Insights into the Anti-Adipogenic and Anti-Inflammatory Potentialities of Probiotics against Obesity

Autores
Kober, A. K. M. Humayun; Saha, Sudeb; Ayyash, Mutamed; Namai, Fu; Nishiyama, Keita; Yoda, Kazutoyo; Villena, Julio Cesar; Kitazawa, Haruki
Año de publicación
2024
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Functional foods with probiotics are safe and effective dietary supplements to improve overweight and obesity. Thus, altering the intestinal microflora may be an effective approach for controlling or preventing obesity. This review aims to summarize the experimental method used to study probiotics and obesity, and recent advances in probiotics against obesity. In particular, we focused on studies (in vitro and in vivo) that used probiotics to treat obesity and its associated comorbidities. Several in vitro and in vivo (animal and human clinical) studies conducted with different bacterial species/strains have reported that probiotics promote anti-obesity effects by suppressing the differentiation of pre-adipocytes through immune cell activation, maintaining the Th1/Th2 cytokine balance, altering the intestinal microbiota composition, reducing the lipid profile, and regulating energy metabolism. Most studies on probiotics and obesity have shown that probiotics are responsible for a notable reduction in weight gain and body mass index. It also increases the levels of anti-inflammatory adipokines and decreases those of pro-inflammatory adipokines in the blood, which are responsible for the regulation of glucose and fatty acid breakdown. Furthermore, probiotics effectively increase insulin sensitivity and decrease systemic inflammation. Taken together, the intestinal microbiota profile found in overweight individuals can be modified by probiotic supplementation which can create a promising environment for weight loss along enhancing levels of adiponectin and decreasing leptin, tumor necrosis factor (TNF)-α, interleukin (IL)-6, monocyte chemotactic protein (MCP)-1, and transforming growth factor (TGF)-β on human health.
Fil: Kober, A. K. M. Humayun. Chittagong Veterinary And Animal Sciences University; Bangladesh
Fil: Saha, Sudeb. Sylhet Agricultural University; Bangladesh. Tohoku University; Japón
Fil: Ayyash, Mutamed. United Arab Emirates University; Emiratos Árabes Unidos
Fil: Namai, Fu. Tohoku University; Japón
Fil: Nishiyama, Keita. Takanashi Milk Products Co.; Japón
Fil: Yoda, Kazutoyo. Takanashi Milk Products Co.; Japón
Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Kitazawa, Haruki. Tohoku University; Japón
Materia
OBESITY
PROBIOTICS
ANTI-INFLAMMATORY ADIPOKINES
PRO-INFLAMMATORY ADIPOKINES
ADIPOCYTES
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/260584
Acceder
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network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Insights into the Anti-Adipogenic and Anti-Inflammatory Potentialities of Probiotics against ObesityKober, A. K. M. HumayunSaha, SudebAyyash, MutamedNamai, FuNishiyama, KeitaYoda, KazutoyoVillena, Julio CesarKitazawa, HarukiOBESITYPROBIOTICSANTI-INFLAMMATORY ADIPOKINESPRO-INFLAMMATORY ADIPOKINESADIPOCYTEShttps://purl.org/becyt/ford/3.1https://purl.org/becyt/ford/3Functional foods with probiotics are safe and effective dietary supplements to improve overweight and obesity. Thus, altering the intestinal microflora may be an effective approach for controlling or preventing obesity. This review aims to summarize the experimental method used to study probiotics and obesity, and recent advances in probiotics against obesity. In particular, we focused on studies (in vitro and in vivo) that used probiotics to treat obesity and its associated comorbidities. Several in vitro and in vivo (animal and human clinical) studies conducted with different bacterial species/strains have reported that probiotics promote anti-obesity effects by suppressing the differentiation of pre-adipocytes through immune cell activation, maintaining the Th1/Th2 cytokine balance, altering the intestinal microbiota composition, reducing the lipid profile, and regulating energy metabolism. Most studies on probiotics and obesity have shown that probiotics are responsible for a notable reduction in weight gain and body mass index. It also increases the levels of anti-inflammatory adipokines and decreases those of pro-inflammatory adipokines in the blood, which are responsible for the regulation of glucose and fatty acid breakdown. Furthermore, probiotics effectively increase insulin sensitivity and decrease systemic inflammation. Taken together, the intestinal microbiota profile found in overweight individuals can be modified by probiotic supplementation which can create a promising environment for weight loss along enhancing levels of adiponectin and decreasing leptin, tumor necrosis factor (TNF)-α, interleukin (IL)-6, monocyte chemotactic protein (MCP)-1, and transforming growth factor (TGF)-β on human health.Fil: Kober, A. K. M. Humayun. Chittagong Veterinary And Animal Sciences University; BangladeshFil: Saha, Sudeb. Sylhet Agricultural University; Bangladesh. Tohoku University; JapónFil: Ayyash, Mutamed. United Arab Emirates University; Emiratos Árabes UnidosFil: Namai, Fu. Tohoku University; JapónFil: Nishiyama, Keita. Takanashi Milk Products Co.; JapónFil: Yoda, Kazutoyo. Takanashi Milk Products Co.; JapónFil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; ArgentinaFil: Kitazawa, Haruki. Tohoku University; JapónMultidisciplinary Digital Publishing Institute2024-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/260584Kober, A. K. M. Humayun; Saha, Sudeb; Ayyash, Mutamed; Namai, Fu; Nishiyama, Keita; et al.; Insights into the Anti-Adipogenic and Anti-Inflammatory Potentialities of Probiotics against Obesity; Multidisciplinary Digital Publishing Institute; Nutrients; 16; 9; 4-2024; 1-222072-6643CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2072-6643/16/9/1373info:eu-repo/semantics/altIdentifier/doi/10.3390/nu16091373info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T09:34:37Zoai:ri.conicet.gov.ar:11336/260584instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 09:34:37.46CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Insights into the Anti-Adipogenic and Anti-Inflammatory Potentialities of Probiotics against Obesity
title Insights into the Anti-Adipogenic and Anti-Inflammatory Potentialities of Probiotics against Obesity
spellingShingle Insights into the Anti-Adipogenic and Anti-Inflammatory Potentialities of Probiotics against Obesity
Kober, A. K. M. Humayun
OBESITY
PROBIOTICS
ANTI-INFLAMMATORY ADIPOKINES
PRO-INFLAMMATORY ADIPOKINES
ADIPOCYTES
title_short Insights into the Anti-Adipogenic and Anti-Inflammatory Potentialities of Probiotics against Obesity
title_full Insights into the Anti-Adipogenic and Anti-Inflammatory Potentialities of Probiotics against Obesity
title_fullStr Insights into the Anti-Adipogenic and Anti-Inflammatory Potentialities of Probiotics against Obesity
title_full_unstemmed Insights into the Anti-Adipogenic and Anti-Inflammatory Potentialities of Probiotics against Obesity
title_sort Insights into the Anti-Adipogenic and Anti-Inflammatory Potentialities of Probiotics against Obesity
dc.creator.none.fl_str_mv Kober, A. K. M. Humayun
Saha, Sudeb
Ayyash, Mutamed
Namai, Fu
Nishiyama, Keita
Yoda, Kazutoyo
Villena, Julio Cesar
Kitazawa, Haruki
author Kober, A. K. M. Humayun
author_facet Kober, A. K. M. Humayun
Saha, Sudeb
Ayyash, Mutamed
Namai, Fu
Nishiyama, Keita
Yoda, Kazutoyo
Villena, Julio Cesar
Kitazawa, Haruki
author_role author
author2 Saha, Sudeb
Ayyash, Mutamed
Namai, Fu
Nishiyama, Keita
Yoda, Kazutoyo
Villena, Julio Cesar
Kitazawa, Haruki
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv OBESITY
PROBIOTICS
ANTI-INFLAMMATORY ADIPOKINES
PRO-INFLAMMATORY ADIPOKINES
ADIPOCYTES
topic OBESITY
PROBIOTICS
ANTI-INFLAMMATORY ADIPOKINES
PRO-INFLAMMATORY ADIPOKINES
ADIPOCYTES
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.1
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Functional foods with probiotics are safe and effective dietary supplements to improve overweight and obesity. Thus, altering the intestinal microflora may be an effective approach for controlling or preventing obesity. This review aims to summarize the experimental method used to study probiotics and obesity, and recent advances in probiotics against obesity. In particular, we focused on studies (in vitro and in vivo) that used probiotics to treat obesity and its associated comorbidities. Several in vitro and in vivo (animal and human clinical) studies conducted with different bacterial species/strains have reported that probiotics promote anti-obesity effects by suppressing the differentiation of pre-adipocytes through immune cell activation, maintaining the Th1/Th2 cytokine balance, altering the intestinal microbiota composition, reducing the lipid profile, and regulating energy metabolism. Most studies on probiotics and obesity have shown that probiotics are responsible for a notable reduction in weight gain and body mass index. It also increases the levels of anti-inflammatory adipokines and decreases those of pro-inflammatory adipokines in the blood, which are responsible for the regulation of glucose and fatty acid breakdown. Furthermore, probiotics effectively increase insulin sensitivity and decrease systemic inflammation. Taken together, the intestinal microbiota profile found in overweight individuals can be modified by probiotic supplementation which can create a promising environment for weight loss along enhancing levels of adiponectin and decreasing leptin, tumor necrosis factor (TNF)-α, interleukin (IL)-6, monocyte chemotactic protein (MCP)-1, and transforming growth factor (TGF)-β on human health.
Fil: Kober, A. K. M. Humayun. Chittagong Veterinary And Animal Sciences University; Bangladesh
Fil: Saha, Sudeb. Sylhet Agricultural University; Bangladesh. Tohoku University; Japón
Fil: Ayyash, Mutamed. United Arab Emirates University; Emiratos Árabes Unidos
Fil: Namai, Fu. Tohoku University; Japón
Fil: Nishiyama, Keita. Takanashi Milk Products Co.; Japón
Fil: Yoda, Kazutoyo. Takanashi Milk Products Co.; Japón
Fil: Villena, Julio Cesar. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Tucumán. Centro de Referencia para Lactobacilos; Argentina
Fil: Kitazawa, Haruki. Tohoku University; Japón
description Functional foods with probiotics are safe and effective dietary supplements to improve overweight and obesity. Thus, altering the intestinal microflora may be an effective approach for controlling or preventing obesity. This review aims to summarize the experimental method used to study probiotics and obesity, and recent advances in probiotics against obesity. In particular, we focused on studies (in vitro and in vivo) that used probiotics to treat obesity and its associated comorbidities. Several in vitro and in vivo (animal and human clinical) studies conducted with different bacterial species/strains have reported that probiotics promote anti-obesity effects by suppressing the differentiation of pre-adipocytes through immune cell activation, maintaining the Th1/Th2 cytokine balance, altering the intestinal microbiota composition, reducing the lipid profile, and regulating energy metabolism. Most studies on probiotics and obesity have shown that probiotics are responsible for a notable reduction in weight gain and body mass index. It also increases the levels of anti-inflammatory adipokines and decreases those of pro-inflammatory adipokines in the blood, which are responsible for the regulation of glucose and fatty acid breakdown. Furthermore, probiotics effectively increase insulin sensitivity and decrease systemic inflammation. Taken together, the intestinal microbiota profile found in overweight individuals can be modified by probiotic supplementation which can create a promising environment for weight loss along enhancing levels of adiponectin and decreasing leptin, tumor necrosis factor (TNF)-α, interleukin (IL)-6, monocyte chemotactic protein (MCP)-1, and transforming growth factor (TGF)-β on human health.
publishDate 2024
dc.date.none.fl_str_mv 2024-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/260584
Kober, A. K. M. Humayun; Saha, Sudeb; Ayyash, Mutamed; Namai, Fu; Nishiyama, Keita; et al.; Insights into the Anti-Adipogenic and Anti-Inflammatory Potentialities of Probiotics against Obesity; Multidisciplinary Digital Publishing Institute; Nutrients; 16; 9; 4-2024; 1-22
2072-6643
CONICET Digital
CONICET
url http://hdl.handle.net/11336/260584
identifier_str_mv Kober, A. K. M. Humayun; Saha, Sudeb; Ayyash, Mutamed; Namai, Fu; Nishiyama, Keita; et al.; Insights into the Anti-Adipogenic and Anti-Inflammatory Potentialities of Probiotics against Obesity; Multidisciplinary Digital Publishing Institute; Nutrients; 16; 9; 4-2024; 1-22
2072-6643
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.mdpi.com/2072-6643/16/9/1373
info:eu-repo/semantics/altIdentifier/doi/10.3390/nu16091373
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
publisher.none.fl_str_mv Multidisciplinary Digital Publishing Institute
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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