An integrated device for magnetically-driven drug release and in situ quantitative measurements: design, fabrication and testing

Autores
Bruvera, Ignacio Javier; Hernández, R.; Mijangos Ugarte, Carmen; Goya, Rodolfo Gustavo
Año de publicación
2015
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
We have developed a device capable of remote triggering and in situ quantification of therapeutic drugs, based on magnetically-responsive hydrogels of poly (N-isopropylacrylamide) and alginate (PNiPAAm). The heating efficiency of these hydrogels measured by their specific power absorption (SPA) values showed that the values between 100 and 300 W/g of the material were high enough to reach the lower critical solution temperature (LCST) of the polymeric matrix within few minutes. The drug release through application of AC magnetic fields could be controlled by time-modulated field pulses in order to deliver the desired amount of drug. Using B12 vitamin as a concept drug, the device was calibrated to measure amounts of drug released as small as 25(2) 109 g, demonstrating the potential of this device for very precise quantitative control of drug release.
Fil: Bruvera, Ignacio Javier. Universidad de Zaragoza. Instituto de Nanociencia de Aragón; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Ópticas. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones Ópticas. Universidad Nacional de La Plata. Centro de Investigaciones Ópticas; Argentina
Fil: Hernández, R.. Instituto en Ciencia y Tecnología de Polímeros; España
Fil: Mijangos Ugarte, Carmen. Instituto en Ciencia y Tecnología de Polímeros; España
Fil: Goya, Rodolfo Gustavo. Universidad de Zaragoza. Instituto de Nanociencia de Aragón; España
Materia
Drug Release
Magnetic Nanoparticles
Magnetic Hyperthermia
Hydrogels
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/47911
Acceder
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oai_identifier_str oai:ri.conicet.gov.ar:11336/47911
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling An integrated device for magnetically-driven drug release and in situ quantitative measurements: design, fabrication and testingBruvera, Ignacio JavierHernández, R.Mijangos Ugarte, CarmenGoya, Rodolfo GustavoDrug ReleaseMagnetic NanoparticlesMagnetic HyperthermiaHydrogelshttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1We have developed a device capable of remote triggering and in situ quantification of therapeutic drugs, based on magnetically-responsive hydrogels of poly (N-isopropylacrylamide) and alginate (PNiPAAm). The heating efficiency of these hydrogels measured by their specific power absorption (SPA) values showed that the values between 100 and 300 W/g of the material were high enough to reach the lower critical solution temperature (LCST) of the polymeric matrix within few minutes. The drug release through application of AC magnetic fields could be controlled by time-modulated field pulses in order to deliver the desired amount of drug. Using B12 vitamin as a concept drug, the device was calibrated to measure amounts of drug released as small as 25(2) 109 g, demonstrating the potential of this device for very precise quantitative control of drug release.Fil: Bruvera, Ignacio Javier. Universidad de Zaragoza. Instituto de Nanociencia de Aragón; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Ópticas. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones Ópticas. Universidad Nacional de La Plata. Centro de Investigaciones Ópticas; ArgentinaFil: Hernández, R.. Instituto en Ciencia y Tecnología de Polímeros; EspañaFil: Mijangos Ugarte, Carmen. Instituto en Ciencia y Tecnología de Polímeros; EspañaFil: Goya, Rodolfo Gustavo. Universidad de Zaragoza. Instituto de Nanociencia de Aragón; EspañaElsevier Science2015-03info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/47911Bruvera, Ignacio Javier; Hernández, R.; Mijangos Ugarte, Carmen; Goya, Rodolfo Gustavo; An integrated device for magnetically-driven drug release and in situ quantitative measurements: design, fabrication and testing; Elsevier Science; Journal of Magnetism and Magnetic Materials; 377; 3-2015; 446-4510304-8853CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1016/j.jmmm.2014.10.149info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0304885314010725?via%3Dihubinfo:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-10-15T15:19:13Zoai:ri.conicet.gov.ar:11336/47911instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-10-15 15:19:13.461CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv An integrated device for magnetically-driven drug release and in situ quantitative measurements: design, fabrication and testing
title An integrated device for magnetically-driven drug release and in situ quantitative measurements: design, fabrication and testing
spellingShingle An integrated device for magnetically-driven drug release and in situ quantitative measurements: design, fabrication and testing
Bruvera, Ignacio Javier
Drug Release
Magnetic Nanoparticles
Magnetic Hyperthermia
Hydrogels
title_short An integrated device for magnetically-driven drug release and in situ quantitative measurements: design, fabrication and testing
title_full An integrated device for magnetically-driven drug release and in situ quantitative measurements: design, fabrication and testing
title_fullStr An integrated device for magnetically-driven drug release and in situ quantitative measurements: design, fabrication and testing
title_full_unstemmed An integrated device for magnetically-driven drug release and in situ quantitative measurements: design, fabrication and testing
title_sort An integrated device for magnetically-driven drug release and in situ quantitative measurements: design, fabrication and testing
dc.creator.none.fl_str_mv Bruvera, Ignacio Javier
Hernández, R.
Mijangos Ugarte, Carmen
Goya, Rodolfo Gustavo
author Bruvera, Ignacio Javier
author_facet Bruvera, Ignacio Javier
Hernández, R.
Mijangos Ugarte, Carmen
Goya, Rodolfo Gustavo
author_role author
author2 Hernández, R.
Mijangos Ugarte, Carmen
Goya, Rodolfo Gustavo
author2_role author
author
author
dc.subject.none.fl_str_mv Drug Release
Magnetic Nanoparticles
Magnetic Hyperthermia
Hydrogels
topic Drug Release
Magnetic Nanoparticles
Magnetic Hyperthermia
Hydrogels
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv We have developed a device capable of remote triggering and in situ quantification of therapeutic drugs, based on magnetically-responsive hydrogels of poly (N-isopropylacrylamide) and alginate (PNiPAAm). The heating efficiency of these hydrogels measured by their specific power absorption (SPA) values showed that the values between 100 and 300 W/g of the material were high enough to reach the lower critical solution temperature (LCST) of the polymeric matrix within few minutes. The drug release through application of AC magnetic fields could be controlled by time-modulated field pulses in order to deliver the desired amount of drug. Using B12 vitamin as a concept drug, the device was calibrated to measure amounts of drug released as small as 25(2) 109 g, demonstrating the potential of this device for very precise quantitative control of drug release.
Fil: Bruvera, Ignacio Javier. Universidad de Zaragoza. Instituto de Nanociencia de Aragón; España. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Centro de Investigaciones Ópticas. Provincia de Buenos Aires. Gobernación. Comisión de Investigaciones Científicas. Centro de Investigaciones Ópticas. Universidad Nacional de La Plata. Centro de Investigaciones Ópticas; Argentina
Fil: Hernández, R.. Instituto en Ciencia y Tecnología de Polímeros; España
Fil: Mijangos Ugarte, Carmen. Instituto en Ciencia y Tecnología de Polímeros; España
Fil: Goya, Rodolfo Gustavo. Universidad de Zaragoza. Instituto de Nanociencia de Aragón; España
description We have developed a device capable of remote triggering and in situ quantification of therapeutic drugs, based on magnetically-responsive hydrogels of poly (N-isopropylacrylamide) and alginate (PNiPAAm). The heating efficiency of these hydrogels measured by their specific power absorption (SPA) values showed that the values between 100 and 300 W/g of the material were high enough to reach the lower critical solution temperature (LCST) of the polymeric matrix within few minutes. The drug release through application of AC magnetic fields could be controlled by time-modulated field pulses in order to deliver the desired amount of drug. Using B12 vitamin as a concept drug, the device was calibrated to measure amounts of drug released as small as 25(2) 109 g, demonstrating the potential of this device for very precise quantitative control of drug release.
publishDate 2015
dc.date.none.fl_str_mv 2015-03
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/47911
Bruvera, Ignacio Javier; Hernández, R.; Mijangos Ugarte, Carmen; Goya, Rodolfo Gustavo; An integrated device for magnetically-driven drug release and in situ quantitative measurements: design, fabrication and testing; Elsevier Science; Journal of Magnetism and Magnetic Materials; 377; 3-2015; 446-451
0304-8853
CONICET Digital
CONICET
url http://hdl.handle.net/11336/47911
identifier_str_mv Bruvera, Ignacio Javier; Hernández, R.; Mijangos Ugarte, Carmen; Goya, Rodolfo Gustavo; An integrated device for magnetically-driven drug release and in situ quantitative measurements: design, fabrication and testing; Elsevier Science; Journal of Magnetism and Magnetic Materials; 377; 3-2015; 446-451
0304-8853
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jmmm.2014.10.149
info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/pii/S0304885314010725?via%3Dihub
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1846083340978880512
score 13.22299

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