Porous Sulfonated PVA Microspheres for Controlled Molecules Delivery: A Methylene Blue Study

Autores
Verón, María Gisela; Soria, L. A.; Prado, Miguel Oscar
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Functionalized PVA microspheres are commonly used as drug carriers in the fields of pharmacy and medicine. With this aim, we obtained and test novel PVA-PVAc-AMPS sulfonated microspheres by free radical suspension polymerization of vinyl acetate (VAc) and 2-acrylamido-2-methyl-1-propanesulfonic sodium salt acid (AMPS), followed by saponification. The microspheres exhibited a porous core-shell structure with excellent sphericity, a mean size of 171 μm, and elasticity modulus comparable with commercial particles currently used in medical applications. Methylene blue (MB) which has shown similar adherence properties as the cytostatic drug doxorubicin was used as a model drug to study the drug loading/release characteristics of the sulfonated microspheres prepared in this work. 20.7 mg g-1 MB per gram of microspheres was the maximum adsorption capacity in two hours using UV-Vis absorption spectroscopy. The experimental data on adsorption were well described by the pseudo-second order kinetic model. The in vitro release profile of loaded MB microspheres showed rapid desorption in the first hour followed by slower MB release, reaching 8.6% elution at four hours. The diffusion process was found to be dominant in the MB desorption from the PVA-PVAc-AMPS microspheres.
Fil: Verón, María Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
Fil: Soria, L. A.. Universidad Nacional de Río Negro; Argentina
Fil: Prado, Miguel Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
Materia
POLYVINYL ALCOHOL
BIOPOLYMERS
COPOLYMERIZATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/167629
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Porous Sulfonated PVA Microspheres for Controlled Molecules Delivery: A Methylene Blue StudyVerón, María GiselaSoria, L. A.Prado, Miguel OscarPOLYVINYL ALCOHOLBIOPOLYMERSCOPOLYMERIZATIONhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Functionalized PVA microspheres are commonly used as drug carriers in the fields of pharmacy and medicine. With this aim, we obtained and test novel PVA-PVAc-AMPS sulfonated microspheres by free radical suspension polymerization of vinyl acetate (VAc) and 2-acrylamido-2-methyl-1-propanesulfonic sodium salt acid (AMPS), followed by saponification. The microspheres exhibited a porous core-shell structure with excellent sphericity, a mean size of 171 μm, and elasticity modulus comparable with commercial particles currently used in medical applications. Methylene blue (MB) which has shown similar adherence properties as the cytostatic drug doxorubicin was used as a model drug to study the drug loading/release characteristics of the sulfonated microspheres prepared in this work. 20.7 mg g-1 MB per gram of microspheres was the maximum adsorption capacity in two hours using UV-Vis absorption spectroscopy. The experimental data on adsorption were well described by the pseudo-second order kinetic model. The in vitro release profile of loaded MB microspheres showed rapid desorption in the first hour followed by slower MB release, reaching 8.6% elution at four hours. The diffusion process was found to be dominant in the MB desorption from the PVA-PVAc-AMPS microspheres.Fil: Verón, María Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; ArgentinaFil: Soria, L. A.. Universidad Nacional de Río Negro; ArgentinaFil: Prado, Miguel Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; ArgentinaTech Reviews Ltd2021-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/167629Verón, María Gisela; Soria, L. A.; Prado, Miguel Oscar; Porous Sulfonated PVA Microspheres for Controlled Molecules Delivery: A Methylene Blue Study; Tech Reviews Ltd; Journal of Materials and Applications; 10; 1; 5-2021; 27-422051-7750CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.xpublication.com/index.php/jma/article/view/545info:eu-repo/semantics/altIdentifier/doi/10.32732/jma.2021.10.1.27info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:56:12Zoai:ri.conicet.gov.ar:11336/167629instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:56:12.36CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Porous Sulfonated PVA Microspheres for Controlled Molecules Delivery: A Methylene Blue Study
title Porous Sulfonated PVA Microspheres for Controlled Molecules Delivery: A Methylene Blue Study
spellingShingle Porous Sulfonated PVA Microspheres for Controlled Molecules Delivery: A Methylene Blue Study
Verón, María Gisela
POLYVINYL ALCOHOL
BIOPOLYMERS
COPOLYMERIZATION
title_short Porous Sulfonated PVA Microspheres for Controlled Molecules Delivery: A Methylene Blue Study
title_full Porous Sulfonated PVA Microspheres for Controlled Molecules Delivery: A Methylene Blue Study
title_fullStr Porous Sulfonated PVA Microspheres for Controlled Molecules Delivery: A Methylene Blue Study
title_full_unstemmed Porous Sulfonated PVA Microspheres for Controlled Molecules Delivery: A Methylene Blue Study
title_sort Porous Sulfonated PVA Microspheres for Controlled Molecules Delivery: A Methylene Blue Study
dc.creator.none.fl_str_mv Verón, María Gisela
Soria, L. A.
Prado, Miguel Oscar
author Verón, María Gisela
author_facet Verón, María Gisela
Soria, L. A.
Prado, Miguel Oscar
author_role author
author2 Soria, L. A.
Prado, Miguel Oscar
author2_role author
author
dc.subject.none.fl_str_mv POLYVINYL ALCOHOL
BIOPOLYMERS
COPOLYMERIZATION
topic POLYVINYL ALCOHOL
BIOPOLYMERS
COPOLYMERIZATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Functionalized PVA microspheres are commonly used as drug carriers in the fields of pharmacy and medicine. With this aim, we obtained and test novel PVA-PVAc-AMPS sulfonated microspheres by free radical suspension polymerization of vinyl acetate (VAc) and 2-acrylamido-2-methyl-1-propanesulfonic sodium salt acid (AMPS), followed by saponification. The microspheres exhibited a porous core-shell structure with excellent sphericity, a mean size of 171 μm, and elasticity modulus comparable with commercial particles currently used in medical applications. Methylene blue (MB) which has shown similar adherence properties as the cytostatic drug doxorubicin was used as a model drug to study the drug loading/release characteristics of the sulfonated microspheres prepared in this work. 20.7 mg g-1 MB per gram of microspheres was the maximum adsorption capacity in two hours using UV-Vis absorption spectroscopy. The experimental data on adsorption were well described by the pseudo-second order kinetic model. The in vitro release profile of loaded MB microspheres showed rapid desorption in the first hour followed by slower MB release, reaching 8.6% elution at four hours. The diffusion process was found to be dominant in the MB desorption from the PVA-PVAc-AMPS microspheres.
Fil: Verón, María Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
Fil: Soria, L. A.. Universidad Nacional de Río Negro; Argentina
Fil: Prado, Miguel Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
description Functionalized PVA microspheres are commonly used as drug carriers in the fields of pharmacy and medicine. With this aim, we obtained and test novel PVA-PVAc-AMPS sulfonated microspheres by free radical suspension polymerization of vinyl acetate (VAc) and 2-acrylamido-2-methyl-1-propanesulfonic sodium salt acid (AMPS), followed by saponification. The microspheres exhibited a porous core-shell structure with excellent sphericity, a mean size of 171 μm, and elasticity modulus comparable with commercial particles currently used in medical applications. Methylene blue (MB) which has shown similar adherence properties as the cytostatic drug doxorubicin was used as a model drug to study the drug loading/release characteristics of the sulfonated microspheres prepared in this work. 20.7 mg g-1 MB per gram of microspheres was the maximum adsorption capacity in two hours using UV-Vis absorption spectroscopy. The experimental data on adsorption were well described by the pseudo-second order kinetic model. The in vitro release profile of loaded MB microspheres showed rapid desorption in the first hour followed by slower MB release, reaching 8.6% elution at four hours. The diffusion process was found to be dominant in the MB desorption from the PVA-PVAc-AMPS microspheres.
publishDate 2021
dc.date.none.fl_str_mv 2021-05
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/167629
Verón, María Gisela; Soria, L. A.; Prado, Miguel Oscar; Porous Sulfonated PVA Microspheres for Controlled Molecules Delivery: A Methylene Blue Study; Tech Reviews Ltd; Journal of Materials and Applications; 10; 1; 5-2021; 27-42
2051-7750
CONICET Digital
CONICET
url http://hdl.handle.net/11336/167629
identifier_str_mv Verón, María Gisela; Soria, L. A.; Prado, Miguel Oscar; Porous Sulfonated PVA Microspheres for Controlled Molecules Delivery: A Methylene Blue Study; Tech Reviews Ltd; Journal of Materials and Applications; 10; 1; 5-2021; 27-42
2051-7750
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.xpublication.com/index.php/jma/article/view/545
info:eu-repo/semantics/altIdentifier/doi/10.32732/jma.2021.10.1.27
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Tech Reviews Ltd
publisher.none.fl_str_mv Tech Reviews Ltd
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.069144

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