Micelle‐to‐vesicle transition of lipoamino Gemini surfactant induced by metallic salts and its effects on antibacterial activity
- Autores
- Pachon Gomez, Erica Marcela; Silva, Oscar Fernando; Der Ohannesian, Martín; Núñez Fernández, Mariana; Oliveira, Rafael Gustavo; Fernández, Mariana Adela
- Año de publicación
- 2022
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Gemini surfactants are amphiphilic molecules formed by two polar heads and two hydrophobic tails joined by a spacer between the polar groups. Their molecular structure gives them particular physico-chemical properties in comparison with their monomeric counterparts. In this work we synthetized a Gemini surfactant (SDDC) derived from the amino acid cystine and decanoic acid. The influence of different metallic salts on the aggregation of the surfactant was studied. SDDC forms core–shell type triaxial ellipsoidal micelles in aqueous solution, but the aggregates suffer a change in morphology, forming vesicles in the presence of copper or silver ions. This behavior was corroborated by TEM and SAXS measurements. With the last technique was possible to estimate that vesicles formed in presence of copper consisted of 7.3 stacked bilayers. It was possible to determine that Cu2+ was reduced to Cu+ in the solution containing SDDC, through EPR and UV–visible spectrophotometry measurements. The reduction of copper was accompanied with the concomitant oxidation of the cystine. The antimicrobial activity of the different aggregates was studied against E. coli and S. aureus and compared with the conventional antibiotic ampicillin. The most efficient system resulted the mixture of SDDC:CuSO4/10:1 against the Gram-negative bacterium, there with the minimum concentration used (0.01 mM) was possible to inhibit 70 % of growth. The new systems characterized in this work have many possibilities for potential applications, mainly in the area of drug delivery systems, templates in the synthesis of nanomaterials or as antibacterial compounds.
Fil: Pachon Gomez, Erica Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Silva, Oscar Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina
Fil: Der Ohannesian, Martín. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Química Aplicada; Argentina
Fil: Núñez Fernández, Mariana. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Química Aplicada; Argentina
Fil: Oliveira, Rafael Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina
Fil: Fernández, Mariana Adela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina - Materia
-
AMINO ACID DERIVATIVE SURFACTANT
ANTIBACTERIAL ACTIVITY
GEMINI SURFACTANT
LIPOAMINO ACID SURFACTANT
METALLOSURFACTANTS
VESICLES - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/204712
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Micelle‐to‐vesicle transition of lipoamino Gemini surfactant induced by metallic salts and its effects on antibacterial activityPachon Gomez, Erica MarcelaSilva, Oscar FernandoDer Ohannesian, MartínNúñez Fernández, MarianaOliveira, Rafael GustavoFernández, Mariana AdelaAMINO ACID DERIVATIVE SURFACTANTANTIBACTERIAL ACTIVITYGEMINI SURFACTANTLIPOAMINO ACID SURFACTANTMETALLOSURFACTANTSVESICLEShttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Gemini surfactants are amphiphilic molecules formed by two polar heads and two hydrophobic tails joined by a spacer between the polar groups. Their molecular structure gives them particular physico-chemical properties in comparison with their monomeric counterparts. In this work we synthetized a Gemini surfactant (SDDC) derived from the amino acid cystine and decanoic acid. The influence of different metallic salts on the aggregation of the surfactant was studied. SDDC forms core–shell type triaxial ellipsoidal micelles in aqueous solution, but the aggregates suffer a change in morphology, forming vesicles in the presence of copper or silver ions. This behavior was corroborated by TEM and SAXS measurements. With the last technique was possible to estimate that vesicles formed in presence of copper consisted of 7.3 stacked bilayers. It was possible to determine that Cu2+ was reduced to Cu+ in the solution containing SDDC, through EPR and UV–visible spectrophotometry measurements. The reduction of copper was accompanied with the concomitant oxidation of the cystine. The antimicrobial activity of the different aggregates was studied against E. coli and S. aureus and compared with the conventional antibiotic ampicillin. The most efficient system resulted the mixture of SDDC:CuSO4/10:1 against the Gram-negative bacterium, there with the minimum concentration used (0.01 mM) was possible to inhibit 70 % of growth. The new systems characterized in this work have many possibilities for potential applications, mainly in the area of drug delivery systems, templates in the synthesis of nanomaterials or as antibacterial compounds.Fil: Pachon Gomez, Erica Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Silva, Oscar Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaFil: Der Ohannesian, Martín. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Química Aplicada; ArgentinaFil: Núñez Fernández, Mariana. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Química Aplicada; ArgentinaFil: Oliveira, Rafael Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; ArgentinaFil: Fernández, Mariana Adela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; ArgentinaElsevier Science2022-02info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/204712Pachon Gomez, Erica Marcela; Silva, Oscar Fernando; Der Ohannesian, Martín; Núñez Fernández, Mariana; Oliveira, Rafael Gustavo; et al.; Micelle‐to‐vesicle transition of lipoamino Gemini surfactant induced by metallic salts and its effects on antibacterial activity; Elsevier Science; Journal of Molecular Liquids; 353; 118793; 2-2022; 1-80167-7322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0167732222003300info:eu-repo/semantics/altIdentifier/doi/10.1016/j.molliq.2022.118793info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:32:31Zoai:ri.conicet.gov.ar:11336/204712instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:32:31.383CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Micelle‐to‐vesicle transition of lipoamino Gemini surfactant induced by metallic salts and its effects on antibacterial activity |
title |
Micelle‐to‐vesicle transition of lipoamino Gemini surfactant induced by metallic salts and its effects on antibacterial activity |
spellingShingle |
Micelle‐to‐vesicle transition of lipoamino Gemini surfactant induced by metallic salts and its effects on antibacterial activity Pachon Gomez, Erica Marcela AMINO ACID DERIVATIVE SURFACTANT ANTIBACTERIAL ACTIVITY GEMINI SURFACTANT LIPOAMINO ACID SURFACTANT METALLOSURFACTANTS VESICLES |
title_short |
Micelle‐to‐vesicle transition of lipoamino Gemini surfactant induced by metallic salts and its effects on antibacterial activity |
title_full |
Micelle‐to‐vesicle transition of lipoamino Gemini surfactant induced by metallic salts and its effects on antibacterial activity |
title_fullStr |
Micelle‐to‐vesicle transition of lipoamino Gemini surfactant induced by metallic salts and its effects on antibacterial activity |
title_full_unstemmed |
Micelle‐to‐vesicle transition of lipoamino Gemini surfactant induced by metallic salts and its effects on antibacterial activity |
title_sort |
Micelle‐to‐vesicle transition of lipoamino Gemini surfactant induced by metallic salts and its effects on antibacterial activity |
dc.creator.none.fl_str_mv |
Pachon Gomez, Erica Marcela Silva, Oscar Fernando Der Ohannesian, Martín Núñez Fernández, Mariana Oliveira, Rafael Gustavo Fernández, Mariana Adela |
author |
Pachon Gomez, Erica Marcela |
author_facet |
Pachon Gomez, Erica Marcela Silva, Oscar Fernando Der Ohannesian, Martín Núñez Fernández, Mariana Oliveira, Rafael Gustavo Fernández, Mariana Adela |
author_role |
author |
author2 |
Silva, Oscar Fernando Der Ohannesian, Martín Núñez Fernández, Mariana Oliveira, Rafael Gustavo Fernández, Mariana Adela |
author2_role |
author author author author author |
dc.subject.none.fl_str_mv |
AMINO ACID DERIVATIVE SURFACTANT ANTIBACTERIAL ACTIVITY GEMINI SURFACTANT LIPOAMINO ACID SURFACTANT METALLOSURFACTANTS VESICLES |
topic |
AMINO ACID DERIVATIVE SURFACTANT ANTIBACTERIAL ACTIVITY GEMINI SURFACTANT LIPOAMINO ACID SURFACTANT METALLOSURFACTANTS VESICLES |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Gemini surfactants are amphiphilic molecules formed by two polar heads and two hydrophobic tails joined by a spacer between the polar groups. Their molecular structure gives them particular physico-chemical properties in comparison with their monomeric counterparts. In this work we synthetized a Gemini surfactant (SDDC) derived from the amino acid cystine and decanoic acid. The influence of different metallic salts on the aggregation of the surfactant was studied. SDDC forms core–shell type triaxial ellipsoidal micelles in aqueous solution, but the aggregates suffer a change in morphology, forming vesicles in the presence of copper or silver ions. This behavior was corroborated by TEM and SAXS measurements. With the last technique was possible to estimate that vesicles formed in presence of copper consisted of 7.3 stacked bilayers. It was possible to determine that Cu2+ was reduced to Cu+ in the solution containing SDDC, through EPR and UV–visible spectrophotometry measurements. The reduction of copper was accompanied with the concomitant oxidation of the cystine. The antimicrobial activity of the different aggregates was studied against E. coli and S. aureus and compared with the conventional antibiotic ampicillin. The most efficient system resulted the mixture of SDDC:CuSO4/10:1 against the Gram-negative bacterium, there with the minimum concentration used (0.01 mM) was possible to inhibit 70 % of growth. The new systems characterized in this work have many possibilities for potential applications, mainly in the area of drug delivery systems, templates in the synthesis of nanomaterials or as antibacterial compounds. Fil: Pachon Gomez, Erica Marcela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina Fil: Silva, Oscar Fernando. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina Fil: Der Ohannesian, Martín. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Química Aplicada; Argentina Fil: Núñez Fernández, Mariana. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Química Aplicada; Argentina Fil: Oliveira, Rafael Gustavo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Centro de Investigaciones en Química Biológica de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Centro de Investigaciones en Química Biológica de Córdoba; Argentina Fil: Fernández, Mariana Adela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Córdoba. Instituto de Investigaciones en Físico-química de Córdoba. Universidad Nacional de Córdoba. Facultad de Ciencias Químicas. Instituto de Investigaciones en Físico-química de Córdoba; Argentina |
description |
Gemini surfactants are amphiphilic molecules formed by two polar heads and two hydrophobic tails joined by a spacer between the polar groups. Their molecular structure gives them particular physico-chemical properties in comparison with their monomeric counterparts. In this work we synthetized a Gemini surfactant (SDDC) derived from the amino acid cystine and decanoic acid. The influence of different metallic salts on the aggregation of the surfactant was studied. SDDC forms core–shell type triaxial ellipsoidal micelles in aqueous solution, but the aggregates suffer a change in morphology, forming vesicles in the presence of copper or silver ions. This behavior was corroborated by TEM and SAXS measurements. With the last technique was possible to estimate that vesicles formed in presence of copper consisted of 7.3 stacked bilayers. It was possible to determine that Cu2+ was reduced to Cu+ in the solution containing SDDC, through EPR and UV–visible spectrophotometry measurements. The reduction of copper was accompanied with the concomitant oxidation of the cystine. The antimicrobial activity of the different aggregates was studied against E. coli and S. aureus and compared with the conventional antibiotic ampicillin. The most efficient system resulted the mixture of SDDC:CuSO4/10:1 against the Gram-negative bacterium, there with the minimum concentration used (0.01 mM) was possible to inhibit 70 % of growth. The new systems characterized in this work have many possibilities for potential applications, mainly in the area of drug delivery systems, templates in the synthesis of nanomaterials or as antibacterial compounds. |
publishDate |
2022 |
dc.date.none.fl_str_mv |
2022-02 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/204712 Pachon Gomez, Erica Marcela; Silva, Oscar Fernando; Der Ohannesian, Martín; Núñez Fernández, Mariana; Oliveira, Rafael Gustavo; et al.; Micelle‐to‐vesicle transition of lipoamino Gemini surfactant induced by metallic salts and its effects on antibacterial activity; Elsevier Science; Journal of Molecular Liquids; 353; 118793; 2-2022; 1-8 0167-7322 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/204712 |
identifier_str_mv |
Pachon Gomez, Erica Marcela; Silva, Oscar Fernando; Der Ohannesian, Martín; Núñez Fernández, Mariana; Oliveira, Rafael Gustavo; et al.; Micelle‐to‐vesicle transition of lipoamino Gemini surfactant induced by metallic salts and its effects on antibacterial activity; Elsevier Science; Journal of Molecular Liquids; 353; 118793; 2-2022; 1-8 0167-7322 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0167732222003300 info:eu-repo/semantics/altIdentifier/doi/10.1016/j.molliq.2022.118793 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf application/pdf application/pdf application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Elsevier Science |
publisher.none.fl_str_mv |
Elsevier Science |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1844612992071630848 |
score |
13.070432 |