Synthesis and characterization of new ruthenium complexes with active ligands against Chagas' disease

Autores
Otero, Lucía; Noblia, Pabla; Gambino, Dinorah; Cerecetto, Hugo; González, Mercedes; Ellena, Javier A.; Piro, Oscar Enrique
Año de publicación
2003
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Chagas' disease, considered incurable, is a major third world parasitosis that affects millions of people in Latin America. Previous work has shown that ruthenium clotrimazole complexes are more active against Trypanosoma cruzi, causative agent of Chagas' disease, than the corresponding free ligand. In this work, the synthesis and characterization of a series of new Ru(II) complexes with different antitrypanosomal active compounds is presented. Complexes of general formulae [RuIICl2(dmso)2L], where dmso=dimethylsulfoxide and L=5-nitro-2-furaldehyde semicarbazone (L1), N4-n-butyl-5-nitro-2-furaldehyde semicarbazone (L2) or 3-(5-nitrofuryl)acroleine semicarbazone (L3), were prepared in good yields by reaction of [RuIICl2(dmso)4] with L in ethanol or toluene solutions. Complexes were characterized by elemental analyses and electronic, FTIR, 1H and 13C NMR spectroscopies. Crystal and molecular structures of [RuCl2(dmso)2L1] and [RuCl2(dmso)2L2] were determined by X-ray diffraction methods. In both crystals the ruthenium metal atom is in a quite similar elongated octahedral environment, equatorially coordinated to the semicarbazone molecule, acting as a bidentate ligand through its azomethynic nitrogen and carbonylic oxygen atoms. The sixfold coordination is completed with the sulfur atoms of two dimethylsulfoxide ligands at cis positions and two chlorine ions at the axial positions. The proposed formula for L3 complex was supported by FTIR, NMR and theoretical studies. NOE-NMR experiments allowed to assign L3 spatial distribution in the complex. © 2002 Elsevier Science B.V. All rights reserved.
Fil: Otero, Lucía. Universidad de la República; Uruguay
Fil: Noblia, Pabla. Universidad de la República; Uruguay
Fil: Gambino, Dinorah. Universidad de la República; Uruguay
Fil: Cerecetto, Hugo. Universidad de la República; Uruguay
Fil: González, Mercedes. Universidad de la República; Uruguay
Fil: Ellena, Javier A.. Universidade de Sao Paulo; Brasil
Fil: Piro, Oscar Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Materia
Chagas' Disease Chemotherapy
Ruthenium Complexes
Semicarbazone Complexes
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/72466
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/72466
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Synthesis and characterization of new ruthenium complexes with active ligands against Chagas' diseaseOtero, LucíaNoblia, PablaGambino, DinorahCerecetto, HugoGonzález, MercedesEllena, Javier A.Piro, Oscar EnriqueChagas' Disease ChemotherapyRuthenium ComplexesSemicarbazone Complexeshttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Chagas' disease, considered incurable, is a major third world parasitosis that affects millions of people in Latin America. Previous work has shown that ruthenium clotrimazole complexes are more active against Trypanosoma cruzi, causative agent of Chagas' disease, than the corresponding free ligand. In this work, the synthesis and characterization of a series of new Ru(II) complexes with different antitrypanosomal active compounds is presented. Complexes of general formulae [RuIICl2(dmso)2L], where dmso=dimethylsulfoxide and L=5-nitro-2-furaldehyde semicarbazone (L1), N4-n-butyl-5-nitro-2-furaldehyde semicarbazone (L2) or 3-(5-nitrofuryl)acroleine semicarbazone (L3), were prepared in good yields by reaction of [RuIICl2(dmso)4] with L in ethanol or toluene solutions. Complexes were characterized by elemental analyses and electronic, FTIR, 1H and 13C NMR spectroscopies. Crystal and molecular structures of [RuCl2(dmso)2L1] and [RuCl2(dmso)2L2] were determined by X-ray diffraction methods. In both crystals the ruthenium metal atom is in a quite similar elongated octahedral environment, equatorially coordinated to the semicarbazone molecule, acting as a bidentate ligand through its azomethynic nitrogen and carbonylic oxygen atoms. The sixfold coordination is completed with the sulfur atoms of two dimethylsulfoxide ligands at cis positions and two chlorine ions at the axial positions. The proposed formula for L3 complex was supported by FTIR, NMR and theoretical studies. NOE-NMR experiments allowed to assign L3 spatial distribution in the complex. © 2002 Elsevier Science B.V. All rights reserved.Fil: Otero, Lucía. Universidad de la República; UruguayFil: Noblia, Pabla. Universidad de la República; UruguayFil: Gambino, Dinorah. Universidad de la República; UruguayFil: Cerecetto, Hugo. Universidad de la República; UruguayFil: González, Mercedes. Universidad de la República; UruguayFil: Ellena, Javier A.. Universidade de Sao Paulo; BrasilFil: Piro, Oscar Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaElsevier Science Sa2003-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/72466Otero, Lucía; Noblia, Pabla; Gambino, Dinorah; Cerecetto, Hugo; González, Mercedes; et al.; Synthesis and characterization of new ruthenium complexes with active ligands against Chagas' disease; Elsevier Science Sa; Inorganica Chimica Acta; 344; 2-2003; 85-940020-1693CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/S0020-1693(02)01277-Xinfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S002016930201277Xinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T10:54:00Zoai:ri.conicet.gov.ar:11336/72466instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 10:54:00.388CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Synthesis and characterization of new ruthenium complexes with active ligands against Chagas' disease
title Synthesis and characterization of new ruthenium complexes with active ligands against Chagas' disease
spellingShingle Synthesis and characterization of new ruthenium complexes with active ligands against Chagas' disease
Otero, Lucía
Chagas' Disease Chemotherapy
Ruthenium Complexes
Semicarbazone Complexes
title_short Synthesis and characterization of new ruthenium complexes with active ligands against Chagas' disease
title_full Synthesis and characterization of new ruthenium complexes with active ligands against Chagas' disease
title_fullStr Synthesis and characterization of new ruthenium complexes with active ligands against Chagas' disease
title_full_unstemmed Synthesis and characterization of new ruthenium complexes with active ligands against Chagas' disease
title_sort Synthesis and characterization of new ruthenium complexes with active ligands against Chagas' disease
dc.creator.none.fl_str_mv Otero, Lucía
Noblia, Pabla
Gambino, Dinorah
Cerecetto, Hugo
González, Mercedes
Ellena, Javier A.
Piro, Oscar Enrique
author Otero, Lucía
author_facet Otero, Lucía
Noblia, Pabla
Gambino, Dinorah
Cerecetto, Hugo
González, Mercedes
Ellena, Javier A.
Piro, Oscar Enrique
author_role author
author2 Noblia, Pabla
Gambino, Dinorah
Cerecetto, Hugo
González, Mercedes
Ellena, Javier A.
Piro, Oscar Enrique
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv Chagas' Disease Chemotherapy
Ruthenium Complexes
Semicarbazone Complexes
topic Chagas' Disease Chemotherapy
Ruthenium Complexes
Semicarbazone Complexes
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Chagas' disease, considered incurable, is a major third world parasitosis that affects millions of people in Latin America. Previous work has shown that ruthenium clotrimazole complexes are more active against Trypanosoma cruzi, causative agent of Chagas' disease, than the corresponding free ligand. In this work, the synthesis and characterization of a series of new Ru(II) complexes with different antitrypanosomal active compounds is presented. Complexes of general formulae [RuIICl2(dmso)2L], where dmso=dimethylsulfoxide and L=5-nitro-2-furaldehyde semicarbazone (L1), N4-n-butyl-5-nitro-2-furaldehyde semicarbazone (L2) or 3-(5-nitrofuryl)acroleine semicarbazone (L3), were prepared in good yields by reaction of [RuIICl2(dmso)4] with L in ethanol or toluene solutions. Complexes were characterized by elemental analyses and electronic, FTIR, 1H and 13C NMR spectroscopies. Crystal and molecular structures of [RuCl2(dmso)2L1] and [RuCl2(dmso)2L2] were determined by X-ray diffraction methods. In both crystals the ruthenium metal atom is in a quite similar elongated octahedral environment, equatorially coordinated to the semicarbazone molecule, acting as a bidentate ligand through its azomethynic nitrogen and carbonylic oxygen atoms. The sixfold coordination is completed with the sulfur atoms of two dimethylsulfoxide ligands at cis positions and two chlorine ions at the axial positions. The proposed formula for L3 complex was supported by FTIR, NMR and theoretical studies. NOE-NMR experiments allowed to assign L3 spatial distribution in the complex. © 2002 Elsevier Science B.V. All rights reserved.
Fil: Otero, Lucía. Universidad de la República; Uruguay
Fil: Noblia, Pabla. Universidad de la República; Uruguay
Fil: Gambino, Dinorah. Universidad de la República; Uruguay
Fil: Cerecetto, Hugo. Universidad de la República; Uruguay
Fil: González, Mercedes. Universidad de la República; Uruguay
Fil: Ellena, Javier A.. Universidade de Sao Paulo; Brasil
Fil: Piro, Oscar Enrique. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
description Chagas' disease, considered incurable, is a major third world parasitosis that affects millions of people in Latin America. Previous work has shown that ruthenium clotrimazole complexes are more active against Trypanosoma cruzi, causative agent of Chagas' disease, than the corresponding free ligand. In this work, the synthesis and characterization of a series of new Ru(II) complexes with different antitrypanosomal active compounds is presented. Complexes of general formulae [RuIICl2(dmso)2L], where dmso=dimethylsulfoxide and L=5-nitro-2-furaldehyde semicarbazone (L1), N4-n-butyl-5-nitro-2-furaldehyde semicarbazone (L2) or 3-(5-nitrofuryl)acroleine semicarbazone (L3), were prepared in good yields by reaction of [RuIICl2(dmso)4] with L in ethanol or toluene solutions. Complexes were characterized by elemental analyses and electronic, FTIR, 1H and 13C NMR spectroscopies. Crystal and molecular structures of [RuCl2(dmso)2L1] and [RuCl2(dmso)2L2] were determined by X-ray diffraction methods. In both crystals the ruthenium metal atom is in a quite similar elongated octahedral environment, equatorially coordinated to the semicarbazone molecule, acting as a bidentate ligand through its azomethynic nitrogen and carbonylic oxygen atoms. The sixfold coordination is completed with the sulfur atoms of two dimethylsulfoxide ligands at cis positions and two chlorine ions at the axial positions. The proposed formula for L3 complex was supported by FTIR, NMR and theoretical studies. NOE-NMR experiments allowed to assign L3 spatial distribution in the complex. © 2002 Elsevier Science B.V. All rights reserved.
publishDate 2003
dc.date.none.fl_str_mv 2003-02
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/72466
Otero, Lucía; Noblia, Pabla; Gambino, Dinorah; Cerecetto, Hugo; González, Mercedes; et al.; Synthesis and characterization of new ruthenium complexes with active ligands against Chagas' disease; Elsevier Science Sa; Inorganica Chimica Acta; 344; 2-2003; 85-94
0020-1693
CONICET Digital
CONICET
url http://hdl.handle.net/11336/72466
identifier_str_mv Otero, Lucía; Noblia, Pabla; Gambino, Dinorah; Cerecetto, Hugo; González, Mercedes; et al.; Synthesis and characterization of new ruthenium complexes with active ligands against Chagas' disease; Elsevier Science Sa; Inorganica Chimica Acta; 344; 2-2003; 85-94
0020-1693
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/S0020-1693(02)01277-X
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S002016930201277X
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science Sa
publisher.none.fl_str_mv Elsevier Science Sa
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.001348

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