Behavioural multigenerational effect induced by the administration of very low doses of zinc during pregnancy, lactation and prepuberal period in the rat

Autores
Ratti, Silvia Gabriela; Sacchi, Osvaldo Jorge; Alvarez, Edgardo Oscar
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
In previous studies from this laboratory, the chronic administration of ZnTe during pregnancy, lactation and prepuberal stages of litters (F1 generation), the behavioural patterns of motivated exploration, lateralized exploration, social activity and survival responses of the maturing rats were modified. In order to find out if these affected behaviours should extend to the next generation, F1 litter rats, exposed previously to tellurium (Te) up to 30 days of age were left at rest with no further treatment up to reach 70 day-old. Then, F1 female rats were mated with normal untreated male rats, and in the next generation (F2), the litter rats at 30 day-old preserved the modified behaviours previously observed in their parents. This evidence suggested that Te effects were intergenerational. In the present work, considering that in the first study ZnTe was used, and it is well known that Zn ion has many physiological functions in the cell, experiments were done in order to define if Zn could have a similar intergenerational effect than Te. Working with the same experimental setup than in previous experiments, but using ZnCl2 instead of ZnTe, results shown that none of the behavioural responses studied were affected in F1 generation. However, in F2 generation lateralized exploration and survival behaviour were inhibited, suggesting that Zn also has an intergenerational effect.
Fil: Ratti, Silvia Gabriela. Universidad Catolica de Cuyo. Sede San Luis. Facultad de Ciencias Medicas. Laboratorio de Epigenesis y Neuropsicofarmacologia Experimental; Argentina
Fil: Sacchi, Osvaldo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Alvarez, Edgardo Oscar. Universidad Catolica de Cuyo. Sede San Luis. Facultad de Ciencias Medicas. Laboratorio de Epigenesis y Neuropsicofarmacologia Experimental; Argentina
Materia
LATERALITY
ZINC
TRACE ELEMENT
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/173084
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Behavioural multigenerational effect induced by the administration of very low doses of zinc during pregnancy, lactation and prepuberal period in the ratRatti, Silvia GabrielaSacchi, Osvaldo JorgeAlvarez, Edgardo OscarLATERALITYZINCTRACE ELEMENThttps://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3In previous studies from this laboratory, the chronic administration of ZnTe during pregnancy, lactation and prepuberal stages of litters (F1 generation), the behavioural patterns of motivated exploration, lateralized exploration, social activity and survival responses of the maturing rats were modified. In order to find out if these affected behaviours should extend to the next generation, F1 litter rats, exposed previously to tellurium (Te) up to 30 days of age were left at rest with no further treatment up to reach 70 day-old. Then, F1 female rats were mated with normal untreated male rats, and in the next generation (F2), the litter rats at 30 day-old preserved the modified behaviours previously observed in their parents. This evidence suggested that Te effects were intergenerational. In the present work, considering that in the first study ZnTe was used, and it is well known that Zn ion has many physiological functions in the cell, experiments were done in order to define if Zn could have a similar intergenerational effect than Te. Working with the same experimental setup than in previous experiments, but using ZnCl2 instead of ZnTe, results shown that none of the behavioural responses studied were affected in F1 generation. However, in F2 generation lateralized exploration and survival behaviour were inhibited, suggesting that Zn also has an intergenerational effect.Fil: Ratti, Silvia Gabriela. Universidad Catolica de Cuyo. Sede San Luis. Facultad de Ciencias Medicas. Laboratorio de Epigenesis y Neuropsicofarmacologia Experimental; ArgentinaFil: Sacchi, Osvaldo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; ArgentinaFil: Alvarez, Edgardo Oscar. Universidad Catolica de Cuyo. Sede San Luis. Facultad de Ciencias Medicas. Laboratorio de Epigenesis y Neuropsicofarmacologia Experimental; ArgentinaTsinghua University Press2021-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/173084Ratti, Silvia Gabriela; Sacchi, Osvaldo Jorge; Alvarez, Edgardo Oscar; Behavioural multigenerational effect induced by the administration of very low doses of zinc during pregnancy, lactation and prepuberal period in the rat; Tsinghua University Press; Journal of Neurorestoratology; 9; 1; 3-2021; 72-802324-2426CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2324242622000572info:eu-repo/semantics/altIdentifier/doi/10.26599/JNR.2021.9040004info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:29:36Zoai:ri.conicet.gov.ar:11336/173084instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:29:37.075CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Behavioural multigenerational effect induced by the administration of very low doses of zinc during pregnancy, lactation and prepuberal period in the rat
title Behavioural multigenerational effect induced by the administration of very low doses of zinc during pregnancy, lactation and prepuberal period in the rat
spellingShingle Behavioural multigenerational effect induced by the administration of very low doses of zinc during pregnancy, lactation and prepuberal period in the rat
Ratti, Silvia Gabriela
LATERALITY
ZINC
TRACE ELEMENT
title_short Behavioural multigenerational effect induced by the administration of very low doses of zinc during pregnancy, lactation and prepuberal period in the rat
title_full Behavioural multigenerational effect induced by the administration of very low doses of zinc during pregnancy, lactation and prepuberal period in the rat
title_fullStr Behavioural multigenerational effect induced by the administration of very low doses of zinc during pregnancy, lactation and prepuberal period in the rat
title_full_unstemmed Behavioural multigenerational effect induced by the administration of very low doses of zinc during pregnancy, lactation and prepuberal period in the rat
title_sort Behavioural multigenerational effect induced by the administration of very low doses of zinc during pregnancy, lactation and prepuberal period in the rat
dc.creator.none.fl_str_mv Ratti, Silvia Gabriela
Sacchi, Osvaldo Jorge
Alvarez, Edgardo Oscar
author Ratti, Silvia Gabriela
author_facet Ratti, Silvia Gabriela
Sacchi, Osvaldo Jorge
Alvarez, Edgardo Oscar
author_role author
author2 Sacchi, Osvaldo Jorge
Alvarez, Edgardo Oscar
author2_role author
author
dc.subject.none.fl_str_mv LATERALITY
ZINC
TRACE ELEMENT
topic LATERALITY
ZINC
TRACE ELEMENT
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv In previous studies from this laboratory, the chronic administration of ZnTe during pregnancy, lactation and prepuberal stages of litters (F1 generation), the behavioural patterns of motivated exploration, lateralized exploration, social activity and survival responses of the maturing rats were modified. In order to find out if these affected behaviours should extend to the next generation, F1 litter rats, exposed previously to tellurium (Te) up to 30 days of age were left at rest with no further treatment up to reach 70 day-old. Then, F1 female rats were mated with normal untreated male rats, and in the next generation (F2), the litter rats at 30 day-old preserved the modified behaviours previously observed in their parents. This evidence suggested that Te effects were intergenerational. In the present work, considering that in the first study ZnTe was used, and it is well known that Zn ion has many physiological functions in the cell, experiments were done in order to define if Zn could have a similar intergenerational effect than Te. Working with the same experimental setup than in previous experiments, but using ZnCl2 instead of ZnTe, results shown that none of the behavioural responses studied were affected in F1 generation. However, in F2 generation lateralized exploration and survival behaviour were inhibited, suggesting that Zn also has an intergenerational effect.
Fil: Ratti, Silvia Gabriela. Universidad Catolica de Cuyo. Sede San Luis. Facultad de Ciencias Medicas. Laboratorio de Epigenesis y Neuropsicofarmacologia Experimental; Argentina
Fil: Sacchi, Osvaldo Jorge. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - Mendoza. Instituto de Medicina y Biología Experimental de Cuyo; Argentina
Fil: Alvarez, Edgardo Oscar. Universidad Catolica de Cuyo. Sede San Luis. Facultad de Ciencias Medicas. Laboratorio de Epigenesis y Neuropsicofarmacologia Experimental; Argentina
description In previous studies from this laboratory, the chronic administration of ZnTe during pregnancy, lactation and prepuberal stages of litters (F1 generation), the behavioural patterns of motivated exploration, lateralized exploration, social activity and survival responses of the maturing rats were modified. In order to find out if these affected behaviours should extend to the next generation, F1 litter rats, exposed previously to tellurium (Te) up to 30 days of age were left at rest with no further treatment up to reach 70 day-old. Then, F1 female rats were mated with normal untreated male rats, and in the next generation (F2), the litter rats at 30 day-old preserved the modified behaviours previously observed in their parents. This evidence suggested that Te effects were intergenerational. In the present work, considering that in the first study ZnTe was used, and it is well known that Zn ion has many physiological functions in the cell, experiments were done in order to define if Zn could have a similar intergenerational effect than Te. Working with the same experimental setup than in previous experiments, but using ZnCl2 instead of ZnTe, results shown that none of the behavioural responses studied were affected in F1 generation. However, in F2 generation lateralized exploration and survival behaviour were inhibited, suggesting that Zn also has an intergenerational effect.
publishDate 2021
dc.date.none.fl_str_mv 2021-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/173084
Ratti, Silvia Gabriela; Sacchi, Osvaldo Jorge; Alvarez, Edgardo Oscar; Behavioural multigenerational effect induced by the administration of very low doses of zinc during pregnancy, lactation and prepuberal period in the rat; Tsinghua University Press; Journal of Neurorestoratology; 9; 1; 3-2021; 72-80
2324-2426
CONICET Digital
CONICET
url http://hdl.handle.net/11336/173084
identifier_str_mv Ratti, Silvia Gabriela; Sacchi, Osvaldo Jorge; Alvarez, Edgardo Oscar; Behavioural multigenerational effect induced by the administration of very low doses of zinc during pregnancy, lactation and prepuberal period in the rat; Tsinghua University Press; Journal of Neurorestoratology; 9; 1; 3-2021; 72-80
2324-2426
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S2324242622000572
info:eu-repo/semantics/altIdentifier/doi/10.26599/JNR.2021.9040004
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Tsinghua University Press
publisher.none.fl_str_mv Tsinghua University Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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