variants on the same chromosome could be additive or multiplicative for changes in function of p53 gene and leading to increase the malignity risk. http://www.oraloncology.com Fil: Zárate, Ana María. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Biología Celular A; Argentina. Fil: Secchi, Dante Gustavo. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina. Fil: Carrica, Victoriano Andrés. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra de Estomatología A; Argentina. Fil: Barra, José Luis. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Departamento Química Biológica; Argentina. Fil: Brunotto, Mabel. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Biología Celular A; Argentina. Otras Ciencias de la Salud |
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Fil: Zárate, Ana María. Universidad Nacional de Córdoba. Facultad de Odontología. Cátedra Biología Celular A; Argentina. |
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2013 |
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2013 |
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