Preliminary Evaluation of Median Lethal Concentrations of Stöber Silica Particles with Various Sizes and Surface Functionalities Towards Fibroblast Cells

Autores
Galindo Gonzalez, Cecilia; Alvarez, Gisela Solange; Camporotondi, Daniela Edhit; Foglia, María Lucía; Aimé, Carole; Diaz, Luis Eduardo; Coradin, Thibaud; Desimone, Martín Federico
Año de publicación
2014
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The application of silica particles in the biomedical field has experienced a great development in recent years, especially in the design of nanoparticles having homogeneous size, structure and amenable to specific grafting. In this way, it becomes possible to control the interaction of nanoparticles with cells in order to meet the requirements for desired applications. This work explores the cytotoxicity of silica particles of various sizes and surface functionality towards L929 fibroblast cells. In particular, the median lethal concentration of the different silica particles has been established. Preliminary investigations of silica nanoparticles prepared by the Stöber method with sizes ranging from 100 nm to 500 nm showed that the largest particles are less harmful for the cells. Moreover, cytotoxicity towards L929 fibroblasts was mainly observed for bare particles, whereas sulfonate-, amine- and thiol-grafted particles had less detrimental effects. This shows the key influence of particle surface curvature and chemistry on nanomaterials cytotoxicity.
Fil: Galindo Gonzalez, Cecilia. Universite Pierre et Marie Curie. Laboratoire de Chimie de la Matière; Francia. Universite de Paris VI; Francia
Fil: Alvarez, Gisela Solange. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Camporotondi, Daniela Edhit. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Foglia, María Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Aimé, Carole. Universite Pierre et Marie Curie. Laboratoire de Chimie de la Matière; Francia. Universite de Paris VI; Francia
Fil: Diaz, Luis Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Coradin, Thibaud. Universite Pierre et Marie Curie. Laboratoire de Chimie de la Matière; Francia. Universite de Paris VI; Francia
Fil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Materia
Median Lethal Concentrations
Silica Particles
Fibroblasts Cells
Cytotoxicity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/30673
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/30673
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Preliminary Evaluation of Median Lethal Concentrations of Stöber Silica Particles with Various Sizes and Surface Functionalities Towards Fibroblast CellsGalindo Gonzalez, CeciliaAlvarez, Gisela SolangeCamporotondi, Daniela EdhitFoglia, María LucíaAimé, CaroleDiaz, Luis EduardoCoradin, ThibaudDesimone, Martín FedericoMedian Lethal ConcentrationsSilica ParticlesFibroblasts CellsCytotoxicityhttps://purl.org/becyt/ford/2.10https://purl.org/becyt/ford/2The application of silica particles in the biomedical field has experienced a great development in recent years, especially in the design of nanoparticles having homogeneous size, structure and amenable to specific grafting. In this way, it becomes possible to control the interaction of nanoparticles with cells in order to meet the requirements for desired applications. This work explores the cytotoxicity of silica particles of various sizes and surface functionality towards L929 fibroblast cells. In particular, the median lethal concentration of the different silica particles has been established. Preliminary investigations of silica nanoparticles prepared by the Stöber method with sizes ranging from 100 nm to 500 nm showed that the largest particles are less harmful for the cells. Moreover, cytotoxicity towards L929 fibroblasts was mainly observed for bare particles, whereas sulfonate-, amine- and thiol-grafted particles had less detrimental effects. This shows the key influence of particle surface curvature and chemistry on nanomaterials cytotoxicity.Fil: Galindo Gonzalez, Cecilia. Universite Pierre et Marie Curie. Laboratoire de Chimie de la Matière; Francia. Universite de Paris VI; FranciaFil: Alvarez, Gisela Solange. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Camporotondi, Daniela Edhit. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Foglia, María Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Aimé, Carole. Universite Pierre et Marie Curie. Laboratoire de Chimie de la Matière; Francia. Universite de Paris VI; FranciaFil: Diaz, Luis Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaFil: Coradin, Thibaud. Universite Pierre et Marie Curie. Laboratoire de Chimie de la Matière; Francia. Universite de Paris VI; FranciaFil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; ArgentinaSpringer2014-08info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/30673Galindo Gonzalez, Cecilia; Alvarez, Gisela Solange; Camporotondi, Daniela Edhit; Foglia, María Lucía; Aimé, Carole; et al.; Preliminary Evaluation of Median Lethal Concentrations of Stöber Silica Particles with Various Sizes and Surface Functionalities Towards Fibroblast Cells; Springer; Silicon; 8-2014; 1-61876-990X1876-9918CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s12633-014-9203-5info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:08:12Zoai:ri.conicet.gov.ar:11336/30673instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:08:13.296CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Preliminary Evaluation of Median Lethal Concentrations of Stöber Silica Particles with Various Sizes and Surface Functionalities Towards Fibroblast Cells
title Preliminary Evaluation of Median Lethal Concentrations of Stöber Silica Particles with Various Sizes and Surface Functionalities Towards Fibroblast Cells
spellingShingle Preliminary Evaluation of Median Lethal Concentrations of Stöber Silica Particles with Various Sizes and Surface Functionalities Towards Fibroblast Cells
Galindo Gonzalez, Cecilia
Median Lethal Concentrations
Silica Particles
Fibroblasts Cells
Cytotoxicity
title_short Preliminary Evaluation of Median Lethal Concentrations of Stöber Silica Particles with Various Sizes and Surface Functionalities Towards Fibroblast Cells
title_full Preliminary Evaluation of Median Lethal Concentrations of Stöber Silica Particles with Various Sizes and Surface Functionalities Towards Fibroblast Cells
title_fullStr Preliminary Evaluation of Median Lethal Concentrations of Stöber Silica Particles with Various Sizes and Surface Functionalities Towards Fibroblast Cells
title_full_unstemmed Preliminary Evaluation of Median Lethal Concentrations of Stöber Silica Particles with Various Sizes and Surface Functionalities Towards Fibroblast Cells
title_sort Preliminary Evaluation of Median Lethal Concentrations of Stöber Silica Particles with Various Sizes and Surface Functionalities Towards Fibroblast Cells
dc.creator.none.fl_str_mv Galindo Gonzalez, Cecilia
Alvarez, Gisela Solange
Camporotondi, Daniela Edhit
Foglia, María Lucía
Aimé, Carole
Diaz, Luis Eduardo
Coradin, Thibaud
Desimone, Martín Federico
author Galindo Gonzalez, Cecilia
author_facet Galindo Gonzalez, Cecilia
Alvarez, Gisela Solange
Camporotondi, Daniela Edhit
Foglia, María Lucía
Aimé, Carole
Diaz, Luis Eduardo
Coradin, Thibaud
Desimone, Martín Federico
author_role author
author2 Alvarez, Gisela Solange
Camporotondi, Daniela Edhit
Foglia, María Lucía
Aimé, Carole
Diaz, Luis Eduardo
Coradin, Thibaud
Desimone, Martín Federico
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Median Lethal Concentrations
Silica Particles
Fibroblasts Cells
Cytotoxicity
topic Median Lethal Concentrations
Silica Particles
Fibroblasts Cells
Cytotoxicity
purl_subject.fl_str_mv https://purl.org/becyt/ford/2.10
https://purl.org/becyt/ford/2
dc.description.none.fl_txt_mv The application of silica particles in the biomedical field has experienced a great development in recent years, especially in the design of nanoparticles having homogeneous size, structure and amenable to specific grafting. In this way, it becomes possible to control the interaction of nanoparticles with cells in order to meet the requirements for desired applications. This work explores the cytotoxicity of silica particles of various sizes and surface functionality towards L929 fibroblast cells. In particular, the median lethal concentration of the different silica particles has been established. Preliminary investigations of silica nanoparticles prepared by the Stöber method with sizes ranging from 100 nm to 500 nm showed that the largest particles are less harmful for the cells. Moreover, cytotoxicity towards L929 fibroblasts was mainly observed for bare particles, whereas sulfonate-, amine- and thiol-grafted particles had less detrimental effects. This shows the key influence of particle surface curvature and chemistry on nanomaterials cytotoxicity.
Fil: Galindo Gonzalez, Cecilia. Universite Pierre et Marie Curie. Laboratoire de Chimie de la Matière; Francia. Universite de Paris VI; Francia
Fil: Alvarez, Gisela Solange. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Camporotondi, Daniela Edhit. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Foglia, María Lucía. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Aimé, Carole. Universite Pierre et Marie Curie. Laboratoire de Chimie de la Matière; Francia. Universite de Paris VI; Francia
Fil: Diaz, Luis Eduardo. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
Fil: Coradin, Thibaud. Universite Pierre et Marie Curie. Laboratoire de Chimie de la Matière; Francia. Universite de Paris VI; Francia
Fil: Desimone, Martín Federico. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Química y Metabolismo del Fármaco. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Instituto de Química y Metabolismo del Fármaco; Argentina
description The application of silica particles in the biomedical field has experienced a great development in recent years, especially in the design of nanoparticles having homogeneous size, structure and amenable to specific grafting. In this way, it becomes possible to control the interaction of nanoparticles with cells in order to meet the requirements for desired applications. This work explores the cytotoxicity of silica particles of various sizes and surface functionality towards L929 fibroblast cells. In particular, the median lethal concentration of the different silica particles has been established. Preliminary investigations of silica nanoparticles prepared by the Stöber method with sizes ranging from 100 nm to 500 nm showed that the largest particles are less harmful for the cells. Moreover, cytotoxicity towards L929 fibroblasts was mainly observed for bare particles, whereas sulfonate-, amine- and thiol-grafted particles had less detrimental effects. This shows the key influence of particle surface curvature and chemistry on nanomaterials cytotoxicity.
publishDate 2014
dc.date.none.fl_str_mv 2014-08
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/30673
Galindo Gonzalez, Cecilia; Alvarez, Gisela Solange; Camporotondi, Daniela Edhit; Foglia, María Lucía; Aimé, Carole; et al.; Preliminary Evaluation of Median Lethal Concentrations of Stöber Silica Particles with Various Sizes and Surface Functionalities Towards Fibroblast Cells; Springer; Silicon; 8-2014; 1-6
1876-990X
1876-9918
CONICET Digital
CONICET
url http://hdl.handle.net/11336/30673
identifier_str_mv Galindo Gonzalez, Cecilia; Alvarez, Gisela Solange; Camporotondi, Daniela Edhit; Foglia, María Lucía; Aimé, Carole; et al.; Preliminary Evaluation of Median Lethal Concentrations of Stöber Silica Particles with Various Sizes and Surface Functionalities Towards Fibroblast Cells; Springer; Silicon; 8-2014; 1-6
1876-990X
1876-9918
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://link.springer.com/article/10.1007/s12633-014-9203-5
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Springer
publisher.none.fl_str_mv Springer
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 12.993085

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