An analysis of the possible protective effect of antipsychotics for SARS-CoV-2 in patients under treatment for severe mental illnesses

Autores
Prokopez, Cintia R.; Vallejos, Miguel; Lopredo, Lorena S.; Sfriso, Luciano E.; Chiapella, Luciana Carla; Arce, Claudio; Corral, Ricardo M.; Cuesta, Manuel J.; Farinola, Romina; Alomo, Martín
Año de publicación
2021
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Since the Severe Acute Respiratory Syndrome coronavirus type 2 (SARS-CoV-2) pandemic has sparked, it was supposed that inpatients with severe mental illnesses (SMI) could be at higher risk of developing the infection, as a consequence of their long stay in closed institutions, adding to the difficulty that SMI entails for compliance with prevention measures, like social distancing or mask wearing. Moreover, people with SMI usually tend to have unhealthy habits, including the use of high amounts of tobacco, a sedentary lifestyle, and an inappropriate diet. These factors, added to the metabolic adverse effects associated with the use of atypical antipsychotics, predispose to respiratory, cardiovascular, and metabolic diseases (Rossler, Salize et al. 2005). It is well known that all these conditions are associated with a severe course of SARS-CoV-2 disease (Chen, Wu et al. 2020, Grasselli, Greco et al. 2020, Zheng, Peng et al. 2020). Since the pandemic started in Argentina, we expected a growing number of infected inpatients among mental health hospitals. To prevent the SARS-CoV-2 spread among patients in closed institutions, a SARS-CoV-2 unit was created to receive all inpatients with a positive test and the absence of symptoms, or the presence of mild symptoms. To our surprise, these units received few patients, and even fewer patients required to be transferred to more complex general hospitals because of the disease severity. These events led us to ask if antipsychotics could have a protective effect on the disease.
Fil: Prokopez, Cintia R.. Hospital Neuropsiquiátrico Braulio Aurelio Moyano; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Farmacología; Argentina
Fil: Vallejos, Miguel. Gobierno de la Ciudad de Buenos Aires. Hospital Municipal "José Tiburcio Borda"; Argentina
Fil: Lopredo, Lorena S.. Hospital Neuropsiquiátrico Braulio Aurelio Moyano; Argentina
Fil: Sfriso, Luciano E.. Hospital Neuropsiquiátrico Braulio Aurelio Moyano; Argentina
Fil: Chiapella, Luciana Carla. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Arce, Claudio. Hospital Neuropsiquiátrico Braulio Aurelio Moyano; Argentina
Fil: Corral, Ricardo M.. Gobierno de la Ciudad de Buenos Aires. Hospital Municipal "José Tiburcio Borda"; Argentina
Fil: Cuesta, Manuel J.. Hospital de Navarra; España. Universidad Pública de Navarra; España
Fil: Farinola, Romina. Gobierno de la Ciudad de Buenos Aires. Hospital Municipal "José Tiburcio Borda"; Argentina
Fil: Alomo, Martín. Hospital Neuropsiquiátrico Braulio Aurelio Moyano; Argentina. Universidad de Buenos Aires; Argentina
Materia
SARS-CoV-2
Covid-19
antipsychotics
COVID-19
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/149839
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/149839
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling An analysis of the possible protective effect of antipsychotics for SARS-CoV-2 in patients under treatment for severe mental illnessesProkopez, Cintia R.Vallejos, MiguelLopredo, Lorena S.Sfriso, Luciano E.Chiapella, Luciana CarlaArce, ClaudioCorral, Ricardo M.Cuesta, Manuel J.Farinola, RominaAlomo, MartínSARS-CoV-2Covid-19antipsychoticsCOVID-19https://purl.org/becyt/ford/3.2https://purl.org/becyt/ford/3https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3Since the Severe Acute Respiratory Syndrome coronavirus type 2 (SARS-CoV-2) pandemic has sparked, it was supposed that inpatients with severe mental illnesses (SMI) could be at higher risk of developing the infection, as a consequence of their long stay in closed institutions, adding to the difficulty that SMI entails for compliance with prevention measures, like social distancing or mask wearing. Moreover, people with SMI usually tend to have unhealthy habits, including the use of high amounts of tobacco, a sedentary lifestyle, and an inappropriate diet. These factors, added to the metabolic adverse effects associated with the use of atypical antipsychotics, predispose to respiratory, cardiovascular, and metabolic diseases (Rossler, Salize et al. 2005). It is well known that all these conditions are associated with a severe course of SARS-CoV-2 disease (Chen, Wu et al. 2020, Grasselli, Greco et al. 2020, Zheng, Peng et al. 2020). Since the pandemic started in Argentina, we expected a growing number of infected inpatients among mental health hospitals. To prevent the SARS-CoV-2 spread among patients in closed institutions, a SARS-CoV-2 unit was created to receive all inpatients with a positive test and the absence of symptoms, or the presence of mild symptoms. To our surprise, these units received few patients, and even fewer patients required to be transferred to more complex general hospitals because of the disease severity. These events led us to ask if antipsychotics could have a protective effect on the disease.Fil: Prokopez, Cintia R.. Hospital Neuropsiquiátrico Braulio Aurelio Moyano; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Farmacología; ArgentinaFil: Vallejos, Miguel. Gobierno de la Ciudad de Buenos Aires. Hospital Municipal "José Tiburcio Borda"; ArgentinaFil: Lopredo, Lorena S.. Hospital Neuropsiquiátrico Braulio Aurelio Moyano; ArgentinaFil: Sfriso, Luciano E.. Hospital Neuropsiquiátrico Braulio Aurelio Moyano; ArgentinaFil: Chiapella, Luciana Carla. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; ArgentinaFil: Arce, Claudio. Hospital Neuropsiquiátrico Braulio Aurelio Moyano; ArgentinaFil: Corral, Ricardo M.. Gobierno de la Ciudad de Buenos Aires. Hospital Municipal "José Tiburcio Borda"; ArgentinaFil: Cuesta, Manuel J.. Hospital de Navarra; España. Universidad Pública de Navarra; EspañaFil: Farinola, Romina. Gobierno de la Ciudad de Buenos Aires. Hospital Municipal "José Tiburcio Borda"; ArgentinaFil: Alomo, Martín. Hospital Neuropsiquiátrico Braulio Aurelio Moyano; Argentina. Universidad de Buenos Aires; ArgentinaElsevier Science2021-06info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/149839Prokopez, Cintia R.; Vallejos, Miguel; Lopredo, Lorena S.; Sfriso, Luciano E.; Chiapella, Luciana Carla; et al.; An analysis of the possible protective effect of antipsychotics for SARS-CoV-2 in patients under treatment for severe mental illnesses; Elsevier Science; Schizophrenia Research; 233; 6-2021; 99-1000920-9964CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.schres.2021.06.019info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0920996421002310info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-29T10:24:03Zoai:ri.conicet.gov.ar:11336/149839instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-29 10:24:04.101CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv An analysis of the possible protective effect of antipsychotics for SARS-CoV-2 in patients under treatment for severe mental illnesses
title An analysis of the possible protective effect of antipsychotics for SARS-CoV-2 in patients under treatment for severe mental illnesses
spellingShingle An analysis of the possible protective effect of antipsychotics for SARS-CoV-2 in patients under treatment for severe mental illnesses
Prokopez, Cintia R.
SARS-CoV-2
Covid-19
antipsychotics
COVID-19
title_short An analysis of the possible protective effect of antipsychotics for SARS-CoV-2 in patients under treatment for severe mental illnesses
title_full An analysis of the possible protective effect of antipsychotics for SARS-CoV-2 in patients under treatment for severe mental illnesses
title_fullStr An analysis of the possible protective effect of antipsychotics for SARS-CoV-2 in patients under treatment for severe mental illnesses
title_full_unstemmed An analysis of the possible protective effect of antipsychotics for SARS-CoV-2 in patients under treatment for severe mental illnesses
title_sort An analysis of the possible protective effect of antipsychotics for SARS-CoV-2 in patients under treatment for severe mental illnesses
dc.creator.none.fl_str_mv Prokopez, Cintia R.
Vallejos, Miguel
Lopredo, Lorena S.
Sfriso, Luciano E.
Chiapella, Luciana Carla
Arce, Claudio
Corral, Ricardo M.
Cuesta, Manuel J.
Farinola, Romina
Alomo, Martín
author Prokopez, Cintia R.
author_facet Prokopez, Cintia R.
Vallejos, Miguel
Lopredo, Lorena S.
Sfriso, Luciano E.
Chiapella, Luciana Carla
Arce, Claudio
Corral, Ricardo M.
Cuesta, Manuel J.
Farinola, Romina
Alomo, Martín
author_role author
author2 Vallejos, Miguel
Lopredo, Lorena S.
Sfriso, Luciano E.
Chiapella, Luciana Carla
Arce, Claudio
Corral, Ricardo M.
Cuesta, Manuel J.
Farinola, Romina
Alomo, Martín
author2_role author
author
author
author
author
author
author
author
author
dc.subject.none.fl_str_mv SARS-CoV-2
Covid-19
antipsychotics
COVID-19
topic SARS-CoV-2
Covid-19
antipsychotics
COVID-19
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.2
https://purl.org/becyt/ford/3
https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv Since the Severe Acute Respiratory Syndrome coronavirus type 2 (SARS-CoV-2) pandemic has sparked, it was supposed that inpatients with severe mental illnesses (SMI) could be at higher risk of developing the infection, as a consequence of their long stay in closed institutions, adding to the difficulty that SMI entails for compliance with prevention measures, like social distancing or mask wearing. Moreover, people with SMI usually tend to have unhealthy habits, including the use of high amounts of tobacco, a sedentary lifestyle, and an inappropriate diet. These factors, added to the metabolic adverse effects associated with the use of atypical antipsychotics, predispose to respiratory, cardiovascular, and metabolic diseases (Rossler, Salize et al. 2005). It is well known that all these conditions are associated with a severe course of SARS-CoV-2 disease (Chen, Wu et al. 2020, Grasselli, Greco et al. 2020, Zheng, Peng et al. 2020). Since the pandemic started in Argentina, we expected a growing number of infected inpatients among mental health hospitals. To prevent the SARS-CoV-2 spread among patients in closed institutions, a SARS-CoV-2 unit was created to receive all inpatients with a positive test and the absence of symptoms, or the presence of mild symptoms. To our surprise, these units received few patients, and even fewer patients required to be transferred to more complex general hospitals because of the disease severity. These events led us to ask if antipsychotics could have a protective effect on the disease.
Fil: Prokopez, Cintia R.. Hospital Neuropsiquiátrico Braulio Aurelio Moyano; Argentina. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Farmacología; Argentina
Fil: Vallejos, Miguel. Gobierno de la Ciudad de Buenos Aires. Hospital Municipal "José Tiburcio Borda"; Argentina
Fil: Lopredo, Lorena S.. Hospital Neuropsiquiátrico Braulio Aurelio Moyano; Argentina
Fil: Sfriso, Luciano E.. Hospital Neuropsiquiátrico Braulio Aurelio Moyano; Argentina
Fil: Chiapella, Luciana Carla. Universidad Nacional de Rosario; Argentina. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina
Fil: Arce, Claudio. Hospital Neuropsiquiátrico Braulio Aurelio Moyano; Argentina
Fil: Corral, Ricardo M.. Gobierno de la Ciudad de Buenos Aires. Hospital Municipal "José Tiburcio Borda"; Argentina
Fil: Cuesta, Manuel J.. Hospital de Navarra; España. Universidad Pública de Navarra; España
Fil: Farinola, Romina. Gobierno de la Ciudad de Buenos Aires. Hospital Municipal "José Tiburcio Borda"; Argentina
Fil: Alomo, Martín. Hospital Neuropsiquiátrico Braulio Aurelio Moyano; Argentina. Universidad de Buenos Aires; Argentina
description Since the Severe Acute Respiratory Syndrome coronavirus type 2 (SARS-CoV-2) pandemic has sparked, it was supposed that inpatients with severe mental illnesses (SMI) could be at higher risk of developing the infection, as a consequence of their long stay in closed institutions, adding to the difficulty that SMI entails for compliance with prevention measures, like social distancing or mask wearing. Moreover, people with SMI usually tend to have unhealthy habits, including the use of high amounts of tobacco, a sedentary lifestyle, and an inappropriate diet. These factors, added to the metabolic adverse effects associated with the use of atypical antipsychotics, predispose to respiratory, cardiovascular, and metabolic diseases (Rossler, Salize et al. 2005). It is well known that all these conditions are associated with a severe course of SARS-CoV-2 disease (Chen, Wu et al. 2020, Grasselli, Greco et al. 2020, Zheng, Peng et al. 2020). Since the pandemic started in Argentina, we expected a growing number of infected inpatients among mental health hospitals. To prevent the SARS-CoV-2 spread among patients in closed institutions, a SARS-CoV-2 unit was created to receive all inpatients with a positive test and the absence of symptoms, or the presence of mild symptoms. To our surprise, these units received few patients, and even fewer patients required to be transferred to more complex general hospitals because of the disease severity. These events led us to ask if antipsychotics could have a protective effect on the disease.
publishDate 2021
dc.date.none.fl_str_mv 2021-06
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/149839
Prokopez, Cintia R.; Vallejos, Miguel; Lopredo, Lorena S.; Sfriso, Luciano E.; Chiapella, Luciana Carla; et al.; An analysis of the possible protective effect of antipsychotics for SARS-CoV-2 in patients under treatment for severe mental illnesses; Elsevier Science; Schizophrenia Research; 233; 6-2021; 99-100
0920-9964
CONICET Digital
CONICET
url http://hdl.handle.net/11336/149839
identifier_str_mv Prokopez, Cintia R.; Vallejos, Miguel; Lopredo, Lorena S.; Sfriso, Luciano E.; Chiapella, Luciana Carla; et al.; An analysis of the possible protective effect of antipsychotics for SARS-CoV-2 in patients under treatment for severe mental illnesses; Elsevier Science; Schizophrenia Research; 233; 6-2021; 99-100
0920-9964
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.schres.2021.06.019
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0920996421002310
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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score 13.070432

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