Sensitive detection of salbutamol using europium-enhanced fluorescence with trioctylphosphine oxide (TOPO) as coligand

Autores
Oliva, Maria de los A.; Olsina, Roberto Antonio; Masi, Adriana Noemi
Año de publicación
2005
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In this work a simple and sensitive fluorimetric method for determination of salbutamol (4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl) phenol) using an Eu enhanced signal was developed. The employed methodology is based on the formation of a ternary complex formed with Eu, salbutamol and trioctylphosphine oxide (TOPO). Intermolecular transfer of energy from the excited organic molecule to the lanthanide followed by lanthanide emission is responsible for excitation of the lanthanide ion in complex solutions and fluorescent enhancement. The luminescence properties of the ternary complex formed with TOPO and optimum formation conditions were investigated. The calibration curve is linear in the range between 6.92-180 μg 1-1 of salbutamol. The detection limit was 2.31 μg 1-1. Common excipients for these formulations were not found to interfere. A proposed method for the assay in commercial aerosols and nebulizer solutions containing salbutamol was applied with very good precision.
Fil: Oliva, Maria de los A.. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Olsina, Roberto Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química. Área de Química Analítica; Argentina
Fil: Masi, Adriana Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Laboratorio de Bromatología; Argentina
Materia
SALBUTAMOL
EUROPIUM-ENHANCED FLUORESCENCE
TRIOCTYLPHOSPHINE OXIDE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/100128
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/100128
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Sensitive detection of salbutamol using europium-enhanced fluorescence with trioctylphosphine oxide (TOPO) as coligandOliva, Maria de los A.Olsina, Roberto AntonioMasi, Adriana NoemiSALBUTAMOLEUROPIUM-ENHANCED FLUORESCENCETRIOCTYLPHOSPHINE OXIDEhttps://purl.org/becyt/ford/1.4https://purl.org/becyt/ford/1In this work a simple and sensitive fluorimetric method for determination of salbutamol (4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl) phenol) using an Eu enhanced signal was developed. The employed methodology is based on the formation of a ternary complex formed with Eu, salbutamol and trioctylphosphine oxide (TOPO). Intermolecular transfer of energy from the excited organic molecule to the lanthanide followed by lanthanide emission is responsible for excitation of the lanthanide ion in complex solutions and fluorescent enhancement. The luminescence properties of the ternary complex formed with TOPO and optimum formation conditions were investigated. The calibration curve is linear in the range between 6.92-180 μg 1-1 of salbutamol. The detection limit was 2.31 μg 1-1. Common excipients for these formulations were not found to interfere. A proposed method for the assay in commercial aerosols and nebulizer solutions containing salbutamol was applied with very good precision.Fil: Oliva, Maria de los A.. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Olsina, Roberto Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química. Área de Química Analítica; ArgentinaFil: Masi, Adriana Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Laboratorio de Bromatología; ArgentinaRoyal Society of Chemistry2005-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/mswordapplication/mswordapplication/pdfhttp://hdl.handle.net/11336/100128Oliva, Maria de los A.; Olsina, Roberto Antonio; Masi, Adriana Noemi; Sensitive detection of salbutamol using europium-enhanced fluorescence with trioctylphosphine oxide (TOPO) as coligand; Royal Society of Chemistry; Analyst; 130; 9; 9-2005; 1312-13170003-26541364-5528CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2005/AN/b508790b#!divAbstractinfo:eu-repo/semantics/altIdentifier/doi/10.1039/B508790Binfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:58Zoai:ri.conicet.gov.ar:11336/100128instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:58.669CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Sensitive detection of salbutamol using europium-enhanced fluorescence with trioctylphosphine oxide (TOPO) as coligand
title Sensitive detection of salbutamol using europium-enhanced fluorescence with trioctylphosphine oxide (TOPO) as coligand
spellingShingle Sensitive detection of salbutamol using europium-enhanced fluorescence with trioctylphosphine oxide (TOPO) as coligand
Oliva, Maria de los A.
SALBUTAMOL
EUROPIUM-ENHANCED FLUORESCENCE
TRIOCTYLPHOSPHINE OXIDE
title_short Sensitive detection of salbutamol using europium-enhanced fluorescence with trioctylphosphine oxide (TOPO) as coligand
title_full Sensitive detection of salbutamol using europium-enhanced fluorescence with trioctylphosphine oxide (TOPO) as coligand
title_fullStr Sensitive detection of salbutamol using europium-enhanced fluorescence with trioctylphosphine oxide (TOPO) as coligand
title_full_unstemmed Sensitive detection of salbutamol using europium-enhanced fluorescence with trioctylphosphine oxide (TOPO) as coligand
title_sort Sensitive detection of salbutamol using europium-enhanced fluorescence with trioctylphosphine oxide (TOPO) as coligand
dc.creator.none.fl_str_mv Oliva, Maria de los A.
Olsina, Roberto Antonio
Masi, Adriana Noemi
author Oliva, Maria de los A.
author_facet Oliva, Maria de los A.
Olsina, Roberto Antonio
Masi, Adriana Noemi
author_role author
author2 Olsina, Roberto Antonio
Masi, Adriana Noemi
author2_role author
author
dc.subject.none.fl_str_mv SALBUTAMOL
EUROPIUM-ENHANCED FLUORESCENCE
TRIOCTYLPHOSPHINE OXIDE
topic SALBUTAMOL
EUROPIUM-ENHANCED FLUORESCENCE
TRIOCTYLPHOSPHINE OXIDE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.4
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv In this work a simple and sensitive fluorimetric method for determination of salbutamol (4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl) phenol) using an Eu enhanced signal was developed. The employed methodology is based on the formation of a ternary complex formed with Eu, salbutamol and trioctylphosphine oxide (TOPO). Intermolecular transfer of energy from the excited organic molecule to the lanthanide followed by lanthanide emission is responsible for excitation of the lanthanide ion in complex solutions and fluorescent enhancement. The luminescence properties of the ternary complex formed with TOPO and optimum formation conditions were investigated. The calibration curve is linear in the range between 6.92-180 μg 1-1 of salbutamol. The detection limit was 2.31 μg 1-1. Common excipients for these formulations were not found to interfere. A proposed method for the assay in commercial aerosols and nebulizer solutions containing salbutamol was applied with very good precision.
Fil: Oliva, Maria de los A.. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Olsina, Roberto Antonio. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Química. Área de Química Analítica; Argentina
Fil: Masi, Adriana Noemi. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - San Luis. Instituto de Química de San Luis. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Instituto de Química de San Luis; Argentina. Universidad Nacional de San Luis. Facultad de Química, Bioquímica y Farmacia. Departamento de Farmacia. Laboratorio de Bromatología; Argentina
description In this work a simple and sensitive fluorimetric method for determination of salbutamol (4-[2-(tert-butylamino)-1-hydroxyethyl]-2-(hydroxymethyl) phenol) using an Eu enhanced signal was developed. The employed methodology is based on the formation of a ternary complex formed with Eu, salbutamol and trioctylphosphine oxide (TOPO). Intermolecular transfer of energy from the excited organic molecule to the lanthanide followed by lanthanide emission is responsible for excitation of the lanthanide ion in complex solutions and fluorescent enhancement. The luminescence properties of the ternary complex formed with TOPO and optimum formation conditions were investigated. The calibration curve is linear in the range between 6.92-180 μg 1-1 of salbutamol. The detection limit was 2.31 μg 1-1. Common excipients for these formulations were not found to interfere. A proposed method for the assay in commercial aerosols and nebulizer solutions containing salbutamol was applied with very good precision.
publishDate 2005
dc.date.none.fl_str_mv 2005-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/100128
Oliva, Maria de los A.; Olsina, Roberto Antonio; Masi, Adriana Noemi; Sensitive detection of salbutamol using europium-enhanced fluorescence with trioctylphosphine oxide (TOPO) as coligand; Royal Society of Chemistry; Analyst; 130; 9; 9-2005; 1312-1317
0003-2654
1364-5528
CONICET Digital
CONICET
url http://hdl.handle.net/11336/100128
identifier_str_mv Oliva, Maria de los A.; Olsina, Roberto Antonio; Masi, Adriana Noemi; Sensitive detection of salbutamol using europium-enhanced fluorescence with trioctylphosphine oxide (TOPO) as coligand; Royal Society of Chemistry; Analyst; 130; 9; 9-2005; 1312-1317
0003-2654
1364-5528
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://pubs.rsc.org/en/content/articlelanding/2005/AN/b508790b#!divAbstract
info:eu-repo/semantics/altIdentifier/doi/10.1039/B508790B
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/msword
application/msword
application/pdf
dc.publisher.none.fl_str_mv Royal Society of Chemistry
publisher.none.fl_str_mv Royal Society of Chemistry
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.13397

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