Risedronate metal complexes potentially active against Chagas disease

Autores
Demoro, Bruno; Caruso, Francesco; Rossi, Miriam; Benítez, Diego; Gonzalez, Mercedes; Cerecetto, Hugo; Parajón Costa, Beatriz Susana; Castiglioni, Jorge; Galizzi. Melina; Docampo, Roberto; Otero, Lucía; Gambino, Dinorah
Año de publicación
2010
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In the search for new metal-based drugs for the treatment of Chagas disease, the most widespread  Latin American parasitic disease, novel complexes of the bioactive ligand risedronate (Ris, (1-hydroxy-1-phosphono-2-pyridin-3-yl-ethyl)phosphonate), [MII(Ris)2]•4H2O, where M = Cu, Co, Mn and Ni, and [NiII(Ris)2(H2O)2]•H2O were synthesized and characterized by using analytical measurements, thermogravimetric analyses, cyclic voltammetry and infrared and Raman spectroscopies. Crystal structures of [CuII(Ris)2]•4H2O and [NiII(Ris)2(H2O)2]•H2O were solved by single crystal X-ray diffraction methods. The complexes, as well as the free ligand, were evaluated in vitro against epimastigotes and intracellular amastigotes of the parasite Trypanosoma cruzi, causative agent of Chagas disease. Results demonstrated that the coordination of risedronate to different metal ions improved the antiproliferative effect against Trypanosoma cruzi, exhibiting growth inhibition values against the intracellular amastigotes ranging the low micromolar levels. In addition, this strong activity could be related to high inhibition of farnesyl diphosphate synthase enzyme. On the other hand, protein interaction studies showed that all the complexes strongly interact with albumin thus providing a suitable means of transporting them to tissues in vivo.
Fil: Demoro, Bruno. Universidad de la República; Uruguay
Fil: Caruso, Francesco. Istituto Chimica Biomolecolare; Italia
Fil: Rossi, Miriam. Vassar College. Department of Chemistry; Estados Unidos
Fil: Benítez, Diego. Universidad de la República; Uruguay
Fil: Gonzalez, Mercedes. Universidad de la República; Uruguay
Fil: Cerecetto, Hugo. Universidad de la República; Uruguay
Fil: Parajón Costa, Beatriz Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: Castiglioni, Jorge. Universidad de la República; Uruguay
Fil: Galizzi. Melina. University of Georgia; Estados Unidos
Fil: Docampo, Roberto. University of Georgia; Estados Unidos
Fil: Otero, Lucía. Universidad de la República; Uruguay
Fil: Gambino, Dinorah. Universidad de la República; Uruguay
Materia
CHAGAS DISEASE
TRYPANOSOMA CRUZI
RISEDRONATE METAL COMPLEXES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/103520
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Risedronate metal complexes potentially active against Chagas diseaseDemoro, BrunoCaruso, FrancescoRossi, MiriamBenítez, DiegoGonzalez, MercedesCerecetto, HugoParajón Costa, Beatriz SusanaCastiglioni, JorgeGalizzi. MelinaDocampo, RobertoOtero, LucíaGambino, DinorahCHAGAS DISEASETRYPANOSOMA CRUZIRISEDRONATE METAL COMPLEXEShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1In the search for new metal-based drugs for the treatment of Chagas disease, the most widespread  Latin American parasitic disease, novel complexes of the bioactive ligand risedronate (Ris, (1-hydroxy-1-phosphono-2-pyridin-3-yl-ethyl)phosphonate), [MII(Ris)2]•4H2O, where M = Cu, Co, Mn and Ni, and [NiII(Ris)2(H2O)2]•H2O were synthesized and characterized by using analytical measurements, thermogravimetric analyses, cyclic voltammetry and infrared and Raman spectroscopies. Crystal structures of [CuII(Ris)2]•4H2O and [NiII(Ris)2(H2O)2]•H2O were solved by single crystal X-ray diffraction methods. The complexes, as well as the free ligand, were evaluated in vitro against epimastigotes and intracellular amastigotes of the parasite Trypanosoma cruzi, causative agent of Chagas disease. Results demonstrated that the coordination of risedronate to different metal ions improved the antiproliferative effect against Trypanosoma cruzi, exhibiting growth inhibition values against the intracellular amastigotes ranging the low micromolar levels. In addition, this strong activity could be related to high inhibition of farnesyl diphosphate synthase enzyme. On the other hand, protein interaction studies showed that all the complexes strongly interact with albumin thus providing a suitable means of transporting them to tissues in vivo.Fil: Demoro, Bruno. Universidad de la República; UruguayFil: Caruso, Francesco. Istituto Chimica Biomolecolare; ItaliaFil: Rossi, Miriam. Vassar College. Department of Chemistry; Estados UnidosFil: Benítez, Diego. Universidad de la República; UruguayFil: Gonzalez, Mercedes. Universidad de la República; UruguayFil: Cerecetto, Hugo. Universidad de la República; UruguayFil: Parajón Costa, Beatriz Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; ArgentinaFil: Castiglioni, Jorge. Universidad de la República; UruguayFil: Galizzi. Melina. University of Georgia; Estados UnidosFil: Docampo, Roberto. University of Georgia; Estados UnidosFil: Otero, Lucía. Universidad de la República; UruguayFil: Gambino, Dinorah. Universidad de la República; UruguayElsevier Science Inc2010-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/103520Demoro, Bruno; Caruso, Francesco; Rossi, Miriam; Benítez, Diego; Gonzalez, Mercedes; et al.; Risedronate metal complexes potentially active against Chagas disease; Elsevier Science Inc; Journal of Inorganic Biochemistry; 104; 12; 12-2010; 1252-12580162-0134CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0162013410001881?via%3Dihubinfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jinorgbio.2010.08.004info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595630/info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T10:47:23Zoai:ri.conicet.gov.ar:11336/103520instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 10:47:23.402CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Risedronate metal complexes potentially active against Chagas disease
title Risedronate metal complexes potentially active against Chagas disease
spellingShingle Risedronate metal complexes potentially active against Chagas disease
Demoro, Bruno
CHAGAS DISEASE
TRYPANOSOMA CRUZI
RISEDRONATE METAL COMPLEXES
title_short Risedronate metal complexes potentially active against Chagas disease
title_full Risedronate metal complexes potentially active against Chagas disease
title_fullStr Risedronate metal complexes potentially active against Chagas disease
title_full_unstemmed Risedronate metal complexes potentially active against Chagas disease
title_sort Risedronate metal complexes potentially active against Chagas disease
dc.creator.none.fl_str_mv Demoro, Bruno
Caruso, Francesco
Rossi, Miriam
Benítez, Diego
Gonzalez, Mercedes
Cerecetto, Hugo
Parajón Costa, Beatriz Susana
Castiglioni, Jorge
Galizzi. Melina
Docampo, Roberto
Otero, Lucía
Gambino, Dinorah
author Demoro, Bruno
author_facet Demoro, Bruno
Caruso, Francesco
Rossi, Miriam
Benítez, Diego
Gonzalez, Mercedes
Cerecetto, Hugo
Parajón Costa, Beatriz Susana
Castiglioni, Jorge
Galizzi. Melina
Docampo, Roberto
Otero, Lucía
Gambino, Dinorah
author_role author
author2 Caruso, Francesco
Rossi, Miriam
Benítez, Diego
Gonzalez, Mercedes
Cerecetto, Hugo
Parajón Costa, Beatriz Susana
Castiglioni, Jorge
Galizzi. Melina
Docampo, Roberto
Otero, Lucía
Gambino, Dinorah
author2_role author
author
author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv CHAGAS DISEASE
TRYPANOSOMA CRUZI
RISEDRONATE METAL COMPLEXES
topic CHAGAS DISEASE
TRYPANOSOMA CRUZI
RISEDRONATE METAL COMPLEXES
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In the search for new metal-based drugs for the treatment of Chagas disease, the most widespread  Latin American parasitic disease, novel complexes of the bioactive ligand risedronate (Ris, (1-hydroxy-1-phosphono-2-pyridin-3-yl-ethyl)phosphonate), [MII(Ris)2]•4H2O, where M = Cu, Co, Mn and Ni, and [NiII(Ris)2(H2O)2]•H2O were synthesized and characterized by using analytical measurements, thermogravimetric analyses, cyclic voltammetry and infrared and Raman spectroscopies. Crystal structures of [CuII(Ris)2]•4H2O and [NiII(Ris)2(H2O)2]•H2O were solved by single crystal X-ray diffraction methods. The complexes, as well as the free ligand, were evaluated in vitro against epimastigotes and intracellular amastigotes of the parasite Trypanosoma cruzi, causative agent of Chagas disease. Results demonstrated that the coordination of risedronate to different metal ions improved the antiproliferative effect against Trypanosoma cruzi, exhibiting growth inhibition values against the intracellular amastigotes ranging the low micromolar levels. In addition, this strong activity could be related to high inhibition of farnesyl diphosphate synthase enzyme. On the other hand, protein interaction studies showed that all the complexes strongly interact with albumin thus providing a suitable means of transporting them to tissues in vivo.
Fil: Demoro, Bruno. Universidad de la República; Uruguay
Fil: Caruso, Francesco. Istituto Chimica Biomolecolare; Italia
Fil: Rossi, Miriam. Vassar College. Department of Chemistry; Estados Unidos
Fil: Benítez, Diego. Universidad de la República; Uruguay
Fil: Gonzalez, Mercedes. Universidad de la República; Uruguay
Fil: Cerecetto, Hugo. Universidad de la República; Uruguay
Fil: Parajón Costa, Beatriz Susana. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Química Inorgánica "Dr. Pedro J. Aymonino". Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Centro de Química Inorgánica "Dr. Pedro J. Aymonino"; Argentina
Fil: Castiglioni, Jorge. Universidad de la República; Uruguay
Fil: Galizzi. Melina. University of Georgia; Estados Unidos
Fil: Docampo, Roberto. University of Georgia; Estados Unidos
Fil: Otero, Lucía. Universidad de la República; Uruguay
Fil: Gambino, Dinorah. Universidad de la República; Uruguay
description In the search for new metal-based drugs for the treatment of Chagas disease, the most widespread  Latin American parasitic disease, novel complexes of the bioactive ligand risedronate (Ris, (1-hydroxy-1-phosphono-2-pyridin-3-yl-ethyl)phosphonate), [MII(Ris)2]•4H2O, where M = Cu, Co, Mn and Ni, and [NiII(Ris)2(H2O)2]•H2O were synthesized and characterized by using analytical measurements, thermogravimetric analyses, cyclic voltammetry and infrared and Raman spectroscopies. Crystal structures of [CuII(Ris)2]•4H2O and [NiII(Ris)2(H2O)2]•H2O were solved by single crystal X-ray diffraction methods. The complexes, as well as the free ligand, were evaluated in vitro against epimastigotes and intracellular amastigotes of the parasite Trypanosoma cruzi, causative agent of Chagas disease. Results demonstrated that the coordination of risedronate to different metal ions improved the antiproliferative effect against Trypanosoma cruzi, exhibiting growth inhibition values against the intracellular amastigotes ranging the low micromolar levels. In addition, this strong activity could be related to high inhibition of farnesyl diphosphate synthase enzyme. On the other hand, protein interaction studies showed that all the complexes strongly interact with albumin thus providing a suitable means of transporting them to tissues in vivo.
publishDate 2010
dc.date.none.fl_str_mv 2010-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/103520
Demoro, Bruno; Caruso, Francesco; Rossi, Miriam; Benítez, Diego; Gonzalez, Mercedes; et al.; Risedronate metal complexes potentially active against Chagas disease; Elsevier Science Inc; Journal of Inorganic Biochemistry; 104; 12; 12-2010; 1252-1258
0162-0134
CONICET Digital
CONICET
url http://hdl.handle.net/11336/103520
identifier_str_mv Demoro, Bruno; Caruso, Francesco; Rossi, Miriam; Benítez, Diego; Gonzalez, Mercedes; et al.; Risedronate metal complexes potentially active against Chagas disease; Elsevier Science Inc; Journal of Inorganic Biochemistry; 104; 12; 12-2010; 1252-1258
0162-0134
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0162013410001881?via%3Dihub
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jinorgbio.2010.08.004
info:eu-repo/semantics/altIdentifier/url/https://www.ncbi.nlm.nih.gov/pmc/articles/PMC5595630/
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Inc
publisher.none.fl_str_mv Elsevier Science Inc
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.001348

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