The emerging role of autophagy in the pathophysiology of diabetes mellitus

Autores
Gonzalez, Claudio D.; Lee, Myung Shik; Marchetti, Piero; Pietropaolo, Massimo; Towns, Roberto; Vaccaro, Maria Ines; Watada, Hirotaka; Wiley, John W.
Año de publicación
2011
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
An emerging body of evidence supports a role for autophagy in the pathophysiology of type 1 and type 2 diabetes mellitus. Persistent high concentrations of glucose lead to imbalances in the antioxidant capacity within the cell resulting in oxidative stress-mediated injury in both disorders. An anticipated consequence of impaired autophagy is the accumulation of dysfunctional organelles such as mitochondria within the cell. Mitochondria are the primary site of the production of reactive oxygen species (ROS), and an imbalance in ROS production relative to the cytoprotective action of autophagy may lead to the accumulation of ROS. Impaired mitochondrial function associated with increased ROS levels have been proposed as mechanisms contributing to insulin resistance. In this article we review and interpret the literature that implicates a role for autophagy in the pathophysiology of type 1 and type 2 diabetes mellitus as it applies to β-cell dysfunction, and more broadly to organ systems involved in complications of diabetes including the cardiovascular, renal and nervous systems.
Fil: Gonzalez, Claudio D.. Hospital CEMIC; Argentina. Universidad de Buenos Aires; Argentina
Fil: Lee, Myung Shik. Samsung Medical Center; Corea del Sur
Fil: Marchetti, Piero. Universita Degli Studi Di Pisa; Italia
Fil: Pietropaolo, Massimo. University Of Michigan; Estados Unidos
Fil: Towns, Roberto. University Of Michigan; Estados Unidos
Fil: Vaccaro, Maria Ines. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Watada, Hirotaka. Juntendo University. School of Medicine; Japón
Fil: Wiley, John W.. University Of Michigan; Estados Unidos
Materia
Autophagy
Diabetes Mellitus
Diabetes Complications
Oxidative Stress
Mitochondria Dysfunction
Autoimmunity
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/13194
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling The emerging role of autophagy in the pathophysiology of diabetes mellitusGonzalez, Claudio D.Lee, Myung ShikMarchetti, PieroPietropaolo, MassimoTowns, RobertoVaccaro, Maria InesWatada, HirotakaWiley, John W.AutophagyDiabetes MellitusDiabetes ComplicationsOxidative StressMitochondria DysfunctionAutoimmunityhttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3An emerging body of evidence supports a role for autophagy in the pathophysiology of type 1 and type 2 diabetes mellitus. Persistent high concentrations of glucose lead to imbalances in the antioxidant capacity within the cell resulting in oxidative stress-mediated injury in both disorders. An anticipated consequence of impaired autophagy is the accumulation of dysfunctional organelles such as mitochondria within the cell. Mitochondria are the primary site of the production of reactive oxygen species (ROS), and an imbalance in ROS production relative to the cytoprotective action of autophagy may lead to the accumulation of ROS. Impaired mitochondrial function associated with increased ROS levels have been proposed as mechanisms contributing to insulin resistance. In this article we review and interpret the literature that implicates a role for autophagy in the pathophysiology of type 1 and type 2 diabetes mellitus as it applies to β-cell dysfunction, and more broadly to organ systems involved in complications of diabetes including the cardiovascular, renal and nervous systems.Fil: Gonzalez, Claudio D.. Hospital CEMIC; Argentina. Universidad de Buenos Aires; ArgentinaFil: Lee, Myung Shik. Samsung Medical Center; Corea del SurFil: Marchetti, Piero. Universita Degli Studi Di Pisa; ItaliaFil: Pietropaolo, Massimo. University Of Michigan; Estados UnidosFil: Towns, Roberto. University Of Michigan; Estados UnidosFil: Vaccaro, Maria Ines. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; ArgentinaFil: Watada, Hirotaka. Juntendo University. School of Medicine; JapónFil: Wiley, John W.. University Of Michigan; Estados UnidosLandes Bioscience2011-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/13194Gonzalez, Claudio D.; Lee, Myung Shik; Marchetti, Piero; Pietropaolo, Massimo; Towns, Roberto; et al.; The emerging role of autophagy in the pathophysiology of diabetes mellitus; Landes Bioscience; Autophagy; 7; 1; 1-2011; 2-111554-8627enginfo:eu-repo/semantics/altIdentifier/doi/10.4161/auto.7.1.13044info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.4161/auto.7.1.13044info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:44:07Zoai:ri.conicet.gov.ar:11336/13194instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:44:07.747CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv The emerging role of autophagy in the pathophysiology of diabetes mellitus
title The emerging role of autophagy in the pathophysiology of diabetes mellitus
spellingShingle The emerging role of autophagy in the pathophysiology of diabetes mellitus
Gonzalez, Claudio D.
Autophagy
Diabetes Mellitus
Diabetes Complications
Oxidative Stress
Mitochondria Dysfunction
Autoimmunity
title_short The emerging role of autophagy in the pathophysiology of diabetes mellitus
title_full The emerging role of autophagy in the pathophysiology of diabetes mellitus
title_fullStr The emerging role of autophagy in the pathophysiology of diabetes mellitus
title_full_unstemmed The emerging role of autophagy in the pathophysiology of diabetes mellitus
title_sort The emerging role of autophagy in the pathophysiology of diabetes mellitus
dc.creator.none.fl_str_mv Gonzalez, Claudio D.
Lee, Myung Shik
Marchetti, Piero
Pietropaolo, Massimo
Towns, Roberto
Vaccaro, Maria Ines
Watada, Hirotaka
Wiley, John W.
author Gonzalez, Claudio D.
author_facet Gonzalez, Claudio D.
Lee, Myung Shik
Marchetti, Piero
Pietropaolo, Massimo
Towns, Roberto
Vaccaro, Maria Ines
Watada, Hirotaka
Wiley, John W.
author_role author
author2 Lee, Myung Shik
Marchetti, Piero
Pietropaolo, Massimo
Towns, Roberto
Vaccaro, Maria Ines
Watada, Hirotaka
Wiley, John W.
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv Autophagy
Diabetes Mellitus
Diabetes Complications
Oxidative Stress
Mitochondria Dysfunction
Autoimmunity
topic Autophagy
Diabetes Mellitus
Diabetes Complications
Oxidative Stress
Mitochondria Dysfunction
Autoimmunity
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv An emerging body of evidence supports a role for autophagy in the pathophysiology of type 1 and type 2 diabetes mellitus. Persistent high concentrations of glucose lead to imbalances in the antioxidant capacity within the cell resulting in oxidative stress-mediated injury in both disorders. An anticipated consequence of impaired autophagy is the accumulation of dysfunctional organelles such as mitochondria within the cell. Mitochondria are the primary site of the production of reactive oxygen species (ROS), and an imbalance in ROS production relative to the cytoprotective action of autophagy may lead to the accumulation of ROS. Impaired mitochondrial function associated with increased ROS levels have been proposed as mechanisms contributing to insulin resistance. In this article we review and interpret the literature that implicates a role for autophagy in the pathophysiology of type 1 and type 2 diabetes mellitus as it applies to β-cell dysfunction, and more broadly to organ systems involved in complications of diabetes including the cardiovascular, renal and nervous systems.
Fil: Gonzalez, Claudio D.. Hospital CEMIC; Argentina. Universidad de Buenos Aires; Argentina
Fil: Lee, Myung Shik. Samsung Medical Center; Corea del Sur
Fil: Marchetti, Piero. Universita Degli Studi Di Pisa; Italia
Fil: Pietropaolo, Massimo. University Of Michigan; Estados Unidos
Fil: Towns, Roberto. University Of Michigan; Estados Unidos
Fil: Vaccaro, Maria Ines. Universidad de Buenos Aires. Facultad de Farmacia y Bioquímica. Departamento de Ciencias Biológicas; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay; Argentina
Fil: Watada, Hirotaka. Juntendo University. School of Medicine; Japón
Fil: Wiley, John W.. University Of Michigan; Estados Unidos
description An emerging body of evidence supports a role for autophagy in the pathophysiology of type 1 and type 2 diabetes mellitus. Persistent high concentrations of glucose lead to imbalances in the antioxidant capacity within the cell resulting in oxidative stress-mediated injury in both disorders. An anticipated consequence of impaired autophagy is the accumulation of dysfunctional organelles such as mitochondria within the cell. Mitochondria are the primary site of the production of reactive oxygen species (ROS), and an imbalance in ROS production relative to the cytoprotective action of autophagy may lead to the accumulation of ROS. Impaired mitochondrial function associated with increased ROS levels have been proposed as mechanisms contributing to insulin resistance. In this article we review and interpret the literature that implicates a role for autophagy in the pathophysiology of type 1 and type 2 diabetes mellitus as it applies to β-cell dysfunction, and more broadly to organ systems involved in complications of diabetes including the cardiovascular, renal and nervous systems.
publishDate 2011
dc.date.none.fl_str_mv 2011-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/13194
Gonzalez, Claudio D.; Lee, Myung Shik; Marchetti, Piero; Pietropaolo, Massimo; Towns, Roberto; et al.; The emerging role of autophagy in the pathophysiology of diabetes mellitus; Landes Bioscience; Autophagy; 7; 1; 1-2011; 2-11
1554-8627
url http://hdl.handle.net/11336/13194
identifier_str_mv Gonzalez, Claudio D.; Lee, Myung Shik; Marchetti, Piero; Pietropaolo, Massimo; Towns, Roberto; et al.; The emerging role of autophagy in the pathophysiology of diabetes mellitus; Landes Bioscience; Autophagy; 7; 1; 1-2011; 2-11
1554-8627
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.4161/auto.7.1.13044
info:eu-repo/semantics/altIdentifier/url/http://www.tandfonline.com/doi/abs/10.4161/auto.7.1.13044
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Landes Bioscience
publisher.none.fl_str_mv Landes Bioscience
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842268646379880448
score 13.13397

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