Porous Sulfonated PVA Microspheres for Controlled Molecules Delivery: A Methylene Blue Study
- Autores
- Verón, María Gisela; Soria, L. A.; Prado, Miguel Oscar
- Año de publicación
- 2021
- Idioma
- inglés
- Tipo de recurso
- artículo
- Estado
- versión publicada
- Descripción
- Functionalized PVA microspheres are commonly used as drug carriers in the fields of pharmacy and medicine. With this aim, we obtained and test novel PVA-PVAc-AMPS sulfonated microspheres by free radical suspension polymerization of vinyl acetate (VAc) and 2-acrylamido-2-methyl-1-propanesulfonic sodium salt acid (AMPS), followed by saponification. The microspheres exhibited a porous core-shell structure with excellent sphericity, a mean size of 171 μm, and elasticity modulus comparable with commercial particles currently used in medical applications. Methylene blue (MB) which has shown similar adherence properties as the cytostatic drug doxorubicin was used as a model drug to study the drug loading/release characteristics of the sulfonated microspheres prepared in this work. 20.7 mg g-1 MB per gram of microspheres was the maximum adsorption capacity in two hours using UV-Vis absorption spectroscopy. The experimental data on adsorption were well described by the pseudo-second order kinetic model. The in vitro release profile of loaded MB microspheres showed rapid desorption in the first hour followed by slower MB release, reaching 8.6% elution at four hours. The diffusion process was found to be dominant in the MB desorption from the PVA-PVAc-AMPS microspheres.
Fil: Verón, María Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
Fil: Soria, L. A.. Universidad Nacional de Río Negro; Argentina
Fil: Prado, Miguel Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina - Materia
-
POLYVINYL ALCOHOL
BIOPOLYMERS
COPOLYMERIZATION - Nivel de accesibilidad
- acceso abierto
- Condiciones de uso
- https://creativecommons.org/licenses/by/2.5/ar/
- Repositorio
- Institución
- Consejo Nacional de Investigaciones Científicas y Técnicas
- OAI Identificador
- oai:ri.conicet.gov.ar:11336/167629
Ver los metadatos del registro completo
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Porous Sulfonated PVA Microspheres for Controlled Molecules Delivery: A Methylene Blue StudyVerón, María GiselaSoria, L. A.Prado, Miguel OscarPOLYVINYL ALCOHOLBIOPOLYMERSCOPOLYMERIZATIONhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1Functionalized PVA microspheres are commonly used as drug carriers in the fields of pharmacy and medicine. With this aim, we obtained and test novel PVA-PVAc-AMPS sulfonated microspheres by free radical suspension polymerization of vinyl acetate (VAc) and 2-acrylamido-2-methyl-1-propanesulfonic sodium salt acid (AMPS), followed by saponification. The microspheres exhibited a porous core-shell structure with excellent sphericity, a mean size of 171 μm, and elasticity modulus comparable with commercial particles currently used in medical applications. Methylene blue (MB) which has shown similar adherence properties as the cytostatic drug doxorubicin was used as a model drug to study the drug loading/release characteristics of the sulfonated microspheres prepared in this work. 20.7 mg g-1 MB per gram of microspheres was the maximum adsorption capacity in two hours using UV-Vis absorption spectroscopy. The experimental data on adsorption were well described by the pseudo-second order kinetic model. The in vitro release profile of loaded MB microspheres showed rapid desorption in the first hour followed by slower MB release, reaching 8.6% elution at four hours. The diffusion process was found to be dominant in the MB desorption from the PVA-PVAc-AMPS microspheres.Fil: Verón, María Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; ArgentinaFil: Soria, L. A.. Universidad Nacional de Río Negro; ArgentinaFil: Prado, Miguel Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; ArgentinaTech Reviews Ltd2021-05info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/167629Verón, María Gisela; Soria, L. A.; Prado, Miguel Oscar; Porous Sulfonated PVA Microspheres for Controlled Molecules Delivery: A Methylene Blue Study; Tech Reviews Ltd; Journal of Materials and Applications; 10; 1; 5-2021; 27-422051-7750CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.xpublication.com/index.php/jma/article/view/545info:eu-repo/semantics/altIdentifier/doi/10.32732/jma.2021.10.1.27info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:54:42Zoai:ri.conicet.gov.ar:11336/167629instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:54:42.631CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse |
dc.title.none.fl_str_mv |
Porous Sulfonated PVA Microspheres for Controlled Molecules Delivery: A Methylene Blue Study |
title |
Porous Sulfonated PVA Microspheres for Controlled Molecules Delivery: A Methylene Blue Study |
spellingShingle |
Porous Sulfonated PVA Microspheres for Controlled Molecules Delivery: A Methylene Blue Study Verón, María Gisela POLYVINYL ALCOHOL BIOPOLYMERS COPOLYMERIZATION |
title_short |
Porous Sulfonated PVA Microspheres for Controlled Molecules Delivery: A Methylene Blue Study |
title_full |
Porous Sulfonated PVA Microspheres for Controlled Molecules Delivery: A Methylene Blue Study |
title_fullStr |
Porous Sulfonated PVA Microspheres for Controlled Molecules Delivery: A Methylene Blue Study |
title_full_unstemmed |
Porous Sulfonated PVA Microspheres for Controlled Molecules Delivery: A Methylene Blue Study |
title_sort |
Porous Sulfonated PVA Microspheres for Controlled Molecules Delivery: A Methylene Blue Study |
dc.creator.none.fl_str_mv |
Verón, María Gisela Soria, L. A. Prado, Miguel Oscar |
author |
Verón, María Gisela |
author_facet |
Verón, María Gisela Soria, L. A. Prado, Miguel Oscar |
author_role |
author |
author2 |
Soria, L. A. Prado, Miguel Oscar |
author2_role |
author author |
dc.subject.none.fl_str_mv |
POLYVINYL ALCOHOL BIOPOLYMERS COPOLYMERIZATION |
topic |
POLYVINYL ALCOHOL BIOPOLYMERS COPOLYMERIZATION |
purl_subject.fl_str_mv |
https://purl.org/becyt/ford/1.4 https://purl.org/becyt/ford/1 |
dc.description.none.fl_txt_mv |
Functionalized PVA microspheres are commonly used as drug carriers in the fields of pharmacy and medicine. With this aim, we obtained and test novel PVA-PVAc-AMPS sulfonated microspheres by free radical suspension polymerization of vinyl acetate (VAc) and 2-acrylamido-2-methyl-1-propanesulfonic sodium salt acid (AMPS), followed by saponification. The microspheres exhibited a porous core-shell structure with excellent sphericity, a mean size of 171 μm, and elasticity modulus comparable with commercial particles currently used in medical applications. Methylene blue (MB) which has shown similar adherence properties as the cytostatic drug doxorubicin was used as a model drug to study the drug loading/release characteristics of the sulfonated microspheres prepared in this work. 20.7 mg g-1 MB per gram of microspheres was the maximum adsorption capacity in two hours using UV-Vis absorption spectroscopy. The experimental data on adsorption were well described by the pseudo-second order kinetic model. The in vitro release profile of loaded MB microspheres showed rapid desorption in the first hour followed by slower MB release, reaching 8.6% elution at four hours. The diffusion process was found to be dominant in the MB desorption from the PVA-PVAc-AMPS microspheres. Fil: Verón, María Gisela. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina Fil: Soria, L. A.. Universidad Nacional de Río Negro; Argentina Fil: Prado, Miguel Oscar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Patagonia Norte; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina |
description |
Functionalized PVA microspheres are commonly used as drug carriers in the fields of pharmacy and medicine. With this aim, we obtained and test novel PVA-PVAc-AMPS sulfonated microspheres by free radical suspension polymerization of vinyl acetate (VAc) and 2-acrylamido-2-methyl-1-propanesulfonic sodium salt acid (AMPS), followed by saponification. The microspheres exhibited a porous core-shell structure with excellent sphericity, a mean size of 171 μm, and elasticity modulus comparable with commercial particles currently used in medical applications. Methylene blue (MB) which has shown similar adherence properties as the cytostatic drug doxorubicin was used as a model drug to study the drug loading/release characteristics of the sulfonated microspheres prepared in this work. 20.7 mg g-1 MB per gram of microspheres was the maximum adsorption capacity in two hours using UV-Vis absorption spectroscopy. The experimental data on adsorption were well described by the pseudo-second order kinetic model. The in vitro release profile of loaded MB microspheres showed rapid desorption in the first hour followed by slower MB release, reaching 8.6% elution at four hours. The diffusion process was found to be dominant in the MB desorption from the PVA-PVAc-AMPS microspheres. |
publishDate |
2021 |
dc.date.none.fl_str_mv |
2021-05 |
dc.type.none.fl_str_mv |
info:eu-repo/semantics/article info:eu-repo/semantics/publishedVersion http://purl.org/coar/resource_type/c_6501 info:ar-repo/semantics/articulo |
format |
article |
status_str |
publishedVersion |
dc.identifier.none.fl_str_mv |
http://hdl.handle.net/11336/167629 Verón, María Gisela; Soria, L. A.; Prado, Miguel Oscar; Porous Sulfonated PVA Microspheres for Controlled Molecules Delivery: A Methylene Blue Study; Tech Reviews Ltd; Journal of Materials and Applications; 10; 1; 5-2021; 27-42 2051-7750 CONICET Digital CONICET |
url |
http://hdl.handle.net/11336/167629 |
identifier_str_mv |
Verón, María Gisela; Soria, L. A.; Prado, Miguel Oscar; Porous Sulfonated PVA Microspheres for Controlled Molecules Delivery: A Methylene Blue Study; Tech Reviews Ltd; Journal of Materials and Applications; 10; 1; 5-2021; 27-42 2051-7750 CONICET Digital CONICET |
dc.language.none.fl_str_mv |
eng |
language |
eng |
dc.relation.none.fl_str_mv |
info:eu-repo/semantics/altIdentifier/url/http://www.xpublication.com/index.php/jma/article/view/545 info:eu-repo/semantics/altIdentifier/doi/10.32732/jma.2021.10.1.27 |
dc.rights.none.fl_str_mv |
info:eu-repo/semantics/openAccess https://creativecommons.org/licenses/by/2.5/ar/ |
eu_rights_str_mv |
openAccess |
rights_invalid_str_mv |
https://creativecommons.org/licenses/by/2.5/ar/ |
dc.format.none.fl_str_mv |
application/pdf application/pdf |
dc.publisher.none.fl_str_mv |
Tech Reviews Ltd |
publisher.none.fl_str_mv |
Tech Reviews Ltd |
dc.source.none.fl_str_mv |
reponame:CONICET Digital (CONICET) instname:Consejo Nacional de Investigaciones Científicas y Técnicas |
reponame_str |
CONICET Digital (CONICET) |
collection |
CONICET Digital (CONICET) |
instname_str |
Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.name.fl_str_mv |
CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas |
repository.mail.fl_str_mv |
dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar |
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1842269302285139968 |
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13.13397 |