Typical experiment vs. in-cell like conditions in magnetic hyperthermia: Effects of media viscosity and agglomeration

Autores
Bruvera, Ignacio Javier; Actis, Daniel Guillermo; Calatayud, María Pilar; Mendoza Zélis, Pedro
Año de publicación
2019
Idioma
inglés
Tipo de recurso
artículo
Estado
versión publicada
Descripción
Magnetic nanoparticles (MNPs) can be used to transform electromagnetic energy into heat in hyperthermic treatment of cancer and other thermally activated therapies. The MNPs heating efficiency depends strongly on the combination of the MNPs’ structural properties and environmental conditions. MNPs hyperthermic yield is usually studied in diluted suspensions, although, in the actual therapy, the particles end mostly aggregated and fixed into cellular structures. In this work, the heating efficiency of low size dispersion Fe3O4 MNPs, defined as the Specific Absorption Rate (SAR), was studied in two conditions: liquid suspension (ferrofluid FF, typical characterization state) and gel matrix (ferrogel FG, mimicking biological application environment). The samples were characterized by TEM, ZFC-FC and SAXS. Their magnetic response to radio-frequency fields was measured by induction in order to obtain SAR values from the magnetization cycles area. 3D maps of SAR versus field amplitude and frequency were elaborated in order to compare the response of fixed and suspended MNPs. Structural characterization shows FG's MNPs agglomerated in a crystal-like mesostructure with a well defined interparticle distance. SAR results show a clear difference of behaviour between liquid and gel matrices, with larger SAR values for the FG sample indicating a lower resonance frequency, inside the studied region, for fixed MNP. Additionally, the local maximum suggested in FG's SAR map indicates a behaviour outside linear response regimen as expected for the applied field amplitudes.
Fil: Bruvera, Ignacio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Fil: Actis, Daniel Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Fil: Calatayud, María Pilar. Universidad de Zaragoza. Facultad de Ciencias. Departamento de Física de la Materia Condensada; España. Universidad de Zaragoza. Instituto de Nanociencia de Aragón; España
Fil: Mendoza Zélis, Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Materia
MAGNETIC HYPERTHERMIA
MAGNETIC NANOPARTICLES
SPECIFIC ABSORPTION RATE
Nivel de accesibilidad
acceso abierto
Condiciones de uso
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
Repositorio
CONICET Digital (CONICET)
Institución
Consejo Nacional de Investigaciones Científicas y Técnicas
OAI Identificador
oai:ri.conicet.gov.ar:11336/129099
Acceder
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network_acronym_str CONICETDig
repository_id_str 3498
network_name_str CONICET Digital (CONICET)
spelling Typical experiment vs. in-cell like conditions in magnetic hyperthermia: Effects of media viscosity and agglomerationBruvera, Ignacio JavierActis, Daniel GuillermoCalatayud, María PilarMendoza Zélis, PedroMAGNETIC HYPERTHERMIAMAGNETIC NANOPARTICLESSPECIFIC ABSORPTION RATEhttps://purl.org/becyt/ford/1.3https://purl.org/becyt/ford/1Magnetic nanoparticles (MNPs) can be used to transform electromagnetic energy into heat in hyperthermic treatment of cancer and other thermally activated therapies. The MNPs heating efficiency depends strongly on the combination of the MNPs’ structural properties and environmental conditions. MNPs hyperthermic yield is usually studied in diluted suspensions, although, in the actual therapy, the particles end mostly aggregated and fixed into cellular structures. In this work, the heating efficiency of low size dispersion Fe3O4 MNPs, defined as the Specific Absorption Rate (SAR), was studied in two conditions: liquid suspension (ferrofluid FF, typical characterization state) and gel matrix (ferrogel FG, mimicking biological application environment). The samples were characterized by TEM, ZFC-FC and SAXS. Their magnetic response to radio-frequency fields was measured by induction in order to obtain SAR values from the magnetization cycles area. 3D maps of SAR versus field amplitude and frequency were elaborated in order to compare the response of fixed and suspended MNPs. Structural characterization shows FG's MNPs agglomerated in a crystal-like mesostructure with a well defined interparticle distance. SAR results show a clear difference of behaviour between liquid and gel matrices, with larger SAR values for the FG sample indicating a lower resonance frequency, inside the studied region, for fixed MNP. Additionally, the local maximum suggested in FG's SAR map indicates a behaviour outside linear response regimen as expected for the applied field amplitudes.Fil: Bruvera, Ignacio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Actis, Daniel Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaFil: Calatayud, María Pilar. Universidad de Zaragoza. Facultad de Ciencias. Departamento de Física de la Materia Condensada; España. Universidad de Zaragoza. Instituto de Nanociencia de Aragón; EspañaFil: Mendoza Zélis, Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; ArgentinaElsevier Science2019-12-01info:eu-repo/semantics/articleinfo:eu-repo/semantics/publishedVersionhttp://purl.org/coar/resource_type/c_6501info:ar-repo/semantics/articuloapplication/pdfapplication/pdfhttp://hdl.handle.net/11336/129099Bruvera, Ignacio Javier; Actis, Daniel Guillermo; Calatayud, María Pilar; Mendoza Zélis, Pedro; Typical experiment vs. in-cell like conditions in magnetic hyperthermia: Effects of media viscosity and agglomeration; Elsevier Science; Journal of Magnetism and Magnetic Materials; 491; 165563; 1-12-2019; 1-180304-8853CONICET DigitalCONICETenginfo:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0304885319310510info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jmmm.2019.165563info:eu-repo/semantics/openAccesshttps://creativecommons.org/licenses/by-nc-sa/2.5/ar/reponame:CONICET Digital (CONICET)instname:Consejo Nacional de Investigaciones Científicas y Técnicas2025-09-03T10:00:38Zoai:ri.conicet.gov.ar:11336/129099instacron:CONICETInstitucionalhttp://ri.conicet.gov.ar/Organismo científico-tecnológicoNo correspondehttp://ri.conicet.gov.ar/oai/requestdasensio@conicet.gov.ar; lcarlino@conicet.gov.arArgentinaNo correspondeNo correspondeNo correspondeopendoar:34982025-09-03 10:00:38.983CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicasfalse
dc.title.none.fl_str_mv Typical experiment vs. in-cell like conditions in magnetic hyperthermia: Effects of media viscosity and agglomeration
title Typical experiment vs. in-cell like conditions in magnetic hyperthermia: Effects of media viscosity and agglomeration
spellingShingle Typical experiment vs. in-cell like conditions in magnetic hyperthermia: Effects of media viscosity and agglomeration
Bruvera, Ignacio Javier
MAGNETIC HYPERTHERMIA
MAGNETIC NANOPARTICLES
SPECIFIC ABSORPTION RATE
title_short Typical experiment vs. in-cell like conditions in magnetic hyperthermia: Effects of media viscosity and agglomeration
title_full Typical experiment vs. in-cell like conditions in magnetic hyperthermia: Effects of media viscosity and agglomeration
title_fullStr Typical experiment vs. in-cell like conditions in magnetic hyperthermia: Effects of media viscosity and agglomeration
title_full_unstemmed Typical experiment vs. in-cell like conditions in magnetic hyperthermia: Effects of media viscosity and agglomeration
title_sort Typical experiment vs. in-cell like conditions in magnetic hyperthermia: Effects of media viscosity and agglomeration
dc.creator.none.fl_str_mv Bruvera, Ignacio Javier
Actis, Daniel Guillermo
Calatayud, María Pilar
Mendoza Zélis, Pedro
author Bruvera, Ignacio Javier
author_facet Bruvera, Ignacio Javier
Actis, Daniel Guillermo
Calatayud, María Pilar
Mendoza Zélis, Pedro
author_role author
author2 Actis, Daniel Guillermo
Calatayud, María Pilar
Mendoza Zélis, Pedro
author2_role author
author
author
dc.subject.none.fl_str_mv MAGNETIC HYPERTHERMIA
MAGNETIC NANOPARTICLES
SPECIFIC ABSORPTION RATE
topic MAGNETIC HYPERTHERMIA
MAGNETIC NANOPARTICLES
SPECIFIC ABSORPTION RATE
purl_subject.fl_str_mv https://purl.org/becyt/ford/1.3
https://purl.org/becyt/ford/1
dc.description.none.fl_txt_mv Magnetic nanoparticles (MNPs) can be used to transform electromagnetic energy into heat in hyperthermic treatment of cancer and other thermally activated therapies. The MNPs heating efficiency depends strongly on the combination of the MNPs’ structural properties and environmental conditions. MNPs hyperthermic yield is usually studied in diluted suspensions, although, in the actual therapy, the particles end mostly aggregated and fixed into cellular structures. In this work, the heating efficiency of low size dispersion Fe3O4 MNPs, defined as the Specific Absorption Rate (SAR), was studied in two conditions: liquid suspension (ferrofluid FF, typical characterization state) and gel matrix (ferrogel FG, mimicking biological application environment). The samples were characterized by TEM, ZFC-FC and SAXS. Their magnetic response to radio-frequency fields was measured by induction in order to obtain SAR values from the magnetization cycles area. 3D maps of SAR versus field amplitude and frequency were elaborated in order to compare the response of fixed and suspended MNPs. Structural characterization shows FG's MNPs agglomerated in a crystal-like mesostructure with a well defined interparticle distance. SAR results show a clear difference of behaviour between liquid and gel matrices, with larger SAR values for the FG sample indicating a lower resonance frequency, inside the studied region, for fixed MNP. Additionally, the local maximum suggested in FG's SAR map indicates a behaviour outside linear response regimen as expected for the applied field amplitudes.
Fil: Bruvera, Ignacio Javier. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Fil: Actis, Daniel Guillermo. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
Fil: Calatayud, María Pilar. Universidad de Zaragoza. Facultad de Ciencias. Departamento de Física de la Materia Condensada; España. Universidad de Zaragoza. Instituto de Nanociencia de Aragón; España
Fil: Mendoza Zélis, Pedro. Consejo Nacional de Investigaciones Científicas y Técnicas. Centro Científico Tecnológico Conicet - La Plata. Instituto de Física La Plata. Universidad Nacional de La Plata. Facultad de Ciencias Exactas. Instituto de Física La Plata; Argentina
description Magnetic nanoparticles (MNPs) can be used to transform electromagnetic energy into heat in hyperthermic treatment of cancer and other thermally activated therapies. The MNPs heating efficiency depends strongly on the combination of the MNPs’ structural properties and environmental conditions. MNPs hyperthermic yield is usually studied in diluted suspensions, although, in the actual therapy, the particles end mostly aggregated and fixed into cellular structures. In this work, the heating efficiency of low size dispersion Fe3O4 MNPs, defined as the Specific Absorption Rate (SAR), was studied in two conditions: liquid suspension (ferrofluid FF, typical characterization state) and gel matrix (ferrogel FG, mimicking biological application environment). The samples were characterized by TEM, ZFC-FC and SAXS. Their magnetic response to radio-frequency fields was measured by induction in order to obtain SAR values from the magnetization cycles area. 3D maps of SAR versus field amplitude and frequency were elaborated in order to compare the response of fixed and suspended MNPs. Structural characterization shows FG's MNPs agglomerated in a crystal-like mesostructure with a well defined interparticle distance. SAR results show a clear difference of behaviour between liquid and gel matrices, with larger SAR values for the FG sample indicating a lower resonance frequency, inside the studied region, for fixed MNP. Additionally, the local maximum suggested in FG's SAR map indicates a behaviour outside linear response regimen as expected for the applied field amplitudes.
publishDate 2019
dc.date.none.fl_str_mv 2019-12-01
dc.type.none.fl_str_mv info:eu-repo/semantics/article
info:eu-repo/semantics/publishedVersion
http://purl.org/coar/resource_type/c_6501
info:ar-repo/semantics/articulo
format article
status_str publishedVersion
dc.identifier.none.fl_str_mv http://hdl.handle.net/11336/129099
Bruvera, Ignacio Javier; Actis, Daniel Guillermo; Calatayud, María Pilar; Mendoza Zélis, Pedro; Typical experiment vs. in-cell like conditions in magnetic hyperthermia: Effects of media viscosity and agglomeration; Elsevier Science; Journal of Magnetism and Magnetic Materials; 491; 165563; 1-12-2019; 1-18
0304-8853
CONICET Digital
CONICET
url http://hdl.handle.net/11336/129099
identifier_str_mv Bruvera, Ignacio Javier; Actis, Daniel Guillermo; Calatayud, María Pilar; Mendoza Zélis, Pedro; Typical experiment vs. in-cell like conditions in magnetic hyperthermia: Effects of media viscosity and agglomeration; Elsevier Science; Journal of Magnetism and Magnetic Materials; 491; 165563; 1-12-2019; 1-18
0304-8853
CONICET Digital
CONICET
dc.language.none.fl_str_mv eng
language eng
dc.relation.none.fl_str_mv info:eu-repo/semantics/altIdentifier/url/https://www.sciencedirect.com/science/article/abs/pii/S0304885319310510
info:eu-repo/semantics/altIdentifier/doi/10.1016/j.jmmm.2019.165563
dc.rights.none.fl_str_mv info:eu-repo/semantics/openAccess
https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
eu_rights_str_mv openAccess
rights_invalid_str_mv https://creativecommons.org/licenses/by-nc-sa/2.5/ar/
dc.format.none.fl_str_mv application/pdf
application/pdf
dc.publisher.none.fl_str_mv Elsevier Science
publisher.none.fl_str_mv Elsevier Science
dc.source.none.fl_str_mv reponame:CONICET Digital (CONICET)
instname:Consejo Nacional de Investigaciones Científicas y Técnicas
reponame_str CONICET Digital (CONICET)
collection CONICET Digital (CONICET)
instname_str Consejo Nacional de Investigaciones Científicas y Técnicas
repository.name.fl_str_mv CONICET Digital (CONICET) - Consejo Nacional de Investigaciones Científicas y Técnicas
repository.mail.fl_str_mv dasensio@conicet.gov.ar; lcarlino@conicet.gov.ar
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