Focal limbic sources create the large slow oscillations of the EEG in human deep sleep

Autores
Morgan, Kyle K.; Hathaway, Evan; Carson, Megan; Fernandez Corazza, Mariano; Shusterman, Roma; Luu, Phan; Tucker, Don M.
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Background: Initial observations with the human electroencephalogram (EEG) have interpreted slow oscillations (SOs) of the EEG during deep sleep (N3) as reflecting widespread surface-negative traveling waves that originate in frontal regions and propagate across the neocortex. However, mapping SOs with a high-density array shows the simultaneous appearance of posterior positive voltage fields in the EEG at the time of the frontal-negative fields, with the typical inversion point (apparent source) around the temporal lobe. Methods: Overnight 256-channel EEG recordings were gathered from 10 healthy young adults. Individual head conductivity models were created using each participant's own structural MRI. Source localization of SOs during N3 was then performed. Results: Electrical source localization models confirmed that these large waves were created by focal discharges within the ventral limbic cortex, including medial temporal and caudal orbitofrontal cortex. Conclusions: Although the functional neurophysiology of deep sleep involves interactions between limbic and neocortical networks, the large EEG deflections of deep sleep are not created by distributed traveling waves in lateral neocortex but instead by relatively focal limbic discharges.
Fil: Morgan, Kyle K.. Brain Electrophysiology Laboratory Company; Estados Unidos
Fil: Hathaway, Evan. Brain Electrophysiology Laboratory Company; Estados Unidos
Fil: Carson, Megan. Brain Electrophysiology Laboratory Company; Estados Unidos
Fil: Fernandez Corazza, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales. Universidad Nacional de La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales; Argentina
Fil: Shusterman, Roma. Brain Electrophysiology Laboratory Company; Estados Unidos
Fil: Luu, Phan. Brain Electrophysiology Laboratory Company; Estados Unidos. University of Oregon; Estados Unidos
Fil: Tucker, Don M.. University of Oregon; Estados Unidos. Brain Electrophysiology Laboratory Company; Estados Unidos
Materia
DENSE-ARRAY EEG
LIMBIC CORTEX
MEMORY
N3 SLEEP
SLEEP
SLOW OSCILLATIONS
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/173830
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/173830
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Focal limbic sources create the large slow oscillations of the EEG in human deep sleepMorgan, Kyle K.Hathaway, EvanCarson, MeganFernandez Corazza, MarianoShusterman, RomaLuu, PhanTucker, Don M.DENSE-ARRAY EEGLIMBIC CORTEXMEMORYN3 SLEEPSLEEPSLOW OSCILLATIONShttps://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3Background: Initial observations with the human electroencephalogram (EEG) have interpreted slow oscillations (SOs) of the EEG during deep sleep (N3) as reflecting widespread surface-negative traveling waves that originate in frontal regions and propagate across the neocortex. However, mapping SOs with a high-density array shows the simultaneous appearance of posterior positive voltage fields in the EEG at the time of the frontal-negative fields, with the typical inversion point (apparent source) around the temporal lobe. Methods: Overnight 256-channel EEG recordings were gathered from 10 healthy young adults. Individual head conductivity models were created using each participant's own structural MRI. Source localization of SOs during N3 was then performed. Results: Electrical source localization models confirmed that these large waves were created by focal discharges within the ventral limbic cortex, including medial temporal and caudal orbitofrontal cortex. Conclusions: Although the functional neurophysiology of deep sleep involves interactions between limbic and neocortical networks, the large EEG deflections of deep sleep are not created by distributed traveling waves in lateral neocortex but instead by relatively focal limbic discharges.Fil: Morgan, Kyle K.. Brain Electrophysiology Laboratory Company; Estados UnidosFil: Hathaway, Evan. Brain Electrophysiology Laboratory Company; Estados UnidosFil: Carson, Megan. Brain Electrophysiology Laboratory Company; Estados UnidosFil: Fernandez Corazza, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales. Universidad Nacional de La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales; ArgentinaFil: Shusterman, Roma. Brain Electrophysiology Laboratory Company; Estados UnidosFil: Luu, Phan. Brain Electrophysiology Laboratory Company; Estados Unidos. University of Oregon; Estados UnidosFil: Tucker, Don M.. University of Oregon; Estados Unidos. Brain Electrophysiology Laboratory Company; Estados UnidosElsevier Science2021-09info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/173830Morgan, Kyle K.; Hathaway, Evan; Carson, Megan; Fernandez Corazza, Mariano; Shusterman, Roma; et al.; Focal limbic sources create the large slow oscillations of the EEG in human deep sleep; Elsevier Science; Sleep Medicine; 85; 9-2021; 291-3021389-9457CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.sleep.2021.07.028info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-nd/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-10T13:24:08Zoai:ri.conicet.gov.ar:11336/173830instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-10 13:24:08.286CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Focal limbic sources create the large slow oscillations of the EEG in human deep sleep
title Focal limbic sources create the large slow oscillations of the EEG in human deep sleep
spellingShingle Focal limbic sources create the large slow oscillations of the EEG in human deep sleep
Morgan, Kyle K.
DENSE-ARRAY EEG
LIMBIC CORTEX
MEMORY
N3 SLEEP
SLEEP
SLOW OSCILLATIONS
title_short Focal limbic sources create the large slow oscillations of the EEG in human deep sleep
title_full Focal limbic sources create the large slow oscillations of the EEG in human deep sleep
title_fullStr Focal limbic sources create the large slow oscillations of the EEG in human deep sleep
title_full_unstemmed Focal limbic sources create the large slow oscillations of the EEG in human deep sleep
title_sort Focal limbic sources create the large slow oscillations of the EEG in human deep sleep
dc.creator.none.fl_str_mv Morgan, Kyle K.
Hathaway, Evan
Carson, Megan
Fernandez Corazza, Mariano
Shusterman, Roma
Luu, Phan
Tucker, Don M.
author Morgan, Kyle K.
author_facet Morgan, Kyle K.
Hathaway, Evan
Carson, Megan
Fernandez Corazza, Mariano
Shusterman, Roma
Luu, Phan
Tucker, Don M.
author_role author
author2 Hathaway, Evan
Carson, Megan
Fernandez Corazza, Mariano
Shusterman, Roma
Luu, Phan
Tucker, Don M.
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv DENSE-ARRAY EEG
LIMBIC CORTEX
MEMORY
N3 SLEEP
SLEEP
SLOW OSCILLATIONS
topic DENSE-ARRAY EEG
LIMBIC CORTEX
MEMORY
N3 SLEEP
SLEEP
SLOW OSCILLATIONS
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Background: Initial observations with the human electroencephalogram (EEG) have interpreted slow oscillations (SOs) of the EEG during deep sleep (N3) as reflecting widespread surface-negative traveling waves that originate in frontal regions and propagate across the neocortex. However, mapping SOs with a high-density array shows the simultaneous appearance of posterior positive voltage fields in the EEG at the time of the frontal-negative fields, with the typical inversion point (apparent source) around the temporal lobe. Methods: Overnight 256-channel EEG recordings were gathered from 10 healthy young adults. Individual head conductivity models were created using each participant's own structural MRI. Source localization of SOs during N3 was then performed. Results: Electrical source localization models confirmed that these large waves were created by focal discharges within the ventral limbic cortex, including medial temporal and caudal orbitofrontal cortex. Conclusions: Although the functional neurophysiology of deep sleep involves interactions between limbic and neocortical networks, the large EEG deflections of deep sleep are not created by distributed traveling waves in lateral neocortex but instead by relatively focal limbic discharges.
Fil: Morgan, Kyle K.. Brain Electrophysiology Laboratory Company; Estados Unidos
Fil: Hathaway, Evan. Brain Electrophysiology Laboratory Company; Estados Unidos
Fil: Carson, Megan. Brain Electrophysiology Laboratory Company; Estados Unidos
Fil: Fernandez Corazza, Mariano. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales. Universidad Nacional de La Plata. Instituto de Investigaciones en Electrónica, Control y Procesamiento de Señales; Argentina
Fil: Shusterman, Roma. Brain Electrophysiology Laboratory Company; Estados Unidos
Fil: Luu, Phan. Brain Electrophysiology Laboratory Company; Estados Unidos. University of Oregon; Estados Unidos
Fil: Tucker, Don M.. University of Oregon; Estados Unidos. Brain Electrophysiology Laboratory Company; Estados Unidos
description Background: Initial observations with the human electroencephalogram (EEG) have interpreted slow oscillations (SOs) of the EEG during deep sleep (N3) as reflecting widespread surface-negative traveling waves that originate in frontal regions and propagate across the neocortex. However, mapping SOs with a high-density array shows the simultaneous appearance of posterior positive voltage fields in the EEG at the time of the frontal-negative fields, with the typical inversion point (apparent source) around the temporal lobe. Methods: Overnight 256-channel EEG recordings were gathered from 10 healthy young adults. Individual head conductivity models were created using each participant's own structural MRI. Source localization of SOs during N3 was then performed. Results: Electrical source localization models confirmed that these large waves were created by focal discharges within the ventral limbic cortex, including medial temporal and caudal orbitofrontal cortex. Conclusions: Although the functional neurophysiology of deep sleep involves interactions between limbic and neocortical networks, the large EEG deflections of deep sleep are not created by distributed traveling waves in lateral neocortex but instead by relatively focal limbic discharges.
publishDate 2021
dc.date.none.fl_str_mv 2021-09
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/173830
Morgan, Kyle K.; Hathaway, Evan; Carson, Megan; Fernandez Corazza, Mariano; Shusterman, Roma; et al.; Focal limbic sources create the large slow oscillations of the EEG in human deep sleep; Elsevier Science; Sleep Medicine; 85; 9-2021; 291-302
1389-9457
CONICET Digital
CONICET
url http://hdl.handle.net/11336/173830
identifier_str_mv Morgan, Kyle K.; Hathaway, Evan; Carson, Megan; Fernandez Corazza, Mariano; Shusterman, Roma; et al.; Focal limbic sources create the large slow oscillations of the EEG in human deep sleep; Elsevier Science; Sleep Medicine; 85; 9-2021; 291-302
1389-9457
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.sleep.2021.07.028
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-nd/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842981336839618560
score 12.48226

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