Reactivation during sleep with incomplete reminder cues rather than complete ones stabilizes long-term memory in humans

Autores
Forcato, Cecilia; Klinzing, Jens G.; Carbone, Julia; Radloff, Michael; Weber, Frederik D.; Born, Jan; Diekelmann, Susanne
Año de publicación
2020
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Reactivation by reminder cues labilizes memories during wakefulness, requiring reconsolidation to persist. In contrast, during sleep, cued reactivation seems to directly stabilize memories. In reconsolidation, incomplete reminders are more effective in reactivating memories than complete reminders by inducing a mismatch, i.e. a discrepancy between expected and actual events. Whether mismatch is likewise detected during sleep is unclear. Here we test whether cued reactivation during sleep is more effective for mismatch-inducing incomplete than complete reminders. We first establish that only incomplete but not complete reminders labilize memories during wakefulness. When complete or incomplete reminders are presented during 40-min sleep, both reminders are equally effective in stabilizing memories. However, when extending the retention interval for another 7 hours (following 40-min sleep), only incomplete but not complete reminders stabilize memories, regardless of the extension containing wakefulness or sleep. We propose that, during sleep, only incomplete reminders initiate long-term memory stabilization via mismatch detection.
Fil: Forcato, Cecilia. Instituto Tecnológico de Buenos Aires. Departamento de Investigación y Doctorado; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Klinzing, Jens G.. Eberhard Karls Universität Tübingen; Alemania. University of Princeton; Estados Unidos
Fil: Carbone, Julia. Eberhard Karls Universität Tübingen; Alemania
Fil: Radloff, Michael. Eberhard Karls Universität Tübingen; Alemania
Fil: Weber, Frederik D.. Radboud Universiteit Nijmegen. Donders Instituto Brain Cognition and Behavior. SNN Machine Learning Group; Países Bajos
Fil: Born, Jan. Eberhard Karls Universität Tübingen; Alemania
Fil: Diekelmann, Susanne. Eberhard Karls Universität Tübingen; Alemania
Materia
RECONSOLIDATION
SLOW WAVE SLEEP
REACTIVATION
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/171674
Acceder
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network_name_str CONICET Digital (CONICET)
spelling Reactivation during sleep with incomplete reminder cues rather than complete ones stabilizes long-term memory in humansForcato, CeciliaKlinzing, Jens G.Carbone, JuliaRadloff, MichaelWeber, Frederik D.Born, JanDiekelmann, SusanneRECONSOLIDATIONSLOW WAVE SLEEPREACTIVATIONhttps://purl.org/becyt/ford/1.7https://purl.org/becyt/ford/1Reactivation by reminder cues labilizes memories during wakefulness, requiring reconsolidation to persist. In contrast, during sleep, cued reactivation seems to directly stabilize memories. In reconsolidation, incomplete reminders are more effective in reactivating memories than complete reminders by inducing a mismatch, i.e. a discrepancy between expected and actual events. Whether mismatch is likewise detected during sleep is unclear. Here we test whether cued reactivation during sleep is more effective for mismatch-inducing incomplete than complete reminders. We first establish that only incomplete but not complete reminders labilize memories during wakefulness. When complete or incomplete reminders are presented during 40-min sleep, both reminders are equally effective in stabilizing memories. However, when extending the retention interval for another 7 hours (following 40-min sleep), only incomplete but not complete reminders stabilize memories, regardless of the extension containing wakefulness or sleep. We propose that, during sleep, only incomplete reminders initiate long-term memory stabilization via mismatch detection.Fil: Forcato, Cecilia. Instituto Tecnológico de Buenos Aires. Departamento de Investigación y Doctorado; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Klinzing, Jens G.. Eberhard Karls Universität Tübingen; Alemania. University of Princeton; Estados UnidosFil: Carbone, Julia. Eberhard Karls Universität Tübingen; AlemaniaFil: Radloff, Michael. Eberhard Karls Universität Tübingen; AlemaniaFil: Weber, Frederik D.. Radboud Universiteit Nijmegen. Donders Instituto Brain Cognition and Behavior. SNN Machine Learning Group; Países BajosFil: Born, Jan. Eberhard Karls Universität Tübingen; AlemaniaFil: Diekelmann, Susanne. Eberhard Karls Universität Tübingen; AlemaniaNature2020-12-04info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/171674Forcato, Cecilia; Klinzing, Jens G.; Carbone, Julia; Radloff, Michael; Weber, Frederik D.; et al.; Reactivation during sleep with incomplete reminder cues rather than complete ones stabilizes long-term memory in humans; Nature; Communications Biology; 3; 1; 4-12-2020; 1-132399-3642CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s42003-020-01457-4info:eu-repo/semantics/altIdentifier/doi/10.1038/s42003-020-01457-4info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-17T11:24:16Zoai:ri.conicet.gov.ar:11336/171674instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-17 11:24:16.711CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Reactivation during sleep with incomplete reminder cues rather than complete ones stabilizes long-term memory in humans
title Reactivation during sleep with incomplete reminder cues rather than complete ones stabilizes long-term memory in humans
spellingShingle Reactivation during sleep with incomplete reminder cues rather than complete ones stabilizes long-term memory in humans
Forcato, Cecilia
RECONSOLIDATION
SLOW WAVE SLEEP
REACTIVATION
title_short Reactivation during sleep with incomplete reminder cues rather than complete ones stabilizes long-term memory in humans
title_full Reactivation during sleep with incomplete reminder cues rather than complete ones stabilizes long-term memory in humans
title_fullStr Reactivation during sleep with incomplete reminder cues rather than complete ones stabilizes long-term memory in humans
title_full_unstemmed Reactivation during sleep with incomplete reminder cues rather than complete ones stabilizes long-term memory in humans
title_sort Reactivation during sleep with incomplete reminder cues rather than complete ones stabilizes long-term memory in humans
dc.creator.none.fl_str_mv Forcato, Cecilia
Klinzing, Jens G.
Carbone, Julia
Radloff, Michael
Weber, Frederik D.
Born, Jan
Diekelmann, Susanne
author Forcato, Cecilia
author_facet Forcato, Cecilia
Klinzing, Jens G.
Carbone, Julia
Radloff, Michael
Weber, Frederik D.
Born, Jan
Diekelmann, Susanne
author_role author
author2 Klinzing, Jens G.
Carbone, Julia
Radloff, Michael
Weber, Frederik D.
Born, Jan
Diekelmann, Susanne
author2_role author
author
author
author
author
author
dc.subject.none.fl_str_mv RECONSOLIDATION
SLOW WAVE SLEEP
REACTIVATION
topic RECONSOLIDATION
SLOW WAVE SLEEP
REACTIVATION
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.7
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Reactivation by reminder cues labilizes memories during wakefulness, requiring reconsolidation to persist. In contrast, during sleep, cued reactivation seems to directly stabilize memories. In reconsolidation, incomplete reminders are more effective in reactivating memories than complete reminders by inducing a mismatch, i.e. a discrepancy between expected and actual events. Whether mismatch is likewise detected during sleep is unclear. Here we test whether cued reactivation during sleep is more effective for mismatch-inducing incomplete than complete reminders. We first establish that only incomplete but not complete reminders labilize memories during wakefulness. When complete or incomplete reminders are presented during 40-min sleep, both reminders are equally effective in stabilizing memories. However, when extending the retention interval for another 7 hours (following 40-min sleep), only incomplete but not complete reminders stabilize memories, regardless of the extension containing wakefulness or sleep. We propose that, during sleep, only incomplete reminders initiate long-term memory stabilization via mismatch detection.
Fil: Forcato, Cecilia. Instituto Tecnológico de Buenos Aires. Departamento de Investigación y Doctorado; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Klinzing, Jens G.. Eberhard Karls Universität Tübingen; Alemania. University of Princeton; Estados Unidos
Fil: Carbone, Julia. Eberhard Karls Universität Tübingen; Alemania
Fil: Radloff, Michael. Eberhard Karls Universität Tübingen; Alemania
Fil: Weber, Frederik D.. Radboud Universiteit Nijmegen. Donders Instituto Brain Cognition and Behavior. SNN Machine Learning Group; Países Bajos
Fil: Born, Jan. Eberhard Karls Universität Tübingen; Alemania
Fil: Diekelmann, Susanne. Eberhard Karls Universität Tübingen; Alemania
description Reactivation by reminder cues labilizes memories during wakefulness, requiring reconsolidation to persist. In contrast, during sleep, cued reactivation seems to directly stabilize memories. In reconsolidation, incomplete reminders are more effective in reactivating memories than complete reminders by inducing a mismatch, i.e. a discrepancy between expected and actual events. Whether mismatch is likewise detected during sleep is unclear. Here we test whether cued reactivation during sleep is more effective for mismatch-inducing incomplete than complete reminders. We first establish that only incomplete but not complete reminders labilize memories during wakefulness. When complete or incomplete reminders are presented during 40-min sleep, both reminders are equally effective in stabilizing memories. However, when extending the retention interval for another 7 hours (following 40-min sleep), only incomplete but not complete reminders stabilize memories, regardless of the extension containing wakefulness or sleep. We propose that, during sleep, only incomplete reminders initiate long-term memory stabilization via mismatch detection.
publishDate 2020
dc.date.none.fl_str_mv 2020-12-04
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/171674
Forcato, Cecilia; Klinzing, Jens G.; Carbone, Julia; Radloff, Michael; Weber, Frederik D.; et al.; Reactivation during sleep with incomplete reminder cues rather than complete ones stabilizes long-term memory in humans; Nature; Communications Biology; 3; 1; 4-12-2020; 1-13
2399-3642
CONICET Digital
CONICET
url http://hdl.handle.net/11336/171674
identifier_str_mv Forcato, Cecilia; Klinzing, Jens G.; Carbone, Julia; Radloff, Michael; Weber, Frederik D.; et al.; Reactivation during sleep with incomplete reminder cues rather than complete ones stabilizes long-term memory in humans; Nature; Communications Biology; 3; 1; 4-12-2020; 1-13
2399-3642
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/http://www.nature.com/articles/s42003-020-01457-4
info:eu-repo/semantics/altIdentifier/doi/10.1038/s42003-020-01457-4
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature
publisher.none.fl_str_mv Nature
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.001348

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