In silico before in vivo: How to predict the heating efficiency of magnetic nanoparticles within the intracellular space

Autores
Sanz, Beatriz; Calatayud, M. Pilar; de Biasi, Emilio; Lima, Enio Junior; Vasquez Mansilla, Marcelo; Zysler, Roberto Daniel; Ibarra, M. Ricardo; Goya, Gerardo Fabian
Año de publicación
2016
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
This work aims to demonstrate the need for in silico design via numerical simulation to produce optimal Fe 3 O 4 -based magnetic nanoparticles (MNPs) for magnetic hyperthermia by minimizing the impact of intracellular environments on heating efficiency. By including the relevant magnetic parameters, such as magnetic anisotropy and dipolar interactions, into a numerical model, the heating efficiency of as prepared colloids was preserved in the intracellular environment, providing the largest in vitro specific power absorption (SPA) values yet reported. Dipolar interactions due to intracellular agglomeration, which are included in the simulated SPA, were found to be the main cause of changes in the magnetic relaxation dynamics of MNPs under in vitro conditions. These results pave the way for the magnetism-based design of MNPs that can retain their heating efficiency in vivo, thereby improving the outcome of clinical hyperthermia experiments.
Fil: Sanz, Beatriz. Universidad de Zaragoza; España
Fil: Calatayud, M. Pilar. Universidad de Zaragoza; España
Fil: de Biasi, Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
Fil: Lima, Enio Junior. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
Fil: Vasquez Mansilla, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
Fil: Zysler, Roberto Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
Fil: Ibarra, M. Ricardo. Universidad de Zaragoza; España
Fil: Goya, Gerardo Fabian. Universidad de Zaragoza; España
Materia
NANOPARTICLES
MAGNETIC
HYPERTHERMIA
INVITRO
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/66672
Acceder
id CONICETDig_a9b0faa74d710088b4d70abd21408e61
oai_identifier_str oai:ri.conicet.gov.ar:11336/66672
network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling In silico before in vivo: How to predict the heating efficiency of magnetic nanoparticles within the intracellular spaceSanz, BeatrizCalatayud, M. Pilarde Biasi, EmilioLima, Enio JuniorVasquez Mansilla, MarceloZysler, Roberto DanielIbarra, M. RicardoGoya, Gerardo FabianNANOPARTICLESMAGNETICHYPERTHERMIAINVITROhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1https://purl.org/becyt/ford/3.4https://purl.org/becyt/ford/3This work aims to demonstrate the need for in silico design via numerical simulation to produce optimal Fe 3 O 4 -based magnetic nanoparticles (MNPs) for magnetic hyperthermia by minimizing the impact of intracellular environments on heating efficiency. By including the relevant magnetic parameters, such as magnetic anisotropy and dipolar interactions, into a numerical model, the heating efficiency of as prepared colloids was preserved in the intracellular environment, providing the largest in vitro specific power absorption (SPA) values yet reported. Dipolar interactions due to intracellular agglomeration, which are included in the simulated SPA, were found to be the main cause of changes in the magnetic relaxation dynamics of MNPs under in vitro conditions. These results pave the way for the magnetism-based design of MNPs that can retain their heating efficiency in vivo, thereby improving the outcome of clinical hyperthermia experiments.Fil: Sanz, Beatriz. Universidad de Zaragoza; EspañaFil: Calatayud, M. Pilar. Universidad de Zaragoza; EspañaFil: de Biasi, Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; ArgentinaFil: Lima, Enio Junior. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; ArgentinaFil: Vasquez Mansilla, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; ArgentinaFil: Zysler, Roberto Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; ArgentinaFil: Ibarra, M. Ricardo. Universidad de Zaragoza; EspañaFil: Goya, Gerardo Fabian. Universidad de Zaragoza; EspañaNature Publishing Group2016-12-07info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/66672Sanz, Beatriz; Calatayud, M. Pilar; de Biasi, Emilio; Lima, Enio Junior; Vasquez Mansilla, Marcelo; et al.; In silico before in vivo: How to predict the heating efficiency of magnetic nanoparticles within the intracellular space; Nature Publishing Group; Scientific Reports; 6; 38733; 7-12-2016; 38733/1-38733/192045-2322CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/doi/10.1038/srep38733info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/srep38733info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:05:00Zoai:ri.conicet.gov.ar:11336/66672instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:05:00.818CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv In silico before in vivo: How to predict the heating efficiency of magnetic nanoparticles within the intracellular space
title In silico before in vivo: How to predict the heating efficiency of magnetic nanoparticles within the intracellular space
spellingShingle In silico before in vivo: How to predict the heating efficiency of magnetic nanoparticles within the intracellular space
Sanz, Beatriz
NANOPARTICLES
MAGNETIC
HYPERTHERMIA
INVITRO
title_short In silico before in vivo: How to predict the heating efficiency of magnetic nanoparticles within the intracellular space
title_full In silico before in vivo: How to predict the heating efficiency of magnetic nanoparticles within the intracellular space
title_fullStr In silico before in vivo: How to predict the heating efficiency of magnetic nanoparticles within the intracellular space
title_full_unstemmed In silico before in vivo: How to predict the heating efficiency of magnetic nanoparticles within the intracellular space
title_sort In silico before in vivo: How to predict the heating efficiency of magnetic nanoparticles within the intracellular space
dc.creator.none.fl_str_mv Sanz, Beatriz
Calatayud, M. Pilar
de Biasi, Emilio
Lima, Enio Junior
Vasquez Mansilla, Marcelo
Zysler, Roberto Daniel
Ibarra, M. Ricardo
Goya, Gerardo Fabian
author Sanz, Beatriz
author_facet Sanz, Beatriz
Calatayud, M. Pilar
de Biasi, Emilio
Lima, Enio Junior
Vasquez Mansilla, Marcelo
Zysler, Roberto Daniel
Ibarra, M. Ricardo
Goya, Gerardo Fabian
author_role author
author2 Calatayud, M. Pilar
de Biasi, Emilio
Lima, Enio Junior
Vasquez Mansilla, Marcelo
Zysler, Roberto Daniel
Ibarra, M. Ricardo
Goya, Gerardo Fabian
author2_role author
author
author
author
author
author
author
dc.subject.none.fl_str_mv NANOPARTICLES
MAGNETIC
HYPERTHERMIA
INVITRO
topic NANOPARTICLES
MAGNETIC
HYPERTHERMIA
INVITRO
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
https://purl.org/becyt/ford/3.4
https://purl.org/becyt/ford/3
dc.description.none.fl_txt_mv This work aims to demonstrate the need for in silico design via numerical simulation to produce optimal Fe 3 O 4 -based magnetic nanoparticles (MNPs) for magnetic hyperthermia by minimizing the impact of intracellular environments on heating efficiency. By including the relevant magnetic parameters, such as magnetic anisotropy and dipolar interactions, into a numerical model, the heating efficiency of as prepared colloids was preserved in the intracellular environment, providing the largest in vitro specific power absorption (SPA) values yet reported. Dipolar interactions due to intracellular agglomeration, which are included in the simulated SPA, were found to be the main cause of changes in the magnetic relaxation dynamics of MNPs under in vitro conditions. These results pave the way for the magnetism-based design of MNPs that can retain their heating efficiency in vivo, thereby improving the outcome of clinical hyperthermia experiments.
Fil: Sanz, Beatriz. Universidad de Zaragoza; España
Fil: Calatayud, M. Pilar. Universidad de Zaragoza; España
Fil: de Biasi, Emilio. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
Fil: Lima, Enio Junior. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
Fil: Vasquez Mansilla, Marcelo. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
Fil: Zysler, Roberto Daniel. Consejo Nacional de Investigaciones Científicas y Técnicas; Argentina. Comisión Nacional de Energía Atómica. Centro Atómico Bariloche; Argentina
Fil: Ibarra, M. Ricardo. Universidad de Zaragoza; España
Fil: Goya, Gerardo Fabian. Universidad de Zaragoza; España
description This work aims to demonstrate the need for in silico design via numerical simulation to produce optimal Fe 3 O 4 -based magnetic nanoparticles (MNPs) for magnetic hyperthermia by minimizing the impact of intracellular environments on heating efficiency. By including the relevant magnetic parameters, such as magnetic anisotropy and dipolar interactions, into a numerical model, the heating efficiency of as prepared colloids was preserved in the intracellular environment, providing the largest in vitro specific power absorption (SPA) values yet reported. Dipolar interactions due to intracellular agglomeration, which are included in the simulated SPA, were found to be the main cause of changes in the magnetic relaxation dynamics of MNPs under in vitro conditions. These results pave the way for the magnetism-based design of MNPs that can retain their heating efficiency in vivo, thereby improving the outcome of clinical hyperthermia experiments.
publishDate 2016
dc.date.none.fl_str_mv 2016-12-07
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/66672
Sanz, Beatriz; Calatayud, M. Pilar; de Biasi, Emilio; Lima, Enio Junior; Vasquez Mansilla, Marcelo; et al.; In silico before in vivo: How to predict the heating efficiency of magnetic nanoparticles within the intracellular space; Nature Publishing Group; Scientific Reports; 6; 38733; 7-12-2016; 38733/1-38733/19
2045-2322
CONICET Digital
CONICET
url http://hdl.handle.net/11336/66672
identifier_str_mv Sanz, Beatriz; Calatayud, M. Pilar; de Biasi, Emilio; Lima, Enio Junior; Vasquez Mansilla, Marcelo; et al.; In silico before in vivo: How to predict the heating efficiency of magnetic nanoparticles within the intracellular space; Nature Publishing Group; Scientific Reports; 6; 38733; 7-12-2016; 38733/1-38733/19
2045-2322
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/doi/10.1038/srep38733
info:eu-repo/semantics/altIdentifier/url/https://www.nature.com/articles/srep38733
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
application/pdf
application/pdf
dc.publisher.none.fl_str_mv Nature Publishing Group
publisher.none.fl_str_mv Nature Publishing Group
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
_version_ 1842269885995941888
score 13.13397

Publicaciones similares