Molecular mechanisms implicated in SARS-CoV-2 liver tropism

Autores
Quarleri, Jorge Fabian; Delpino, María Victoria
Año de publicación
2022
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
The coronavirus disease 2019 (COVID-19) pandemic is caused by severe acuterespiratory syndrome coronavirus 2 (SARS-CoV-2). Hepatic involvement iscommon in SARS-CoV-2-infected individuals. It is currently accepted that thedirect and indirect hepatic effects of SARS-CoV-2 infection play a significant rolein COVID-19. In individuals with pre-existing infectious and non-infectious liverdisease, who are at a remarkably higher risk of developing severe COVID-19 anddeath, this pathology is most medically relevant. This review emphasizes thecurrent pathways regarded as contributing to the gastrointestinal and hepaticailments linked to COVID-19-infected patients due to an imbalanced interactionamong the liver, systemic inflammation, disrupted coagulation, and the lung.
Fil: Quarleri, Jorge Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Delpino, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Materia
SARS-CoV2
LIVER
COVID-19
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/213178
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/213178
network_acronym_str CONICETDig
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network_name_str CONICET Digital (CONICET)
spelling Molecular mechanisms implicated in SARS-CoV-2 liver tropismQuarleri, Jorge FabianDelpino, María VictoriaSARS-CoV2LIVERCOVID-19https://purl.org/becyt/ford/3.3https://purl.org/becyt/ford/3The coronavirus disease 2019 (COVID-19) pandemic is caused by severe acuterespiratory syndrome coronavirus 2 (SARS-CoV-2). Hepatic involvement iscommon in SARS-CoV-2-infected individuals. It is currently accepted that thedirect and indirect hepatic effects of SARS-CoV-2 infection play a significant rolein COVID-19. In individuals with pre-existing infectious and non-infectious liverdisease, who are at a remarkably higher risk of developing severe COVID-19 anddeath, this pathology is most medically relevant. This review emphasizes thecurrent pathways regarded as contributing to the gastrointestinal and hepaticailments linked to COVID-19-infected patients due to an imbalanced interactionamong the liver, systemic inflammation, disrupted coagulation, and the lung.Fil: Quarleri, Jorge Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaFil: Delpino, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; ArgentinaW J G Press2022-12info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/213178Quarleri, Jorge Fabian; Delpino, María Victoria; Molecular mechanisms implicated in SARS-CoV-2 liver tropism; W J G Press; World Journal of Gastroenterology; 28; 48; 12-2022; 6875-68871007-93272219-2840CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.wjgnet.com/1007-9327/full/v28/i48/6875.htminfo:eu-repo/semantics/altIdentifier/doi/10.3748/wjg.v28.i48.6875info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T09:50:52Zoai:ri.conicet.gov.ar:11336/213178instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 09:50:53.022CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Molecular mechanisms implicated in SARS-CoV-2 liver tropism
title Molecular mechanisms implicated in SARS-CoV-2 liver tropism
spellingShingle Molecular mechanisms implicated in SARS-CoV-2 liver tropism
Quarleri, Jorge Fabian
SARS-CoV2
LIVER
COVID-19
title_short Molecular mechanisms implicated in SARS-CoV-2 liver tropism
title_full Molecular mechanisms implicated in SARS-CoV-2 liver tropism
title_fullStr Molecular mechanisms implicated in SARS-CoV-2 liver tropism
title_full_unstemmed Molecular mechanisms implicated in SARS-CoV-2 liver tropism
title_sort Molecular mechanisms implicated in SARS-CoV-2 liver tropism
dc.creator.none.fl_str_mv Quarleri, Jorge Fabian
Delpino, María Victoria
author Quarleri, Jorge Fabian
author_facet Quarleri, Jorge Fabian
Delpino, María Victoria
author_role author
author2 Delpino, María Victoria
author2_role author
dc.subject.none.fl_str_mv SARS-CoV2
LIVER
COVID-19
topic SARS-CoV2
LIVER
COVID-19
purl_subject.fl_str_mv https://purl.org/becyt/ford/3.3
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv The coronavirus disease 2019 (COVID-19) pandemic is caused by severe acuterespiratory syndrome coronavirus 2 (SARS-CoV-2). Hepatic involvement iscommon in SARS-CoV-2-infected individuals. It is currently accepted that thedirect and indirect hepatic effects of SARS-CoV-2 infection play a significant rolein COVID-19. In individuals with pre-existing infectious and non-infectious liverdisease, who are at a remarkably higher risk of developing severe COVID-19 anddeath, this pathology is most medically relevant. This review emphasizes thecurrent pathways regarded as contributing to the gastrointestinal and hepaticailments linked to COVID-19-infected patients due to an imbalanced interactionamong the liver, systemic inflammation, disrupted coagulation, and the lung.
Fil: Quarleri, Jorge Fabian. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
Fil: Delpino, María Victoria. Consejo Nacional de Investigaciones Científicas y Técnicas. Oficina de Coordinación Administrativa Houssay. Instituto de Investigaciones Biomédicas en Retrovirus y Sida. Universidad de Buenos Aires. Facultad de Medicina. Instituto de Investigaciones Biomédicas en Retrovirus y Sida; Argentina
description The coronavirus disease 2019 (COVID-19) pandemic is caused by severe acuterespiratory syndrome coronavirus 2 (SARS-CoV-2). Hepatic involvement iscommon in SARS-CoV-2-infected individuals. It is currently accepted that thedirect and indirect hepatic effects of SARS-CoV-2 infection play a significant rolein COVID-19. In individuals with pre-existing infectious and non-infectious liverdisease, who are at a remarkably higher risk of developing severe COVID-19 anddeath, this pathology is most medically relevant. This review emphasizes thecurrent pathways regarded as contributing to the gastrointestinal and hepaticailments linked to COVID-19-infected patients due to an imbalanced interactionamong the liver, systemic inflammation, disrupted coagulation, and the lung.
publishDate 2022
dc.date.none.fl_str_mv 2022-12
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/213178
Quarleri, Jorge Fabian; Delpino, María Victoria; Molecular mechanisms implicated in SARS-CoV-2 liver tropism; W J G Press; World Journal of Gastroenterology; 28; 48; 12-2022; 6875-6887
1007-9327
2219-2840
CONICET Digital
CONICET
url http://hdl.handle.net/11336/213178
identifier_str_mv Quarleri, Jorge Fabian; Delpino, María Victoria; Molecular mechanisms implicated in SARS-CoV-2 liver tropism; W J G Press; World Journal of Gastroenterology; 28; 48; 12-2022; 6875-6887
1007-9327
2219-2840
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.wjgnet.com/1007-9327/full/v28/i48/6875.htm
info:eu-repo/semantics/altIdentifier/doi/10.3748/wjg.v28.i48.6875
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv W J G Press
publisher.none.fl_str_mv W J G Press
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269059592224768
score 13.13397

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